@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4DA_HUMAN: (2016-01-13 )
MEMENCTRVKEFIFLGLTQNREVSLVLFLFLLLVYVTTLLGNLLIMVTVTCESRLHTPMYFLLHNLSIADICFSSITVPKVLVDLLSERKTISFNHCFTQMFLFHLIGGVDVFSLSVMALDRYVAISKPLHYATIMSRDHCIGLTVAAWLGGFVHSIVQISLLLPLPFCGPNVLDTFYCDVHRVLKLAHTDIFILELLMISNNGLLTTLWFFLLLVSYIVILSLPKSQAGEGRRKAISTCTSHITVVTLHFVPCIYVYARPFTALPMDKAISVTFTVISPLLNPLIYTLRNHEMKSAMRRLKRRLVPSDRK
Atome Classification :
(20 SA)
-----------------......-...----------------10........---------------20...----------------.....30.--------------..------.....40---...----.....50........60....--....70--.-.------------....-..80.....-...90.......-------..100..-.....110.......120.......130...---....140----........---150....---...160...---..-----.---.170......-.----------180.......190--.......200......-.------------.210..-------------.....220---...-------------......230----------.---------------------.----.-----.....----.240......--------.250-------------------..--------...-..260.--.----.------.----...-.---------270...-....280.......290.......300-----------------........310--------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------ME
M
E
N
C
-
T
R
V
----------------
K
E
F
I
F
L
GLTQ---------------NR
E
V
S
----------------
L
V
L
F
L
F
L
L
--------------
L
V
------
Y
V
T
T
L
LG---N
L
L
----
I
M
V
T
V
TCESRLH
T
P
M
Y
F
L
L
HN--L
S
I
A
D
I
--
C
-
F
------------SSI
T
-
V
P
K
V
L
V
D
L
L
-SER
K
-
T
I
S
F
N
H
C
-------
F
T
Q
M
F
L
F
-
H
L
IGG
V
D
V
F
S
L
S
V
M
A
L
D
R
Y
VAISKP
L
H
Y
A
T
I---MSRDHC-----
I
G
L
T
V
A
A
W
---
L
G
G
F
V
H
S
---
I
V
Q
I
S
L
L
LP---LP-----F---CG
P
N
V
L
D
T
F
Y
-
C
----------
D
V
H
R
V
L
K
L
AH
T
D
I
--
F
I
L
E
L
L
M
IS-NN
G
L
L
T
-
T
------------
L
W
F
F
L
L
-------------
L
V
S
Y
I
V
-----
I
LS-------------LPKSQAG------------E---------------------
G
----
R
-----
R
K
A
I
S
----
T
CTS
H
I
T
V
V
T
--------
L
HF
V
-------------------
P
C
--------
I
Y
V
-YAR-PF--T----A------L----PMD-K---------
A
I
S
V
T
F
-
T
V
I
S
P
L
L
N
P
L
I
Y
T
L
R
N
H
E
M
K
S
A
M
R
R
L
------------------
K
R
RLVPSDRK---------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
87.54
20%
-121
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------------
M
N
G
-
T
E
G
----------------
P
N
F
Y
V
P
F
S
N
K
---------------
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
--------------
L
L
------
I
M
L
G
F
P
I
---
N
F
L
----
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
--
L
A
V
A
D
L
--
F
-
M
------------
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
-------
N
L
E
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F
F
A
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T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
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N
F
R
----
F
G
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N
H
A
-----
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M
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V
A
F
T
W
---
V
M
A
L
A
C
A
APP
L
V
G
W
S
R
Y
I
P
E
GM
Q
C
-----
S
---
C
G
I
-------------------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
--
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
-
V
------------
I
F
F
C
Y
G
-------------
Q
L
---------
V
F
T
-------------
V
K
E
A
A
A
S
------------
A
---------------------
T
----
T
-----
Q
K
A
E
K
----
E
V
T
R
M
V
I
I
M
V
--------
I
A
F
L
-------------------
I
C
--------
W
L
P
-
Y
A
G
-
V
A
--
F
----
Y
------
I
----
F
T
H
-
Q
GSDFGPIFM
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
------------------
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.87
21%
-147
- C1 -
3REY
1
AA2AR_HUMAN
A:
[14-304]
------------------------------------------------------------------------------------------------
L
--------------
A
I
------
A
V
L
A
I
L
G
---
N
V
L
----
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
I
--
L
-
V
------------
G
V
L
A
-
I
P
F
A
I
----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
--
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
-----
A
G
I
I
A
I
C
W
---
V
L
S
F
A
------
I
G
L
T
P
M
L
G
---
W
N
-----
N
---
C
G
Q
P
------G
C
----------
G
E
G
Q
V
A
C
L
-
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
-
N
F
F
A
C
V
-
L
------------
V
P
L
L
L
M
-------------
L
G
V
Y
L
R
-----
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
------------
S
---------------------
T
----
L
-----
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
-------------------
N
C
--------
F
T
F
-
F
C
P
-
D
C
--
S
----
H
------
A
----
P
L
W
L
M
---------
Y
L
A
I
V
L
-
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.78
21%
-144
- C1 -
3PWH
1
?
