@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2T8_HUMAN: (2016-01-13 )
MENGSYTSYFILLGLFNHTRAHQVLFMMVLSIVLTSLFGNSLMILLIHWDHRLHTPMYFLLSQLSLMDVMLVSTTVPKMAADYLTGSKAISRAGCGAQIFFLPTLGGGECFLLAAMAYDRYAAVCHPLRYPTLMSWQLCLRMNLSCWLLGAADGLLQAVATLSFPYCGAHEIDHFFCETPVLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLHMRSTEARKKAFATCSSHVAVVGLFYGAAIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVKNSEVKGALTRCMGRCVALSRE
Atome Classification :
(20 SA)
.......--..10...----------------.---------------....20........30..-.....---.40........50........-----60........70....-....80-.......-.90........100.......110..----.....120.......130.......140.......150...-....160.......170.......180-------------------.....--.-----.190.......200...--.--....--210....-...220----.....-.------------..-----------.--------------------230-.-----------.....---------------..240.....-----..-------250.-------......260--.------.----.----..--.--.270-----.........280.......290.......300-.------------------......310---------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MENGS
Y
T
--
S
Y
F
I
L
L
G----------------L---------------FNH
T
R
A
H
Q
V
L
F
M
M
V
L
S
I
V
-
L
T
S
LF---GN
S
L
M
I
L
L
I
HWDHRLH
T
P
M
Y
F
-----
L
L
S
Q
L
S
L
M
D
V
M
L
VSTT-
V
P
K
M
A
A
-
D
Y
LTG
S
K
-
A
I
SRAGCG
A
Q
I
F
F
L
P
TLGGG
E
C
F
L
L
A
----
A
M
A
Y
D
R
Y
A
A
V
CHPLRYP
T
L
M
S
W
Q
L
C
L
RMNL
S
C
W
L
L
G
A
A
D
G
L
-
L
Q
A
V
A
T
LSFPYCG
A
H
E
I
D
H
F
FCET
P
V
L
-------------------
V
R
L
AC--A-----D
T
S
V
F
E
N
A
M
Y
I
C
C
-
V
L
M
--
L
--
L
V
P
F
--
S
L
I
L
S
S
Y
-
G
L
I
L
------
A
A
V
L
H
-M------------RS-----------
T
--------------------
E
A
--
R
-----------
K
K
A
F
A
---------------
T
C
S
S
H
V
A
V
V
G
-----
L
F
-------
Y
G
A
A
-------
I
F
T
YMRPKS--H------R----S----T
N
--
H
--
D
K
-------
V
V
S
A
F
Y
T
M
F
T
P
L
L
N
P
L
I
Y
SVKN
S
E
V
K
G
A
L
T
R
C
-
M
------------------
G
R
C
VALSRE---------------------------
13
PsiBlast_PDB
95.09
22%
-128
- C4 -
2YDO
3
?
A:
[14-312]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
-
A
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
-------------------
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
-
L
------------
K
Q
-----------
M
--------------------
E
S
---T
L
---------
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
I
V
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
H
V
L
R
Q
Q
E
---------------------------
14
PsiBlast_PDB
94.34
22%
-131
- C4 -
2YDV
6
?
A:
[14-312]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
-
A
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
-------------------
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
-
L
------------
K
Q
-----------
M
--------------------
E
S
--
Q
S
T
L
--------
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
I
V
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
H
V
L
R
Q
Q
E
---------------------------
9
PsiBlast_PDB
94.09
22%
-140
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
-
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
-------------------
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPG
E
R
A
-----------
R
--------------------
S
T
--
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
I
A
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
----------------------------------
7
PsiBlast_PDB
93.37
22%
-141
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
-
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
-------------------
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPGE
R
A
-----------
R
--------------------
S
T
--
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
I
A
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
----------------------------------
10
PsiBlast_PDB
93.25
22%
-140
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
-
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
-------------------
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPG
E
R
A
-----------
R
--------------------
S
T
--
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
I
A
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
----------------------------------
8
PsiBlast_PDB
93.00
22%
-139
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
-
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
-------------------
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPG
E
R
A
-----------
R
--------------------
S
T
--
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
I
A
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
----------------------------------
16
PsiBlast_PDB
92.78
22%
-132
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[14-312]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
-
A
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
-------------------
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
-
L
------------
K
Q
-----------
M
--------------------
E
S
--
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
I
V
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
---------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
H
V
L
R
Q
Q
E
---------------------------
6
PsiBlast_PDB
92.75
22%
-141
- C4 -
3PWH
1
?
