@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5M8_HUMAN: (2016-01-13 )
MRRNCTLVTEFILLGLTSRRELQILLFTLFLAIYMVTVAGNLGMIVLIQANAWLHMPMYFFLSHLSFVDLCFSSNVTPKMLEIFLSEKKSISYPACLVQCYLFIALVHVEIYILAVMAFDRYMAICNPLLYGSRMSKSVCSFLITVPYVYGALTGLMETMWTYNLAFCGPNEINHFYCADPPLIKLACSDTYNKELSMFIVAGWNLSFSLFIICISYLYIFPAILKIRSTEGRQKAFSTCGSHLTAVTIFYATLFFMYLRPPSKESVEQGKMVAVFYTTVIPMLNLIIYSLRNKNVKEALIKELSMKIYFS
Atome Classification :
(20 SA)
-------------------.....---....----------------10....---....----------------20......-..30--------...----------.....40..-----......50.-----.......60....-...-.70....---------.--------------------------...80........90........----------100.....-------------..--110.......120---.----------.......130.-.......140.......150...---....160.-..----....--------------------------170.......180-------.......-------190--.--.-------.....200.......210..----------...-------------..--------------220.------..---..-..230---------.--------------------.......-------------.240..-......250----------------.......260--.--.-.---.----.--------..---270----------........280.......290.......300--.-...--------------------...310-------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------MRR
N
C
---
T
L
V
T
----------------
E
F
I
L
LG---LTSR----------------
R
E
L
Q
I
L
L
F
-
T
L
F
L
--------
A
I
Y
----------
M
V
T
VAGNL
G
-----
M
I
V
L
I
QAN
A
-----
W
L
H
M
P
M
Y
F
F
L
S
H
L
-
S
F
V
-
D
L
C
FSSN---------V--------------------------
T
P
K
M
L
E
I
F
L
S
EKKSIS
Y
P
A
C
L
V
Q
----------
C
Y
L
F
I
A
L
V
-------------
H
V
--
E
I
Y
I
L
A
V
M
A
F
D
R
----
Y
----------
M
A
I
C
N
P
L
L-YG-S
R
M
S
K
S
V
C
S
F
L
I
T
V
P
Y
V
Y
G
A
L
T
G
---
L
M
E
T
M
W
TY-N
L
----
A
FCG--------------------------PNEI
N
H
F
YCADP
P
-------
L
I
K
L
A
CS-------DTY--N--K-------
E
L
S
M
F
I
V
AGWN
L
S
F
S
L
F
I
I
C
----------
I
S
Y
-------------
L
Y
--------------
I
F
P
A
------
I
L
---
K
I-RST-----------E--------------------
G
R
Q
K
A
F
S
-------------
T
CG-S
H
-
L
T
A
V
T
I
F
Y
A
----------------
T
L
F
F
M
YLRPP--
S
--
K
-
E
---
S
----V--------EQ---G
K
-----------
M
V
A
V
F
Y
T
T
V
I
P
M
L
N
L
I
I
Y
S
LRNK
N
V
K
E
A
L
I
K
--E-L
S
M
--------------------
K
I
Y
FS--------------
40
Fugue
85.99
16%
-141
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------
M
N
G
---
T
E
G
P
----------------
N
F
Y
V
P
F
---
S
N
K
T
GVVRSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
-
A
Y
M
F
--------
L
L
I
----------
M
L
G
F
P
I
N
F
L
-----
T
L
Y
V
T
V
Q
H
K
-----
K
L
R
T
P
L
N
Y
I
L
L
N
L
-
A
V
A
-
D
L
F
M
V
F
G
---------
G
--------------------------
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
----------
G
F
F
A
T
L
G
G
-------------
E
I
--
A
L
W
S
L
V
V
L
A
I
E
R
----
Y
----------
V
V
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
---
G
V
A
F
T
W
V
M
-
A
L
----
A
C
A
A
--------------------------
P
P
L
V
G
-
W
S
R
Y
I
P
E
-------
