@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4N4_HUMAN: (2016-01-13 )
MKIANNTVVTEFILLGLTQSQDIQLLVFVLILIFYLIILPGNFLIIFTIRSDPGLTAPLYLFLGNLAFLDASYSFIVAPRMLVDFLSEKKVISYRGCITQLFFLHFLGGGEGLLLVVMAFDRYIAICRPLHCSTVMNPRACYAMMLALWLGGFVHSIIQVVLILRLPFCGPNQLDNFFCDVRQVIKLACTDMFVVELLMVFNSGLMTLLCFLGLLASYAVILCHVRRAASEGKNKAMSTCTTRVIIILLMFGPAIFIYMCPFRALPADKMVSLFHTVIFPLMNPMIYTLRNQEVKTSMKRLLSRHVVCQVDFIIRN
Atome Classification :
(20 SA)
------------.........10........20...----------------.....30....----...-.40....-....50..--......60........70.......-.-.80.....-...90-.........100.......110.....-..120.......130...---....140.....-..150.......160.....-----.-------.170.......----180.......190..--......200.......210.......220----------------------------....-.--------------...230----------.--------------------........240.....---..250.-......260.--------.----.-----.---...---------270.......280.......290-----.........300-------------.......------310....-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MKIAN
N
T
V
V
T
E
F
I
L
LGLTQSQ
D
I
Q
----------------
L
L
V
F
V
L
I
L
I
F
Y
----
L
I
I-LPG
N
F
L
I
-
I
F
T
IRSDP--GL
T
A
P
L
Y
L
F
L
G
N
L
A
F
LD-AS
Y
S
F
I
V
-
A
-
P
R
M
L
V
D
F
L
-SEKK--
V
I
S
Y
R
G
C
I
T
Q
L
F
F
L
H
F
LGGGE
G
L
L
L
V
V
-
M
A
F
D
R
Y
I
A
I
CRPLHCSTV---MN
P
R
A
C
Y
A
M
M
L
A
-
L
W
L
G
G
F
V
H
S
I
I
Q
V
V
L
I
LRLP-----F-------CG
P
N
Q
L
D
N
F
F
C
----
D
V
R
Q
V
I
K
L
A
C
T
-
D
M
F
--
V
V
E
L
L
M
V
F
NS
G
L
M
T
L
L
C
F
L
G
L
L
A
S
Y
A
V
I
-----------------------------
L
C
H
V
-
R
--------------
R
A
A
S------------E--------------------GKN
K
A
M
S
T
C
T
T
R
V
I
I
I
---
L
L
MFG
P
-
A
I
F
I
Y
MCPFR--------A----L-----
P
---
A
D
K
---------
M
V
S
L
F
H
T
V
I
F
P
L
M
N
P
M
I
Y
T
LR-------
N
Q
E
V
K
T
S
M
K
R
L
L
-------------
S
RH
V
V
C
Q
------
V
D
F
I
I
RN-------
57
HHSearch
92.39
18%
-154
- C6 -
2Z73
5
OPSD_TODPA
A:
[32-334]
---------------------------------
A
V
Y
----------------
Y
S
L
G
I
F
I
G
I
C
G
----
I
I
G
-
C
G
G
N
G
I
V
-
I
Y
L
F
T
K
T
K
--
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
-
F
T
F
S
L
V
N
G
F
-
P
L
M
T
I
S
C
F
-
L
K
K
W
--
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
-
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
-----
L
-----------
E
G
V
L
C
N
C
----
S
F
D
Y
I
S
R
------
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-----------------------------
V
M
S
V
S
N
--------------
H
E
K
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
---
L
L
S
W
S
P
-
Y
A
V
V
A
L
L
A
Q
F
--------
G
----
P
LEWVT
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
-------
H
P
K
F
R
E
A
I
S
Q
T
F
-------------
P
W
V
L
T
C
C
------
Q
F
D
D
K
E
T
-------
55
HHSearch
85.91
17%
-152
- C6 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
-----------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
----
V
T
S
-
V
V
G
N
V
V
V
-
M
W
I
I
L
A
H
K
--
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
-
A
S
M
A
A
F
N
-
T
-
V
V
N
F
T
Y
A
V
-
H
N
E
W
--
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
-
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
-
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-
E
-----
T
-----------
M
P
S
R
V
V
C
----
M
I
E
W
P
E
H
P
----
N
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-----------------------------
G
I
T
L
-
W
--------------
A
S
E
I
PGDSSDRYH
E
Q
V
S
--------------------
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
---
A
I
C
W
L
P
-
F
H
I
F
F
L
L
P
Y
I
--------
N
PDLY
L
K----
K
FI
Q
Q
V
Y
---------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
-------
N
D
R
F
R
L
G
F
K
H
A
F
-------------
R
C
C
P
F
I
S
------
A
G
D
Y
E
G
L
-------
2
PsiBlast_PDB
84.67
20%
-128
- C6 -
4WW3
5
OPSD_TODPA
A:
[56-328]
-----------------------------------------------------------------------------------------
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
-
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
--
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
-
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
------------------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
-
N
I
L
--
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
---
V
-----------------------------
S
N
H
E
-
