@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4Q2_HUMAN: (2016-01-13 )
MDKNQTEVMREFFLSGFSQTPSIEAGLFVLFLFFYMSIWVGNVLIMVTVASDKYLNSSPMYFLLGNLSFLDLCYSTVTTPKLLADFFNHEKLISYDQCIVQLFFLHFVGAAEMFLLTVMAYDRYVAICRPLHYTTVMSRGLCCVLVAASWMGGFVHSTVQTILTVHLPFCGPNQVENFFCDVPPVIKLACADTFVIELLMVSNSGLISTISFVVLISSYTTILVKIRSKEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFSVDKMVSVLYNVITPMLNPLIYTLRNKEVKSAMQKLWVRNGLTWKKQET
Atome Classification :
(20 SA)
-----------.........10.......--.--20........30.--.......40........50........60........70.......-.80--------.......-..90..-......100.......110.......120.......130---......---...140.......150.......160-......-----.170.......180.......190..--.....200......-----.210..--.....220.--.----------------------------------..--.-----..------------230-------------------..--------.......240.......250....-...260-.----------.----.--.---...---------.270..------...---..280.......290......--.300.......310.---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MDK
N
Q
T
E
V
M
R
E
F
F
L
SGFS--Q--TPSI
E
A
G
L
F
V
L
F
L
--
F
F
Y
M
S
I
W
VG
N
V
L
I
M
V
T
VASDKYLNSS
P
M
Y
F
L
LGN
L
S
F
L
D
L
C
Y
STVT-
T
P
---------
K
L
L
A
D
F
F-
N
H
E
K
L
I
-
S
Y
D
Q
C
I
V
Q
L
F
F
L
H
F
V
G
A
A
E
M
F
L
L
T
V
M
A
YD
R
Y
V
A
I
CR
P
-----
L
H
Y
T
T
V
---
M
SR
G
L
C
C
V
L
V
A
A
S
W
M
G
G
F
V
H
S
T
V
Q
T
I
-
L
T
V
HLP-----FCG
P
N
Q
V
E
N
FFCDVPP
V
I
K
L
AC
A
D
T
F
--
V
I
E
L
L
M
VSNS
G
L
I
S
-----
T
I
S
F
V
V
--LISS
Y
T
T
I
L
--
V
----------------------------------
K
I
--R-----SK------------E---------------------G
R
--------
R
K
A
L
S
T
C
A
S
H
L
M
V
V
T
LFFG
P
C
I
F
I
-
Y
ARPF--S----------T----F--
S
---
V
D
K
---------
M
V
S
V
L
Y
------
N
V
I
---
T
P
M
L
N
P
L
I
Y
T
LR
N
K
E
V
K
S
A
M
Q
--
K
L
W
V
RNGLTWKKQET---------------
34
HHSearch
88.47
15%
-132
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-333]
-------------------------------------
V
Y
Y
S
L
G
I
F
I
G
--
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
-
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
---------
L
M
T
I
S
C
F
-
L
K
K
W
I
F
-
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
-----
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
G
A
Y
T
-----
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-----
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
-----
F
G
P
I
L
I
--
I
F
F
C
Y
F
N
I
V
--
M
S
V--------------------------------
S
N
--
H
-----
E
K
------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
--------
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
-
A
L
L
A
Q
--
F
----------
G
PLE-
W
VT
P
---
Y
A
A
---------
Q
L
P
V
M
F
------
A
K
A
---
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
--
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
---------------
15
PsiBlast_PDB
87.52
20%
-134
- C2 -
4GBR
1
ADRB2_HUMAN
A:
[7-283]
----------------------------------------
G
M
G
I
V
M
S
--
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
-
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---------
F
G
A
A
H
I
L
-
T
K
T
W
T
F
-
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
-----
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
H
-----
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
----
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
-----
Y
V
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
--
Q
----------------------------------
E
A
--
K
-----
R
Q
------------
L
---------------------
Q
K
IDKFC
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
--
Q
----------
D
----
N
--
L
---
I
R
K
---------
E
V
Y
I
L
L
------
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
--
E
L
L
C
L
-------------------------
11
PsiBlast_PDB
87.49
24%
-122
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[11-296]
--------------------------------------
E
A
G
M
S
L
L
M
A
--
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
-
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-
L
C
E
L
W
T
-
S
L
D
V
L
C
V
---------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
-----
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
----
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
-----
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
D
-
F
--
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
Y
R
E
A
K
--
E
----------------------------------
Q
I
--
R
K
IDRA
S
K
------------
R
---------------------
K
R
V
M
L
M
R
E
--
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
--
F
F
-
L
V
N
I
V
--
N
----------
V
----
F
--
N
---
R
D
L
---------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
---
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
--
R
L
L
A
F
-------------------------
9
PsiBlast_PDB
87.22
24%
-122
- C2 -
2YCW
7
ADRB1_MELGA
A:
[11-296]
--------------------------------------
E
A
G
M
S
L
L
M
A
--
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
-
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
RG
T
W
L
W
G
S
F
-
L
C
E
L
W
T
-
S
L
D
V
L
C
V
---------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
-----
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
----
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