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
--
N
--
N
-------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
----------
F
C
Y
-------------
G
Q
--------------
L
V
F
T
------
V
K
---
E
A
-
A
A
S
-----------
A
--------------------
T
T
Q
K
A
E
K
-------------
E
V
T
-
R
M
-
V
I
I
M
V
I
A
F
L
----------------
I
C
W
L
P
Y
A
G
V
A
--
F
--
Y
-
I
---
F
----
T
--------
H
Q
---
G
S
DFGPIFM----
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
--
T
-
L
C
C
--------------------
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A
32
HHSearch
78.35
17%
-132
- C4 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
----------------------------------------------------------------------------------
W
A
-
A
A
Y
T
--------
V
I
V
----------
V
T
S
V
V
G
N
V
V
-----
V
M
W
I
I
L
A
H
K
-----
R
M
R
T
V
T
N
Y
F
L
V
N
L
-
A
F
A
-
E
A
S
M
A
A
F
---------
N
--------------------------
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
----------
N
F
F
P
I
A
A
V
-------------
F
A
--
S
I
Y
S
M
T
A
V
A
F
D
R
----
Y
----------
M
A
I
I
H
P
L
Q
-
P
R
-
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
---
F
P
Q
G
Y
Y
S
--
T
------
T
-
E
--------------------------
T
-
M
P
S
R
V
V
C
M
I
E
W
-------
P
E
H
---
P
-------
N
K
I
--
Y
--
E
-------
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
----------
Y
A
Y
-------------
T
V
--------------
V
G
I
T
------
L
W
---
A
S
-
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
R
K
V
V
K
-------------
M
M
I
-
V
V
-
V
C
T
F
A
I
C
W
L
----------------
P
F
H
I
F
F
L
L
P
Y
--
I
--
N
-
P
D--
L
YL--
K
--------
K
F
I
Q
Q
V
Y
-----------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
--
A
-
F
R
C
--------------------
C
P
F
I
S
--------------
34
HHSearch
78.16
16%
-139
- C4 -
2Z73
5
OPSD_TODPA
A:
[34-333]
-------------------------------------------------------------------------------
Y
Y
S
L
G
-
I
F
I
G
--------
I
C
G
----------
I
I
G
C
G
G
N
G
I
-----
V
I
Y
L
F
T
K
T
K
-----
S
L
Q
T
P
A
N
M
F
I
I
N
L
-
A
F
S
-
D
F
T
F
S
L
V
---------
N
G
-------------------------
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
----------
G
F
I
G
G
I
F
G
-------------
F
M
--
S
I
M
T
M
A
M
I
S
I
D
R
----
Y
----------
N
V
I
G
R
P
M
A
-
A
S
-
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
---
I
G
P
I
F
G
W
G
-
A
------
Y
-
T
--------------------------
L
-
E
G
V
L
C
N
C
S
F
D
Y
-------
I
S
------------
R
D
S
--
T
--
T
-------
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
----------
F
C
Y
-------------
F
N
--------------
I
V
M
S
------
V
S
---
N
H
-
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
-------------
I
S
I
-
V
I
-
V
S
Q
F
L
L
S
W
S
----------------
P
Y
A
V
V
A
L
L
A
Q
--
F
--
G
-
P
LEW
V
----
T
--------
P
Y
---
A
A
-----------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
--
T
-
F
P
W
--------------------
V
L
T
C
C
--------------
48
Fugue
77.55
21%
-155
- C1 -
4R5O
10
?
