@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4CD_HUMAN: (2016-01-13 )
MANRNNVTEFILLGLTENPKMQKIIFVVFSVIYINAMIGNVLIVVTITASPSLRSPMYFFLAYLSFIDACYSSVNTPKLITDSLYENKTILFNGCMTQVFGEHFFRGVEVILLTVMAYDHYVAICKPLHYTTVMKQHVCSLLVGVSWVGGFLHATIQILFICQLPFCGPNVIDHFMCDLYTLINLACTNTHTLGLFIAANSGFICLLNCLLLLVSCVVILYSLKTHSLEARHEALSTCVSHITVVILSFIPCIFVYMRPPATLPIDKAVAVFYTMITSMLNPLIYTLRNAQMKNAIRKLCSRKAISSVK
Atome Classification :
(20 SA)
------------......-...-10......---------------.---.20....--------------....--30........-40.--.......50........60.-.......70....-....80------.........90-.---.-......100-.......110.-----......120....-..------.130.......-140.......150-----------...-..--------....-160.-..-----....170..-....--.180.......190...--------....-..200-----.......210.-.----.....220.......------------230-------------------.......--..240....-----...250---........-260-------.-----.-----.---...---------..270.......280.......290.......----------------300.......------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MANRNN-
V
T
E
-
F
I
L
L
GLTE---------------N---P
K
M
Q
K
I
I
--------------
F
V
V
F
--
S
V
I
Y
I
N
A
MIG-
N
V
L
--
I
V
V
T
I
TASPSLR
S
P
M
Y
F
F
L
A
-
Y
L
S
F
I
D
A
C
Y
SSVN-TP
K
L
I
-------
T
D
S
LYEN
K
T
I
L
-F---
N
-
G
C
M
T
Q
V
F
G
E
-
H
F
F
R
G
V
E
V
I
L
L
-----
T
V
M
AYD
H
Y
V
A
I
CK-
P
L
------
H
Y
T
T
V
M
K
Q
H
V
C
-
S
L
L
V
G
V
S
W
V
G
G
-------------
F
L
H
-
A
T
--------
I
Q
I
L
-
F
I
CQ-LP-----FC
G
P
N
V
I
D
H
-
F
M
C
D
--
L
Y
T
L
I
N
LACTNT--
H
T
L
--------
G
L
F
I
-AANS
G
-----
F
I
C
L
L
N
C
L
L
L
L
-
V
----
S
C
V
V
I
L
Y
SLKTH
S
L
E
------------
A
---------------------
R
H
E
A
L
S
T
--
C
V
S
H
I
T
V
V
I
-----
L
S
F
I
P
----
C
I
F
V
Y
MRP-PA--------T-----L-----P---
I
D
K
---------
A
V
A
V
F
Y
T
M
I
T
S
M
L
N
P
L
I
Y
T
L
R
N
A
Q
M
K
N
A
I
R
K
L
----------------
C
S
R
K
AISSVK------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
86.45
17%
-137
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-334]
---------------------------------------------------
A
V
Y
Y
S
L
--------------
G
I
F
I
--
G
I
C
G
I
I
G
C
G
G
-
N
G
I
--
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
-
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
-------
I
S
C
F
L
K
K
W
I
F
G
-
F
---
A
-
A
C
K
V
Y
G
F
I
G
-
G
I
F
G
F
M
S
I
M
T
M
-----
A
M
I
S
I
D
R
Y
N
V
I
G
R
-
P
M
------
A
A
S
K
K
M
S
H
R
R
A
-
F
I
M
I
I
F
V
W
L
W
S
-------------
V
L
W
-
A
I
--------
G
P
I
F
-
G
W
G
A
-
Y
T
---------
L
E
G
V
L
-
C
N
C
S
--
F
D
Y
I
S
R
-----
D
--
S
T
T
--------
R
S
N
I
-
L
C
M
F
I
-----
L
G
F
F
G
P
I
L
I
I
F
-
F
----
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
--
S
I
V
I
V
S
Q
F
L
-----
L
S
W
S
P
----
Y
A
V
V
A
L
L
A
-
Q
F
--------
G
-----
P
LEWVT
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
----------------
F
P
W
V
L
T
C
C
Q
F
------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
83.21
18%
-141
* C3 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
-------------------------------------------------------
L
W
--------------
A
A
A
Y
--
T
V
I
V
V
T
S
V
V
G
-
N
V
V
--
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
