@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5MB_HUMAN: (2016-01-13 )
MSNTNGSAITEFILLGLTDCPELQSLLFVLFLVVYLVTLLGNLGMIMLMRLDSRLHTPMYFFLTNLAFVDLCYTSNATPQMSTNIVSEKTISFAGCFTQCYIFIALLLTEFYMLAAMAYDRYVAIYDPLRYSVKTSRRVCICLATFPYVYGFSDGLFQAILTFRLTFCRSSVINHFYCADPPLIKLSCSDTYVKEHAMFISAGFNLSSSLTIVLVSYAFILAAILRIKSAEGRHKAFSTCGSHMMAVTLFYGTLFCMYIRPPTDKTVEESKIIAVFYTFVSPVLNPLIYSLRNKDVKQALKNVLR
Atome Classification :
(20 SA)
-------------------------------------------.........10-------------....--.....20......----..30.------.......40..--......50........60........70.....-.-..80..---....-..-90........100....----.--..110.......120.......130.---.......140.......150..------.....160.......170-------------.........180.-.....-------.-190..------.....200.-----......210.......220.....-----..230.--------------------..--------......240.......250.......260.------.---.--..--.---.270--------.....--...280---.........290.......300...-----------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------MSNT
N
G
S
A
I
T
--------------
E
F
I
L
--LGLTD
C
P
E
L
Q
S
L
L
----
F
V
L
F
L
------
V
V
Y
L
V
T
L
LG
N
L
--
G
M
I
M
L
M
R
L
DSRLH
T
P
M
Y
F
F
L
T
N
L
A
F
V
D
L
CYTSN-A-TPQMST---NIVS-EK-
T
I
S
F
A
G
C
F
T
Q
C
Y
I
F
I
A
L
----
L
--
L
T
E
F
Y
M
L
A
A
M
A
YD
R
Y
V
A
I
YDP
L
R
Y
-
S
---VKTS
R
R
V
C
I
C
LAT
F
P
Y
VYGFS
D
------
G
L
F
Q
A
I
L
T
F
R
L
T
F
C
R
S
---------------
S
V
I
N
H
F
YCADP
P
L
-
I
K
L
SC-------S-D
T
Y
V
K
------
E
H
A
M
F
I
SAG-----FNLSS
S
L
T
I
V
L
V
S
Y
A
F
I
L
A
A
I
L
R
I-----KSA--E--------------------G
R
--------
H
K
A
F
S
T
CG
S
H
M
M
A
V
T
L
F
Y
G
T
L
F
C
M
Y
IRPPT------D---K--TV--E---ES
K
---------
I
I
A
V
F
--
Y
T
F
V
-----
S
P
V
L
N
P
L
I
Y
S
L
R
N
K
D
V
K
Q
A
L
K
N
VLR-----------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
90.31
24%
-132
- C5 -
2Y01
12
ADRB1_MELGA
A:
[9-299]
--------------------------------------------------------------------------------
Q
W
E
A
G
M
----
S
L
L
M
A
------
L
V
V
L
L
I
V
A
G
N
V
--
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
-
V
P
F
G
A
T
---
L
V
V
---
R
-
G
T
W
L
W
G
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
---
V
W
A
I
S
A
--------
L
V
S
F
L
P
I
M
M
H
W
W
R
D
---------------
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
C
-------
C
-
D
-
F
V
T
------
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
------
N
---
R
--
D
L
--
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
-----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
88.36
24%
-134
- C5 -
2Y02
13
ADRB1_MELGA
A:
[9-299]
--------------------------------------------------------------------------------
Q
W
E
A
G
M
----
S
L
L
M
A
------
L
V
V
L
L
I
V
A
G
N
V
--
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
-
V
P
F
G
A
T
---
L
V
V
---
R
-
G
T
W
L
W
G
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
---
V
W
A
I
S
A
--------
L
V
S
F
L
P
I
M
M
H
W
W
R
D
---------------
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
C
-------
C
-
D
-
F
V
T
------
N
R
A
Y
A
I
A
S
S
I
I
SF
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
------
N
---
R
--
D
L
--
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
-----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
88.03
24%
-133
- C5 -
2Y00
13
ADRB1_MELGA
A:
[9-299]
--------------------------------------------------------------------------------
Q
W
E
A
G
M
----
S
L
L
M
A
------
L
V
V
L
L
I
V
A
G
N
V
--
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
-
V
P
F
G
A
T
---
L
V
V
---
R
-
G
T
W
L
W
G
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
---
V
W
A
I
S
A
--------
L
V
S
F
L
P
I
M
M
H
W
W
R
D
---------------
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
C
-------
C
-
D
-
F
V
T
------
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
------
N
---
R
--
D
L
--
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
-----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.03
24%
-131
- C5 -
2YCW
7
ADRB1_MELGA
A:
[9-297]
--------------------------------------------------------------------------------
Q
W
E
A
G
M
----
S
L
L
M
A
------
L
V
V
L
L
I
V
A
G
N
V
--
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
-
V
P
F
G
A
T
---
L
V
V
---
R
-
G
T
W
L
W
G
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
---
V
W
A
I
S
A
--------
L
V
S
F
L
P
I
M
M
H
W
W
R
D
---------------
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
C
-------
C
-
D
-
F
V
T
------
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
-----
D
R
A
--
S
--------------------
K
R
KR
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
------
N
---
R
--
D
L
--