A:
[2-427]
----DDCEDLHLGNLAH
Y
P
N
V
L
K
G
---
T
F
P
T
----------------
E
S
Q
V
L
E
---
L
G
E
T
----------------
L
E
I
T
P
E
L
L
-
N
P
E
G
--------
A
T
Y
----------
S
W
L
V
N
G
K
E
Y
STEP
T
F
S
Y
K
I
D
N
P
C
-----
R
A
D
L
S
C
I
I
K
N
K
Y
G
-
K
V
E
M
S
T
S
F
S
S
N
HNFSK
G
F
F
Y
V
--------------------------
A
D
G
T
F
N
F
Y
D
T
E
K
K
-
T
A
Y
Q
D
C
Y
A
S
L
N
AGKTLGIG
N
Y
D
S
A
N
I
I
-------------
H
S
NG
K
F
Y
L
L
V
G
T
S
T
S
N
RDH
F
Y
----------
I
V
D
A
K
T
L
Y
-
Y
E
N
S
A
V
V
G
A
N
L
S
G
L
T
I
L
N
E
Q
Y
G
L
V
T
G
D
G
I
R
R
I
D
L
K
S
L
-
N
N
----
V
R
I
K
--------------------------
N
E
R
L
L
C
F
Y
N
S
I
I
Y
-------
N
G
K
V
L
S
N
-------
D
T
Y
--
K
--
D
ES
K
V
K
Y
Y
D
V
N
E
L
I
A
A
K
E
G
E
A
P
A
V
T
E
L
D
----------
I
I
Q
K
Q
K
I
N
F
V
L
A
KDG
N
V
Y
--------------
T
L
E
S
A
DNGCN
I
V
---
K
I
-
K
N
D
-----------
F
--------------------
T
L
E
K
V
F
A
NFQPAKGPYHSSP
T
I
G
M
V
A
-
S
E
T
E
N
I
I
Y
L
V
S
TDG
A
I
Y
K
Y
I
LGDSD
S
L
K
A
P
F
I
A
A
E
--
S
--
G
-
V
---
S
----
I
T
A
P
L
Q
L
NQ
Q
S
---
G
E
-----------
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
I
V
V
Y
S
K
D
G
K
V
L
H
T
V
D
C
G
--
E
S
V
P
S
--------------------
Q
I
L
F
N
N-------------
42
Fugue
72.12
15%
-119
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------MN
G
T
E
G
PNFYVP
F
S
N
K
T
---
G
V
V
R
----------------
S
P
F
E
A
P
QYY
L
A
E
P
----------------
W
Q
F
S
M
L
A
A
-
Y
M
F
L
--------
L
I
M
----------
L
G
F
P
I
N
F
L
T
-----
L
Y
V
T
V
Q
H
K
K
------
L
R
T
P
L
N
Y
I
L
L
N
L
-
A
V
A
-
D
L
F
M
V
F
G
---------
G
--------------------------
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
----------
G
F
F
A
T
L
G
G
-------------
E
I
--
A
L
W
S
L
V
V
L
A
I
E
R
----
Y
----------
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
---
P
L
V
G
W
S
R
Y
-
I
P
E
GMQ
C
S
C
G
--------------------------
I
D
----
Y
Y
T
P
H
-----------------------
E
E
T
--
N
--
N
-------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
----------
F
C
Y
-------------
G
Q
--------------
L
V
F
T
------
V
K
---
E
A
-
A
A
Q
-----------
Q
--------------------
Q
E
S
A
T
T
Q
-------------
K
A
E
-
K
E
-
V
T
R
M
V
I
I
M
V
----------------
I
A
F
L
I
C
W
L
P
Y
--
A
--
G
-
V
---
A
----
F
--------
Y
I
---
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
--
T
-
L
C
C
GKNPLGDDEA
S
T
T
V
S
K
TETS
Q
V
A
P
A
--------------
30
HHSearch
70.41
13%
-129
- C4 -
1U19
14
OPSD_BOVIN
A:
[42-326]
---------------------------------------------------------------------------------
M
L
A
-
A
Y
M
F
--------
L
L
I
----------
M
L
G
F
P
I
N
F
L
-----
T
L
Y
V
T
V
Q
H
K
-----
K
L
R
T
P
L
N
Y
I
L
L
N
L
-
A
V
A
-
D
L
F
M
V
F
G
---------
G
--------------------------
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
----------
G
F
F
A
T
L
G
G
-------------
E
I
--
A
L
W
S
L
V
V
L
A
I
E
R
----
Y
----------
V
V
V
C
K
P
M
S
-
N
F
-
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
W
S
-
R
------
Y
-
I
--------------------------
P
-
E
G
M
Q
C
S
C
G
I
D
Y
-------
Y
T
P
---
H
-------
E
E
T
--
N
--
N
-------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
----------
F
C
Y
-------------
G
Q
--------------
L
V
F
T
------
V
K
---
E
A
-
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
K
E
V
T
R
-------------
M
V
I
-
I
M
-
V
I
A
F
L
I
C
W
L
----------------
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
-
S
