@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5I1_HUMAN: (2016-01-13 )
MEFTDRNYTLVTEFILLGFPTRPELQIVLFLMFLTLYAIILIGNIGLMLLIRIDPHLQTPMYFFLSNLSFVDLCYFSDIVPKMLVNFLSENKSISYYGCALQFYFFCTFADTESFILAAMAYDRYVAICNPLLYTVVMSRGICMRLIVLSYLGGNMSSLVHTSFAFILKYCDKNVINHFFCDLPPLLKLSCTDTTINEWLLSTYGSSVEIICFIIIIISYFFILLSVLKIRSFSGRKKTFSTCASHLTSVTIYQGTLLFIYSRPSYLYSPNTDKIISVFYTIFIPVLNPLIYSLRNKDVKDAAEKVLRSKVDSS
Atome Classification :
(20 SA)
------------.........10........20........30........-40........50........60........70........-80.......-.90........100..----.....110.......120.......130-.....---..140.......150.......160.......-170.......180.......190.-------.--.--.....200--.......210.......220......---------.230------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------......240.-----......----------------------250------------.......260.....------------.----.------270.......280.......290..-----.-...---.300.....--------------------..310..-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MEFTDRN
Y
T
L
V
T
E
F
I
L
LGFPTRP
E
L
Q
I
V
L
F
L
M
F
L
T
L
Y
A
I
-
I
L
IGNI
G
L
M
L
L
I
RIDPHLQ
T
P
M
Y
F
F
L
SNL
S
F
V
D
L
C
Y
F
S
D
I
-
V
P
K
M
L
V
N
F
L
-SENK
S
I
S
Y
Y
G
C
A
L
Q
F
Y
----
F
F
C
T
FADT
E
S
F
I
L
A
A
M
A
YD
R
Y
V
A
I
C
N
P
L
-
L
Y
T
V
V
---MSR
G
I
C
M
R
L
I
V
L
S
Y
LGG
N
M
S
S
L
V
H
T
S
F
A
F
I
L
K
-
Y
C
D
K
N
V
I
N
H
F
FCDLPP
L
L
K
L
SC-T-------D--
T
--
T
I
N
E
W
L
L
S
--TYGS
S
V
E
I
I
C
F
I
I
I
I
I
S
Y
F
F
I
L
L
S
V
L
---------
K
I
RS------------------------------------------------------------------------------------------------------------------------------------------------------------------F-------------------------------------------------------------------------------------------------------------------------------------------------------------------SGR
K
K
T
F
S
T
C
-----
A
S
H
L
T
S
----------------------
V
T
I
------------YQ
G
T
L
L
F
I
YSRPSYL------------Y----S------PNT
D
K
I
I
S
V
F
Y
T
I
F
I
P
V
L
N
P
L
I
Y
S
L
-----R-NK
D
---
V
K
D
A
A
E
K
V
L
--------------------
R
S
KVDSS-----------------------------
40
Fugue
80.05
19%
-131
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
----
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
-----------------
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
-
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
-
G
I
------
D
YY
T
--
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
FTVKEAA--
A
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
----------------------
W
L
P
------------
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
------------
F
----
G
------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
-----
M
-
N
K
Q
---
F
R
N
C
M
V
T
T
L
--------------------
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------
21
HHSearch
79.33
19%
-132
* C3 *
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
-
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
----
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
-
G
--
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
S
---------------------
N
A
A
V
T
F
--
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
---------
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
-----
L
A
I
L
L
A
----------------------
F
I
I
------------
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
AP----------
C
----
I
------
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
-----
C
-
N
A
T
---
F
K
K
T
F
K
H
L
L
--------------------
M
-----------------------------------
7
PsiBlast_PDB
77.69
21%
-124
- C3 -
2RH1
9
ADRB2_HUMAN (first)
A:
[36-310]
----------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
--
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
-
A
T
H
Q
E
A
I
N
C
Y
-------
A
E
E
T
C
-
C
-------
D
--
F
--
F
T
N
Q
------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
--------------
S
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
A
K
R
Q
L
N
I
---------
F
E
M
----------------------
L
R
I
------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
------------
Y
----
T
------
I
G
I
G
H
L
L
T
K
S
-----
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
-
N
T
N
GVI
T
K
D
E
A
E
K
L
F
--------------------
N
Q
D
V
D
A
A
-----------------------------
12
PsiBlast_PDB
77.00
21%
-125
- C3 -
3PDS
4
ADRB2_HUMAN (first)
A:
[5-279]
----------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
-
M
K
M
W
T
F
G
N
F
W
C
--
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
-
A
T
H
Q
E
A
I
N
C
Y
-------
A
E
E
T
C
-
C
-------
D
--
F
--
F
T
N
Q
------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
--------------
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
A
K
R
Q
L
N
I
---------
F
E
M
----------------------
L
R
I
------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
------------
Y
----
T
------
I
G
I
G
H
L
L
T
K
S
-----
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
-
N
T
N
GVI
T
K
D
E
A
E
K
L
F
--------------------
N
Q
D
V
D
A
A
-----------------------------
23
HHSearch
76.76
16%
-138
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
-
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
----
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
-
T
----
H
Q
E
A
I
N
C
Y
A
E
E
----
T
C
-
C
-------
D
--
F
--
F
T
N
Q
A
Y
A
I
--
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
---------
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF-
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
K
A
L
K
T
L
-----
G
I
I
M
G
T
----------------------
F
T
L
------------
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
DN----------
L
----
I
------
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
------
R
-
S
P
D
---
F
R
I
A
F
Q
E
L
L
--------------------
C
L
----------------------------------
