@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4K2_HUMAN: (2016-01-13 )
MDVGNKSTMSEFVLLGLSNSWELQMFFFMVFSLLYVATMVGNSLIVITVIVDPHLHSPMYFLLTNLSIIDMSLASFATPKMITDYLTGHKTISFDGCLTQIFFLHLFTGTEIILLMAMSFDRYIAICKPLHYASVISPQVCVALVVASWIMGVMHSMSQVIFALTLPFCGPYEVDSFFCDLPVVFQLACVDTYVLGLFMISTSGIIALSCFIVLFNSYVIVLVTVKHHSSRGSSKALSTCTAHFIVVFLFFGPCIFIYMWPLSSFLTDKILSVFYTIFTPTLNPIIYTLRNQEVKIAMRKLKNRFLNFNKAMPS
Atome Classification :
(20 SA)
--------------.........10........20........30........40........50........60........70-.......-..80.....-...90........100...---....110..--.....120.......130...---....140.......150.......160......-----.-.170.......180.......-190....---------.....200.......210.......220....-----...230-----------.---------------------.......240.......250.......260.-------.-----.-----.---.-----..---------270.......280....-----...290.......300--------..--......---------------310..-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MDVGN
K
S
T
M
S
E
F
V
L
L
GLSNS
W
E
L
Q
M
F
F
F
M
V
F
S
L
L
Y
V
A
T
M
VGN
S
L
I
V
I
T
V
I
VDPHLHS
P
M
Y
F
L
LTN
L
S
I
I
D
--
M
S
L
A
SFA-
T
P
K
M
I
T
D
Y
L-TGH
K
T
ISF
D
G
C
L
T
Q
I
F
F
L
H
---LFTG
T
E
I
I
L
--
L
M
AMSFD
R
Y
I
A
I
CKP
L
H
Y
A
SV---I
S
P
Q
V
C
V
A
L
V
V
A
S
W
I
M
G
V
M
H
S
M
S
Q
V
I
-
F
A
L
TLP-----F-CGP
Y
E
V
D
S
F
FC
D
L
P
V
V
F
Q
L
A
C
-
V
--
D
T
Y
V
---------
L
G
L
F
M
ISTS
G
I
I
A
L
S
C
F
I
V
L
FNS
Y
V
I
V
L
V
T
V
K-----HHSSR------------G---------------------SS
K
A
L
S
T
C
T
A
H
F
I
V
V
F
L
FFG
P
C
I
F
I
Y
MW
P
L
S
-------
S
-----
F
-----
L
---
T
-----
D
K
---------
I
L
S
V
F
Y
T
I
FTPTL
N
P
I
I
-----
Y
T
LRN
Q
E
V
K
I
A
M
R
K
L
---------
K
N
--
R
F
L
N
F
N---------------KAMPS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
89.64
22%
-168
- C1 -
3CAP
6
OPSD_BOVIN
A:
[31-317]
------------------------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
-
T
--
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
---
L
--
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
--
D
Y
Y
T
PHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
---
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
-----
I
-----
F
---
T
-----
H
Q
GSDFG
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
-----
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---------
L
C
--
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
88.62
18%
-137
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
---
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
-
C
G
I
--------
D
Y
Y
T
P
H
E
E
T
N
-
N
--
E
S
F
V
---------
I
Y
M
F
V
V
----
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----
A
A
A
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
-----
I
-----
F
---
T
-----
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
-----
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPST
T
V
--
S
K
T
E
T
S
---------------
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
88.40
18%
-130
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
---
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
-
C
G
I
--------
D
Y
Y
T
P
H
E
E
T
N
-
N
--
E
S
F
V
---------
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
-----
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
-----
I
-----
F
---
T
-----
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
-----
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---------
L
C
--
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETS
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.75
22%
-146
- C1 -
2X72
5
GNAT1_BOVIN (first)
A:
[34-318]
------------------------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
Q
G
F
F
A
T
---
L
--
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
--
D
Y
Y
T
PHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
---
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
-----
I
-----
F
---
T
-----
H
Q
G
S
C
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
-----
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---------
L
C
--
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
81.26
14%
-151
- C1 -
2Z73
5
OPSD_TODPA
A:
[33-333]
------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
--
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
---
I
F
G
F
M
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
G
A
Y
T
-----
L
-----
E
G
V
L
C
N
C
S
F
D
Y
I
S
--------
R
D
S
T
---------
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
-----
N
H
E
K
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
-------
G
PLE--
W
VT---
P
---
Y
-----
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
-----
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
---------
F
P
--
W
V
L
T
C
C
---------------
Q
F
D
D
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
80.50
17%
-146
- C1 -
1U19
14
OPSD_BOVIN
A:
[41-328]
--------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
---
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
-----
P
-----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
----
H
--
E
E
T
N
---------
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-----
E
A
A
A
Q
------------
Q
QESA
T
T
Q
K
A
------------
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q-----
G
-----
S
DFG--
P
---
I
-----
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
-----
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---------
L
C
--
C
G
K
N
P
L
---------------
G
D
D