---
D
F---
G
--------
P
I
---
F
M
-----------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
--
T
-
L
C
C
--------------------
G
K
N
P
L
--------------
49
Fugue
67.50
18%
-159
* C3 *
3G8Q
2
CDAT8_METKA
A:
[1-278]
-------------------
M
K
V
S
L
AGQ
T
V
D
V
----------------
K
K
I
L
N
E
---
I
P
K
R
----------------
T
V
T
A
A
L
L
E
G
G
E
I
V
--------
A
V
E
E
A
D
DEH
A
E
R
K
L
V
R
R
H
D
V
E
G
-----
K
V
V
F
V
T
A
R
P
-----
C
L
Y
C
A
R
E
L
A
E
A
G
V
A
G
V
V
-
Y
L
G
R
G
R
G
---------
L
--------------------------
G
P
Y
Y
L
A
R
S
G
V
E
V
V
E
V
H
P
D
E
P
L
G
Y
----------
D
P
V
D
R
L
D
V
-------------
L
L
--
T
F
G
G
N
P
Y
L
T
E
E
D
----
V
----------
A
A
R
V
Y
C
L
L
-
T
G
-
R
-------
G
F
D
A
D
I
A
P
A
P
E
N
L
S
G
---
R
V
E
I
M
V
T
R
-
G
--------
D
--------------------------
P
D
E
A
V
E
L
L
K
E
E
L
P
-------
V
F
----------------------------
R
I
R
R
F
L
I
S
G
E
F
D
R
D
E
L
R
E
R
I
----------
L
E
D
-----------------------------
I
E
P
R
------
I
L
D
P
F
A
V
-
R
A
R
-----------
I
--------------------
A
R
A
G
A
F
S
-------------
S
------
S
R
E
A
E
V
F
I
G
----------------
D
V
L
T
S
V
G
R
E
V
--
N
--
L
-
N
---
D
-------------------
P
-----------
R
T
V
V
T
V
D
V
L
G
P
R
V
S
V
G
V
E
K
R
---------------------------------------------------------
27
HHSearch
65.89
21%
-160
- C4 -
3EML
8
ENLYS_BPT4
A:
[22-221]
--------------------------------------------------------------------------------
S
V
Y
I
-
T
V
E
L
--------
A
I
A
----------
V
L
A
I
L
G
N
V
L
-----
V
C
W
A
V
W
L
N
S
-----
N
L
Q
N
V
T
N
Y
F
V
V
S
L
-
A
A
A
-
D
I
A
V
G
V
L
---------
A
--------------------------
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
----------
A
C
F
V
L
V
L
T
-------------
Q
S
--
S
I
F
S
L
L
A
I
A
I
D
R
----
Y
----------
I
A
I
R
I
P
L
R
-
Y
N
-
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
-
N
C
----
G
Q
---------------------------------
S
Q
G
C
G
E
G
Q
----------
V
A
C
L
-------
F
E
D
--
V
VP
M
-------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
----------
G
V
Y
-------------
L
R
--------------
I
F
L
A
------
A
R
---
R
Q
-
L
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
-------------
G
L
R
-
L
K
-
I
Y
K
D
T
E
G
Y
Y
----------------
T
I
G
I
G
H
L
L
T
K
--
S
--
P
-
S
---
L
----
N
--------
A
A
---
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
--
R
-
G
I
L
--------------------
R
N
A
K
L
--------------
24
HHSearch
65.11
20%
-141
- C4 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-235]
-------------------------------------------------------------------------------
V
V
G
M
G
-
I
V
M
S
--------
L
I
V
----------
L
A
I
V
F
G
N
V
L
-----
V
I
T
A
I
A
K
F
E
-----
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
-
D
L
V
M
G
L
A
---------
V
--------------------------
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
----------
T
S
I
D
V
L
C
V
-------------
T
A
--
S
I
E
T
L
C
V
I
A
V
D
R
----
Y
----------
F
A
I
T
S
P
F
K
-
Y
Q
-
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
---
F
L
P
I
Q
M
H
W
-
Y
-----
R
A
-----------------------------
T
H
Q
E
A
I
N
C
Y
A
E
-----------
E
T
C
C
-------
D
F
F
--
T
--
N
-------
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
----------
F
V
Y
-------------
S
R
--------------
V
F
Q
E
------
A
K
---
R
Q
-
L
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
-------------
G
L
R
-
L