-
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
-------
T
Y
A
V
H
N
E
W
Y
Y
G
-
L
---
F
-
Y
C
K
F
H
N
F
F
P
-
I
A
A
V
F
A
S
I
Y
S
M
-----
T
A
V
A
F
D
R
Y
M
A
I
I
H
-
P
L
------
Q
P
R
L
--
S
A
T
A
T
-
K
V
V
I
C
V
I
W
V
L
A
-------------
L
L
L
-
A
F
--------
P
Q
G
Y
-
Y
S
T
T
-
E
----------
T
M
P
S
R
-
V
V
C
M
--
I
E
W
P
E
H
P
---
N
K
--
I
Y
E
--------
K
V
Y
H
-
I
C
V
T
V
-----
L
I
Y
F
L
P
L
L
V
I
G
-
Y
----
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
S
A
---------------------
K
R
K
V
V
K
M
--
M
I
V
V
V
C
T
F
A
-----
I
C
W
L
P
----
F
H
I
F
F
L
L
P
-
Y
I
--------
N
PDLYL
K
-----
K
FI
Q
Q
V
Y
---------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
----------------
F
R
C
C
P
F
I
S
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
80.26
16%
-115
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
-
V
V
R
-
S
P
F
E
A
P
Q
Y
---------------
Y
LAE
P
W
Q
F
S
M
L
--------------
A
A
Y
M
--
F
L
L
I
M
L
G
F
P
I
-
N
F
L
--
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
-
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
-------
Y
T
S
L
H
G
Y
F
V
F
G
-
P
---
T
-
G
C
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
L
-----
V
V
L
A
I
E
R
Y
V
V
V
C
K
-
P
M
------
S
N
F
R
-
F
G
E
N
H
A
-
I
M
G
V
A
F
T
W
V
M
A
-------------
L
A
C
-
A
A
--------
P
P
L
V
G
W
S
R
Y
-
I
P
E
GMQC
S
C
G
I
---------
D
--
Y
Y
T
P
H
E
E
T
N
N
E
S
--
F
V
I
--------
Y
M
F
V
-
V
H
---------
F
I
I
P
L
I
V
I
F
F
-
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
--
V
T
R
M
V
I
I
M
V
-----
I
A
F
L
I
----
C
W
L
P
Y
A
G
V
-
A
F
--------
Y
-----
I
-----
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
----------------
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
77.78
17%
-106
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------
M
N
G
T
E
G
-
P
N
F
-
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
---
P
W
Q
F
S
M
L
--------------
A
A
Y
M
--
F
L
L
I
M
L
G
F
P
I
-
N
F
L
--
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
-
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
-------
Y
T
S
L
H
G
Y
F
V
F
G
-
P
---
T
-
G
C
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
L
-----
V
V
L
A
I
E
R
Y
V
V
V
C
K
-
P
M
------
S
N
F
R
F
G
E
N
H
A
--
I
M
G
V
A
F
T
W
V
M
A
-------------
L
A
C
-
A
A
--------
P
P
L
V
-
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
---------
D
--
Y
Y
T
P
H
E
E
T
N
N
E
S
--
F
V
I
--------
Y
M
F
V
-
V
H
F
I
I
-----
P
L
I
V
I
F
F
C
Y
G
Q
-
L
----
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
--
V
T
R
M
V
I
I
M
V
-----
I
A
F
L
I
----
C
W
L
P
Y
A
G
V
-
A
F
--------
Y
-----
I
-----
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
PA----------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.46
20%
-121
- C3 -
4WW3
5
OPSD_TODPA
A:
[52-320]
--------------------------------------------------------------------------------------------------
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
-
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
-------
T
I
S
C
F
L
K
K
W
I
F
G
F
---
A
-
A
C
K
V
Y
G
F
I
G
-
G
I
F
G
F
M
S
I
M
T
M
-----