-----
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
D
-
F
--
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
Y
R
E
A
K
--
E
----------------------------------
Q
I
--
R
K
IDRA
S
K
------------
R
---------------------
K
R
V
M
L
M
R
E
--
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
--
F
F
-
L
V
N
I
V
--
N
----------
V
----
F
--
N
---
R
D
L
---------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
---
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
--
R
L
L
A
F
-------------------------
8
PsiBlast_PDB
86.04
24%
-121
- C2 -
2VT4
8
ADRB1_MELGA
A:
[11-296]
--------------------------------------
E
A
G
M
S
L
L
M
A
--
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
-
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-
L
C
E
L
W
T
-
S
L
D
V
L
C
V
---------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
-----
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
----
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
-----
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
D
-
F
--
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
Y
R
E
A
K
--
E
----------------------------------
Q
I
--
R
-------------------------------------------
E
-------
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
--
F
F
-
L
V
N
I
V
--
N
----------
V
----
F
--
N
---
R
D
L
---------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
---
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
--
R
L
L
A
--------------------------
12
PsiBlast_PDB
84.97
24%
-119
- C2 -
2YCY
6
ADRB1_MELGA
A:
[11-296]
--------------------------------------
E
A
G
M
S
L
L
M
A
--
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
-
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-
L
C
E
L
W
T
-
S
L
D
V
L
C
V
---------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
-----
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
----
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
-----
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
D
-
F
--
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
Y
R
E
A
K
--
E
----------------------------------
Q
I
--
R
DRA--
S
K
------------
R
---------------------
K
R
V
M
L
M
R
E
--
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
--
F
F
-
L
V
N
I
V
--
N
----------
V
----
F
--
N
---
R
D
L
---------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
---
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
--
R
L
L
A
F
-------------------------
30
HHSearch
84.78
16%
-127
* C2 *
2KS9
1
NK1R_HUMAN
A:
[33-329]
---------------------------------------
V
L
W
A
A
A
Y
T
--
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
-
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
---------
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
-
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
-----
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-
Y
S
T
T
-
E
-----
T
----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
-----
F
L
P
L
L
V
--
I
G
Y
A
Y
T
V
V
G
--
I
----------------------------------
T
L
WA
S
-----
E
I
PGDSSDRYH
E
Q
V
S
---------------------
A
K
--------
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
-
F
L
L
P
Y
--
I
----------
N
PDLY
L
K-
K
FI
Q
Q
V
Y
---------
L
A
I
M
W
L
------
A
M
S
---
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
--
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
---------------
40
Fugue
83.15
19%
-114
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
--
Y
LA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
--
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---------
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
-
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-----
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
--------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
--
V
I
Y
M
F
V
V
-----
H
F
-----
I
I
P
L
I
V
--
I
F
F
C
Y
G
Q
L
V
--
F
----------------------------------
T
V
--
K
-----
E
A
AAS---------
A
---------------------
T
T
--------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
--
F
----------
Y
----
I
--
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
------
A
K
T
---
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
--
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
TETS
Q
V
A
P
A------
10
PsiBlast_PDB
81.11
24%
-116
- C2 -
2YCX
3
ADRB1_MELGA
A:
[11-294]
--------------------------------------
E
A
G
M
S
L
L
M
A
--
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
-
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-
L
C
E
L
W
T
-
S
L
D
V
L
C
V
---------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
-----
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
----
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
-----
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
D
-
F
--
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
Y
R
E
A
K
--
E
----------------------------------
Q
I
--
R
K
I
DRA
S
K
------------
R
---------------------
K
R
V
M
L
M
R
E
--
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
--
F
F
-
L
V
N
I
V
--
N
----------
V