K
-
I
Y
K
D
T
E
G
Y
Y
----------------
T
I
G
I
G
H
L
L
T
K
--
S
--
P
-
S
---
L
----
N
--------
A
A
---
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
--
R
-
G
I
L
--------------------
R
N
A
K
L
--------------
28
HHSearch
64.99
15%
-123
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
-------------------------------------------------------------------------------
K
Y
V
V
I
-
I
A
Y
A
--------
L
V
F
----------
L
L
S
L
L
G
N
S
L
-----
V
M
L
V
I
L
Y
S
R
-----
V
G
R
S
V
T
D
V
Y
L
L
N
L
-
A
L
A
-
D
L
L
F
A
L
----------
T
--------------------------
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
----------
S
L
L
K
E
V
N
F
-------------
Y
S
--
G
I
L
L
L
A
C
I
S
V
D
R
----
Y
----------
L
A
I
V
H
A
T
R
-
T
L
-
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
---
L
P
F
F
L
F
R
--
Q
------
A
Y
H
--------------------------
P
N
-
N
S
S
P
V
C
Y
E
V
L
-------
G
N
----
D
-------
T
A
K
--
W
--
R
-------
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
----------
F
C
Y
-------------
G
F
--------------
T
L
R
T
------
L
F
---
K
A
-
H
-
M
-----------
G
--------------------
Q
K
H
R
A
M
R
-------------
V
I
F
-
A
V
-
V
L
I
F
L
L
C
W
L
----------------
P
Y
N
L
V
L
L
A
D
T
L
M
R
TQ
V
I
Q
E--
S
C
E
R
R
N
--------
N
I
G
R
-
A
L
-----------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
--
I
-
L
A
M
--------------------
H
G
-----------------
43
Fugue
63.60
20%
-99
- C3 -
4OWT
-
INT3_HUMAN
A:
[1-466]
GGRL
L
L
S
T
SLDAKD
E
L
E
E
R
L
E
R
-
C
M
--
S
I
V
T
S
M
T
AGVS
E
R
E
A
N
D
A
L
N
A
Y
V
C
K
G
---
L
P
Q
H
----------------
E
E
I
C
L
G
L
F
-
T
L
I
L
T
E
PAQ
A
Q
K
C
Y
R
----------
D
L
A
L
V
S
R
D
G
M----
N
I
V
L
N
K
I
N
Q
I
L
M
EK
Y
L
K
L
Q
D
T
C
R
T
Q
L
V
-
W
L
V
-
R
E
L
V
K
S
G
---------
V
LG
A
D
G
V
C
M
T
F
M
K
Q
IAGGDVT
A
K
N
I
W
L
A
E
S
V
L
D
I
L
T
E
Q
R
E
W
V
L
K
S
S
I
L
I
A
M
A
--------
V
Y
T
Y
L
R
L
I
V
D
HHGT
A
Q
L
Q
A
L
R
Q
K
--
E
V
D
F
C
I
S
L
L
R
E
R
----
F
M
E
C
L
MIG
R
D
L
V
R
L
L
Q
N
V
A
-
R
I
-
P
E
F
E
L
L
W
K
D
I
I
H
N
P
Q
A
L
S
P
Q
F
T
G
---
I
L
Q
L
L
Q
S
R
T
S
R
----
K
F
L
A
C
R
L
T
P
D
M
E
T
K
L
L
F
M
T
S
RVRFGQQ
K
R
Y
Q
D
W
F
Q
R
Q
Y
L
S
T
P
D
S
Q
S
L
R
C
D
L
I
R
Y
I
C
G
-------
V
V
H
P
S
N
--
E
-------
V
L
S
S
D
I
L
P
R
W
A
I
I
G
W
L
L
T
T
C
TS
N
V
A
A
S
N
A
K
L
A
L
-------------
F
Y
DWLFFSPDKDSIMN
I
E
P
A
------
I
L
----
V
M
H
H
S
M----------
K
--------------------
P
H
P
A
I
T
A
-------------
T
L
L
-
D
F
M
C
R
I
I
P
N
F
Y
-------------------------
P
P
--
L
--
E
-
G
---
H
----
V
--------
R
Q
---
G
V
-----------
F
S
S
L
N
H
I
V
E
K
R
V
L
A
H
L
A
P
L
F
D
N
P
K
L
D
K
E
L
R
A
M
L
R
-
E
K
F
--------------------
P
E
F
C
S
--------------
8
PsiBlast_PDB
60.38
25%
-150
- C4 -
4AMJ
5
ADRB1_MELGA
A:
[21-148]
--------------------------------------------------------------------------------------------------
V
V
----------
L
L
I
V
A
G
N
V
L
-----
V
I
A
A
I
G
S
T
Q
-----
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
-
D
L
V
V
G
L
L
---------
V
--------------------------
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
----------
T
S
L
D
V
L
C
V
-------------
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
----
Y
----------
L
A
I
T
S
P
F
R
-
Y
Q
-
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
---
F
L
P
I
M
M
H
W
-
W
R
----
D
E
D
P
--------------------------
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