A
M
I
S
I
D
R
Y
N
V
I
G
R
-
P
M
------
A
A
S
K
K
M
S
H
R
R
A
-
F
I
M
I
I
F
V
W
L
W
S
-------------
V
L
W
-
A
I
--------
G
P
I
F
-------------
G
W
G
A
Y
T
L
E
G
-
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
--
N
I
L
--------
C
M
F
I
-
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
K
E
L
R
------------
K
---------------------
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
--------
V
-----
T
-----
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
----------------
F
P
W
V
L
T
C
C
Q
F
------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.28
20%
-121
- C3 -
3AYN
3
OPSD_TODPA
A:
[60-328]
--------------------------------------------------------------------------------------------------
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
-
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
-------
T
I
S
C
F
L
K
K
W
I
F
G
F
---
A
-
A
C
K
V
Y
G
F
I
G
-
G
I
F
G
F
M
S
I
M
T
M
-----
A
M
I
S
I
D
R
Y
N
V
I
G
R
-
P
M
------
A
A
S
K
K
M
S
H
R
R
A
-
F
I
M
I
I
F
V
W
L
W
S
-------------
V
L
W
-
A
I
--------
G
P
I
F
-------------
G
W
G
A
Y
T
L
E
G
-
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
--
N
I
L
--------
C
M
F
I
-
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
K
E
L
R
------------
K
---------------------
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
--------
V
-----
T
-----
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
----------------
F
P
W
V
L
T
C
C
Q
F
------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
77.01
21%
-146
- C1 -
4KQ7
6
?
A:
[2-374]
---------------
Q
S
N
M
T
N
E
M
F
D
L
A
K
L
K
S
---------------
G
---
V
K
N
K
R
I
S
STDPTGGNRDHLEP
F
K
P
G
--
E
K
R
I
I
A
D
I
K
G
M
G
V
I
N
H
I
W
V
T
I
A
P
P
P
P
T
L
S
R
N
D
I
I
I
R
M
Y
W
D
G
N
D
--
Y
P
S
V
E
-
S
P
I
G
P
F
F
GQGWD
E
R
Y
N
Y
A
S
L
P
L
S
-
A
G
P
E
N
-
G
T
G
L
S
C
Y
F
A
M
P
F
E
K
G
A
R
I
E
I
E
N
QSDR
N
I
D
A
F
Y
F
Y
V
D
Y
L
E
M
A
K
LPKD
M
G
R
F
H
A
W
Y
N
H
N
L
T
E
A
L
P
E
G
E
T
E
W
G
V
T
G
A
Q
K
P
N
TTGERN
Y
V
F
M
E
T
Q
G
K
G
H
F
V
G
I
N
Y
Y
-
V
H
C
P
-
T
P
M----
W
Y
G
E
G
--
D
D
M
W
F
I
D
--
G
E
K
V
P
S
L
I
G
T
G
T
--
E
D
F
F
NTAWCPK
E
A
F
S
-
H
P
Y
F
G
-----
Y
P
R
V
N
N
D
I
G
W
L
G
R
----
T
H
V
Y
R
F
F
I
E
D
P
I
F
F
E
------------------------------------
K
S
L
K
G
--
T
I
E
H
G
S
N
N
N
-----
L
T
L
D
L
----
S
T
V
A
Y
W
Y
Q
-
D
S
--------
A
-----
V
-----
A
---
L
P
E
---------
A
----
P
T
K
A
Q
R
A
P
K
P
F
I
N
H
V
D
I
H
R
W
R
D
A
W
R
K
S
----------------
K
G
N
K
A
T
L
W
G
N
E-----------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.79
20%
-123
- C3 -
2Z73
5
OPSD_TODPA
A:
[60-328]
--------------------------------------------------------------------------------------------------
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
-
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
-------
T
I
S
C
F
L
K
K
W
I
F
G
F
---
A
-
A
C
K
V
Y
G
F
I
G
-
G
I
F
G
F
M
S
I
M
T
M
-----
A
M
I
S
I
D
R
Y
N
V
I
G
R
-
P
M
------
A
A
S
K
K
M
S
H
R
R
A
-
F
I
M
I
I
F
V
W
L
W
S
-------------
V
L
W
-
A
I
--------
G
P
I
F
-------------
G
W
G
A
Y
T
L
E
G
-
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