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
------------
A
--------------------
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
--------
P
----
L
EWVT-
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
-------
H
P
K
F
R
E
A
I
S
Q
T
F
-------------
P
W
V
L
T
C
C
------
Q
F
D
D
K
E
T
-------
4
PsiBlast_PDB
82.98
20%
-126
- C6 -
3AYM
3
OPSD_TODPA
A:
[64-336]
-----------------------------------------------------------------------------------------
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
-
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
--
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
-
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
------------------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
-
N
I
L
--
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
---
V
-----------------------------
S
N
H
E
-
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
------------
A
--------------------
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
--------
P
----
L
EWVT-
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
-------
H
P
K
F
R
E
A
I
S
Q
T
F
-------------
P
W
V
L
T
C
C
------
Q
F
D
D
K
E
T
-------
1
PsiBlast_PDB
82.32
20%
-131
- C6 -
2ZIY
3
OPSD_TODPA
A:
[63-335]
-----------------------------------------------------------------------------------------
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
-
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
--
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
-
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
------------------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
-
N
I
L
--
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
---
V
-----------------------------
S
N
H
E
-
K
E
M
A
A
M
A
K
R
LN
A
K
E
L
R
K
A
Q
------------
A
--------------------
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
--------
P
----
L
EWVT-
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
-------
H
P
K
F
R
E
A
I
S
Q
T
F
-------------
P
W
V
L
T
C
C
------
Q
F
D
D
K
E
T
-------
64
Fugue
82.22
19%
-142
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
----
M
L
G
-
F
P
I
N
F
L
T
-
L
Y
V
T
V
Q
H
K
--
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
M
V
F
G
G
-
F
-
T
T
T
L
Y
T
S
L
-
H
G
Y
F
--
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-----
P
-------
E
G
------------------
M
Q
C
S
C
G
I
D
Y
Y
--
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
-----------------------------
F
C
Y
G
-
Q
L
VFTVKE-------
A
A
A
S
------------
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
---
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
--------
Y
----
I
-----
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
-------
N
K
Q
F
R
N
C
M
V
T
T
L
-------------
C
C
G
K
N
P
S
------
T
T
V
S
K
T
E
TS
Q
V
A
P
A
3
PsiBlast_PDB
82.06
20%
-129
- C6 -
2Z73
5
OPSD_TODPA
A:
[64-336]
-----------------------------------------------------------------------------------------
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
-
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
--
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
-
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
------------------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
-
N
I
L
--
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
---
V
-----------------------------
S
N
H
E
-
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
------------
A
--------------------
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
--------
P
----
L
EWVT-
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
-------
H
P
K
F
R
E
A
I
S
Q
T
F
-------------
P
W
V
L
T
C
C
------
Q
F
D
D
K
E
T
-------
5
PsiBlast_PDB
80.58
20%
-127
- C6 -
3AYN
3
OPSD_TODPA
A:
[64-336]
-----------------------------------------------------------------------------------------
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
-
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
--
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
-
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
------------------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
-
N
I
L
--