A:
[14-304]
------------------------------------------------------------------------------------------------
L
--------------
A
I
------
A
V
L
A
I
L
G
---
N
V
L
----
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
I
--
L
-
V
------------
G
V
L
A
-
I
P
F
A
I
----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
--
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
-----
A
G
I
I
A
I
C
W
---
V
L
S
F
A
------
I
G
L
T
P
M
L
G
---
W
N
-----
N
---
C
G
Q
P
------G
C
----------
G
E
G
Q
V
A
C
L
-
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
-
N
F
F
A
C
V
-
L
------------
V
P
L
L
L
M
-------------
L
G
V
Y
L
R
-----
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
------------
S
---------------------
T
----
L
-----
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
-------------------
N
C
--------
F
T
F
-
F
C
P
-
D
C
--
S
----
H
------
A
----
P
L
W
L
M
---------
Y
L
A
I
V
L
-
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.48
21%
-144
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[14-304]
------------------------------------------------------------------------------------------------
L
--------------
A
I
------
A
V
L
A
I
L
G
---
N
V
L
----
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
I
--
L
-
V
------------
G
V
L
A
-
I
P
F
A
I
----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
--
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
-----
A
G
I
I
A
I
C
W
---
V
L
S
F
A
------
I
G
L
T
P
M
L
G
---
W
N
-----
N
---
C
G
Q
P
------G
C
----------
G
E
G
Q
V
A
C
L
-
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
-
N
F
F
A
C
V
-
L
------------
V
P
L
L
L
M
-------------
L
G
V
Y
L
R
-----
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
------------
S
---------------------
T
----
L
-----
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
-------------------
N
C
--------
F
T
F
-
F
C
P
-
D
C
--
S
----
H
------
A
----
P
L
W
L
M
---------
Y
L
A
I
V
L
-
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.40
21%
-143
- C1 -
3UZC
1
AA2AR_HUMAN
A:
[14-304]
------------------------------------------------------------------------------------------------
L
--------------
A
I
------
A
V
L
A
I
L
G
---
N
V
L
----
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
I
--
L
-
V
------------
G
V
L
A
-
I
P
F
A
I
----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
--
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
-----
A
G
I
I
A
I
C
W
---
V
L
S
F
A
------
I
G
L
T
P
M
L
G
---
W
N
-----
N
---
C
G
Q
P
------G
C
----------
G
E
G
Q
V
A
C
L
-
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
-
N
F
F
A
C
V
-
L
------------
V
P
L
L
L
M
-------------
L
G
V
Y
L
R
-----
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
------------
S
---------------------
T
----
L
-----
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
-------------------
N
C
--------
F
T
F
-
F
C
P
-
D
C
--
S
----
H
------
A
----
P
L
W
L
M
---------
Y
L
A
I
V
L
-
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.03
21%
-140
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[14-304]
------------------------------------------------------------------------------------------------
L
--------------
A
I
------
A
V
L
A
I
L
G
---
N
V
L
----