----
F
--
N
---
R
D
L
---------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
---
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
--------------------------------
29
HHSearch
76.49
16%
-129
- C2 -
1U19
14
OPSD_BOVIN
A:
[40-331]
--------------------------------------
F
S
M
L
A
A
Y
M
F
--
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---------
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
-
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-----
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
-----
P
----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
-----
I
I
P
L
I
V
--
I
F
F
C
Y
G
Q
L
V
--
F
TV--------------------------------
K
E
--
A
-----
A
A
------------
Q
QQESA
T
T
Q
K
------------
A
E
--------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
Y
I
F
T
H
Q
----------
G
SD--
F
G-
P
---
I
F
M
---------
T
I
P
A
F
F
------
A
K
T
---
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
--
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
---------------
42
Fugue
76.09
19%
-106
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
YL
A
--
E
P
W
Q
F
S
M
L
A
A
Y
M
F
--
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---------
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
-
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-----
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
H
E
E
T
----
N
N
E
S
F
--
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
-----
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
--
A
----------------------------------
Q
Q
--
Q
-----
E
S
------------
A
---------------------
T
T
--------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
--
F
----------
Y
----
I
--
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
------
A
K
T
---
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
--
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
32
HHSearch
69.83
15%
-112
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
--
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
-
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
---------
I
W
A
A
S
K
--
V
N
G
W
I
F
-
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
-----
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-
F
R
Q
A
Y
H
-----
P
----
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
---
T
A
K
---
W
R
M
V
L
R
I
L
P
H
T
F
G
F
-----
I
V
P
L
F
V
--
M
L
F
C
Y
G
F
T
L
R
T
L
----------------------------------
F
K
--
A
-----
H
M
------------
G
---------------------
Q
K
--------
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
-
L
L
A
D
T
--
L
M
RTQVIQE
S
C
E
R
R
--
N
--
N
I
G
-
R
A
L
---------
D
A
T
E
I
L
------
G
F
L
---
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
--
K
I
L
A
M
H
G
-----------------------
47
Fugue
66.50
13%
-109
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------------
S
F
K
C
A
L
T
K
T
G
F
---
Q
--
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
--
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
-----
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
T
-
L
P
---------
A
L
I
F
Y
Y
F
-
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
KSL
G
R
L
K
K
K
N
A
---
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
-
R
K
N
K
T
I
-----
T
C
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
--
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
-----
V
R
A
L
I
Y
--
K
M
K
K
Y
T
C
T
V
--
C
G
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKD
Q
F
--
E
-----
E
V
------------
E
---------------------
E
P
--------
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
-
V
M
K
T
M
--
N
----------
L
----
R
--
A
---
R
L
D
---------
F
Q
T
P
A
M
------
C
A
F
---
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
-----------------
31
HHSearch
63.60
20%
-136
- C2 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-221]
-----------------------------------------
Y
A
L
S
Y
C
--
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
-
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
---------
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
-
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
-----
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
N
T
--------
T
----
G
D
P
T
V
C
S
I
S
----------
N
--
P
-
D
F
V
-
I
Y
S
S
V
V
S
F
-----
Y
L
P
F
G
V
--
T
V
L
V
Y
A
R
I
Y
--
V
----------------------------------
V
L
--
K
-----
Q
R
------------
R
---------------------
R
K
--------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
-
T
I
G
I
G
--
H
----------
L
----
L
--
T
---
K
S
P
---------
S
L
N
A
A
K
------
S
E
L
---
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
--
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
---------------
23
HHSearch
62.46
18%
-131
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[36-230]
----------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
--
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
-
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---------
F
G
A
A
H
I
L
-
M
K
M
W
T
F
-
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
-----
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
