@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4KF_HUMAN: (2016-01-13 )
MLTSLTDLCFSPIQVAEIKSLPKSMNETNHSRVTEFVLLGLSSSRELQPFLFLTFSLLYLAILLGNFLIILTVTSDSRLHTPMYFLLANLSFIDVCVASFATPKMIADFLVERKTISFDACLAQIFFVHLFTGSEMVLLVSMAYDRYVAICKPLHYMTVMSRRVCVVLVLISWFVGFIHTTSQLAFTVNLPFCGPNKVDSFFCDLPLVTKLACIDTYVVSLLIVADSGFLSLSSFLLLVVSYTVILVTVRNRSSASMAKARSTLTAHITVVTLFFGPCIFIYVWPFSSYSVDKVLAVFYTIFTLILNPVIYTLRNKEVKAAMSKLKSRYLKPSQVSVVIRNVLFLETK
Atome Classification :
(20 SA)
.........10........20........30........40........50.-.......60....---....70........80........90...--.....100..--....---..110........120....---...130......--.140.......150.......---160.......170.....-..180..-.-....190----.-----.......200.......210..--.....220.......230-........240.......250------..--------------------------------------------------------------------------------------------------------------------------------------------------------------------.....260......------.270...--------...--------.280.......------290..---------.--.....300.......310.......320..-.....330-----.......340......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLT
S
L
T
D
L
CFSP
I
Q
V
A
E
I
K
S
L
P
K
S
MNET
N
H
S
R
V
T
E
F
V
LLGLSSSREL
Q
P
F
L
F
-
L
T
F
S
L
L
Y
L
A
I
L
LG---N
F
L
I
I
L
T
VTSDSRLH
T
P
M
Y
F
L
L
A
N
L
S
F
I
D
--
V
C
V
A
SFA-
T
P
--
K
M
I
A
---
D
F
L
-
V
ERKTI
S
F
D
A
C
L
A
Q
I
F
---
F
V
HLFTG
S
E
M
V
L
--
L
V
SMAYD
R
Y
V
A
I
C
K
P
L
H
Y
M
T
V
---
M
SR
R
V
C
V
V
L
V
L
I
S
W
F
V
G
F
-
I
HTT
S
Q
L
-
A
-
F
T
V
NLP-----F-----CGP
N
K
V
D
S
F
FCD
L
P
L
V
T
K
L
A
C
I
--
D
T
Y
V
V
S
L
L
I
VADS
G
F
L
S
--
L
S
S
F
L
L
L
V
V
S
Y
T
V
I
L
V
T
V
RNR------SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
M
A
K
A
RS
T
L
T
A
H
I
------
T
V
V
T
L
FF--------G
P
C
--------
I
F
I
Y
V
WPFSSY------
S
-
V
D
K
---------
V
--
L
A
V
F
Y
T
I
F
T
L
I
L
N
P
V
I
Y
T
LR
N
K
E
V
K
A
A
M
S
K
-
L
K
S
RYLK
P
-----
S
Q
V
S
V
V
I
R
N
V
L
F
L
ETK
28
HHSearch
89.97
22%
-155
- C5 -
3EML
13
ENLYS_BPT4
A:
[21-472]
-----------------------------------------------
S
S
V
Y
I
-
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
---
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
---
F
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
-
A
I
G
L
T
P
M
-
L
-
G
W
N
N
C
G
-----
Q
------------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
FE
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
------
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
------
G
L
F
A
L
C
W
--------
L
P
L
--------
H
I
I
N
C
F
T
F
F
C
P
DCSHAP
L
-
W
L
M
---------
Y
--
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
-
I
I
R
S
H
V
L
R
-----
Q
---------------
41
Fugue
85.98
18%
-112
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
--
T
T
L
Y
---
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
A
P
P
L
-
V
G
W
S
R
Y
I
P
E
GMQC
S
-----
C
G
I
D
----
Y
Y
T
P
----
H
E
E
T
N
N
--
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
--
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
------
I
I
M
V
I
A
F
--------
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
------
F
-
T
H
Q
GSDFGPIFM
T
--
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-
T
L
C
C
G
K
N
P
LGDDE
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
40
Fugue
85.74
19%
-121
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
---------
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
--
T
T
L
Y
---
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
A
P
P
L
-
V
G
W
S
R
Y
I
P
E
GMQC
S
-----
C
G
I
--------
D
Y
Y
T
P
H
E
E
T
N
N
--
E
S
F
V
I
Y
M
F
V
V
H
-----
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A-----
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
------
I
I
M
V
I
A
F
--------
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
------
F
-
T
H
Q
GSDFGPIFM
T
--
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-
T
L
C
C
G
K
N
P
-----
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-
23
HHSearch
85.53
20%
-148
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
---------------------------------------------
V
W
V
V
G
M
G
-
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
--
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
---
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
---
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
-
Q
-
M
H
W
Y
R
A
-----
T
---------
H
Q
E
A
I
N
C
Y
A
E
E
----
T
C
C
--
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
------
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
L
K
T
L
G
I
I
M
------
G
T
F
T
L
C
W
--------
L
P
F
--------
F
I
V
N
I
V
H
V
I
Q
D
NLIR--
K
-
E
V
Y
---------
I
--
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
-
L
L
C
L
-------------------------
8
PsiBlast_PDB
82.74
23%
-160
- C5 -
3REY
1
AA2AR_HUMAN
A:
[21-305]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--
I
L
V
G
V
L
A
-
I
P
----------
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
--------------------------
10
PsiBlast_PDB
82.68
23%
-156
- C5 -
3UZA
1
AA2AR_HUMAN
A:
[21-305]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--
I
L
V
G
V
L
A
-
I
P
----------
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
--------------------------
2
PsiBlast_PDB
82.61
23%
-159
- C5 -
3VGA
1
AA2AR_HUMAN
A:
[21-308]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--
I
A
V
G
V
L
A
-
I
P
----------
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-----------------------
32
HHSearch
82.37
22%
-148
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------
Y
A
-
L
S
Y
C
A
L
I
L
A
I
V
F
G
---
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
--
L
L
V
A
T
L
V
-
M
P
--
W
V
V
Y
---
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
---
L
D
V
M
M
C
T
A
S
I
W
N
--
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
-
A
V
S
C
P
L
L
-
F
-
G
F
N
T
T
-----------------
G
D
P
T
V
C
S
I
S
N
------------
P
--
D
F
V
I
Y
S
S
V
V
S
F
--
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
------
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
------
G
A
F
I
V
C
W
--------
L
P
F
--------
F
L
T
H
V
L
N
T
H
C
Q
TCHVS-
P
-
E
L
Y
---------
S
--
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
-
I
L
S
C
-------------------------
7
PsiBlast_PDB
82.30
23%
-156
- C5 -
3PWH
1
?