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
---
V
-----------------------------
S
N
H
E
-
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
------------
A
--------------------
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
--------
P
----
L
EWVT-
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
-------
H
P
K
F
R
E
A
I
S
Q
T
F
-------------
P
W
V
L
T
C
C
------
Q
F
D
D
K
E
T
-------
63
Fugue
79.02
19%
-136
- C6 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
----------------
F
S
M
L
A
A
Y
M
F
L
L
----
I
M
L
G
F
P
I
N
F
L
T
-
L
Y
V
T
V
Q
H
K
--
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
M
V
F
G
G
-
F
-
T
T
T
L
Y
T
S
L
-
H
G
Y
F
--
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
-------
C
G
I
D
----
Y
Y
T
----
P
H
E
E
T
----
N
N
-
E
S
F
--
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-----------------------------
E
A
A
A
-
Q
--------------
Q
Q
E
S
------------
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
---
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
--------
Y
----
I
-----
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
-------
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
------
T
S
Q
V
A
P
A
-------
69
Fugue
78.46
16%
-151
- C6 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------------
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
----------------
Y
L
P
A
V
Y
I
L
V
F
I
----
I
G
F
-
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
--
W
S
G
I
S
V
Y
M
F
--
N
L
A
L
A
D
-
F
L
Y
V
L
T
L
-
P
-
A
L
I
F
Y
Y
F
N
-
K
T
D
W
--
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
-
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
-
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
-
V
W
L
I
-
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
-----
V
R
KNKTIT
C
Y
D
T
T
S
D
E
Y
L
R
----
S
Y
F
I
Y
S
M
C
T
T
V
-
A
M
F
--
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
VCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCP
L
C
G
V
-
G
--------------
K
D
Q
F
------------
E
--------------------
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
---
V
L
T
V
F
A
-
V
S
Y
I
P
F
H
V
M
K
--------
T
----
M
-----
N
---
L
R
A
---------
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
-------
V
T
R
G
L
A
S
L
N
S
C
V
-------------
N
P
I
L
Y
F
L
------
A
G
D
T
F
R
R
R------
54
HHSearch
77.41
18%
-145
- C6 -
1U19
14
OPSD_BOVIN
A:
[37-331]
--------------------------------
P
W
Q
F
----------------
S
M
L
A
A
Y
M
F
L
L
I
----
M
L
G
-
F
P
I
N
F
L
T
-
L
Y
V
T
V
Q
H
K
--
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
M
V
F
G
G
-
F
-
T
T
T
L
Y
T
S
L
-
H
G
Y
F
--
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-----
P
-----------
E
G
M
Q
C
S
C
----
G
I
D
Y
Y
T
P
---
H
-
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----------------------------
V
F
T
V
-
K
--------------
E
A
A
A
------------
Q
QQESA
T
T
Q
K
-----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
---
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q------
G
SD--
F
-----
G
P--
I
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
-------
N
K
Q
F
R
N
C
M
V
T
T
L
-------------
C
C
G
K
N
P
L
------
G
D
D
E
A
S
T
-------
51
HHSearch
73.19
18%
-132
- C6 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
---------------------------------
L
N
K
----------------
Y
V
V
I
I
A
Y
A
L
V
F
----
L
L
S
-
L
L
G
N
S
L
V
-
M
L
V
I
L
Y
S
R
--
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
-
L
L
F
A
L
T
--
L
-
P
I
W
A
A
S
K
--
V
N
G
W
--
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
-
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
-
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
-----
P
-----------
N
N
S
S
P
V
C
----
Y
E
V
L
G
N
D
---
T
-
A
K
---
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-----------------------------
L
R
T
L
-
F
--------------
K
A
H
M
------------
G
--------------------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
---
L
L
C
W
L
P
-
Y
N
L
V
L
L
A
D
T
L
M
RTQVIQE
S
C
E
R
R
N
-----
N
I
G
-
R
A
L
---------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
-------
G
Q
N
F
R
H
G
F
L
K
I
L
-------------
A
M
H
G
-----------------------
65
Fugue
71.50
18%
-179
- C1 -
4PHR
4
?