A:
[14-305]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
-
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
-------------------
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPGE
R
A
-----------
R
--------------------
S
T
--
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
I
A
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
----------------------------------
12
PsiBlast_PDB
91.65
22%
-139
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[14-308]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
-
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
-------------------
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
-
L
------------
K
Q
-----------
M
--------------------
E
S
--
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
I
V
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
H
V
L
-------------------------------
11
PsiBlast_PDB
91.54
22%
-143
- C4 -
3VG9
8
?
A:
[14-309]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
-
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
-------------------
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
-
L
------------
K
Q
-----------
M
--------------------
E
S
--
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
I
V
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
H
V
L
R
------------------------------
15
PsiBlast_PDB
91.46
22%
-137
- C4 -
4UG2
3
?
A:
[14-309]
--------------------------------------------------------------
L
A
I
A
-
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-----
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
-
A
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
----
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
-------------------
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
--
V
--
L
V
P
L
--
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
-
L
---------------------------------------------------A
R
S
T
L
------
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
I
V
G
-----
L
F
A
L
C
W
L
P
L
H
I
I
N
-------
C
F
T
F
F
C
P
D
C
--
S
------
H
----
A
----
P
L
--
W
--
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
------------------
R
S
H
V
L
R
------------------------------
39
Fugue
85.54
18%
-114
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
--
P
N
F
Y
V
P
F
SNKTGVVRSPFEAPQY
Y
---------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-----
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
-
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
----
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
---------
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
------
Y
I
P
E
G
-------------------
M
Q
C
S
C
--
G
I
DYYT
P
H
E
E
T
N
N
E
S
F
V
I
Y
-
M
F
V
VH
F
--
I
I
P
L
--
I
V
I
F
F
C
Y
-
G
Q
L
V
------
F
T
V
K
E
-
A
------------
A
A
-----------
S
--------------------
A
T
--
T
-----------
Q
K
A
E
K
---------------
E
V
T
R
M
V
I
I
M
V
-----
I
A
-------
F
L
I
C
-------
W
L
P
Y
A
G
V
A
F
--
Y
------
I
----
F
----
T
H
--
Q
--
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
------------------
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------
33
HHSearch
84.88
17%
-132
- C4 -
2Z73
5
OPSD_TODPA
A:
[33-333]
-----------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
-
I
I
G
C
G
---
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
-----
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
-
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
----
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
-
G
P
I
F
G
W
G
A
Y
---
T
-
L
E
G
V
L
C
N
C
S
F
D
Y
I
-------------------
S
R
------------
D
S
T
T
R
S
N
I
L
C
M
F
-
I
L
G
--
F
--
F
G
P
I
--
L
I
I
F
F
C
Y
-
F
N
I
V
------
M
S
V
S
N
-
H
------------
E
K
-----------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
--
E
-----------
M
R
L
A
K
---------------
I
S
I
V
I
V
S
Q
F
L
-----
L
S
-------
W
S
P
Y
-------
A
V
V
A
L
L
A
Q
F
--
G
------
P
LEW-
V
----
T
P
--
Y
--
A
A
