@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4E1_HUMAN: (2016-01-13 )
MEEAILLNQTSLVTYFRLRGLSVNHKARIAMFSMFLIFYVLTLIGNVLIVITIIYDHRLHTPMYFFLSNLSFIDVCHSTVTVPKMLRDVWSEEKLISFDACVTQMFFLHLFACTEIFLLTVMAYDRYVAICKPLQYMIVMNWKVCVLLAVALWTGGTIHSIALTSLTIKLPYCGPDEIDNFFCDVPQVIKLACIDTPYVLEILIVSNSGLISVVCFVVLVVSYAVILVSLRQQISKGKWKALSTCAAHLTVVTLFLGHCIFIYSRPSTSLPEDKAVSVFFTAVTPLLNPIIYTLRNEEMKSALNKLVGRKERKEEK
Atome Classification :
(20 SA)
-------------.........10-------.........20........30.--......-.40....---....50.......-.60........70........-----------80-..----......90.....---....100........110.......120.....-----------..130.......---140.......150.......160.......170-----.-----.......180-------------.......190.-..--.---.--------.-----.200........210....---...220.......230....------------.---------------------..240...----..-----------------..250..--------.....260....-----.--.---.-------270---...---------.....280.......290-........300.....--..310....---------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------ME
E
A
I
L
LNQ
T
--------
S
L
V
T
Y
F
R
LRGLSVN
H
K
A
R
I
A
M
F
--
S
M
F
L
I
F
-
Y
V
L
T
L
IG---N
V
L
I
V
I
T
I
I
YDHR-LH
T
P
M
Y
F
F
L
SN
L
S
F
I
D
V
C
H
ST-----------V
T
-
V
P
----
K
M
L
R
D
V
W-SEEKL---
I
S
F
D
A
-
C
V
T
Q
M
F
F
L
H
L
F
A
C
T
E
I
F
L
L
T
V
M
A
YD
R
Y
-----------
V
A
I
CKP
L
Q
Y
M
I
V
---MN
W
K
V
C
V
L
L
A
V
A
L
WTG
G
T
I
H
S
I
A
L
T
S
L
T
I
KL-P-----Y-----C
G
P
D
E
I
D
N
F
F
-------------CD
V
P
Q
V
I
K
L
AC-ID--T---
P
--------
Y
-----
V
L
-
E
I
L
I
VSNS
G
L
I
S
V
V
C
F
---
V
V
L
V
V
S
Y
A
V
I
L
V
S
L
R
Q
Q
I
SK------------G---------------------K
W
K
A
L
S
T
C
----
A
A
-----------------
H
L
T
V
V
T
L
--------
F
LG
H
C
I
F
I
YSRP-----S--T---S-------L-P---EDK---------A
V
S
V
F
F
T
A
V
T
P
L
L
N
P
I
I
--
Y
T
L
R
N
E
E
M
K
S
A
L
N
K
L
V--G
R
K
E
RKEEK---------------------------------
20
PsiBlast_PDB
88.68
20%
-135
- C3 -
3C9L
13
OPSD_BOVIN
A:
[32-317]
-----------------------------------------------
A
E
P
W
Q
F
--
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
---
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
--------
N
F
R
F
-----------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
-
A
L
----
A
-----
C
A
A
P
P
L
V
G
W
S
-------------
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
YY
T
---
P
HEETN
N
E
S
F
-----
V
I
-
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
---
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
----
T
R
-----------------
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----
G
--
S
---
D
-------
F
G
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
D
D
E
----------------------------------
19
PsiBlast_PDB
86.92
20%
-141
- C3 -
3CAP
6
OPSD_BOVIN
A:
[32-317]
-----------------------------------------------
A
E
P
W
Q
F
--
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
---
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
--------
N
F
R
F
-----------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
-
A
L
----
A
-----
C
A
A
P
P
L
V
G
W
S
-------------
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
YY
T
---
P
HEETN
N
E
S
F
-----
V
I
-
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
---
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
----
T
R
-----------------
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----
G
--
S
---
D
-------
F
G
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
-------------------------------------
11
PsiBlast_PDB
81.55
20%
-113
- C3 -
2X72
5
GNAT1_BOVIN (first)
A:
[40-318]
----------------------------------------------------
F
--
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
---
F
G
P
T
G
-
C
N
L
Q
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
--------
N
F
R
F
-----------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
-
A
L
----
A
-----
C
A
A
P
P
L
V
G
W
S
-------------
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
YY
T
---
P
HEETN
N
E
S
F
-----
V
I
-
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
---
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
----
T
R
-----------------
