@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2Y1_HUMAN: (2016-01-13 )
MGSFNTSFEDGFILVGFSDWPQLEPILFVFIFIFYSLTLFGNTIIIALSWLDLRLHTPMYFFLSHLSLLDLCFTTSTVPQLLINLCGVDRTITRGGCVAQLFIYLALGSTECVLLVVMAFDRYAAVCRPLHYMAIMHPHLCQTLAIASWGAGFVNSLIQTGLAMAMPLCGHRLNHFFCEMPVFLKLACADTEGTEAKMFVARVIVVAVPAALILGSYVHIAHAVLRVKSTAGRRKAFGTCGSHLLVVFLFYGSAIYTYLQSIHNYSEREGKFVALFYTIITPILNPLIYTLRNKDVKGALWKVLWRGRDSG
Atome Classification :
(20 SA)
----------------.........10........20....----------------....30........40........50........60........70......-..80........90........100.----......110..---------------.....120.......130.......140.......150.......160.....-----..170.......-180.......-------190.--......200....--...210.......220....-.-----..230--.-----------.--------------------.......----240.----------......-----250.......260...------------.--...270------....--....280........290.......300.......310----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MGSFNTSFED
G
F
I
L
V
GFSDWPQL
E
P
----------------
I
L
F
V
F
I
F
I
F
Y
S
L
T
LFG
N
T
I
I
I
A
L
S
W
L
D
L
R
LH
T
P
M
Y
F
F
L
S
H
L
S
L
L
D
L
CFTT
S
T
-
V
P
Q
L
L
I
N
L
CGVDRTITRG
G
C
V
A
Q
L
F
I
----
Y
L
ALGST
E
C
V
L
---------------
L
V
V
M
A
F
D
R
Y
A
A
V
C
R
P
L
H
Y
M
A
IM
H
P
H
L
C
Q
T
L
A
I
ASW
G
A
G
F
V
N
S
L
I
Q
T
G
L
A
M
A
M
P
-----
L
C
G
H
R
L
N
H
F
F
CE-M
P
V
F
L
K
L
A
CA-------DTEG--T
E
A
K
M
F
V
A
R
V
I
V
V
--
A
V
P
A
A
L
I
L
G
S
Y
V
H
I
A
H
A
V
L
R
-
V
-----KST----A-----------G--------------------R
R
K
A
F
G
T----C
G
S
H
----------
L
L
V
V
F
L
-----
F
Y
G
S
A
I
Y
T
Y
L
Q
S
I
HNY------------S--ERE
G
K
-------
F
V
A
L
--
F
Y
T
I
I
T
-
P
I
L
N
P
L
I
Y
T
LRNKDV
K
G
A
L
W
K
V
L
WRGRDSG-----------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.49
21%
-130
- C3 -
4GBR
1
ADRB2_HUMAN
A:
[20-286]
----------------------------------------------------------------------
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
----
D
V
L
C
V
T
A
S
I
E
T
---------------
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
--------
I
V
S
G
L
T
S
F
L
P
-----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
-
Q
L
Q
KID
K
F
C
----
L
-----------
K
--------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
----------
T
L
C
W
L
P
-----
F
F
I
V
N
I
V
H
V
I
Q
D
--
N
L
------------
I
--
R
K
E
V
Y
-------
I
L
L
N
--
W
I
G
Y
V
N
-
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
89.30
18%
-145
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
PFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
----
A
T
L
G
G
E
I
A
L
W
S
---------------
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--------------
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
-----
A
A
S
----
A
-----------
T
--------------------
T
Q
K
A
E
K
E
----
V
T
R
M
----------
V
I
I
M
V
I
-----
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
------------
F
--
T
H
Q
G
S
DFGPIFM
T
I
P
A
--
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
88.26
17%
-133
- C3 -
2Z73
5
OPSD_TODPA
A:
[34-332]
---------------------------------------
Y
Y
----------------
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
----
G
G
I
F
G
F
M
S
I
M
T
---------------
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
--------
T
L
E
G
V
L
C
N
C
S
-
F
D
Y
I
S
R
------------
D
S
T
--
T
R
S
N
I
L
C
M
F
I
L
G
F
--
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
-
H
-----
E
K
E
----
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
----
S
I
V
I
----------
V
S
Q
F
L
L
-----
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
LEW---------
V
--
T
P
Y
A
A
-------
Q
L
P
V
--
M
F
A
K
A
S
-
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
84.40
18%
-118
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFSNK
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
---
P
W
Q
F
S
----------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
----
A
T
L
G
G
E
I
A
L
W
S
---------------
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
---
I
D
Y
Y
T
P
-
H
E
E
T
----------------
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
-----
A
A
Q
QQES
A
-----------
T
--------------------
T
Q
K
A
E
K
E
----
V
T
R
M
----------
V
I
I
M
V
I
-----
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
------------
F
--
T
H
Q
G
S
DFGPIFM
T
I
P
A
--
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
78.49
16%
-114
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------
D
E
V
W
V
V
----------------
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
----
D
V
L
C
V
T
A
S
I
E
T
---------------
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
E
-
T
C
------
C
D
-------
F
F
T
N
--
Q
A
Y
A
I
A
S
S
I
V
S
F
---
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
-----
N
I
F
----
E
-----------
M
--------------------
L
R
I
D
E
G
L
----
R
L
K
I
----------
Y
K
D
T
E
G
-----
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
------------
N
--
A
A
K
S
E
-------
L
D
K
A
--
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
30
HHSearch
77.86
12%
-134
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
----------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
----
P
I
A
A
V
F
A
S
I
Y
S
---------------
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
--------
T
M
P
S
R
V
V
C
M
-
I
E
W
P
E
H
P
----------
N
K
I
Y
--
E
K
V
Y
H
