@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5BC_HUMAN: (2016-01-13 )
MENNTEVTEFILVGLTDDPELQIPLFIVFLFIYLITLVGNLGMIELILLDSCLHTPMYFFLSNLSLVDFGYSSAVTPKVMVGFLTGDKFILYNACATQFFFFVAFITAESFLLASMAYDRYAALCKPLHYTTTMTTNVCACLAIGSYICGFLNASIHTGNTFRLSFCRSNVVEHFFCDAPPLLTLSCSDNYISEMVIFFVVGFNDLFSILVILISYLFIFITIMKMRSPEGRQKAFSTCASHLTAVSIFYGTGIFMYLRPNSSHFMGTDKMASVFYAIVIPMLNPLVYSLRNKEVKSAFKKTVGKAKASIGFIF
Atome Classification :
(20 SA)
.........10......---------------..20...----------------.....30........40........50........60........70....-..---..80........90-........100.......110........120.....-----..130.....-------..140--...-....150.......160.......170......-.180.....-------..190.-------......200.......210.......220----......-.230---------.--------------------....-------....240...---....-------250----------........260..------.------.--...270---------.....-------------....280--.----........290........300.......310..------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MENNT
E
V
T
E
F
I
L
V
GLTD---------------DPEL
Q
I
P
----------------
L
F
I
V
F
L
F
I
Y
L
I
T
L
VGNL
G
M
I
E
L
I
L
L
D
S
C
L
H
T
P
M
Y
F
F
L
SNL
S
L
V
DFGYSSAV-
T
P
---
K
V
M
V
G
F
LTGD
K
F
I
L
-
Y
N
A
C
A
T
Q
F
F
F
F
V
A
F
I
T
A
E
S
-
F
L
L
A
S
M
A
Y
D
R
Y
A
A
L
CKP-----LH
Y
T
T
TM
T
T
N
-------
V
C
A
C
L
--
A
I
G
-
S
Y
I
C
G
F
L
NASIHTG
N
T
F
R
L
S
F
C
R
S
N
V
V
E
H
F
FCD-AP
P
L
L
T
L
SC-------SD
N
Y
I
S
-------
E
M
V
I
F
F
V
V
G
F
N
D
L
F
S
I
L
V
I
L
I
S
Y
L
F
I
F
I
T
----
I
M
KMRS-PE-----------
G
--------------------
R
Q
K
A
-------
F
S
T
C
A
S
H
L
T
A
---
V
S
I
F
-------YG-----------
T
G
I
F
M
Y
LRPNSSH------F------M--
G
T
D
K
-----------
M
A
S
V
F
-------------
Y
A
I
V
I
----
P
----
M
L
N
P
L
V
Y
S
L
R
-
N
K
E
V
K
S
A
F
K
K
T
VGKAKASIGFIF------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.80
24%
-156
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-----------
P
--------------------
G
E
R
A
-------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
-------
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
----
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.49
24%
-155
- C1 -
3PWH
1
?
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-----------
P
--------------------
G
E
R
A
-------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
-------
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
----
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.33
24%
-158
- C1 -
3REY
1
AA2AR_HUMAN
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-----------
P
--------------------
G
E
R
A
-------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
-------
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
----
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.30
24%
-154
- C1 -
3UZC
1
AA2AR_HUMAN
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-----------
P
--------------------
G
E
R
A
-------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
-------
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
----
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.67
24%
-155
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
-----
F
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-----------
P
--------------------
G
E
R
A
-------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
-------
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
----
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
83.95
17%
-135
- C1 -
2Z73
5
OPSD_TODPA
A:
[33-334]
-----------------------------------
V
Y
Y
S
----------------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
I
S
C
F
L
K
K
W
I
F
G
-
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
-
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
-----
M
A
A
S
K
K
M
S
H
R
-------
R
A
F
I
M
--
I
I
F
-
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
-
F
D
Y
I
S
------------
R
D
S
T
T
-------
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
----
V
S
N
H
E
K
-
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
-------
A
K
I
S
I
V
I
V
S
Q
---
F
L
L
S
-------
W
S
-----------
P
Y
A
V
V
A
L
L
A
Q
F
G
P
LEW---
V
------
T
--
P
Y
A
A
-----------
Q
L
P
V
M
-------------
F
A
K
A
S
----
A
----
I
H
N
P
M
I
Y
S
V
S
-
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
83.89
18%
-113
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
---------------
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
-
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-----
M
S
N
F
R
F
G
E
N
H
-------
A
I
M
G
V
--
A
F
T
-
W
V
M
A
L
A
C
A
A
P
P
L
V
G
---------------
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
I
D
Y
Y
T
PHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
-
S
A
-----------
T
--------------------
T
Q
K
A
-------
E
K
E
V
T
R
M
V
I
I
---
M
V
I
A
F
L
I
C
W
L
P
Y
A
-----------
G
V
A
F
Y
I
F
T
H
Q
G
S
D
------
F
------
G
--
P
I
F
M
-----------
T
I
P
A
F
-------------
F
A
K
T
S
----
A
----
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.48
24%
-151
- C1 -
4UHR
1
AA2AR_HUMAN
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
------
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-----------
P
--------------------
G
E
R
A
-------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
-------
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
----
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.77
24%
-156
- C1 -
3VG9
8
?