A:
[21-305]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--
I
L
V
G
V
L
A
-
I
P
----------
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
--------------------------
11
PsiBlast_PDB
82.29
23%
-158
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[21-305]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--
I
L
V
G
V
L
A
-
I
P
----------
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
--------------------------
9
PsiBlast_PDB
82.09
23%
-158
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[21-305]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--
I
L
V
G
V
L
A
-
I
P
----------
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
--------------------------
4
PsiBlast_PDB
81.43
23%
-138
- C5 -
2YDV
6
?
A:
[21-312]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
--
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
--------
F
V
L
V
L
T
A
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ES
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
Q
-
1
PsiBlast_PDB
81.27
23%
-154
- C5 -
3VG9
8
?
A:
[21-309]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--
I
A
V
G
V
L
A
-
I
P
----------
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
----------------------
5
PsiBlast_PDB
80.80
23%
-140
- C5 -
4UG2
3
?
A:
[21-309]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
--
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
--------
F
V
L
V
L
T
A
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
----------------------
27
HHSearch
80.79
17%
-144
- C5 -
2Z73
5
OPSD_TODPA
A:
[31-335]
--------------------------------------------
D
A
V
Y
Y
S
L
G
-
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
--
F
T
F
S
L
V
N
G
F
P
--
L
M
T
I
---
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
---
I
G
G
I
F
G
F
M
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
-
L
W
A
I
G
P
I
-
F
-
G
W
G
A
Y
T
-----
L
---------
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
--
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
------
S
Q
F
L
L
S
W
--------
S
P
Y
--------
A
V
V
A
L
L
A
Q
F
G
P
LEWVT-
P
-
Y
A
A
---------
Q
--
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
-
T
F
P
W
V
L
T
C
-----
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
3
PsiBlast_PDB
80.69
23%
-136
- C5 -
2YDO
3
?
A:
[21-312]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
--
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
--------
F
V
L
V
L
T
A
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
--
25
HHSearch
79.96
19%
-150
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------
P
L
V
-
V
V
L
S
T
I
C
L
V
T
V
G
L
---
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
--
L
I
V
G
A
V
V
-
M
P
--
M
N
I
L
---
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
---
M
D
Y
V
A
S
T
A
S
I
F
S
--
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
-
L
W
V
I
P
I
L
-
G
-
W
-
N
H
------------------
R
R
E
D
K
C
E
T
D
F
Y
--------
D
---
V
T
W
F
K
V
M
T
A
I
I
N
F
--
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
------
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
------
A
A
F
I
L
C
W
--------
I
P
Y
--------
F
I
F
F
M
V
I
A
F
C
K
NCCN--
E
-
H
L
H
---------
M
--
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
-
I
L
H
I
-------------------------
6
PsiBlast_PDB
78.29
23%
-138
- C5 -
4UHR
1
AA2AR_HUMAN
A:
[21-312]
---------------------------------------------------------------
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
--
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
--------
F
V
L
V
L
T
A
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
-
W
N
N
--------------
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
L
--
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
------
A
-
P
L
W
---------
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----
Q
E
P
F
K
A
A
A
A
-------
22
HHSearch
77.80
16%
-143
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
------------------------------------------------
V
F
I
V
-
L
V
A
G
S
L
S
L
V
T
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
--
L
I
I
G
V
F
S
-
M
N
--
L
Y
T
L
---
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
---
L
D
Y
V
V
S
N
A
S
V
M
N
--
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
-
I
L
W
A
P
A
I
-
L
-
F
W
Q
F
I
V
-----
G
-----
V
--
R
T
V
E
D
G
E
C
Y
I
Q
F
F
-----------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
--
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
------
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP--
S
R
E
K
K
V
T
R
T
I
L
A
I
L
------
L
A
F
I
I
T
W
--------
A
P
Y
--------
N
V
M
V
L
I
N
T
F
C
A
PCIP--
N
-
T
V
W
---------
T
--
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
-
L
L
M
--------------------------
16
PsiBlast_PDB
77.63
23%
-148
- C5 -
2X72
5
GNAT1_BOVIN (first)
A:
[36-318]
-----------------------------------------------
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
-
T
T
L
Y
T
S
L
H
---
G
Y
F
-
V
F
G
P
T
----
G
C
N
L
Q
G
F
---
F
A
T
L
--
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
-
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
-----
E
GMQCS
C
G
---
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
--
Y
M
F
V
V
H
F
I
I
P
-----
L
I
--
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
------
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--------
F
Y
I
F
T
H
Q
G
S
C
F
------
G
P
I
F
M
---------
T
--
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-
T
L
C
C
G
K
N
----------------------