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----
G
--
S
---
C
-------
F
G
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
-------------------------------------
39
HHSearch
81.12
16%
-134
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-333]
-----------------------------------------------
V
Y
Y
S
L
G
--
I
F
I
G
I
C
-
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
-
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
-----------
V
N
G
F
P
----
L
M
T
I
S
C
F
-
L
K
K
W
I
---
F
G
F
A
A
-
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
-----------
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
--------------
T
-
L
E
G
V
L
C
N
-------------
C
S
F
D
Y
I
S
R
--------
D
------------
S
-----
T
T
-
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
---
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
----
I
V
-----------------
I
V
S
Q
F
L
L
--------
S
W
S
P
Y
A
V
V
A
L
L
A
-----
Q
FG
P
LEW
V
-------
T
-
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
--
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
W
V
L
T
C
C
Q
F
---------------------------------
36
HHSearch
80.19
17%
-136
* C3 *
2KS9
1
NK1R_HUMAN
A:
[34-325]
--------------------------------------------------
L
W
A
--
A
A
Y
T
V
I
-
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
-
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
-----------
F
N
-
T
V
----
V
N
F
T
Y
A
V
-
H
N
E
W
Y
---
Y
G
L
F
Y
-
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
-----------
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
--------------
E
-
T
M
P
S
R
V
V
-------------
C
M
I
E
W
P
E
H
P
----
N
--
K
------------
I
-----
Y
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
---
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
S
A
---------------------
K
R
K
V
V
K
M
M
----
I
V
-----------------
V
V
C
T
F
A
I
--------
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
NP-
D
--
L
---
Y
-------
L
K
K
FI
Q
Q
V
Y
---------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
--
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
--
R
C
C
P
F
I
S
A
G
---------------------------------
46
Fugue
79.83
16%
-101
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------
M
N
G
T
E
G
P
N
F
Y
VPFSNKTG
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
--
A
A
Y
M
F
L
-
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
---
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
GMQC
S
-----
C
G
I
D
----
Y
Y
-------------
T
P
H
E
E
T
N
------
N
--
E
---
S
--------
F
-----
V
I
-
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
---
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
----
T
R
-----------------
M
V
I
I
M
V
I
--------
A
F
L
I
C
W
L
P
Y
A
G
V
-----
A
--
F
---
Y
-------
I
-
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA-----------------
51
Fugue
79.82
18%
-148
- C2 -
4L9B
5
?
A:
[2-393]
VLKGINFP
E
N
E
A
S
I
L
D
L
A
M
Q
N
R
S
--------
G
V
L
D
G
M
T
I
D
I
L
N
T
T
S
N
-
Q
L
A
L
F
H
G
T
A
V
L
Q
G
-
Y
G
I
E
I
T
G
---
A
P
D
V
L
V
D
T
T
-
G
Q
S
-
N
E
T
M
L
L
C
L
T
I
D
L
N
Q
V
N
V
P
S
G
T
AVDYKQ
I
R
L
E
F
L
D
-
V
P
----
T
L
L
K
Q
Y
W
-
R
D
H
S
L
HDL
I
D
P
R
R
-
V
I
S
M
P
L
Y
W
I
T
F
G
Q
T
G
T
T
P
L
Y
E
Q
I
K
S
N
Y
IDNSGNPAYGI
A
A
R
C
E
N
F
N
H
F
I
N
---
K
V
A
V
Q
S
I
P
I
N
G
V
A
N
R
P
V
S
S
T
A
S
Q
L
T
N
Y
K
V
W
R
N
P
-----
Y
L----
C
S
Q
D
P
R
D
K
F
A
P
D
N
L
V
I
EEDGI
Y
R
I
D
I
S
G
S
I
N
I
A
N
-
Y
T
--
F
---
P
--------
A
RVG
G
R
Y
F
-
Q
I
V
C
A
R
N
S
S
A
N
N
L
A
E
F
GAE
Q
H
L
P
P
S
G
V
W
T
R
R
V
L
V
G
E
Y
T
A
------------
G
---------------------
M
---
T
E
Q
A
----
F
S
-----------------
S
V
A
T
I
S
L
--------
F
K
G
D
N
F
F
L
Q
F
E
T
-----
G
--
T
---
N
-------
T
-
S
---
R
D
S
---------
A
Y
N
N
G
Y
G
T
S
G
T
H
L
R
N
F
S
--
Y
T
L
E
R
V
G
------
D
L
N
--
G
T
A
Y
Y
D
N
G
T
F--------------------------------
45
Fugue
78.88
15%
-116
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
--------
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
--
A
A
Y
M
F
L
-
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
---
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