--
N
I
L
--------
C
M
F
I
-
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
K
E
L
R
------------
K
---------------------
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
--------
V
-----
T
-----
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
----------------
F
P
W
V
L
T
C
C
Q
F
------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.31
20%
-124
- C3 -
2ZIY
2
OPSD_TODPA
A:
[59-327]
--------------------------------------------------------------------------------------------------
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
-
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
-------
T
I
S
C
F
L
K
K
W
I
F
G
F
---
A
-
A
C
K
V
Y
G
F
I
G
-
G
I
F
G
F
M
S
I
M
T
M
-----
A
M
I
S
I
D
R
Y
N
V
I
G
R
-
P
M
------
A
A
S
K
K
M
S
H
R
R
A
-
F
I
M
I
I
F
V
W
L
W
S
-------------
V
L
W
-
A
I
--------
G
P
I
F
-------------
G
W
G
A
Y
T
L
E
G
-
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
--
N
I
L
--------
C
M
F
I
-
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
K
E
L
R
------------
K
---------------------
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
--------
V
-----
T
-----
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
----------------
F
P
W
V
L
T
C
C
Q
F
------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
75.52
14%
-117
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------
D
---
E
V
W
V
V
G
M
--------------
G
I
V
M
--
S
L
I
V
L
A
I
V
F
G
-
N
V
L
--
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
-
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
-------
A
H
I
L
M
K
M
W
T
F
G
-
N
---
F
-
W
C
E
F
W
T
S
I
D
-
V
L
C
V
T
A
S
I
E
T
L
-----
C
V
I
A
V
D
R
Y
F
A
I
T
S
-
P
F
------
K
Y
Q
S
L
L
T
K
N
K
A
-
R
V
I
I
L
M
V
W
I
V
S
-------------
G
L
T
-
S
F
--------
L
P
I
Q
-
M
-------------
H
W
Y
R
A
T
H
-
Q
E
A
I
--
N
C
Y
A
E
E
T
C
C
D
F
F
--
T
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
-----
F
Y
V
P
L
V
I
M
V
F
V
-
Y
----
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
------------
M
---------------------
L
R
I
D
E
G
L
--
R
L
K
I
Y
K
D
T
E
-----
G
Y
Y
T
I
----
G
I
G
H
L
L
T
K
-
S
P
--------
S
-----
L
-----
N
---
A
A
K
---------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
----------------
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
9
PsiBlast_PDB
74.97
20%
-119
- C3 -
3AYM
3
OPSD_TODPA
A:
[60-328]
--------------------------------------------------------------------------------------------------
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
-
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
-------
T
I
S
C
F
L
K
K
W
I
F
G
F
---
A
-
A
C
K
V
Y
G
F
I
G
-
G
I
F
G
F
M
S
I
M
T
M
-----
A
M
I
S
I
D
R
Y
N
V
I
G
R
-
P
M
------
A
A
S
K
K
M
S
H
R
R
A
-
F
I
M
I
I
F
V
W
L
W
S
-------------
V
L
W
-
A
I
--------
G
P
I
F
-------------
G
W
G
A
Y
T
L
E
G
-
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
--
N
I
L
--------
C
M
F
I
-
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
K
E
L
R
------------
K
---------------------
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
--------
V
-----
T
-----
