@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4F4_HUMAN: (2016-01-13 )
MVTEFIFLGLSDSQELQTFLFMLFFVFYGGIVFGNLLIVITVVSDSHLHSPMYFLLANLSLIDLSLSSVTAPKMITDFFSQRKVISFKGCLVQIFLLHFFGGSEMVILIAMGFDRYIAICKPLHYTTIMCGNACVGIMAVAWGIGFLHSVSQLAFAVHLPFCGPNEVDSFYCDLPRVIKLACTDTYRLDIMVIANSGVLTVCSFVLLIISYTIILMTIQHCPLDKSSKALSTLTAHITVVLLFFGPCVFIYAWPFPIKSLDKFLAVFYSVITPLLNPIIYTLRNKDMKTAIRRLRKWDAHSSVKF
Atome Classification :
(20 SA)
----....-----...-----------------..----------------10........20........30........40........50........60......----..70.........80........90........100.......110.......120.......130.......140.......150..-.....-160---.........170.......----------180--....--...190.....-------..200.......210...---------....220.------------.---------------------.---------...-------------------.230.......240--......-...250----...-----.--.------------..---260----........270.......280.......290...----------------....300...--------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MV
T
E
-----
F
I
F
-----------------LG----------------LS
D
S
Q
E
L
Q
T
F
L
F
M
L
F
F
V
F
Y
G
G
I
V
FG
N
L
L
I
V
I
T
VVSDSHLH
S
P
M
Y
F
L
L
AN
L
S
L
I
D
L
SLS----SVT-
A
P
K
M
I
T
D
F
F
SQRK
V
I
S
F
K
G
C
L
V
Q
I
F
L
L
H
FFGG
S
E
M
V
I
L
I
A
MGF
D
R
Y
I
A
I
CKP
L
H
Y
T
T
I
MCGN
A
C
V
G
I
M
A
V
A
W
G
I
G
F
L
H
S
V
S
Q
L
A
-
F
A
V
HL-P-----FCGP
N
E
V
D
S
F
Y
CD
L
P
R
V
I
K
----------
L
AC--T
D
T
Y
--
R
L
D
I
M
V
I
ANS
G
-------
V
L
T
V
C
S
F
V
L
L
I
I
S
Y
T
I
I
L
---------
M
T
I
QHCPL------------D---------------------K---------S
S
K
-------------------
A
L
S
T
L
T
A
H
I
T
V
V
----
L
LFFG
P
-
C
V
F
I
Y
A----WPF-----
P
--
I
------------
K
S
---
L
D
-----
K
F
L
A
V
F
Y
S
V
I
T
P
L
L
N
P
I
I
Y
T
LRNK
D
M
K
T
A
I
R
R
L
R
----------------KWDAHSSVKF--------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
89.09
23%
-148
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
K
E
G
K
AGCGEGQ---
V
A
C
LF
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
-
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.35
23%
-157
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
-----SQGCGEGQ--
V
A
C
L
F
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.01
23%
-159
- C2 -
3VG9
8
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
-----SQGCGEGQ--
V
A
C
L
F
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.84
23%
-157
- C2 -
3REY
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
L
F
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.34
23%
-155
- C2 -
3PWH
1
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
LF
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
87.32
23%
-155
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
L
F
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.15
23%
-152
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
L
F
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
87.01
23%
-152
- C2 -
2YDO
3
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
K
E
G
K
A
H
S
Q
GCGEGQ
V
A
C
LF
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
----------------------------------------------------T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.98
23%
-151
- C2 -
4UG2
3
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
K
E
G
K
A
H
S
Q
GCGEGQ
V
A
C
LF
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
86.64
23%
-153
- C2 -
2YDV
6
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
K
E
G
K
A
H
S
Q
GCGEGQ
V
A
C
LF
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
--------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.59
23%
-152
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
L
F
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
----
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
79.51
15%
-142
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
----
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-
Y
S
T
T
--
E
-----
T
----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
---------------
P
N
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
-------
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
---------
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
V
S
---------------------
A
---------
K
R
K
-------------------
V
V
K
M
M
I
V
V
V
C
T
F
----
A
I
C
W
L
P
-
F
H
I
F
F
L
----
L
P
Y
-----
I
--
N
PDLYL-------
K
K
FI
Q
Q
V
-----
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
----------------
R
C
C
P
F
I
S
A
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
79.21
19%
-125
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----
M
N
G
T
E
G
PNF
Y
V
P
-----------------
F
S
NKTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
H
E
E
T
--------------
N
--
N
E
S
F
--
V
I
Y
M
F
V
V
H
F
I
I
-------
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
Q
Q
Q
E
S
------------
A
---------------------
T
---------
T
Q
K
-------------------
A
E
K
E
V
T
R
M
V
I
I
M
----
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS
D
--
F
------------
G
P
---
I
F
-----
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
79.02
16%
-141