-----
E
GMQC
S
C
G
I
D
----
Y
Y
-------------
T
P
H
E
E
T
N
------
N
--
E
---
S
--------
F
-----
V
I
-
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
---
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
T
Q
K
------------
A
---------------------
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-----------------
F
L
I
C
W
L
P
--------
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----
G
--
S
---
D
-------
F
G
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------------
18
PsiBlast_PDB
75.94
20%
-122
- C3 -
1LN6
1
OPSD_BOVIN
A:
[40-315]
---------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
FPI
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
---
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
--------
N
F
R
F
-----------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
-
A
L----
A
-----
C
A
A
P
P
L
V
G
W
S
-------------
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
YY
T
---
P
HEETNNES
F
-----
V
I
-
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
---
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
----
T
R
-----------------
M
V
I
I
M
V
I
A
F
LICWLP
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----
G
--
S
---
D
-------
F
G
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
F
R
N
C
M
V
V
A
T
--
T
L
C
C
G
K
N
P
L
---------------------------------
54
Fugue
75.72
16%
-135
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------------------------------
S
F
K
-
C
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
--
A
V
Y
I
L
V
-
F
I
I
G
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
M
K
-
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
-----------
L
T
-
L
P
----
A
L
I
F
Y
Y
F
-
N
K
T
D
W
---
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
-----------
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
------
I
V
V
V
A
I
S
P
I
L
-
F
-----
Y
-----
S
G
T
G
V
R
K
N
---------------------
K
T
I
T
C
-
Y
D
--
T
TSD
E
--------
Y
-----
L
R
-
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
---
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
------------
K
---------------------
K
Y
T
C
T
V
C
G
----
Y
I
Y
N
PEDGDPDNGVNPGTD
F
K
D
I
V
C
P
--------
L
C
G
V
G
K
D
Q
F
E
E
V
-----
E
--
E
---
P
-------
L
-----
R
R
K
---------
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
--
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR
34
HHSearch
75.24
16%
-125
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
------------------------------------------------
K
Y
V
V
I
--
I
A
Y
A
L
V
-
F
L
L
S
L
L
G
---
N
S
L
V
M
L
V
I
L
Y
S
R
V
-
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
------------
T
-
L
P
----
I
W
A
A
S
K
--
V
N
G
W
I
---
F
G
T
F
L
-
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
-----------
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
--------------
H
-
P
N
N
S
S
P
V
-------------
C
Y
E
V
L
G
N
------
D
--
T
---
A
--------
K
-----
W
R
-
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
---
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
M
G
------------
Q
---------------------
K
H
R
A
M
R
V
I
----
F
A
-----------------
V
V
L
I
F
L
L
--------
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
RT
Q
--
V
---
I
QE
S
C
E
R
R
N
-
N
I
G
-
R
A
L
---------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
--
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
--
A
M
H
G
--------------------------------------
37
HHSearch
72.06
14%
-128
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-328]
-------------------------------------------------
S
M
L
A
--
A
Y
M
F
L
L
-
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
---
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
--------------
I
P
-
E
G
M
Q
C
S
-------------
C
G
I
D
Y
Y
T
P
----
H
E
--
E
------------
T
-----
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
---
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
QESA
T
T
Q
K
A
------------
E
K
E
V
T
R
M
V
----
I
I
-----------------
M
V
I
A
F
L
I
--------