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
79.87
17%
-143
- C1 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
---------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
--
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
---
A
A
V
F
A
S
I
Y
S
--
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-
Y
S
T
T
E
T
-----------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
------
N
K
I
Y
---------
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
-----
A
S
E
I
P
GDSSDRYH
E
Q
V
S
A
---------------------
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
-------
N
-----
P
DLYLK
K
FI
Q
Q
-----
V
Y
---------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
-----
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
---------
F
R
--
C
C
P
F
I
S
---------------
A
G
D
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.53
22%
-153
- C1 -
1LN6
1
OPSD_BOVIN
A:
[40-315]
---------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
LF
M
V
F
G
G
F
T
-
T
--
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
---
L
--
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
--
D
Y
Y
T
PHEETNNES
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
---
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
EAAAQ
Q
Q
E
S
A
------------
T
---------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
-----
I
-----
F
---
T
-----
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
-----
Y
I
M
M
N
K
Q
F
R
N
C
M
V
V
A
---------
T
T
--
L
C
C
G
K
N
---------------
P
L
G
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
71.23
14%
-123
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
--
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
---
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
--------
T
H
Q
E
A
I
N
C
Y
A
E
-----
E
T
C
C
-
D
--
F
F
T
N
---------
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
-----
Q
L
N
I
F
------------
E
---------------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-------
P
-----
S
-----
L
---
N
-----
A
A
---------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
-----
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---------
V
R
--
G
I
L
R
N
A
---------------
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL---------------
45
Fugue
70.95
16%
-137
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
--------------------
P
C
F
R
E
------
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
--
L
L
F
V
I
-
T
-
L
P
F
W
A
V
D
A
V
-
A
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
---
V
N
L
Y
S
S
V
W
I
--
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
-
F
A
N
V
S
E
-----
A
-
D
D
---------------
R
Y
I
C
-
D
--
R
F
Y
P
---------
N
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
-----
S
K
L
S
H
------------
S
---------------------
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
-------
H
-----
L
-----
L
---
T
KSPS
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
---------
L
R
NA
K
L
K
P
V
Y
---------------
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
29
HHSearch
68.42
16%
-130
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
-----------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
--
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
---
V
N
F
Y
S
G
I
L
L
--
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-
F
R
Q
A
Y
H
-----
P
-----
N
N
S
S
P
V
C
Y
E
V
L
G
N
-----
D
--
T
A
K
W
---------
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
-----
K
A
H
M
G
------------
Q
---------------------
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
RTQVIQ
E
S
C
E
R
R
N
N
I
---
G
---
R
-----
A
L
---------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
-----
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
---------
L
A
--
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
63.51
22%
-149
- C1 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-225]
----------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
--
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
---
M
M
C
T
A
S
I
W
N
--
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
N
T
T
-------------
G
D
P
T
V
C
S
I
S
N
-------------
P
---------
D
-
F
-
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
-----
Q
R
R
R
K
------------
N
---------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
-------
T
-----
K
-----
S
---
P
-----
S
L
---------
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
-----
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
---------
D
A
--
A
V
R
G
I
L
---------------
R
N
A
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
63.20
18%
-150
- C1 -
3EML
8
ENLYS_BPT4
A:
[18-220]
----------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
---
V
L
T
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
-----
Q
--------
S
Q
G
C
G
E
G
Q
---
V
A
C
-
L
FE
D
V
V
P
---------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----
R
Q
L
N
I
------------
F
---------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-------
S
-----
P
-----
S
---
L
-----
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-----
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
---------
A
V
--
R
G
I
L
R
N
---------------
A
K
L
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
62.69
19%
-142
- C1 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-234]
--------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