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
-----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.31
24%
-129
- C5 -
2VT4
8
ADRB1_MELGA
A:
[10-297]
---------------------------------------------------------------------------------
W
E
A
G
M
----
S
L
L
M
A
------
L
V
V
L
L
I
V
A
G
N
V
--
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
-
V
P
F
G
A
T
---
L
V
V
---
R
-
G
T
W
L
W
G
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
---
V
W
A
I
S
A
--------
L
V
S
F
L
P
I
M
M
H
W
W
R
D
---------------
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
C
-------
C
-
D
-
F
V
T
------
N
R
A
Y
A
I
A
S
S
I
I
SF
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------------------------------
E
-------
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
------
N
---
R
--
D
L
--
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
-----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.86
24%
-123
- C5 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
--------------------------------------------------------------------------------
Q
W
E
A
G
M
----
S
L
L
M
A
------
L
V
V
L
L
I
V
A
G
N
V
--
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
-
V
P
F
G
A
T
---
L
V
V
---
R
-
G
T
W
L
W
G
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
---
V
W
A
I
S
A
--------
L
V
S
F
L
P
I
M
M
H
W
W
R
D
---------------
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
C
-------
C
-
D
-
F
V
T
------
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
-----
D
R
A
--
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
------
N
---
R
--
D
L
--
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
-----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.68
24%
-127
- C5 -
2YCZ
2
ADRB1_MELGA
A:
[9-297]
--------------------------------------------------------------------------------
Q
W
E
A
G
M
----
S
L
L
M
A
------
L
V
V
L
L
I
V
A
G
N
V
--
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
-
V
P
F
G
A
T
---
L
V
V
---
R
-
G
T
W
L
W
G
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
---
V
W
A
I
S
A
--------
L
V
S
F
L
P
I
M
M
H
W
W
R
D
---------------
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
C
-------
C
-
D
-
F
V
T
------
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
-----
D
R
A
--
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
------
N
---
R
--
D
L
--
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
-----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.32
24%
-128
- C5 -
4GBR
1
ADRB2_HUMAN
A:
[14-284]
-----------------------------------------------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
--
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
-
V
-
V
P
F
G
A
A
---
H
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
----
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
SLL
T
K
N
K
A
R
V
I
I
L
M
V
W
I
--
V
S
G
L
T
S
------
F
L
P
I
Q
M
H
W
Y
R
A
T
--
H
Q
---------------
E
A
I
N
C
Y
--------
A
E
E
T
C
-------
C
-
D
F
F
T
N
------
Q
A
Y
A
I
A
S
S
I
-----
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
KID
K
F
C
--
L
--------------------
K
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
------
Q
---
D
--
N
L
IR
K
---
E
V
Y
---------
I
L
L
N
W
--
I
G
Y
V
-----
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.52
24%
-126
- C5 -
2YCY
6
ADRB1_MELGA
A:
[10-297]
---------------------------------------------------------------------------------
W
E
A
G
M
----
S
L
L
M
A
------
L
V
V
L
L
I
V
A
G
N
V
--
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
-
V
P
F
G
A
T
---
L
V
V
---
R
-
G
T
W
L
W
G
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
---
L
M
T
R
A
R
A
K
V
I
I
C
T
---
V
W
A
I
S
A
--------
L
V
S
F
L
P
I
M
M
H
W
W
R
D
---------------
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
C
-------
C
-
D
-
F
V
T
------
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-------
D
R
A
--
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
------
N
---
R
--
D
L
--
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
-----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.55
24%
-143
- C5 -
4LDL
3
ADRB2_HUMAN
A:
[191-461]
-----------------------------------------------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
--
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
-
V
-
V
P
F
G
A
A
---
H
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
----
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
S
LL
T
K
N
K
A
R
V
I
I
L
M
V
W
I
--
V
S
G
L
T
-----------
S
F
L
P
I
Q
M
H
W
Y
R
A
---------------
T
H
Q
E
A
I
N
C
----
Y
-
A
E
E
T
C
-------
C
-
D
F
F
T
N
------
Q
A
Y
A
I
A
S
S
I