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
------
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-----------
P
--------------------
G
E
R
A
-------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
-------
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
----
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
82.51
18%
-136
- C1 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------
L
----------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
---
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
-
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
-
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
-----
L
Q
P
R
L
--
S
A
T
-------
A
T
K
V
V
--
I
C
V
-
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
-----
M
P
S
R
V
V
C
M
-
I
E
W
P
E
H
P
----------
N
K
I
Y
E
-------
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
----
L
W
A
S
E
I
-
P
G
DSSDRYH
E
Q
V
S
A
--------------------
K
R
K
V
-------
V
K
M
M
I
V
V
V
C
T
---
F
A
I
C
-------
W
L
-----------
P
F
H
I
F
F
L
L
P
Y
I
N
P
------
D
LYLKKF
I
--
Q
Q
V
Y
-----------
L
A
I
M
W
-------------
L
A
M
S
S
----
T
----
M
Y
N
P
I
I
Y
C
C
L
-
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.99
24%
-154
- C1 -
2YDV
6
?
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
------
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q----------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
-------
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
----
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.29
24%
-152
- C1 -
3VGA
1
AA2AR_HUMAN
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
------
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-----------
P
--------------------
G
E
R
A
-------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
-------
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
----
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.19
24%
-155
- C1 -
4UG2
3
?
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
------
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
-------------------------------------------
A
-------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
-------
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
----
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.43
24%
-150
- C1 -
2YDO
3
?
A:
[12-303]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
------
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
-------
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
-----------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
----
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
78.53
15%
-110
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
-
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-----
M
-------------------------
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
E
E
T
N
N
-------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
-
Q
Q
-----------
Q
--------------------
E
S
A
T
-------
T
Q
K
A
E
K
E
V
T
R
---
M
V
I
I
-------
M
V
-----------
I
A
F
L
I
C
W
L
P
Y
A
G
V
------
A
------
F
--
Y
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
-------------
F
A
K
T
S
----
A
----
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA--------------------------------------------------------------------------------------------------------------------------
27
HHSearch
76.68
15%
-124
- C1 -
1U19
14
OPSD_BOVIN
A:
[41-328]
-------------------------------------
S
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
-
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-----
M
S
N
F
R
-
F
G
E
N
-------
H
A
I
M
G
--
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
----
E
G
M
Q
C
S
C
G
-
I
D
Y
Y
T
---
P
-------
H
E
E
T
N
N
-------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
-
Q
Q
-----------
Q
ESA
T
T
Q
K
A
------------
E
K
E
V
-------
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
-------
W
L
-----------
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
GSD---
F
------
G
--
P
I
F
M
-----------
T
I
P
A
F
-------------
F
A
K
T
S
----
A
----
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
73.95
14%
-123
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
---------
S
F
K
C
A
L
T
K
---------------
T
G
F
Q
F
Y
Y
----------------
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
--
P
---
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
-
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
KSL
G
R
L
K
K
K
N
A
I
C
I
S
-------
V
L
V
W
L
--
I
V
V
-
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
S
D
E
Y
-
L
R
-
S
Y
F
I
Y
S
M
C
T
-------
T
V
A
M
F
C
-------
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
----
G
Y
I
Y
N
P
-
E
D
-----------
G
--------------------
D
P
D
N
GVNPGTD
F
K
D
I
V
C
P
L
C
G
---
V
G
K
D
-------
Q
F
-----------
E
E
V
E
E
P
L
R
R
K
S
I
Y
------
L
------
V
--
I
I
V
L
-----------
T
V
F
A
V
-------------
S
Y
I
P
F
----
H
----
V
M
K
T
M
N
L
R
A
R
-
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR------------------------------------------------------------------------------------------------------------------
43
Fugue
72.72
17%
-118
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
V
G
----------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
M
K
M
W
T
F
G
-
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
-
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
-----
F
K
Y
Q
S
L
L
T
K
N
-------
K
A
R
V
I
--
I
L
M
-
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
----
R
A
T
H
Q
E
A
I
N
C
Y
-
A
E
E
T
---
C
C
-------
D
F
F
T
N
Q
-------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
----
K
R
Q
L
N
I
-
F
E
-----------
M
--------------------
L
R
I
D
-------
E
G
L
R
L
K
I
Y
K
D
---
T
E
G
Y
-------
Y
T
-----------
I
G
I
G
H
L
L
T
K
S
P
S
L
------
N
------
A
--
A
K
S
E
-----------
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
----
Q
----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
28
HHSearch
66.10
15%
-124
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
----------------------------------
L
N
K
Y
V
----------------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
---
I
W
A
A
S
K
-
V
N
G
W
I
F
G
-
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
-
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
-----
T
R
T
L
T
-
Q
K
R
H
-------
L
V
K
F
V
--
C
L
G
-
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
P
----
N
N
S
S
P
V
C
Y
-
E
V
L
G
N
---
D
--------
T
A
K
W
R
-------
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
----
L
F
K
A
H
M
-
G
------------
Q
--------------------
K
H
R
A
-------
M
R
V
I
F
A
V
V
L
I
---
F
L
L
C
-------
W
L
-----------
P
Y
N
L
V
L
L
A
D
T
L
M
R
TQVIQE
S
C
E
R
R
--
N
N
I
G
R
A
L
-----------
D
A
T
E
I
-------------
L
G
F
L
H
----
S
----
C
L
N
P
I
I
Y
A
F
I
-
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.16
25%
-165
- C1 -
3EML
8
ENLYS_BPT4
A:
[27-222]
----------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
------
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
--------------
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
----
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
----
A
R
R
Q
L
N
-
I
F
-----------
E
--------------------
M
L
R
I
-------
D
E
G
L
R
L
K
I
Y
K
---
D
T
E
G
-------
Y
Y
-----------
T
I
G
I
G
H
L
L
T
K
S
P
S
------
L
------
N
--
A
A
K
S
-----------
E
L
D
K
A
-------------
I
G
R
N
T
----
N
----
G
V
I
T
K
D
E
A
E
K
-
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
------------------------------------------------------------------------------------------------------------------------------------------