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
----------------
F
P
W
V
L
T
C
C
Q
F
------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
74.46
15%
-134
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-327]
------------------------------------------------------
S
M
L
--------------
A
A
Y
M
--
F
L
L
I
M
L
G
F
P
I
-
N
F
L
--
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
-
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
-------
Y
T
S
L
H
G
Y
F
V
F
G
-
P
---
T
-
G
C
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
L
-----
V
V
L
A
I
E
R
Y
V
V
V
C
K
-
P
M
------
S
N
F
R
F
-
G
E
N
H
A
-
I
M
G
V
A
F
T
W
V
M
A
-------------
L
A
C
-
A
A
--------
P
P
L
V
-
G
W
S
R
-
Y
I
--------
P
-
E
G
M
Q
-
C
S
C
G
--
I
D
Y
Y
T
P
---
H
E
E
--
T
N
N
--------
E
S
F
V
-
I
Y
M
F
V
-----
V
H
F
I
I
P
L
I
V
I
F
-
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
QESA
T
T
Q
K
A
------------
E
K
E
V
T
R
M
--
V
I
I
M
V
I
A
F
L
-----
I
C
W
L
P
----
Y
A
G
V
A
F
Y
I
-
F
T
H
Q------
G
-----
S
DFG--
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
----------------
L
C
C
G
K
N
P
L
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
70.21
16%
-133
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
---------------------------------------------------
L
N
K
Y
V
V
--------------
I
I
A
Y
--
A
L
V
F
L
L
S
L
L
G
-
N
S
L
--
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
-
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
-------
A
S
K
-
V
N
G
W
I
F
G
-
T
---
F
-
L
C
K
V
V
S
L
L
K
-
E
V
N
F
Y
S
G
I
L
L
L
-----
A
C
I
S
V
D
R
Y
L
A
I
V
H
-
A
T
------
R
T
L
T
Q
-
K
R
H
L
V
-
K
F
V
C
L
G
C
W
G
L
S
-------------
M
N
L
-
S
L
--------
P
F
F
L
-
F
R
Q
A
-
Y
-------
H
-
P
-
N
N
S
S
-
P
V
C
Y
--
E
V
L
G
N
D
---
T
-
A
--
K
W
R
--------
M
V
L
R
-
I
L
P
H
T
-----
F
G
F
I
V
P
L
F
V
M
L
-
F
----
C
Y
G
F
T
L
R
T
L
F
K
A
H
M
G
------------
Q
---------------------
K
H
R
A
M
R
V
--
I
F
A
V
V
L
I
F
L
-----
L
C
W
L
P
----
Y
N
L
V
L
L
A
D
-
T
L
M
RTQVIQE
S
C
E
R
R
-
N
-----
N
I
G
-
R
A
L
---------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
----------------
L
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
67.29
20%
-144
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-221]
------------------------------------------------------
S
V
Y
--------------
I
T
V
E
--
L
A
I
A
V
L
A
I
L
G
-
N
V
L
--
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
-
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
-------
T
I
S
T
--
G
F
C
A
A
-
C
---
H
-
G
C
L
F
I
A
C
F
V
-
L
V
L
T
Q
S
S
I
F
S
L
-----
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
-
K
G
I
I
A
I
C
W
V
L
S
-------------
F
A
I
-
G
L
--------
T
P
M
L
-
G
W
N
N
-
C
G
-----
Q
-------
S
-
Q
G
C
G
--
E
G
Q
---
V
A
C
L
F
E
DV
V
P
M
--------
N
Y
M
V
-
Y
F
N
F
F
-----
A
C
V
L
V
P
L
L
L
M
L
-
G
----
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
------------
F
---------------------
E
M
L
R
I
D
E
--
G
L
R
L
K
I
Y
K
D
-----
T
E
G
Y
Y
----
T
I
G
I
G
H
L
L
-
T
K
--------
S
-----
P
-----
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
----------------