I
C
V
T
V
L
I
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
-
S
-----
E
I
P
----
G
DSSDRYH
E
Q
V
S
A
--------------------
K
R
K
V
V
K
M
----
M
I
V
V
----------
V
C
T
F
A
I
-----
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
DLYL--------
K
KF
I
Q
Q
V
Y
-------
L
A
I
M
--
W
L
A
M
S
S
-
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
76.81
15%
-129
* C3 *
1U19
14
OPSD_BOVIN
A:
[41-327]
----------------------------------------
S
----------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
----
A
T
L
G
G
E
I
A
L
W
S
---------------
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
--------
Y
I
P
E
G
M
Q
C
S
C
G
-
I
D
Y
Y
T
P
---
H
-------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
-----
A
A
Q
----
Q
-----------
Q
ESA
T
T
Q
K
A
------------
E
K
E
V
T
R
M
----
V
I
I
M
----------
V
I
A
F
L
I
-----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
GSD---------
F
--
G
P
I
F
M
-------
T
I
P
A
--
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.34
22%
-149
- C3 -
1F88
7
OPSD_BOVIN
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
I
DYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
------------------------
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.65
22%
-145
- C3 -
3C9L
13
OPSD_BOVIN
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
IDYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
--------------------
Q
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
73.21
22%
-147
- C3 -
4PXF
7
OPSD_BOVIN
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
IDYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
--------------------
Q
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.96
22%
-146
- C3 -
2I35
3
OPSD_BOVIN
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
I
DYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
--------------------
Q
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
72.65
15%
-117
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
---------------------------------------
K
Y
----------------
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
V
-
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
----
K
E
V
N
F
Y
S
G
I
L
L
---------------
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
--------
A
Y
H
P
N
N
S
S
P
V
C
Y
-
E
V
L
G
N
D
-----------
T
A
K
W
--
R
M
V
L
R
I
L
P
H
T
F
G
F
--
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
-
A
-----
H
M
G
----------------
Q
--------------------
K
H
R
A
M
R
V
----
I
F
A
V
----------
V
L
I
F
L
L
-----
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
TQVIQE
S
C
E
R
R
N
N
--
I
G
R
A
L
-------
D
A
T
E
--
I
L
G
F
L
H
-
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.21
22%
-150
- C3 -
3PXO
5
OPSD_BOVIN
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
IDYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
--------------------
Q
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.03
22%
-152
- C3 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
IDYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
--------------------
Q
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.78
22%
-151
- C3 -
3PQR
9
OPSD_BOVIN
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
IDYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
--------------------
Q
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.66
22%
-153
- C3 -
3DQB
6
GNAT1_BOVIN (first)
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
IDYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
--------------------
Q
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.18
22%
-155
- C3 -
3CAP
5
OPSD_BOVIN
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
IDYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
--------------------
Q
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.74
22%
-112
- C3 -
1HZX
14
OPSD_BOVIN
A:
[78-327]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
I
DYYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
-------------------------
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
69.36
22%
-150
- C3 -
2I36
2
OPSD_BOVIN
A:
[75-326]
-----------------------------------------------------------------------------------------------------------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
-------------
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
I
D
YYT--
P
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
T
-
V
-----
K
E
A
----
A
-----------
A
--------------------
Q
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
ICWLP
Y
A
G
V
A
F
Y
I
F
---
T
H
Q
G
------------
S
--
D
F
G
P
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
68.95
20%
-141
- C3 -
3EML
8
ENLYS_BPT4
A:
[23-222]
---------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
----
V
L
V
L
T
Q
S
S
I
F
S
---------------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
-----
Q
------
S
Q
G
C
G
-
E
G
Q
---
V
A
C
L
-------
F
E
D
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
-
Q
-----
L
N
I
----
F
-----------
E
--------------------
M
L
R
I
D
E
G
----
L
R
L
K
----------
I
Y
K
D
T
E
-----
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
------------
L
--
N
A
A
K
S
-------
E
L
D
K
--
A
I
G
R
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------