14
PsiBlast_PDB
75.39
20%
-113
- C3 -
2X72
5
GNAT1_BOVIN (first)
A:
[51-316]
--------------------------
I
M
L
G
F
P
----------
I
N
F
L
T
L
Y
V
T
-
V
Q
------------
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
Q
G
F
----
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
-
G
IDYYTPH
E
--
E
--
T
N
N
E
S
F
V
I
--
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
---------
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
A
T
T
Q
K
A
-----
E
K
E
V
T
R
----------------------
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
C
------------
F
----
G
------
P
-
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
-----
M
-
N
K
Q
---
F
R
N
C
M
V
T
T
L
--------------------
C
C
G
K
N
-------------------------------
28
HHSearch
74.61
16%
-144
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-469]
-------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
-
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
----
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
-
Q
-------
S
Q
G
C
G
E
G
Q
V
---
A
C
-
L
-------
F
--
E
DV
V
P
M
N
Y
M
V
Y
--
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
---------
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
-----
A
I
I
V
G
L
----------------------
F
A
L
------------
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
PDCS--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
-----
R
-
I
R
E
---
F
R
Q
T
F
R
K
I
I
--------------------
R
S
H
V
L
R
Q
-----------------------------
20
PsiBlast_PDB
74.20
20%
-135
- C3 -
3NYA
3
ADRB2_HUMAN (first)
A:
[40-311]
-------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
--
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
--
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
-
A
T
H
Q
E
A
I
N
C
Y
-------
A
E
E
T
C
-
C
-------
D
--
F
--
F
T
N
Q
------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
--------------
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
A
K
R
Q
L
N
I
---------
F
E
M
----------------------
L
R
I
------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
------------
Y
----
T
------
I
G
I
G
H
L
L
T
K
S
-----
P
S
L
N
A
A
K
S
E
L
D
K
A
IG
R
-
N
T
N
GVI
T
K
D
E
A
E
K
L
F
--------------------
N
Q
D
V
D
A
A
-----------------------------
18
PsiBlast_PDB
74.19
20%
-138
- C3 -
3NY8
7
ENLYS_BPT4
A:
[40-311]
-------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
--
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
--
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
-
A
T
H
Q
E
A
I
N
C
Y
-------
A
E
E
T
C
-
C
-------
D
--
F
--
F
T
N
Q
------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
--------------
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
A
K
R
Q
L
N
I
---------
F
E
M
----------------------
L
R
I
------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
------------
Y
----
T
------
I
G
I
G
H
L
L
T
K
S
-----
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
-
N
T
N
GVI
T
K
D
E
A
E
K
L
F
--------------------
N
Q
D
V
D
A
A
-----------------------------
17
PsiBlast_PDB
73.89
20%
-142
- C3 -
3D4S
6
ENLYS_BPT4
A:
[40-311]
-------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
--
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
--
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
-
A
T
H
Q
E
A
I
N
C
Y
-------
A
E
E
T
C
-
C
-------
D
--
F
--
F
T
N
Q
------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
--------------
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
A
K
R
Q
L
N
I
---------
F
E
M
----------------------
L
R
I
------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
------------
Y
----
T
------
I
G
I
G
H
L
L
T
K
S
-----
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
-
N
T
N
GVI
T
K
D
E
A
E
K
L
F
--------------------
N
Q
D
V
D
A
A
-----------------------------
29
HHSearch
73.46
15%
-141
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-333]
-----------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
-
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
----
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
-
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
-----
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
---------------
D
--
S
T
T
R
S
N
I
L
--
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
---------
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
-----
I
V
I
V
S
Q
----------------------
F
L
L
------------
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
PLE---------
W
----
V
------
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
-----
S
-
H
P
K
---
F
R
E
A
I
S
Q
T
F
--------------------
P
W
V
L
T
C
C
-----------------------------
41
Fugue
73.38
19%
-96
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
----
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
------------------
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
-------
D
YY
T
--
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
FTVKEAAAQ
Q
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
----------------------
V
I
A
------------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
------------
F
----
T
H
QGSDF
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
-----
M
-
N
K
Q
---
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
TE
T
S
Q
V
A
P
A
-----------------------------
19
PsiBlast_PDB
73.37
20%
-140
- C3 -
3NY9
4
ADRB2_HUMAN (first)
A:
[40-311]
-------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
--
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
--
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
-
A
T
H
Q
E
A
I
N
C
Y
-------
A
E
E
T
C
-
C
-------
D
--
F
--
F
T
N
Q
------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
--------------
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