A:
[1-277]
---------------------
S
E
F
E
L
M
K
R
L
S
E
I
K
V
L
----------------
P
I
L
E
S
L
K
Y
I
K
H
N
H
A
S
V
V
R
-
F
G
D
G
E
I
D
-
L
M
T
G
H
S
I
P
YQ
D
Y
N
E
K
L
A
K
R
L
Q
Q
I
L
Q
T
K
-
S
D
E
K
L
L
V
-
C
L
P
D
V
F
-------
S
N
--
M
D
R
Y
N
Q
N
A
R
H
F
W
E
R
H
F
L
K
Y
S
E
F
Y
L
N
C
C
D
A
P
F
Y
G
S
T
F
I
S
R
P
Y
I
D
L
I
D
---
K
S
P
S
E
A
Y
F
E
S
L
K
E
L
W
R
G
-------
K
D
L
L
I
V
E
G
A
-----
T
-------
S
R
S
G
V
G
N
D
L
F
V
----
A
A
S
S
I
K
R
L
V
C
P
-
S
K
----------------------
N
A
F
Q
Y
Y
D
E
I
-----------------------------
L
R
L
T
-
E
--------------
K
N
A
-----------------------------------
K
N
R
----------
L
I
---
L
V
M
L
G
P
-
T
A
K
V
L
V
A
D
L
T
T
K
G
Y
Q
---
A
----
I
-----
D
---
L
G
H
---------
I
D
S
E
Y
E
W
Y
E
M
G
A
T
Y
K
V
K
L
T
N
K
HTAEFNY
D
E
G
I
E
L
E
F
S
Q
E
Y
-------------
Q
E
Q
I
V
A
R
------
I
G
------------
46
HHSearch
71.28
20%
-158
* C6 *
3RZE
2
ENLYS_BPT4 (first)
A:
[10-198]
-----------------------------------------------------
P
L
V
V
V
L
S
T
I
C
----
L
V
T
-
V
G
L
N
L
L
V
-
L
Y
A
V
R
S
E
R
--
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
-
L
I
V
G
A
V
V
-
M
-
P
M
N
I
L
Y
L
L
-
M
S
K
W
--
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
-
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
-
A
W
F
L
S
F
L
W
V
I
P
I
L
-
G
W
N
H
--------------------
R
R
E
D
K
C
----
E
T
D
F
Y
-------
D
----
V
T
W
-
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
-----------------------------
Y
K
A
V
-
R
--------------
Q
H
C
N
------------
I
--------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
---
D
T
E
G
Y
Y
-
T
I
G
I
G
H
L
L
T
K
--------
S
----
P
-----
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
-------
A
E
K
L
F
N
Q
D
V
D
A
A
-------------
V
R
G
I
L
R
N
------
A
K
L
K
P
V
Y
-------
48
HHSearch
70.12
19%
-166
- C6 -
3EML
8
ENLYS_BPT4
A:
[22-219]
----------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
----
V
L
A
-
I
L
G
N
V
L
V
-
C
W
A
V
W
L
N
S
--
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-
I
A
V
G
V
L
A
-
I
-
P
F
A
I
T
I
S
---
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
-
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
-----
Q
--------------
S
Q
G
C
----
G
E
G
Q
---
V
A
C
L
-
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----------------------------
F
L
A
A
-
R
--------------
R
Q
L
N
------------
I
--------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
---
D
T
E
G
Y
Y
-
T
I
G
I
G
H
L
L
T
K
--------
S
----
P
-----
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
-------
A
E
K
L
F
N
Q
D
V
D
A
A
-------------
V
R
G
I
L
R
N
------
A
K
L
K
P
V
Y
-------
47
HHSearch
70.04
17%
-159
- C6 -
2RH1
6
ADRB2_HUMAN (first)
A:
[36-233]
-------------------------------
D
E
V
W
V
----------------
V
G
M
G
I
V
M
S
L
I
V
----
L
A
I
-
V
F
G
N
V
L
V
-
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
-
L
V
M
G
L
A
V
-
V
-
P
F
G
A
A
H
I
L
-
M
K
M
W
--
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
-
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
-
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
-----
T
-----------
H
Q
E
A
I
N
C
----
Y
A
E
----
E
T
C
C
-
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-----------------------------
F
Q
E
A
-
K
--------------
R
Q
L
N
------------
I
--------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
---
D
T
E
G
Y
Y
-
T
I
G
I
G
H
L
L
T
K
--------
S
----
P
-----
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
-------
A
E
K
L
F
N
Q
D
V
D
A
A
-------------
V
R
G
I
L
R
N
------
A
K
L
K
P
V
Y
-------
53
HHSearch
63.95
19%
-162
- C6 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-224]
------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