--
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
---
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
-----
T
-
H
Q
----
E
A
I
N
C
Y
A
E
----
E
T
C
-
C
--
D
F
F
T
---------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-----
R
Q
L
N
I
------------
F
---------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-------
S
-----
P
-----
S
---
L
-----
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-----
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
---------
A
V
--
R
G
I
L
R
N
---------------
A
K
L
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
59.48
18%
-152
* C1 *
3UON
2
ACM2_HUMAN (first)
A:
[24-214]
--------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
--
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
---
V
V
S
N
A
S
V
M
N
--
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
Q
F
I
V
-----
G
-
V
--
R
T
V
E
D
G
E
C
Y
I
Q
F
F
------------
S
---------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
-----
S
R
I
N
I
------------
F
---------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-------
S
-----
P
-----
S
---
L
-----
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-----
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
---------
A
V
--
R
G
I
L
R
N
---------------
A
K
L
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
59.24
19%
-136
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-237]
------------------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
--
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
---
V
N
L
Y
S
S
V
W
I
--
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
-
F
A
N
V
S
E
-----------
A
D
D
R
Y
I
C
D
R
F
Y
P
N
--------
D
L
-
W
---------
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
-----
H
S
G
S
N
------------
I
---------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
-------
K
-----
S
-----
P
---
S
-----
L
N
---------
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
---------
A
A
--
V
R
G
I
L
R
---------------
N
A
K
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
56.71
17%
-139
- C1 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-199]
---------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
--
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
---
V
A
S
T
A
S
I
F
S
--
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
-
N
H
--------------
R
R
E
D
K
C
E
T
D
F
Y
---------
D
------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
-----
Q
H
C
N
I
------------
F
---------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-------
S
-----
P
-----
S
---
L
-----
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-----
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
---------
A
V
--
R
G
I
L
R
N
---------------
A
K
L
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
56.51
21%
-155
- C1 -
4MQT
2
ACM2_HUMAN
A:
[41-178]
--------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
--
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
---
V
V
S
N
A
S
V
M
N
--
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
Q
F
I
V
-----
G
-
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
S
N
A
A
V
T
F
-
G
--
T
A
I
A
---------
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
P
S
R
E
K
K
V
T
R
T
I
-----
L
A
I
L
L
------------
A
---------------------
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
P
N
T
V
W
T
I
G
Y
-------
W
-----
L
-----
C
---
Y
-----
I
N
---------
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
-----
T
F
K
H
L
L
M
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
56.46
22%
-147
- C1 -
4IAR
1
C562_ECOLX
A:
[20-153]
-------------------------------------
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
--
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
-
T
G
R
W
T
L
---
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
--
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
F
F
-
W
R
Q
A
S
E
-----
C
-
V
V
N
T
D
H
I
L
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
-
T
--
L
L
L
I
---------
A
L
Y
G
R
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
-----
K
A
D
N
A
------------
A
---------------------
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
-------
P
-----
E
-----
M
---
K
-----
D
F
---------
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
-----
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
---------
L
K
--
T
T
R
N
A
Y
---------------
I
Q
K
Y
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
55.12
14%
-141
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[62-248]
------------------------------------
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
--
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
--
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
---
V
A
L
S
A
S
V
F
S
--
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
-
G
W
N
C
I
-------------
S
A
L
S
S
C
S
T
V
L
P
----------
L
Y
----------
H
K
H
Y
-
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
-----
T
R
N
I
F
------------
E
---------------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-------
P
-----
S
-----
L
---
N
-----
A
A
---------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
-----
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---------
V
R
--
G
I
L
R
N
A
---------------
K
L
K
P
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------