-----
T
H
----
Q
E
A
I
N
C
Y
A
E
----
E
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
-----
Y
V
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
--
Q
----------------------------------
E
A
--
K
-----
R
Q
------------
L
---------------------
N
I
--------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
-
G
I
G
H
L
--
L
----------
T
----
K
--
S
---
P
S
L
---------
N
A
A
K
S
E
------
L
D
K
---
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
--
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
---------------
25
HHSearch
61.66
16%
-139
- C2 -
3EML
8
ENLYS_BPT4
A:
[21-216]
--------------------------------------
S
S
V
Y
I
T
V
E
L
--
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
---------
F
A
I
T
I
S
T
---
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
-----
Q
-------
S
Q
G
C
G
E
G
Q
---
V
A
C
L
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-----
L
V
P
L
L
L
--
M
L
G
V
Y
L
R
I
F
--
L
----------------------------------
A
A
--
R
-----
R
Q
------------
L
---------------------
N
I
--------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
-
G
I
G
H
L
--
L
----------
T
----
K
--
S
---
P
S
L
---------
N
A
A
K
S
E
------
L
D
K
---
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
--
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
---------------
3
PsiBlast_PDB
57.97
25%
-145
- C2 -
4U15
1
ACM3_RAT
A:
[13-142]
-----------------------------------------
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
-
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
---------
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
-
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
-----
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
-
F
W
Q
Y
F
V
-----
G
K
R
T
V
P
P
G
E
C
F
I
Q
F
L
S
E
P
T
I
T
F
G
T
A
I
--
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-----
W
R
I
Y
K
E
--
T
E
K
M
N
I
F
E
M
--
L
----------------------------------
R
I
--
D
-----
E
G
------------
G
---------------------
G
S
--------
G
G
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-
K
L
K
P
V
--
Y
----------
D
----
S
--
L
---
D
A
V
---------
R
R
A
A
L
I
------
N
M
V
---
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
--
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
---------------
22
HHSearch
57.76
16%
-136
- C2 -
3UON
2
ACM2_HUMAN (first)
A:
[24-210]
---------------------------------------
V
F
I
V
L
V
A
G
--
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
-
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
---------
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
-
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
-----
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
Q
F
I
V
-----
G
V
--
R
T
V
E
D
G
E
C
Y
I
Q
F
F
-----------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
-----
Y
L
P
V
I
I
--
M
T
V
L
Y
W
H
I
S
--
R
----------------------------------
A
S
--
K
-----
S
R
------------
I
---------------------
N
I
--------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
-
G
I
G
H
L
--
L
----------
T
----
K
--
S
---
P
S
L
---------
N
A
A
K
S
E
------
L
D
K
---
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
--
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
---------------
4
PsiBlast_PDB
57.66
25%
-151
- C2 -
4U16
1
?
A:
[13-142]
-----------------------------------------
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
-
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
---------
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
-
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
-----
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
-
F
W
Q
Y
F
V
-----
G
K
R
T
V
P
P
G
E
C
F
I
Q
F
L
S
E
P
T
I
T
F
G
T
A
I
--
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-----
W
R
I
Y
K
E
--
T
E
K
M
N
I
F
E
M
--
L
----------------------------------
R
I
--
D
-----
E
G
------------
G
---------------------
G
S
--------
G
G
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-
K
L
K
P
V
--
Y
----------
D
----
S
--
L
---
D
A
V
---------
R
R
A
A
L
I
------
N
M
V
---
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
--
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
---------------
2
PsiBlast_PDB
57.29
25%
-156
- C2 -
4U14
1
ENLYS_BPT4
A:
[13-142]
-----------------------------------------
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
-
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
---------
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
-
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
-----
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
-
F
W
Q
Y
F
V
-----
G
K
R
T
V
P
P
G
E
C
F
I
Q
F
L
S
E
P
T
I
T
F
G
T
A
I
--
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-----
W
R
I
Y
K
E
--
T
E
K
M
N
C
F
E
M
--
L
----------------------------------
R
I
--
D
-----
E
G
------------
L
---------------------
R
L
--------
K
I
Y
K
D
C
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
-
N
A
A
K
S
--
E
----------
L
----
D
--
K
---
A
I
G
---------
R
N
T
N
G
V
------
I
T
K
---
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
---------------