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
64.61
17%
-132
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
------------------------------------------------------
V
G
M
--------------
G
I
V
M
--
S
L
I
V
L
A
I
V
F
G
-
N
V
L
--
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
-
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
-------
A
H
I
L
M
K
M
W
T
F
G
-
N
---
F
-
W
C
E
F
W
T
S
I
D
-
V
L
C
V
T
A
S
I
E
T
L
-----
C
V
I
A
V
D
R
Y
F
A
I
T
S
-
P
F
------
K
Y
Q
S
L
L
T
K
N
K
A
-
R
V
I
I
L
M
V
W
I
V
S
-------------
G
L
T
-
S
F
--------
L
P
I
Q
-
M
H
W
Y
-
R
A
---------
T
H
Q
E
A
-
I
N
C
Y
--
A
E
----
E
T
C
C
D
F
--
F
T
N
--------
Q
A
Y
A
-
I
A
S
S
I
-----
V
S
F
Y
V
P
L
V
I
M
V
-
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
------------
F
---------------------
E
M
L
R
I
D
E
--
G
L
R
L
K
I
Y
K
D
-----
T
E
G
Y
Y
----
T
I
G
I
G
H
L
L
-
T
K
--------
S
-----
P
-----
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
----------------
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
64.35
24%
-149
- C3 -
4U16
1
?
A:
[9-183]
----------------------------------------------------
I
W
Q
V
V
--------------
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
-
N
I
L
--
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
-
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
-
N
L
F
-------
T
T
Y
I
I
M
N
R
W
A
L
-
G
---
N
L
A
C
D
L
W
L
S
I
D
-
Y
V
A
S
N
A
S
V
M
N
L
-----
L
V
I
S
F
D
R
Y
F
S
I
T
R
-
P
L
------
T
Y
R
A
K
R
T
T
K
R
A
-
G
V
M
I
G
L
A
W
V
I
S
-------------
F
V
L
-
W
A
--------
P
A
I
L
-
F
W
Q
Y
--------
F
V
G
K
R
T
V
P
P
-
G
E
C
------
F
I
Q
F
L
S
E
P
T
--
I
T
F
--------
G
T
A
I
-
A
A
F
Y
M
-----
P
V
T
I
M
T
I
L
Y
W
R
-
I
----
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
------------
D
---------------------
E
G
G
G
S
G
G
--
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
----
V
R
G
I
L
R
N
A
-
K
L
--------
K
-----
P
-----
V
---
Y
D
S
---------
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
----------------
Q
K
R
W
D
E
A
A
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.17
24%
-148
- C3 -
4U15
1
ACM3_RAT
A:
[9-183]
----------------------------------------------------
I
W
Q
V
V
--------------
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
-
N
I
L
--
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
-
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
-
N
L
F
-------
T
T
Y
I
I
M
N
R
W
A
L
-
G
---
N
L
A
C
D
L
W
L
S
I
D
-
Y
V
A
S
N
A
S
V
M
N
L
-----
L
V
I
S
F
D
R
Y
F
S
I
T
R
-
P
L
------
T
Y
R
A
K
R
T
T
K
R
A
-
G
V
M
I
G
L
A
W
V
I
S
-------------
F
V
L
-
W
A
--------
P
A
I
L
-
F
W
Q
Y
--------
F
V
G
K
R
T
V
P
P
-
G
E
C
------
F
I
Q
F
L
S
E
P
T
--
I
T
F
--------
G
T
A
I
-
A
A
F
Y
M
-----
P
V
T
I
M
T
I
L
Y
W
R
-
I
----
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
------------
D
---------------------
E
G
G
G
S
G
G
--
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
----
V
R
G
I
L
R
N
A
-
K
L
--------
K
-----
P
-----
V
---
Y
D
S
---------
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
----------------
Q
K
R
W
D
E
A
A