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
I
--
L
-
V
------------
G
V
L
A
-
I
P
F
A
I
----------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
--
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
-----
A
G
I
I
A
I
C
W
---
V
L
S
F
A
------
I
G
L
T
P
M
L
G
---
W
N
-----
N
---
C
G
Q
P
------G
C
----------
G
E
G
Q
V
A
C
L
-
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
-
N
F
F
A
C
V
-
L
------------
V
P
L
L
L
M
-------------
L
G
V
Y
L
R
-----
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
------------
S
---------------------
T
----
L
-----
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
-------------------
N
C
--------
F
T
F
-
F
C
P
-
D
C
--
S
----
H
------
A
----
P
L
W
L
M
---------
Y
L
A
I
V
L
-
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.05
21%
-144
- C1 -
3C9M
1
OPSD_BOVIN
A:
[40-317]
-----------------------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
--------------
I
-----------
M
L
G
F
P
I
N
F
L
----
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
--
L
A
V
A
D
L
F
M
V
-
F
------------
G
G
F
T
-
T
--
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
-------
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
-----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
---
L
V
G
W
S
R
Y
I
P
---
E
G
-----
M
QCS
C
G
---------
I
----------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
--
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
-
V
------------
I
F
F
C
Y
G
-------------
Q
L
V
F
T
V
-----
K
E
A
-------------
A
A
Q
Q
Q
E
S
------------
A
---------------------
T
----
T
-----
Q
K
A
E
K
----
E
V
T
R
M
V
I
I
M
V
--------
I
A
F
L
-------------------
I
C
W
L
P
Y
A
G
V
A
F
Y
I
-
F
T
H
-
Q
G
--
S
----
C
------
F
G---
P
I
F
-
M
---------
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
------------------
L
C
C
G
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
84.75
17%
-134
- C1 -
2Z73
5
OPSD_TODPA
A:
[32-333]
----------------------------------------------------------------------
A
V
Y
----------------
Y
S
L
G
I
F
I
G
--------------
I
C
------
G
I
I
G
C
G
G
---
N
G
I
----
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
--
L
A
F
S
D
F
--
T
-
F
------------
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
-
I
F
G
F
A
A
C
-------
K
V
Y
G
F
I
G
-
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
-----
F
I
M
I
I
F
V
W
---
L
W
S
V
L
W
A
---
I
G
P
I
F
G
W
G
A
---
Y
T
-----
L
-------
E
G
V
L
C
N
-
C
----------
S
F
D
Y
I
S
-----
R
D
--
S
T
T
R
S
N
I
L
C
-
M
F
I
L
G
F
-
F
------------
G
P
I
L
I
I
-------------
F
F
C
Y
F
N
-----
I
V
M
-------------
S
V
S
N
H
E
K
------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
----
E
-----
M
R
L
A
K
----
I
S
I
V
I
V
S
Q
F
L
--------
L
S
W
S
-------------------
P
Y
--------
A
V
V
-
A
L
L
-
A
Q
--
F
----
G
PLE---
W
VT--
P
Y
A
-
A
---------
Q
L
P
V
M
F
-
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
------------------
F
P
W
V
L
T
C
C
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
81.12
18%
-117
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------------
M
N
G
T
-
E
G
P
----------------
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
----------------
S
M
L
A
A
Y
M
F
--------------
L
L
------
I
M
L
G