----
L
A
I
-
V
F
G
N
G
L
V
-
C
M
A
V
L
K
E
R
--
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
-
L
L
V
A
T
L
V
-
M
-
P
W
V
V
Y
L
E
V
T
G
G
V
W
--
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
-
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
-
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
-------------------
G
D
P
T
V
C
----
S
I
S
-----------
N
--
P
-
D
F
V
-
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
-----------------------------
Y
V
V
L
-
K
--------------
Q
R
R
R
------------
K
--------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
---
Y
K
D
T
E
G
-
Y
Y
T
I
G
I
G
H
L
L
--------
T
----
K
-----
S
---
P
S
L
---------
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
-------
D
E
A
E
K
L
F
N
Q
D
V
D
-------------
A
A
V
R
G
I
L
------
R
N
A
K
L
K
P
-------
50
HHSearch
62.56
16%
-151
- C6 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-236]
---------------------------------
F
N
K
----------------
I
F
L
P
T
I
Y
S
I
I
F
----
L
T
G
-
I
V
G
N
G
L
V
-
I
L
V
M
G
Y
Q
K
--
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
-
L
L
F
V
-
I
T
-
L
-
P
F
W
A
V
D
A
V
--
A
N
W
--
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
-
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
-
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
-----------------
A
D
D
R
Y
I
C
----
D
R
F
Y
P
N
-------
D
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
-----------------------------
I
S
K
L
-
S
--------------
H
S
G
S
------------
N
--------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
---
K
D
T
E
G
Y
-
Y
T
I
G
I
G
H
L
L
T
--------
K
----
S
-----
P
---
S
L
N
---------
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
-------
E
A
E
K
L
F
N
Q
D
V
D
A
-------------
A
V
R
G
I
L
R
------
N
A
K
L
K
P
V
-------
45
HHSearch
60.53
15%
-165
- C6 -
3UON
2
ACM2_HUMAN (first)
A:
[24-213]
----------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
----
L
V
T
-
I
I
G
N
I
L
V
-
M
V
S
I
K
V
N
R
--
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
-
L
I
I
G
V
F
S
-
M
-
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
--
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
-
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
-
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
-----
G
---------
V
R
T
V
E
D
G
E
C
----
Y
I
Q
F
F
------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
-----------------------------
S
R
A
S
-
K
--------------
S
R
I
N
------------
I
--------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
---
D
T
E
G
Y
Y
-
T
I
G
I
G
H
L
L
T
K
--------
S
----
P
-----
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
-------
A
E
K
L
F
N
Q
D
V
D
A
A
-------------
V
R
G
I
L
R
N
------
A
K
L
K
P
V
Y
-------
71
Fugue
59.65
13%
-112
- C2 -
3W54
5
AOX_TRYBB
A:
[32-295]
----------------------------
V
W
G
H
T
Q
L
N
----------------
R
L
S
F
L
E
T
V
P
V
V
----
P
L
R
-
V
S
D
E
S
S
E
-
D
R
P
T
W
S
L
P
--
D
I
E
N
V
A
I
T
H
K
K
P
N
G
L
V
D
T
L
A
Y
R
S
V
R
-
T
-
C
R
W
L
F
D
T
F
-
S
L
Y
R
FG
S
I
T
E
S
K
V
I
S
R
C
L
F
L
E
T
V
A
G
V
P
G
M
V
G
G
M
-
L
R
H
L
S
S
L
R
Y
M
T
R
D
K
------------------------
G
W
I
N
T
L
L
V
E
A
E
N
E
R
M
H
-----
L
-------
M
T
F
I
E
L
R
Q
P
G
-----
L
P
L
R
V
S
I
I
I
T
Q
-
A
I
M
--
Y
L
F
L
L
V
A
Y
V
I
S
P
R
F
V
H
R
F
V
G
Y
L
E
E
E
A
V
I
-----------------------------
T
Y
T
G
-
V
--------------
M
R
A
I
------------
D
--------------------
E
G
R
----------------------------
L
R
P
T
K
--------
N
----
D
-----
V
---
P
E
V
---------
A
R
V
Y
W
N
L
S
K
N
A
T
F
R
D
L
I
N
V
I
R
-------
A
D
E
A
E
H
R
V
V
N
H
T
-------------
F
A
D
M
H
E
K
RLQNSV
N
P
F
V
V
L
K
-------