-------
F
V
T
N
R
A
Y
-------
A
I
A
--
S
--
S
-------
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
----------
E
A
K
-------------
E
Q
--------------
S
R
V
M
------
L
M
---
R
E
-
H
K
A
-----------
L
--------------------
K
T
L
G
I
I
M
-------------
G
V
F
-
T
L
-
C
W
L
P
F
F
L
V
N
----------------
I
V
N
V
F
N
R
D
L
V
--
P
--
D
-
W
---
L
----
F
--------
V
A
---
F
N
-----------
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------
23
HHSearch
60.06
22%
-150
- C4 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-200]
---------------------------------------------------------------------------------
P
L
V
-
V
V
L
S
--------
T
I
C
----------
L
V
T
V
G
L
N
L
L
-----
V
L
Y
A
V
R
S
E
R
-----
K
L
H
T
V
G
N
L
Y
I
V
S
L
-
S
V
A
-
D
L
I
V
G
A
V
---------
V
--------------------------
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
----------
L
S
M
D
Y
V
A
S
-------------
T
A
--
S
I
F
S
V
F
I
L
C
I
D
R
----
Y
----------
R
S
V
Q
Q
P
L
R
-
Y
L
-
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
---
I
P
I
L
G
W
-
N
-
H
--------------------------------------
R
R
E
D
K
C
E
T
D
F
-------
Y
-------------
D
-------
V
-------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
----------
W
F
Y
-------------
A
K
--------------
I
Y
K
A
------
V
R
---
Q
H
-
C
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
-------------
G
L
R
-
L
K
-
I
Y
K
D
T
E
G
Y
Y
----------------
T
I
G
I
G
H
L
L
T
K
--
S
--
P
-
S
---
L
----
N
--------
A
A
---
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
--
R
-
G
I
L
--------------------
R
N
A
K
L
--------------
16
PsiBlast_PDB
59.49
25%
-141
- C4 -
4GPO
-
ADRB1_MELGA
A:
[21-148]
--------------------------------------------------------------------------------------------------
V
V
----------
L
L
I
V
A
G
N
V
L
-----
V
I
A
A
I
G
S
T
Q
-----
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
-
D
L
V
V
G
L
L
---------
V
--------------------------
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
----------
T
S
L
D
V
L
C
V
-------------
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
----
Y
----------
L
A
I
T
S
P
F
R
-
Y
Q
-
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
---
F
L
P
I
M
M
H
W
-
W
R
----
D
E
D
P
--------------------------
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
-------
F
V
T
N
R
A
Y
-------
A
I
A
--
S
--
S
-------
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
----------
E
A
K
-------------
E
Q
--------------
V
M
L
M
------
R
E
---
H
K
-
A
L
K
-----------
T
--------------------
L
G
I
I
M
G
V
-------------
F
T
L
-
C
W
-
L
P
F
F
L
V
N
I
V
----------------
N
V
F
N
R
D
L
V
P
D
--
W
--
L
-
F
---
V
----
A
--------
F
N
---
W
L
-----------
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
----------------------------------------------------
14
PsiBlast_PDB
59.44
25%
-144
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[21-148]
--------------------------------------------------------------------------------------------------
V
V
----------
L
L
I
V
A
G
N
V
L
-----
V
I
A
A
I
G
S
T
Q
-----
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
-
D
L
V
V
G
L
L
---------
V
--------------------------
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
----------
T
S
L
D
V
L
C
V
-------------
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