F
P
I
---
N
F
L
----
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
--
L
A
V
A
D
L
--
F
-
M
------------
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
-------
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
-----
M
G
V
A
F
T
W
V
---
M
A
L
A
C
A
A
---
P
P
L
V
G
W
S
R
Y
---
I
P
E
GMQC
S
---
C
G
I
D
----
Y
Y
-
T
----------
P
----
H
E
E
T
N
N
E
S
--
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
-
V
------------
I
F
F
C
Y
G
-------------
Q
L
V
F
T
V
-----
K
E
A
-------------
A
A
Q
Q
Q
E
S
------------
A
---------------------
T
----
T
-----
Q
K
A
E
K
----
E
V
T
R
M
V
I
I
M
V
--------
I
A
F
L
-------------------
I
C
--------
W
L
P
-
Y
A
G
-
V
A
--
F
----
Y
------
I
----
F
T
H
-
Q
GSDFGPIFM
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.49
22%
-131
- C1 -
2X72
5
GNAT1_BOVIN (first)
A:
[43-318]
-----------------------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
--------------
I
-----------
M
L
G
F
P
I
N
F
L
----
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
--
L
A
V
A
D
L
F
M
V
-
F
------------
G
G
F
T
-
T
--
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
-------
N
L
Q
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
-----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
---
L
V
G
W
S
R
Y
I
P
---
E
G
-----
M
QCS
C
G
---------
I
----------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
--
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
-
V
------------
I
F
F
C
Y
G
-------------
Q
L
V
F
T
V
-----
K
E
A
-------------
A
A
Q
Q
Q
E
S
------------
A
---------------------
T
----
T
-----
Q
K
A
E
K
----
E
V
T
R
M
V
I
I
M
V
--------
I
A
F
L
-------------------
I
C
W
L
P
Y
A
G
V
A
F
Y
I
-
F
T
H
-
Q
G
--
S
----
C
------
F
G
---
P
I
F
-
M
---------
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
------------------
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
78.26
15%
-129
* C1 *
2KS9
1
NK1R_HUMAN
A:
[34-325]
------------------------------------------------------------------------------------------
L
W
A
A
A
Y
T
--------------
V
I
------
V
V
T
S
V
V
G
---
N
V
V
----
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
--
L
A
F
A
E
A
--
S
-
M
------------
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
-
Y
Y
G
L
F
Y
C
-------
K
F
H
N
F
F
P
-
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
-----
K
V
V
I
C
V
I
W
---
V
L
A
L
L
L
A
---
F
P
Q
G
Y
Y
S
T
T
---
E
T
-------------
M
P
S
R
V
V
-
C
----------
M
I
E
W
P
E
H
P
---
N
K
--
I
Y
E
K
V
Y
H
I
C
-
V
T
V
L
I
Y
-
F
------------
L
P
L
L
V
I
-------------
G
Y
A
Y
T
V
-----
V
G
I
-------------
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
V
S
---------------------
A
----
K
-----
R
K
V
V
K
----
M
M
I
V
V
V
C
T
F
A
--------
I
C
W
L
-------------------
P
F
--------
H
I
F
-
F
L
L
-
P
Y
--
I
----
N
PDLYL-
K
KFI-
Q
Q
V
-
Y
---------
L
A
I
M
W
L
-
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
------------------
F
R
C
C
P
F
I
S
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
78.21
18%
-132
- C1 -
1U19
14
OPSD_BOVIN
A:
[41-327]
-----------------------------------------------------------------------------------------
S
M
L
A
A
Y
M
F
--------------
L
L
------
I
M
L
G
F
P
I
---
N
F
L
----
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
