@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2J3_HUMAN: (2016-01-13 )
MNDDGKVNASSEGYFILVGFSNWPHLEVVIFVVVLIFYLMTLIGNLFIIILSYLDSHLHTPMYFFLSNLSFLDLCYTTSSIPQLLVNLWGPEKTISYAGCMIQLYFVLALGTTECVLLVVMSYDRYAAVCRPLHYTVLMHPRFCHLLAVASWVSGFTNSALHSSFTFWVPLCGHRQVDHFFCEVPALLRLSCVDTHVNELTLMITSSIFVLIPLILILTSYGAIVRAVLRMQSTTGLQKVFGTCGAHLMAVSLFFIPAMCIYLQPPSGNSQDQGKFIALFYTVVTPSLNPLIYTLRNKVVRGAVKRLMGWE
Atome Classification :
(20 SA)
-------------.........10........20..---------------......30........40...---.....50........60........70........80.......------..90.......------.100.......110.......120.......130.......140...---....150........160.......170.......180.......190-.-------....------.-.200.......--210.......220---....----....230...-----------.--------------------.----...240.......250.......260--------.......-.--------.---270---....-------.---...280...-....290.......300......-------.310--------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MNDDGKVNASSE
G
Y
F
I
L
V
GFSNW---------------P
H
L
E
V
V
I
F
V
V
V
L
I
F
Y
L
M
T
L
I
G
---
N
L
F
I
I
I
L
S
Y
L
D
S
HLH
T
P
M
Y
F
F
L
SNL
S
F
L
D
L
CYTT
S
S
-
I
P
Q
L
L
V
N
------LWGPEK
T
I
S
Y
A
------
G
C
M
I
Q
L
Y
F
V
L
ALGTT
E
C
V
L
L
V
V
MSY
D
R
Y
A
A
V
CR
P
L
H
Y
T
V
LMH
P
R
F
C
H
---
L
L
A
V
A
-
S
W
V
S
G
F
T
N
S
A
LHSS
F
T
F
W
V
PLCGHR
Q
V
D
H
F
F
C
E
V
P
A
L
L
R
L
S
C
-
V
-------DTH
V
------
N
-
E
L
T
L
M
I
T
S
S
I
F
--
V
L
I
P
L
I
L
I
L
TS
Y
----
G
A
I
V
----
R
A
V
L
R
-
M
QST-----------T--------------------
G
----
L
Q
K
V
F
G
T
C
G
A
H
L
M
A
V
S
L
F
F
I
P
A
M
C
----------
I
Y
L
QPPS-G--------N---S-Q---DQ
G
K
-------
F
---
I
A
L
F
Y
T
VVT-PS
L
N
P
L
I
Y
T
L
R
N
K
V
V
R
G
A
V
K
R
LM-------GWE---------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.70
21%
-164
- C3 -
3REY
1
AA2AR_HUMAN
A:
[8-303]
--------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
---
G
I
I
A
I
-
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
-------
F
E
D
V
------
V
-
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
----
R
Q
L
K
Q
-
M
E
S
Q
PLPGE
R
A
R
---
S
--------------------
T
----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
---
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
---
A
-
P
---
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.38
21%
-163
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[8-303]
--------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
---
G
I
I
A
I
-
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
-------
F
E
D
V
------
V
-
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
----
R
Q
L
K
Q
-
M
E
S
Q
PLPG
E
R
A
R
---
S
--------------------
T
----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
---
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
---
A
-
P
---
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
87.36
21%
-163
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[8-303]
--------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
---
G
I
I
A
I
-
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
-------
F
E
D
V
------
V
-
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
----
R
Q
L
K
Q
-
M
E
S
Q
PLPG
E
R
A
R
---
S
--------------------
T
----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
---
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
---
A
-
P
---
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.15
21%
-162
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[8-303]
--------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
---
G
I
I
A
I
-
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
-------
F
E
D
V
------
V
-
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
----
R
Q
L
K
Q
-
M
E
S
Q
PLPG
E
R
A
R
---
S
--------------------
T
----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
---
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
---
A
-
P
---
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.13
21%
-163
- C3 -
3PWH
1
?