-------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
-
F
------------------
P
W
V
L
T
C
C
Q
F
---------------------------
29
HHSearch
83.62
16%
-128
* C4 *
2KS9
1
NK1R_HUMAN
A:
[34-325]
--------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
-
V
T
S
V
V
---
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
-----
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
-
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
----
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
-
P
Q
G
Y
Y
S
T
T
----
E
-
T
M
P
S
R
V
V
C
M
I
E
W
P
-------------------
E
H
P
----------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
-
V
L
I
--
Y
--
F
L
P
L
--
L
V
I
G
Y
A
Y
-
T
V
V
G
------
I
T
L
W
A
-
S
------------
E
I
PGDSSDRYH
E
Q
V
--------------------
S
A
--
K
-----------
R
K
V
V
K
---------------
M
M
I
V
V
V
C
T
F
A
-----
I
C
-------
W
L
P
F
-------
H
I
F
F
L
L
P
Y
I
--
N
------
P
DLYL
K
----
K
F
--
I
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
-
F
------------------
R
C
C
P
F
I
S
A
G
---------------------------
40
Fugue
81.12
17%
-111
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
--
N
F
Y
V
P
F
S
----------------
N
KTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-----
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
-
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
----
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
---------
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
A
L
A
C
A
A
P
P
L
V
G
---
W
S
R
Y
I
P
E
G
----------------------
M
Q
C
S
C
--
G
I
DYYT
P
H
E
E
T
N
N
E
S
F
V
I
Y
-
M
F
V
--
V
HF
I
I
P
L
--
I
V
I
F
F
C
Y
-
G
Q
L
V
FTVKEA
A
A
Q
Q
Q
-
E
------------
S
A
-----------
T
--------------------
T
Q
--
K
-----------
A
E
K
E
V
---------------
T
R
M
V
I
I
M
V
I
A
-----
F
L
I
C
W
L
P
--
Y
A
G
V
-------
A
F
Y
I
F
T
H
Q
G
--
S
------
D
----
F
----
G
P
--
I
--
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------------
42
Fugue
77.42
17%
-122
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----
S
F
K
-------
C
A
----------------
L
---------------
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
-
I
I
G
F
L
---
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
-----
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
T
-
L
P
A
L
I
F
-
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
----
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
-----
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
-----------------------
S
D
--
E
-----
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
-
V
A
M
--
F
--
C
V
P
L
--
V
L
I
L
G
C
Y
-
G
L
I
V
------
R
A
L
I
Y
K
M
------------
K
K
-----------
Y
--------------------
T
C
--
T
-----------
V
C
G
Y
I
Y
N
PEDGDPDNGVNPG
T
D
F
K
D
I
V
C
P
L
-----
C
G
-------
V
G
K
D
-------
Q
F
E
E
V
E
E
P
L
--
R
------
R
----
K
----
S
I
--
Y
L
V
I
I
-------
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
------------------
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR
28
HHSearch
76.53
19%
-114
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[40-322]
-------------------------------------------------------
Y
V
V
I
I
A
Y
A
L
V
F
-
L
L
S
L
L
---
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
-----
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
-
S
K
V
-
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
----
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
-
P
F
F
L
F
R
Q
A
---
Y
H
P
-
N
N
S
S
P
V
C
Y
E
V
L
G
-------------------
N
D
-----------
T
A
K
W
R
M
V
L
R
I
L
P
H
-
T
F
G
--
F
--
I
V
P
L
--
F
V
M
L
F
C
Y
-
G
F
T
L
------
R
T
L
F
K
-
A
------------
H
------------
M
--------------------
G
Q
--
K
-----------
H
R
A
M
R
---------------
V
I
F
A
V
V
L
I
F
L
-----
L
C
-------
W
L
P
Y
-------
N
L
V
L
L
A
D
T
L
--
M
RTQVIQ
E
----
S
C
E
R
R
N
N
I
G
R
--
A
L
-------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
-
L
------------------
A
M
H
G
--------------------------------
46
Fugue
73.78
18%
-144
- C3 -
4RNZ
9
?