A
K
R
Q
L
N
I
---------
F
E
M
----------------------
L
R
I
------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
------------
Y
----
T
------
I
G
I
G
H
L
L
T
K
S
-----
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
-
N
T
N
GVI
T
K
D
E
A
E
K
L
F
--------------------
N
Q
D
V
D
A
A
-----------------------------
32
HHSearch
72.44
16%
-139
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
-
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
----
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
--------
T
G
D
P
T
V
C
S
I
S
N
----------------------
P
D
--
F
V
I
--
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
---------
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
-----
A
I
V
L
G
A
----------------------
F
I
V
------------
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
------------
Q
TCH-
V
------
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
-----
F
-
N
I
E
---
F
R
K
A
F
L
K
I
L
--------------------
S
C
----------------------------------
24
HHSearch
68.74
14%
-139
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
-
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
----
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
---------
R
R
E
D
K
C
E
T
D
F
Y
D
---------------------
V
T
W
F
K
V
--
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
---------
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
L
-----
G
F
I
M
A
A
----------------------
F
I
L
------------
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
------------
K
NC--
C
------
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
-----
C
-
N
E
N
---
F
K
K
T
F
K
R
I
L
--------------------
H
I
----------------------------------
22
HHSearch
68.48
17%
-138
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-496]
-----------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
-
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
----
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
------
S
E
A
D
D
R
Y
I
C
D
R
F
Y
P
N
----------------
D
--
L
W
V
V
V
F
Q
F
--
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
---------
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
-----
V
I
L
I
L
A
----------------------
F
F
A
------------
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
----
T
------
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
-----
L
-
G
A
K
---
F
K
T
S
A
Q
H
A
L
--------------------
T
S
G
R
P
L
E
-----------------------------
49
Fugue
67.96
17%
-119
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------------
S
F
K
C
A
L
T
K
T
G
F
-----
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
-
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
----
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
K
---
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
--------
I
L
F
-
Y
S
G
T
G
V
R
K
N
--------
K
T
I
T
C
-
Y
-------
D
--
T
--
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
---------
R
A
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
K
K
Y
T
C
T
V
C
-----
G
Y
I
Y
N
P
EDGDPDNGVNPGTDFKDIVCPL
C
G
V
------------
G
K
D
Q
F
E
E
V
E
E
P
L
R
R
K
------------
S
----
I
------
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
-----
R
A
R
L
D
---
F
Q
T
P
A
M
C
A
F
--------------------
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR
31
HHSearch
67.26
16%
-110
- C3 -
1U19
14
OPSD_BOVIN
A:
[39-327]
------------------------------------
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
-
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
----
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-----
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
-----------
E
--
E
--
T
N
N
E
S
F
V
I
--
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
---------
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
-----
I
I
M
V
I
A
----------------------
F
L
I
------------
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS---------
D
----
F
------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
-----
M
-
N
K
Q
---
F
R
N
C
M
V
T
T
L
--------------------
C
C
G
K
N
P
L
-----------------------------
27
HHSearch
66.66
17%
-127
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
-----------------------------------
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
-
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
----
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
------------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
--------
I
S
A
L
S
S
C
S
T
V
L
P
L
---------------------
Y
H
K
H
Y
I
--
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
---------
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
L
K
T
V
-----
I
I
V
L
S
V
----------------------
F
I
A
------------
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
------------
K
VKTC
D
------
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
-----
T
-
N
K
E
---
M
R
R
A
F
I
R
I
M
--------------------
G
R
P
L
--------------------------------
30
HHSearch
66.39
13%
-139
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
--------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
-
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
----
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
------
E
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------
N
--
K
--
I
Y
E
K
V
Y
H
I
--
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
---------
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
-----
I
V
V
V
C
T
----------------------
F
A
I
------------
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
------------
P
----
D
LYLKKF
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
-----
L
-
N
D
R
---
F
R
L
G
F
K
H
A
F
--------------------
R
C
C
P
F
I
S
-----------------------------