-----
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ---
K
F
A
--
L
--------------------
K
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
------
Q
---
D
--
N
L
IR
K
---
E
V
Y
---------
I
L
L
N
W
--
I
G
Y
V
-----
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.89
24%
-141
- C5 -
4LDE
3
A:
[191-461]
-----------------------------------------------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
--
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
-
V
-
V
P
F
G
A
A
---
H
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
----
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
--
V
S
G
L
T
-----------
S
F
L
P
I
Q
M
H
W
Y
R
A
---------------
T
H
Q
E
A
I
N
C
----
Y
-
A
E
E
T
C
-------
C
-
D
F
F
T
N
------
Q
A
Y
A
I
A
S
S
I
-----
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ---
K
F
A
--
L
--------------------
K
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
------
Q
---
D
--
N
L
IR
K
---
E
V
Y
---------
I
L
L
N
W
--
I
G
Y
V
-----
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.87
24%
-143
- C5 -
4QKX
2
ADRB2_HUMAN
A:
[191-461]
-----------------------------------------------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
--
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
-
V
-
V
P
F
G
A
A
---
C
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
----
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
S
LL
T
K
N
K
A
R
V
I
I
L
M
V
W
I
--
V
S
G
L
T
-----------
S
F
L
P
I
Q
M
H
W
Y
R
A
---------------
T
H
Q
E
A
I
N
C
----
Y
-
A
E
E
T
C
-------
C
-
D
F
F
T
N
------
Q
A
Y
A
I
A
S
S
I
-----
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ---
K
F
A
--
L
--------------------
K
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
------
Q
---
D
--
N
L
IR
K
---
E
V
Y
---------
I
L
L
N
W
--
I
G
Y
V
-----
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.87
24%
-141
- C5 -
4LDO
3
A:
[191-461]
-----------------------------------------------------------------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
--
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
-
V
-
V
P
F
G
A
A
---
H
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
----
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
--
V
S
G
L
T
-----------
S
F
L
P
I
Q
M
H
W
Y
R
A
---------------
T
H
Q
E
A
I
N
C
----
Y
-
A
E
E
T
C
-------
C
-
D
F
F
T
N
------
Q
A
Y
A
I
A
S
S
I
-----
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ---
K
F
A
--
L
--------------------
K
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
------
Q
---
D
--
N
L
IR
K
---
E
V
Y
---------
I
L
L
N
W
--
I
G
Y
V
-----
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
81.09
18%
-130
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------------------------MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
--------------
P
F
E
A
PQ
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
----
A
Y
M
F
L
------
L
I
M
L
G
F
P
I
-
N
F
--
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
T
T
L
Y
T
---
S
L
H
G
-
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
----
G
--
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------------------
N
F
R
F
G
E
N
H
------
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---------------
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-
E
E
T
N
N
------
E
S
F
V
I
Y
M
F
V
-----
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
-----
A
A
Q
QQ
E
--------------------
S
A
--------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
------
A
---
F
--
Y
I
--
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
--
F
A
K
T
-----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
81.09
18%
-118
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------------------------------------------
M
N
G
T
E
G
P
N
F
Y
VPFSNKTGVVRSPF
E
A
P
Q
--
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
----
A
Y
M
F
L
------
L
I
M
L
G
F
P
I
N
F
L
--
T
L
Y
V
T
V
Q
H
K
-
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
T
T
L
Y
T
---
S
L
H
G
-
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
----
G
--
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--
N
---
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
------
A
--------------
A
---------------
P
P
L
V
G
W
S
R
Y
I
P
E
G
-
M
Q
C
S
C
-------
G
I
D
Y
Y
T
P
HEETN
N
E
S
F
V
I
Y
M
F
V
-----
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
-----
A
A
S
--
A
--------------------
T
T
--------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
------
Y
---
I
--
F
T
--
H
---
Q
G
S
DFGPIFM--
T
I
P
A
F
--
F
A
K
T
-----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