----
Y
----------
L
A
I
T
S
P
F
R
-
Y
Q
-
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
---
F
L
P
I
M
M
H
W
-
W
R
----
D
E
D
P
--------------------------
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
-------
F
V
T
N
R
A
Y
-------
A
I
A
--
S
--
S
-------
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
----------
E
A
K
-------------
E
Q
--------------
I
R
K
I
------
D
R
---
A
S
-
K
R
K
-----------
R
--------------------
V
M
L
M
R
E
H
-------------
K
A
L
-
K
T
-
L
G
I
I
M
G
V
F
T
----------------
L
C
W
L
P
F
F
L
V
N
--
I
--
V
-
N
---
V
----
F
--------
N
R
---
D
L
-----------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
--
K
-
A
F
K
--------------------
R
L
L
A
F
--------------
2
PsiBlast_PDB
59.37
25%
-149
- C4 -
2Y00
7
ADRB1_MELGA
A:
[21-148]
--------------------------------------------------------------------------------------------------
V
V
----------
L
L
I
V
A
G
N
V
L
-----
V
I
A
A
I
G
S
T
Q
-----
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
-
D
L
V
V
G
L
L
---------
V
--------------------------
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
----------
T
S
L
D
V
L
C
V
-------------
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
----
Y
----------
L
A
I
T
S
P
F
R
-
Y
Q
-
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
---
F
L
P
I
M
M
H
W
-
W
R
----
D
E
D
P
--------------------------
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
-------
F
V
T
N
R
A
Y
-------
A
I
A
--
S
--
S
-------
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
----------
E
A
K
-------------
E
Q
--------------
S
R
V
M
------
L
M
---
R
E
-
H
K
A
-----------
L
--------------------
K
T
L
G
I
I
M
-------------
G
V
F
-
T
L
-
C
W
L
P
F
F
L
V
N
----------------
I
V
N
V
F
N
R
D
L
V
--
P
--
D
-
W
---
L
----
F
--------
V
A
---
F
N
-----------
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------
10
PsiBlast_PDB
59.29
25%
-149
- C4 -
3ZPR
7
ADRB1_MELGA
A:
[21-148]
--------------------------------------------------------------------------------------------------
V
V
----------
L
L
I
V
A
G
N
V
L
-----
V
I
A
A
I
G
S
T
Q
-----
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
-
D
L
V
V
G
L
L
---------
V
--------------------------
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
----------
T
S
L
D
V
L
C
V
-------------
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
----
Y
----------
L
A
I
T
S
P
F
R
-
Y
Q
-
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
---
F
L
P
I
M
M
H
W
-
W
R
----
D
E
D
P
--------------------------
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
-------
F
V
T
N
R
A
Y
-------
A
I
A
--
S
--
S
-------
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
----------
E
A
K
-------------
E
Q
--------------
M
L
M
R
------
E
H
---
K
A
-
L
K
T
-----------
L
--------------------
G
I
I
M
G
V
F
-------------
T
L
C
-
W
L
-
P
F
F
L
V
N
I
V
N
----------------
V
F
N
R
D
L
V
P
D
W
--
L
--
F
-
V
---
A
----
F
--------
N
W
---
L
G
-----------
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
----------------------------------------------------
7
PsiBlast_PDB
59.23
25%
-142
- C4 -
4AMI
3
ADRB1_MELGA
A:
[21-148]
--------------------------------------------------------------------------------------------------
V
V
----------
L
L
I
V
A
G
N
V
L
-----
V
I
A
A