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
---
H
--
Q
GSD
F
-------
G
-
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
L
G
D
---------------------------------
31
HHSearch
68.00
19%
-161
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-220]
-------------------------------------------------
S
V
Y
I
--
T
V
E
L
A
I
-
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
-----------
L
A
-
I
P
----
F
A
I
T
I
S
T
---
G
F
C
---
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
-----
Q
------------
S
Q
G
-------------
C
G
E
G
Q
---
V
A
C
-
L
F
--
E
---
D
--------
V
-----
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
---
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
------------
F
---------------------
E
M
L
R
I
D
E
G
----
L
R
-----------------
L
K
I
Y
K
D
T
--------
E
G
Y
Y
T
I
G
I
G
H
L
L
-----
T
--
K
---
S
-------
P
-
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
--
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
--
V
R
G
I
L
R
N
A
K
---------------------------------
29
HHSearch
64.14
19%
-150
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-234]
-------------------------------------------------
V
G
M
G
--
I
V
M
S
L
I
-
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
-
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
----
F
G
A
A
H
I
L
-
M
K
M
W
T
---
F
G
N
F
W
-
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
-----------
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
-
A
-----
T
---------
H
Q
E
A
I
N
-------------
C
Y
A
E
----
E
T
C
-
C
D
--
F
------------
F
-----
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
---
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
------------
F
---------------------
E
M
L
R
I
D
E
G
----
L
R
-----------------
L
K
I
Y
K
D
T
--------
E
G
Y
Y
T
I
G
I
G
H
L
L
-----
T
--
K
---
S
-------
P
-
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
--
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
--
V
R
G
I
L
R
N
A
K
---------------------------------
27
HHSearch
61.16
16%
-142
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[25-214]
--------------------------------------------------
F
I
V
--
L
V
A
G
S
L
-
S
L
V
T
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
-
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
-----------
F
S
-
M
N
----
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
---
L
G
P
V
V
-
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
-----------
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
-------------
V
G
V
R
T
V
E
D
G
E
-------------
C
Y
I
Q
F
------------------------
F
-----
S
N
-
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
---
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
------------
F
---------------------
E
M
L
R
I
D
E
G
----
L
R
-----------------
L
K
I
Y
K
D
T
--------
E
G
Y
Y
T
I
G
I
G
H
L
L
-----
T
--
K
---
S
-------
P
-
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
--
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
--
V
R
G
I
L
R
N
A
K
---------------------------------
35
HHSearch
60.67
19%
-154
- C3 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-224]
---------------------------------------------------
Y
A
--
L
S
Y
C
A
L
-
I
L
A
I
V
F
G
---
N
G
L
V
C
M
A
V
L
K
E
R
A
-
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
-----------
L
V
-
M
P
----
W
V
V
Y
L
E
V
T
G
G
V
W
N
---
F
S
R
I
C
-
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
-----------
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
-----------------
T
-
G
D
P
T
V
-------------
C
S
I
-------------
S
------------
N
--------
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
---
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
------------
N
---------------------
I
F
E
M
L
R
I
D
----
E
G
-----------------
L
R
L
K
I
Y
K
--------
D
T
E
G
Y
Y
T
I
G
I
G
H
-----
L
--
L
---
T
-------
K
-
S
---
P
S
L
---------
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
--
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
--
A
A
V
R
G
I
L
R
N
---------------------------------
1
PsiBlast_PDB