A:
[1-369]
M
E
R
L
V
W
D
KL
T
L
L
G
F
L
E
K
N
HIPQ
K
L
--------
Y
---------------
Y
N
L
S
S
Q
D
K
E
L
S
A
E
I
Q
S
N
V
-
T
Y
Y
T
L
R
D
A
N
N
T
L
I
Q
A
L
I
P
I
S
Q
D
L
Q
I
H
I
Y
K
K
GE
D
Y
F
L
D
F
I
P
I
I
F
T
R
K
E
K
T
L
-
L
L
S
L
Q
T
S
P
Y
Q
D
I
I
K
-
A
T
N
D
P
L
L
A
N
Q
L
M
N
A
Y
K
K
S
V
P
F
K
R
L
V
K
N
D
K
I
A
I
V
Y
T
R
D
Y
R
V
G
Q
A
F
G
Q
P
T
I
K
M
A
M
V
S
S
R
-
S
N
Q
Y
Y
L
F
S
H
S
N
G
H
---------
Y
Y
D
S
K
A
Q
E
V
A
G
F
L
L
E
T
P
V
K
YTRISSPFSYGRFHRPHY
G
V
D
Y
A
A
--
K
-----
H
G
S
L
I
H
S
A
S
D
G
R
V
-
G
F
M
--
G
--
V
K
A
G
YG
K
V
V
E
I
H
L
-
N
E
L
R
------
L
V
Y
A
H
-
M
------------
S
A
-----------
F
--------------------
A
N
GL
K
-----------
K
G
S
F
V
---------------
K
K
G
Q
I
I
G
R
V
G
STG
P
H
L
H
-------
F
G
V
Y
K
NSRPIN
P
L
G
Y
I
R
T
A
----------
K
----
S
----
K
L
--
H
--
G
K
-------
Q
R
E
V
F
L
E
K
A
Q
R
S
K
Q
K
L
E
E
L
L
K
T
H
S
F
E
K
N
S
F
Y
L
-
L
------------------
E
G
F
L
E
H
H
H
H
---------------------------
31
HHSearch
73.11
17%
-99
- C4 -
1U19
14
OPSD_BOVIN
A:
[41-325]
-------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-----
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
-
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
----
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
W
S
R
---
Y
I
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
-------------------
T
P
H
----------
E
E
T
N
N
E
S
F
V
I
Y
M
F
-
V
V
H
--
F
--
I
I
P
L
--
I
V
I
F
F
C
Y
-
G
Q
L
V
------
F
T
V
K
E
-
A
------------
A
A
-----------
Q
QQESA
T
T
Q
------------
K
A
--
E
-----------
K
E
V
T
R
---------------
M
V
I
I
M
V
I
A
F
L
-----
I
C
-------
W
L
P
Y
-------
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D---
F
----
G
P
--
I
--
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
------------------
C
C
G
K
N
P
L
G
D
---------------------------
1
PsiBlast_PDB
71.81
25%
-130
- C4 -
5C1M
5
?
A:
[18-219]
--------------------------------------------------------
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
---
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
-----
Y
I
F
N
L
A
L
A
D
A
-
L
A
T
S
T
-
L
P
F
Q
S
V
-
N
Y
L
M
G
T
W
-
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
----
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
A
T
T
K
Y
R
Q
-
G
S
I
D
C
T
L
T
F
S
H
------------------------------------
P
T
W
Y
W
E
N
L
L
K
I
C
V
F
I
F
A
--
F
--
I
M
P
V
--
L
I
I
T
V
C
Y
-
G
L
M
I
------
L
R
L
K
S
-
V
------------
R
M
-----------
L
--------------------
S
G
--
S
-----------
K
E
K
D
R
---------------
N
L
R
R
I
T
R
M
V
L
-----
V
V
-------
V
A
V
F
-------
I
V
C
W
T
P
I
H
I
--
Y
------
V
----
I
----
I
K
--
A
--
L
I
-------
T
I
P
E
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
-
L
------------------
D
E
N
F
K
R
C
F
----------------------------