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
63.63
18%
-151
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
------------------------------------------------------
V
F
I
--------------
V
L
V
A
--
G
S
L
S
L
V
T
I
I
G
-
N
I
L
--
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
-
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
-------
L
Y
T
V
I
G
Y
W
P
L
G
-
P
---
V
-
V
C
D
L
W
L
A
L
D
-
Y
V
V
S
N
A
S
V
M
N
L
-----
L
I
I
S
F
D
R
Y
F
C
V
T
K
-
P
L
------
T
Y
P
V
K
R
T
T
K
M
A
-
G
M
M
I
A
A
A
W
V
L
S
-------------
F
I
L
-
W
A
--------
P
A
I
L
-
F
W
Q
F
-
I
-------
V
G
V
R
T
V
E
D
-
G
E
C
Y
--
I
Q
F
F
-----------
S
N
--------
A
A
V
T
-
F
G
T
A
I
-----
A
A
F
Y
L
P
V
I
I
M
T
-
V
----
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
------------
F
---------------------
E
M
L
R
I
D
E
--
G
L
R
L
K
I
Y
K
D
-----
T
E
G
Y
Y
----
T
I
G
I
G
H
L
L
-
T
K
--------
S
-----
P
-----
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
----------------
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
63.38
17%
-135
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-200]
-------------------------------------------------------
P
L
--------------
V
V
V
L
--
S
T
I
C
L
V
T
V
G
L
-
N
L
L
--
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
-
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
-------
L
Y
L
L
M
S
K
W
S
L
G
-
R
---
P
-
L
C
L
F
W
L
S
M
D
-
Y
V
A
S
T
A
S
I
F
S
V
-----
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
-
P
L
------
R
Y
L
K
Y
R
T
K
T
R
A
-
S
A
T
I
L
G
A
W
F
L
S
-------------
F
L
W
-
V
I
--------
P
I
L
G
-
W
N
H
---------------
R
R
E
-
D
K
C
E
--
T
D
F
Y
-----------
D
V
--------
T
W
F
K
-
V
M
T
A
I
-----
I
N
F
Y
L
P
T
L
L
M
L
-
W
----
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
------------
F
---------------------
E
M
L
R
I
D
E
--
G
L
R
L
K
I
Y
K
D
-----
T
E
G
Y
Y
----
T
I
G
I
G
H
L
L
-
T
K
--------
S
-----
P
-----
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
----------------
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
61.46
24%
-149
- C3 -
4DAJ
2
ACM3_RAT (first)
A:
[9-183]
----------------------------------------------------
I
W
Q
V
V
--------------
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
-
N
I
L
--
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
-
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
-
N
L
F
-------
T
T
Y
I
I
M
N
R
W
A
L
-
G
---
N
L
A
C
D
L
W
L
S
I
D
-
Y
V
A
S
N
A
S
V
M
N
L
-----
L
V
I
S
F
D
R
Y
F
S
I
T
R
-
P
L
------
T
Y
R
A
K
R
T
T
K
R
A
-
G
V
M
I
G
L
A
W
V
I
S
-------------
F
V
L
-
W
A
--------
P
A
I
L
-
F
W
Q
Y
--------
F
V
G
K
R
T
V
P
P
-
G
E
C
------
F
I
Q
F
L
S
E
P
T
--
I
T
F
--------
G
T
A
I
-
A
A
F
Y
M
-----
P
V
T
I
M
T
I
L
Y
W
R
-
I
----
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
------------
D
---------------------
E
G
L
R
L
K
I
--
Y
K
D
T
E
G
Y
Y
T
-----
I
G
I
G
H
----
L
L
T
K
S
P
S
L
-
N
A
--------
A
-----
K
-----
S
---
E
L
D
---------
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
----------------
R
N
A
K
L
K
P
V
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------