I
G
S
T
Q
-----
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
-
D
L
V
V
G
L
L
---------
V
--------------------------
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
----------
T
S
L
D
V
L
C
V
-------------
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
----
Y
----------
L
A
I
T
S
P
F
R
-
Y
Q
-
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
---
F
L
P
I
M
M
H
W
-
W
R
----
D
E
D
P
--------------------------
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
-------
F
V
T
N
R
A
Y
-------
A
I
A
--
S
--
S
-------
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
----------
E
A
K
-------------
E
Q
--------------
L
M
R
E
------
H
K
---
A
L
-
K
T
L
-----------
G
--------------------
I
I
M
G
V
F
T
-------------
L
C
W
-
L
P
-
F
F
L
V
N
I
V
N
V
----------------
F
N
R
D
L
V
P
D
W
L
--
F
--
V
-
A
---
F
----
N
--------
W
L
---
G
Y
-----------
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------
12
PsiBlast_PDB
58.95
25%
-146
- C4 -
2YCW
5
ADRB1_MELGA
A:
[21-148]
--------------------------------------------------------------------------------------------------
V
V
----------
L
L
I
V
A
G
N
V
L
-----
V
I
A
A
I
G
S
T
Q
-----
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
-
D
L
V
V
G
L
L
---------
V
--------------------------
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
----------
T
S
L
D
V
L
C
V
-------------
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
----
Y
----------
L
A
I
T
S
P
F
R
-
Y
Q
-
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
---
F
L
P
I
M
M
H
W
-
W
R
----
D
E
D
P
--------------------------
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
-------
F
V
T
N
R
A
Y
-------
A
I
A
--
S
--
S
-------
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
----------
E
A
K
-------------
E
Q
--------------
I
R
K
I
------
D
R
---
A
S
-
K
R
K
-----------
R
--------------------
V
M
L
M
R
E
H
-------------
K
A
L
-
K
T
-
L
G
I
I
M
G
V
F
T
----------------
L
C
W
L
P
F
F
L
V
N
--
I
--
V
-
N
---
V
----
F
--------
N
R
---
D
L
-----------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
--
K
-
A
F
K
--------------------
R
L
L
A
F
--------------
5
PsiBlast_PDB
58.91
25%
-148
- C4 -
2Y03
5
ADRB1_MELGA
A:
[21-148]
--------------------------------------------------------------------------------------------------
V
V
----------
L
L
I
V
A
G
N
V
L
-----
V
I
A
A
I
G
S
T
Q
-----
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
-
D
L
V
V
G
L
L
---------
V
--------------------------
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
----------
T
S
L
D
V
L
C
V
-------------
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
----
Y
----------
L
A
I
T
S
P
F
R
-
Y
Q
-
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
---
F
L
P
I
M
M
H
W
-
W
R
----
D
E
D
P
--------------------------
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
-------
F
V
T
N
R
A
Y
-------
A
I
A
--
S
--
S
-------
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
----------
E
A
K
-------------
E
Q
--------------
I
R
S
R
------
V
M
---
L
M
-
R
E
H
-----------
K
--------------------
A
L
K
T
L
G
I
-------------
I
M
G
-
V
F
-
T
L
C
W
L
P
F
F
L
----------------
V
N
I
V
N
V
F
N
R
D
--
L
--
V
-
P
---
D
----
W
--------
L
F
---
V
A
-----------
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------