--
L
A
V
A
D
L
--
F
-
M
------------
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
-------
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
-----
I
M
G
V
A
F
T
W
---
V
M
A
L
A
C
A
---
A
P
P
L
V
G
W
S
R
---
Y
-----------
I
P
-
E
G
M
Q
C
S
-
C
----------
G
I
D
Y
Y
T
P
---
H
E
E
--
T
N
N
E
S
F
V
I
Y
-
M
F
V
V
H
F
-
I
------------
I
P
L
I
V
I
-------------
F
F
C
Y
G
Q
-----
L
V
F
-------------
T
V
K
E
A
A
A
------------
Q
QQESA
T
T
Q
K
------------
A
----
E
-----
K
E
V
T
R
----
M
V
I
I
M
V
I
A
F
L
--------
I
C
W
L
-------------------
P
Y
--------
A
G
V
-
A
F
Y
-
I
F
T
H
Q
----
G
------
S
DFG-
P
I
F
-
M
---------
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
------------------
L
C
C
G
K
N
P
L
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
76.01
17%
-126
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------
S
F
K
C
-
A
-------------------------
L
T
K
---------------
T
G
F
Q
F
----------------
Y
Y
L
P
A
V
Y
I
--------------
L
V
------
F
I
I
G
F
L
G
---
N
S
V
----
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
--
L
A
L
A
D
F
--
L
-
Y
------------
V
-
L
T
-
L
P
A
L
I
F
Y
Y
F
-
N
K
T
D
W
I
F
G
D
A
M
C
-------
K
L
Q
R
F
I
F
-
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
-----
I
C
I
S
V
L
V
W
---
L
----
I
V
---
V
V
A
I
S
P
I
L
F
---
Y
S
-----
G
---
T
G
V
R
K
N
K
T
I
T
-
C
YDTTSDEY
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
--
F
C
V
P
L
V
L
I
L
-
G
C
Y
G
L
I
-
V
------------
R
A
L
I
Y
K
-------------
M
K
K
Y
T
C
TVCG
Y
I
Y
N
-------------
P
E
D
G
D
P
D
------------
N
---------------------
G
----
V
NPGTD
F
K
D
I
V
----
C
P
L
C
G
V
G
K
D
Q
--------
F
E
E
V
-------------------
E
E
--------
P
L
R
-
R
K
S
-
I
Y
--
L
----
V
------
I
----
I
V
L
-
T
---------
V
F
A
V
S
Y
-
I
P
F
H
-
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
------------------
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR-------------------------------------------------------------------------------------------------------------------------------
45
Fugue
75.43
13%
-119
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------------------------------------
D
E
V
W
V
----------------
V
G
M
G
I
V
M
S
--------------
L
I
------
V
L
A
I
V
F
G
---
N
V
L
----
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
--
L
A
C
A
D
L
--
V
-
M
------------
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
-
T
F
G
N
F
W
C
-------
E
F
W
T
S
I
D
-
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
-----
R
V
I
I
L
M
V
W
---
I
V
S
G
L
T
S
---
F
L
P
I
Q
M
H
W
Y
---
R
A
-----------
T
H
Q
E
A
I
N
C
-
Y
----------
A
E
E
T
C
C
D
F
F
T
N
Q
A
--
Y
A
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
-
I
------------
M
V
F
V
Y
S
-------------
R
V
F
Q
E
A
-----
K
R
Q
-------------
L
N
I
F
E
M
L
------------
R
---------------------
I
----
D
-----
E
G
L
R
L
----
K
I
Y
K
D
T
E
G
Y
Y
--------
T
I
G
I
-------------------
G
H
--------
L
L
T
-
K
S
P
-
S
L
--
N
----
A
------
A
----
K
S
E
-
L
---------
D
K
A
I
G
R
-
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
------------------
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
31
HHSearch
71.75
17%
-118
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