78.65
16%
-130
- C5 -
2Z73
5
OPSD_TODPA
A:
[34-331]
----------------------------------------------------------------------------------
Y
Y
S
L
----
G
I
F
I
G
------
I
C
G
I
I
G
C
G
G
N
G
--
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
-
N
G
F
P
L
M
T
I
---
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
----
G
--
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
-
S
---
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
------
A
I
G
P
I
F
G
-
W
--
G
A
Y
T
----------------
L
E
G
V
L
C
N
C
S
F
D
Y
I
-
S
-------------
R
D
S
T
T
------
R
S
N
I
L
C
M
F
I
-----
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
-----
E
K
E
--
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
--------
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
------
G
PLE
W
--
V
T
--
P
---
Y
A
A
---------
Q
L
P
V
M
--
F
A
K
A
-----
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
75.85
17%
-133
* C5 *
2KS9
1
NK1R_HUMAN
A:
[35-321]
-------------------------------------------------------------------------------------
W
----
A
A
A
Y
T
------
V
I
V
V
T
S
V
V
G
N
V
--
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
-
N
-
T
V
V
N
F
T
---
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
----
V
--
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
-
R
---
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
------
A
F
P
Q
G
Y
Y
--
S
-
T
T
-
E
----------------
T
M
P
S
R
V
V
C
M
I
E
W
P
-
E
H
P
-----------
N
K
I
Y
E
------
K
V
Y
H
I
C
V
T
V
-----
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
-----
E
I
P
--
G
DSSDRYH
E
Q
V
S
---------
A
K
--------
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
------
N
PDL
Y
--
L
K
--
K
FI
Q
Q
V
Y
---------
L
A
I
M
W
--
L
A
M
S
-----
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
74.57
18%
-135
- C1 -
1YT3
11
RND_ECOLI
A:
[1-375]
M
N
Y
Q
M
I
TT
D
D
A
L
A
S
L
C
E
A
V
RAFP
A
I
A
L
D
T
E
F
V
R
T
RTYYPQLG
L
I
Q
L
F
D
G
E
H
L
A
--------------
L
I
D
P
--
L
G
I
T
D
W
S
P
L
K
A
I
L
R
DPS
I
T
K
F
L
H
AG
S
E
D
L
E
V
F
L
N
V
F
G
E
L
PQ
P
L
I
D
T
Q
I
L
A
A
F
C
G
R
P
M
S
W
G
F
A
S
M
V
E
E
Y
S
G
V
T
L
D
-
K
-
S
E
S
R
T
D
WLA
R
P
L
T
-
E
R
-
Q
C
E
Y
A
A
A
D
V
W
----
Y
L
L
----
P
--
I
T
A
K
L
M
V
E
T
E
A
S
G
W
L
P
A
A
L
D
E
C
R
L
-
M
---
Q
M
R
R
Q
E
V
V
A
P
E
D
A
W
R
D
I
T
N
A
W
Q
LR
T
R
Q
L
A
C
L
Q
L
L
A
D
W
R
L
R
K
A
R
E
R
DLAVNFVVR
E
E
H
L
W
S
V
A
R
Y
M
P
G
S
L
G
E
L
-
D
S
L
G
L
-------
S
-
G
S
E
I
R
------
F
H
G
K
T
L
L
A
L
-----
V
E
K
A
Q
T
L
-----
P
E
D
A
L
P
Q
P
M
L
N
L
-----
M
D
M
--
P
--------------------
G
Y
--------
R
K
A
F
K
A
I
K
S
L
I
T
D
V
S
E
T
H
K
---------
I
S
------
A
---
E
--
L
L
--
A
---
S
R
R
---------
Q
I
N
Q
L
--
L
N
W
H
W
KLKP
Q
N
N
L
P
E
L
I
S
G
W
R
G
E
L
M
A
E
A
L
H
N
L
L
Q
EYPQ-------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
69.94
16%
-119
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------------------------------------------------
D
E
V
W
V
V
G
M
----
G
I
V
M
S
------
L
I
V
L
A
I
V
F
G
N
V
--
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
-
V
-
V
P
F
G
A
A
---
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
----
V
--
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
---
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
------
S
F
L
P
I
Q
M
H
W
Y
----
R
A
---------------
T
H
Q
E
A
I
N
C
Y
A
E
E
T
----
C
C
-------
D
-
F
F
T
N
Q
------
A
Y
A
I
A
S
S
I
V
-----
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
-----
N
I
F
--
E
--------------------
M
L
--------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
------
S
---
L
--
N
A
--
A
---
K
S
E
---------
L
D
K
A
I
--
G
R
N
T
N----
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
28
HHSearch
69.12
16%
-105
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[40-321]
-----------------------------------------------------------------------------------
Y
V
V
----
I
I
A
Y
A
------
L
V
F
L
L
S
L
L
G
N
S
--
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
---
L
P
I
W
A
A
---
S
K
V
N
-
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
----
F
--
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
-
L
---
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
------
S
L
P
F
F
L
F
--
R
-
Q
A
Y
H
----------------
P
N
N
S
S
P
V
C
Y
E
V
L
G
-
N
D
------------
T
A
K
W
R
------
M
V
L
R
I
L
P
H
T
-----
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
-----
H
M
---
G
--------------------
Q
K
--------
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
RTQVI
Q
E--
S
C
E
R
R
--
N
N
I
G
R
A
L
---------
D
A
T
E
I
--
L
G
F
L
-----
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------