A:
[8-303]
--------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
---
G
I
I
A
I
-
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
-------
F
E
D
V
------
V
-
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
----
R
Q
L
K
Q
-
M
E
S
Q
PLPGE
R
A
R
---
S
--------------------
T
----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
---
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
---
A
-
P
---
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
83.23
21%
-133
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPF
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
-
E
P
W
---------------
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
---
L
T
L
Y
V
T
V
Q
H
--
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
------
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
---
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
------
Y
I
P
E
G
M
Q
C
S
C
-
G
I
DYYTPH
E
E
T
N
------
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
----
F
T
V
K
E
-
A
A
A
S
-----------
A
--------------------
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
----------
P
Y
A
G
V
A
F
-
Y
--------
I
---
F
-
T
---
H
Q
G
S
DFGPIFM
T
---
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
KNPSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
79.78
20%
-127
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------
M
N
G
-----
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
VVRSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
------
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
---
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
-
G
I
DYYTPH
E
E
T
N
------
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
----
F
T
V
K
E
-
A
A
A
Q
-----------
Q
--------------------
Q
ESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
----------
P
Y
A
G
V
A
F
-
Y
--------
I
---
F
-
T
---
H
Q
G
S
DFGPIFM
T
---
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPL
G
D
D
EA
S
T
T
V
S
K
TETSQVAPA----------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
79.44
23%
-129
- C3 -
1F88
7
OPSD_BOVIN
A:
[45-314]
-----------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
-------
D
Y
Y
T
PHEETN
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
FTVK
E
A
A
A
-----
S
-----------
A
--------------------
T
----
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
----------
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
---
G
-
S
---
D
F
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.21
23%
-124
- C3 -
3C9L
13
OPSD_BOVIN
A:
[45-314]
-----------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
-------
D
Y
Y
T
PHEETN
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
-
Q
Q
E
S
-----------
A
--------------------
T
----
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
----------
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
---
G
-
S
---
D
F
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
78.91
16%
-137
- C3 -
2Z73
5
OPSD_TODPA
A:
[34-332]
------------------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
------
C
F
L
K
K
W
I
F
G
F
A
------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
---
I
M
I
I
F
-
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
----
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------------
R
D
S
T
------
T
-
R
S
N
I
L
C
M
F
I
L
G
--
F
F
G
P
I
L
I
I
F
F
C
Y
----
F
N
I
V
----
M
S
V
S
N
-
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
----
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
----------
V
A
L
L
A
Q
F
-
G
--------
P
LEW
V
-
T
---
P
Y
A
A
-------
Q
---
L
P
V
M
F
A
K
A
S
-
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-------
P
W
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.99
23%
-130
- C3 -
3DQB
4
GNAT1_BOVIN (first)
A:
[45-314]
-----------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
-------
D
Y
Y
T
PHEETN
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
-
Q
Q
E
S
-----------
A
--------------------
T
----
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
----------
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
---
G
-
S
---
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.79
23%
-128
- C3 -
4J4Q
8
GNAT1_BOVIN (first)
A:
[45-314]
-----------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
-------
D
Y
Y
T
PHEETN
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
-
Q
Q
E
S
-----------
A
--------------------
T
----
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
----------
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
---
G
-
S
---
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.59
23%
-131
- C3 -
3PQR
9
OPSD_BOVIN
A:
[45-314]
-----------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
-------
D
Y
Y
T
PHEETN
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
-
Q
Q
E
S
-----------
A
--------------------
T
----
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
----------
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
---
G
-
S
---
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.31
23%
-129
- C3 -
3PXO
4
OPSD_BOVIN
A:
[45-314]
-----------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
-------
D
Y
Y
T
PHEETN
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
-
Q
Q
E
S
-----------
A
--------------------
T
----
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
----------
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
---
G
-
S
---
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.34
23%
-127
- C3 -
3CAP
4
OPSD_BOVIN
A:
[45-314]
-----------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
-------
D
Y
Y
T
PHEETN
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
-
Q
Q
E
S
-----------
A
--------------------
T
----
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
----------
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
---
G
-
S
---
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
74.33
14%
-139
* C3 *
2KS9
1
NK1R_HUMAN
A:
[35-322]
---------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
------
A
V
H
N
E
W
Y
Y
G
L
F
------
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
---
V
V
I
C
V
-
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
---
E
-
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------
N
K
I
Y
------
E
-
K
V
Y
H
I
C
V
T
V
L
I
--
Y
F
L
P
L
L
V
I
G
Y
A
Y
----
T
V
V
G
----
I
T
L
W
A
-
S
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
----
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
----------
F
F
L
L
P
Y
I
-
N
PD------
L
---
Y
L
K
KFI
Q
Q
V
Y
-------
L
---
A
I
M
W
L
A
M
S
S
-
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-------
R
C
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
73.99
18%
-134
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-324]
-------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
------
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
---
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
---
I
-
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
----
H
-------
E
E
T
N
------
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
----
F
T
V
K
E
-
A
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
----------
V
A
F
Y
I
F
T
H
Q
GS------
D
---
F
-
G
---
P
I
F
M
-------
T
---
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
72.63
16%
-119
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------
D
---------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
------
I
L
M
K
M
W
T
F
G
N
F
------
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
---
V
I
I
L
M
-
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
---------
D
F
F
T
------
N
-
Q
A
Y
A
I
A
S
S
I
V
S
--
F
Y
V
P
L
V
I
M
V
F
V
Y
----
S
R
V
F
----
Q
E
A
K
R
Q
L
N
I
F
-----------
E
--------------------
M
----
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
----------
H
L
L
T
K
S
P
-
S
--------
L
---
N
-
A
---
A
K
S
E
-------
L
---
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
-------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
13
PsiBlast_PDB
70.55
23%
-115
- C3 -
1LN6
1
OPSD_BOVIN
A:
[45-312]
-----------------------------------------------------------------
F
L
L
I
M
L
G
FPI
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
SLHGYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
NHA
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
-------
D
Y
Y
T
PHEETN
N
-
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
TVK
E
A
A
A
Q
-
Q
Q
E
S
-----------
A
--------------------
T
----
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
----------
I
C
W
L
P
Y
A
-
G
V
A
F
Y
IFTH
Q
---
G
-
S
---
D
F
G
P
-------
I
FMT
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
V
A
T
-------
T
L
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
68.97
22%
-158
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-221]
-------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
------
S
T
--
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
---
G
I
I
A
I
-
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
---
V
A
C
-
L
-------
F
E
D
V
V-----
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
L
V
P
L
L
L
M
L
G
V
Y
----
L
R
I
F
----
L
A
A
R
R
-
Q
L
N
I
-----------
F
--------------------
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
----------
G
H
L
L
T
K
S
-
P
--------
S
---
L
-
N
---
A
A
K
S
-------
E
---
L
D
K
A
I
G
R
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-------
I
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------