-----------------------------------------------------------------------
N
K
----------------
Y
V
V
I
I
A
Y
A
--------------
L
V
------
F
L
L
S
L
L
G
---
N
S
L
----
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
--
L
A
L
A
D
L
--
L
-
F
------------
A
L
-
T
-
L
P
I
W
A
A
S
K
--
V
N
G
W
-
I
F
G
T
F
L
C
-------
K
V
V
S
L
L
K
-
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
-----
K
F
V
C
L
G
C
W
---
G
L
S
M
N
L
S
---
L
P
F
F
L
F
R
Q
A
---
Y
H
-----------
P
-
N
N
S
S
P
V
-
C
----------
Y
E
V
L
G
N
D
---
T
A
K
---
W
R
M
V
L
R
I
L
-
P
H
T
F
G
F
-
I
------------
V
P
L
F
V
M
-------------
L
F
C
Y
G
F
-----
T
L
R
-------------
T
L
F
K
A
H
M
------------
G
---------------------
Q
----
K
-----
H
R
A
M
R
----
V
I
F
A
V
V
L
I
F
L
--------
L
C
W
L
-------------------
P
Y
--------
N
L
V
-
L
L
A
-
D
T
--
L
M
RTQ
V
IQE
S
C
E
R
R
N
N
I
G
R
A
-
L
---------
D
A
T
E
I
L
-
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
------------------
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
70.68
20%
-87
- C1 -
4OWT
-
INT3_HUMAN
A:
[1-466]
GGRL
L
L
S
T
SLDAKD
E
L
E
E
R
L
E
R
C
M
S
I
V
T
S
M
T
AGVS
E
R
E
A
N
D
A
L
N
A
Y
V
C
K
G
L
P
Q
---------------
H
E
E
I
C
----------------
L
G
L
F
T
L
I
L
T
E
PAQ
A
Q
K
C
Y
R
D
L
A
L
V
SRDGM
N
I
V
L
N
K
I
N
---
Q
I
L
M
EKY
L
K
L
Q
D
T
C
R
T
Q
L
V
W
L
V
R
E
L
V
K
S
GV
L
G
A
D
G
V
--
C
M
T
F
M
K
Q
IAGGDVT
A
K
N
I
W
-
L
A
E
S
V
L
D
I
L
-
T
E
Q
R
-
E
W
V
L
K
----------
S
S
I
L
I
A
M
A
V
Y
T
Y
L
R
L
I
V
D
H
H
G
T
A
Q
L
Q
A
L
R
Q
K
E
V
D
F
C
I
S
---
L
L
R
E
R
F
M
E
C
L
M
I
G
R
D
L
V
R
L
---
L
Q
N
-
V
A
R
---
I
P
E
F
E
L
L
W
K
---
D
I
-----
I
---
H
N
P
Q
A
L
S
P
Q
F
-
T
----------
G
I
L
Q
L
L
Q
S
R
T
S
R
K
--
F
L
A
C
R
L
T
P
D
M
E
T
K
L
L
F
M
T
S
RVRFGQQ
K
R
Y
Q
D
W
F
Q
R
Q
YLSTPDS
Q
S
L
R
C
D
L
I
R
Y
I
C
-----
G
V
V
-------------
H
P
S
N
E
V
L
------------
S
---------------------
S
DILP
R
-----
W
A
I
I
G
W
L
L
T
T
C
T
S
N
V
A
A
S
N
--------
A
K
L
A
L
F
Y
DWLFFSPDKDSIMNI
E
P
A
--------
I
L
V
M
H
H
S
M
K
P
--
H
----
P
------
A
----
I
T
A
-
T
---------
L
L
D
--
F
M
C
R
I
I
P
N
F
Y
P
P
L
E
G
H
V
R
Q
G
V
F
S
S
L
N
H
I
------------------
V
E
K
R
V
L
A
H
L
A
P
L
F
D
NPKLD
K
E
L
R
A
M
L
R
E
K
FPEFCS--------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
64.77
20%
-148
- C1 -
3EML
8
ENLYS_BPT4
A:
[22-220]
-----------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
--------------
A
I
------
A
V
L
A
I
L
G
---
N
V
L
----
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
I
--
A
-
V
------------
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
-
C
A
A
C
H
G
C
-------
L
F
I
A
C
F
V
-
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
-----
K
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
N
---
C
G
-----
Q
----------
S
Q
G
-
C
----------
G
E
G
Q
V
---
A
C
L
F
E
DV
V
P
M
N
Y
M
V
Y
F
-
N
F
F
A
C
V
-
L
------------
V
P
L
L
L
M
-------------
L
G
V
Y
L
R
-----
I
F
L
-------------
A
A
R
R
Q
L
N
------------
I
---------------------
F
----
E
-----
M
L
R
I
D
----
E
G
L
R
L
K
I
Y
K
D
--------
T
E
G
Y
-------------------
Y
T
--------
I
G
I
-
G
H
L
-
L
T
--
K
----
S
------
P
----
S
L
N
-
A
---------
A
K
S
E
L
D
-
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
------------------
A
V
R
G
I
L
R
N
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.21