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-332]
---------------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
----
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
G
A
Y
-
T
-----
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----------------
R
D
S
--
T
T
R
S
N
I
L
C
M
F
I
-------
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
---------
M
S
V
S
N
H
E
K
------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
---------
E
M
R
-------------------
L
A
K
I
S
I
V
I
V
S
Q
F
----
L
L
S
W
S
P
-
Y
A
V
V
A
L
----
L
A
Q
-----
F
--
G
PLEWV-------
T
P
---
Y
A
-----
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
----------------
P
W
V
L
T
C
C
Q
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
74.97
15%
-133
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
P
N
-----
F
Y
V
PFSNKTGVVRSPFEAPQ
Y
Y
----------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
-
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
H
E
E
--------------
T
N
--
N
E
S
F
--
V
I
Y
M
F
V
V
H
F
I
I
-------
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
S
A
T
T
Q
------------
K
---------------------
A
---------
E
K
E
-------------------
V
T
R
M
V
I
I
M
V
I
A
F
----
L
I
C
W
L
P
-
Y
A
G
V
A
F
----
Y
I
F
T
H
QGS
D
--
F
------------
G
P
---
I
F
-----
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
S
T
T
V
SKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
73.67
16%
-129
* C2 *
1U19
14
OPSD_BOVIN
A:
[41-328]
-----------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
-
I
--------
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---------------
H
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
-------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---------
F
T
V
K
E
A
A
A
------------
Q
---------------------
Q
QESA
T
T
Q
K
A
E
K
E
-------------------
V
T
R
M
V
I
I
M
V
I
A
F
----
L
I
C
W
L
P
-
Y
A
G
V
A
F
----
Y
I
F
T
H
---
Q
--
G
SDF---------
G
P
---
I
F
-----
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
L
G
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
70.24
16%
-122
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
----
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
-
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-
F
R
Q
A
Y
-
H
--------
P
-
N
N
S
S
P
V
C
Y
E
V
L
G
N
----------------
D
T
A
K
--
W
R
M
V
L
R
I
L
P
H
T
-------
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
---------
R
T
L
F
K
A
H
M
------------
G
---------------------
Q
---------
K
H
R
-------------------
A
M
R
V
I
F
A
V
V
L
I
F
----
L
L
C
W
L
P
-
Y
N
L
V
L
L
----
A
D
T
-----
L
M
R
T
QVIQE
S
C
E
R
R
N
N
I
G
---
R
A
-----
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
----------------
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.87
20%
-134
- C2 -
1LN6
1
OPSD_BOVIN
A:
[55-313]
----------------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FGGF
T
T
T
-
L
Y
T
S
L
H
G
Y
F
----
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-
A
F
T
W
-------
V
M
A
L
A
-
C
A
A
P
--
P
-----
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
----------
C
S
C
--
G
I
D
Y
--
Y
T
P
H
E
E
T
N
N
E
S
FVIYMFV
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---------
F
T
V
K
E
A
A
A
------------
Q
---------------------
Q
QESAT----
T
Q
K
-------------------
A
E
K
E
V
T
R
M
V
I
I
M
----
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-----
T
--
H
------------
Q
G
---
S
D
FGPIF
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
V
A
T
----------------
T
L
C
C
G
K
N
P
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
67.80
12%
-122
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
----
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
-
M
-------------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
----------
T
C
C
--
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
-------
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
---------
E
A
K
R
Q
L
N
I
------------
F
---------------------
E
---------
M
L
R
-------------------
I
D
E
G
L
R
L
K
I
Y
K
D
TEGY
Y
T
I
G
I
G
-
H
L
L
T
K
S
----
P
S
L
-----
N
--
A
------------
A
K
---
S
E
-----
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
----------------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
26
HHSearch
66.38
22%
-151
- C2 -
3EML
8
ENLYS_BPT4
A:
[21-219]
----------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
----
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
-
G
-----
Q
-------
S
Q
G
C
G
E
G
Q
V
-------------
A
C
--
L
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
-------
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---------
L
A
A
R
R
Q
L
N
------------
I
---------------------
F
---------
E
M
L
-------------------
R
I
D
E
G
L
R
L
K
I
Y
K
----
D
T
E
G
Y
Y
-
T
I
G
I
G
H
----
L
L
T
-----
K
--
S
------------
P
S
---
L
N
-----
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
----------------
V
R
G
I
L
R
N
A
K
L
--------------------------------------------------------------------------------------------------------------------------------------------------------