58.24
25%
-160
- C3 -
4EJ4
1
ENLYS_BPT4 (first)
A:
[15-159]
-------------------------------------------------
I
A
I
T
--
A
L
Y
S
A
V
-
C
A
V
G
L
L
G
---
N
V
L
V
M
F
G
I
V
R
Y
T
K
-
L
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
-
A
T
-----------
S
T
-
L
P
F
Q
S
A
K
Y
L
M
E
T
W
-
P
F
G
E
L
---
L
C
--
K
-
A
V
L
S
I
D
Y
Y
N
M
F
--
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
-----------
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
Q
-
P
-----
R
-----
D
G
A
V
V
C
M
L
Q
F
-------------
P
S
P
S
W
Y
W
D
T
V
T
-
K
I
--
C
---
V
--------
F
-----
L
F
-
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
---
L
L
R
L
R
S
V
R
N
I
F
E
M
L
R
I
D
E
G
L
------------
R
---------------------
L
K
I
Y
K
N
T
E
----
G
Y
-----------------
Y
T
I
G
I
G
H
--------
L
L
T
K
S
P
S
L
N
A
A
K
-----
S
--
E
---
L
-------
D
-
K
---
A
I
G
---------
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
--
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
--
K
P
V
Y
D
S
L
D
A
---------------------------------
3
PsiBlast_PDB
56.96
24%
-152
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[123-267]
-------------------------------------------------
I
A
I
T
--
A
L
Y
S
A
V
-
C
A
V
G
L
L
G
---
N
V
L
V
M
F
G
I
V
R
Y
T
K
-
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
-
A
T
-----------
S
T
-
L
P
F
Q
S
A
K
Y
L
M
E
T
W
-
P
F
G
E
L
---
L
C
--
K
-
A
V
L
S
I
D
Y
Y
N
M
F
--
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
-----------
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
-----
R
-----
D
G
A
V
V
C
M
L
Q
F
-------------
P
S
P
S
W
Y
W
D
T
V
T
-
K
I
--
C
---
V
--------
F
-----
L
F
-
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
---
L
L
G
S
K
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
------------
V
---------------------
V
G
A
F
V
V
C
W
----
A
P
-----------------
I
H
I
F
V
I
V
--------
W
T
L
V
D
I
D
R
R
D
P
L
-----
V
--
V
---
A
-------
A
-
L
---
H
L
C
---------
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
--
L
D
E
N
F
K
R
C
F
R
Q
L
C
-----------------------------------------------
30
HHSearch
55.91
16%
-146
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-237]
----------------------------------------------
F
N
K
I
F
L
P
--
T
I
Y
S
I
I
-
F
L
T
G
I
V
G
---
N
G
L
V
I
L
V
M
G
Y
Q
K
K
-
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
------------
I
T
-
L
P
----
F
W
A
V
D
A
V
--
A
N
W
Y
---
F
G
N
F
L
-
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
-----------
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
----------------
E
A
D
D
R
Y
I
-------------
C
D
R
F
Y
P
N
------
D
---------------
L
-----
W
V
-
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
---
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
------------
I
---------------------
F
E
M
L
R
I
D
E
----
G
L
-----------------
R
L
K
I
Y
K
D
--------
T
E
G
Y
Y
T
I
G
I
G
H
L
-----
L
--
T
---
K
-------
S
-
P
---
S
L
N
---------
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
--
A
V
R
G
I
L
R
N
A
---------------------------------
2
PsiBlast_PDB
55.56
24%
-145
- C3 -
4N6H
15
C562_ECOLX (first)
A:
[126-270]
-------------------------------------------------
I
A
I
T
--
A
L
Y
S
A
V
-
C
A
V
G
L
L
G
---
N
V
L
V
M
F
G
I
V
R
Y
T
K
-
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
-
A
T
-----------
S
T
-
L
P
F
Q
S
A
K
Y
L
M
E
T
W
-
P
F
G
E
L
---
L
C
--
K
-
A
V
L
S
I
D
Y
Y
N
M
F
--
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
-----------
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
-----
R
-----
D
G
A
V
V
C
M
L
Q
F
-------------
P
S
P
S
W
Y
W
D
T
V
T
-
K
I
--
C
---
V
--------
F
-----
L
F
-
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
---
L
L
R
L
R
S
V
R
L
L
S
G
S
K
E
K
D
R
S
L
------------
R
---------------------
R
I
T
R
M
V
L
V
----
V
V
-----------------
G
A
F
V
V
C
W
--------
A
P
I
H
I
F
V
I
V
W
T
L
-----
V
--
D
---
I
-------
D
-
R
---
R
D
P
---------
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
--
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
--
C
F
R
Q
L
C
R
K
P
---------------------------------