18%
-145
- C1 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-234]
-----------------------------------------------------------------------------------------
V
G
M
G
I
V
M
S
--------------
L
I
------
V
L
A
I
V
F
G
---
N
V
L
----
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
--
L
A
C
A
D
L
--
V
-
M
------------
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
-
T
F
G
N
F
W
C
-------
E
F
W
T
S
I
D
-
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
-----
R
V
I
I
L
M
V
W
---
I
V
S
G
L
T
S
---
F
L
P
I
Q
M
H
W
Y
---
R
A
-----
T
---
H
----
Q
E
A
I
N
-
C
----------
Y
A
E
----
E
T
C
C
D
F
--
F
T
N
Q
A
Y
A
I
A
-
S
S
I
V
S
F
-
Y
------------
V
P
L
V
I
M
-------------
V
F
V
Y
S
R
-----
V
F
Q
-------------
E
A
K
R
Q
L
N
------------
I
---------------------
F
----
E
-----
M
L
R
I
D
----
E
G
L
R
L
K
I
Y
K
D
--------
T
E
G
Y
-------------------
Y
T
--------
I
G
I
-
G
H
L
-
L
T
--
K
----
S
------
P
----
S
L
N
-
A
---------
A
K
S
E
L
D
-
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
------------------
A
V
R
G
I
L
R
N
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
62.15
20%
-145
- C1 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-224]
-------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
--------------
A
L
------
I
L
A
I
V
F
G
---
N
G
L
----
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
--
L
A
V
A
D
L
--
L
-
V
------------
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
-
N
F
S
R
I
C
C
-------
D
V
F
V
T
L
D
-
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
-----
A
L
M
I
T
A
V
W
---
V
L
A
F
A
V
S
---
C
P
L
L
F
G
F
N
T
---
T
---------------
G
D
P
T
V
-
C
----------
S
I
S
N
------------
P
D
-
F
-
V
I
Y
-
S
S
V
V
S
F
-
Y
------------
L
P
F
G
V
T
-------------
V
L
V
Y
A
R
-----
I
Y
V
-------------
V
L
K
Q
R
R
R
------------
K
---------------------
N
----
I
-----
F
E
M
L
R
----
I
D
E
G
L
R
L
K
I
Y
--------
K
D
T
E
-------------------
G
Y
--------
Y
T
I
-
G
I
G
-
H
L
--
L
----
T
------
K
----
S
P
S
-
L
---------
N
A
A
K
S
E
-
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
------------------
D
A
A
V
R
G
I
L
R
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
61.32
18%
-154
- C1 -
3UON
2
ACM2_HUMAN (first)
A:
[24-213]
-----------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
--------------
S
L
------
S
L
V
T
I
I
G
---
N
I
L
----
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
--
L
A
C
A
D
L
--
I
-
I
------------
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
-
P
L
G
P
V
V
C
-------
D
L
W
L
A
L
D
-
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
-----
G
M
M
I
A
A
A
W
---
V
L
S
F
I
L
W
---
A
P
A
I
L
F
W
Q
F
---
I
V
-----
G
---
V
--
R
T
V
E
D
G
E
-
C
----------
Y
I
Q
F
F
-----------
S
N
A
A
V
T
F
G
-
T
A
I
A
A
F
-
Y
------------
L
P
V
I
I
M
-------------
T
V
L
Y
W
H
-----
I
S
R
-------------
A
S
K
S
R
I
N
------------
I
---------------------
F
----
E
-----
M
L
R
I
D
----
E
G
L
R
L
K
I
Y
K
D
--------
T
E
G
Y
-------------------
Y
T
--------
I
G
I
-
G
H
L
-
L
T
--
K
----
S
------
P
----
S
L
N
-
A
---------
A
K
S
E
L
D
-
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
------------------
A
V
R
G
I
L
R
N
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------