@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5P3_HUMAN: (2016-01-13 )
MGTGNDTTVVEFTLLGLSEDTTVCAILFLVFLGIYVVTLMGNISIIVLIRRSHHLHTPMYIFLCHLAFVDIGYSSSVTPVMLMSFLRKETSLPVAGCVAQLCSVVTFGTAECFLLAAMAYDRYVAICSPLLYSTCMSPGVCIILVGMSYLGGCVNAWTFIGCLLRLSFCGPNKVNHFFCDYSPLLKLACSHDFTFEIIPAISSGSIIVATVCVIAISYIYILITILKMHSTKGRHKAFSTCTSHLTAVTLFYGTITFIYVMPKSSYSTDQNKVVSVFYTVVIPMLNPLIYSLRNKEIKGALKRELRIKIFS
Atome Classification :
(20 SA)
--------------.........10........-20........30.---.--......40........50........60........70......-..80.....-...90........100....-----...110.......120..--.....130...---....140.......150.......160.......170.......180..-.....190-.----.-.-....200......-------.210------.......220..-....------------------.230----------.--------------------.......240.......250.......260.--.--------.----.----...270-------.......280.......290.......300.......310---------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MGTGN
D
T
T
V
V
E
F
T
L
LGLSE-
D
T
T
V
C
A
I
L
F
L
V
F
L
---
G
--
I
Y
V
V
T
L
MGN
I
S
I
I
V
L
I
RRSHHLHT
P
M
Y
I
F
L
C
H
L
A
F
V
DIGYSSSV-
T
P
V
M
L
M
S
F
L
-
R
K
ETSL
P
V
A
G
C
V
A
Q
L
C
S
V
V
T
-----FG
T
A
E
C
F
L
L
A
A
M
A
Y
D
R
Y
V
--
A
I
C
S
P
L
L
Y
S
T
C---MSP
G
V
C
I
I
L
V
G
M
S
Y
L
G
G
C
V
N
A
W
T
F
I
G
C
L
L
R
L
SFCGPNKV
N
H
F
FC
D
Y
S
P
L
-
L
K
L
ACSHD-
F
----
T
-
F
-
E
I
I
PAISSGS
I
I
V
-------
A
T
V
C
------
V
I
A
I
S
Y
I
Y
I
L
I
T
-
I
L
K
M------------------HST-----------K--------------------G
R
H
K
A
F
S
T
C
T
S
H
L
T
A
V
T
L
F
Y
G
T
I
T
F
I
Y
V
MPK--S--------S----Y----STDQ
N
K
-------
V
V
S
V
F
Y
T
V
V
I
P
M
L
N
P
L
I
Y
S
L
R
N
K
E
I
K
G
A
L
K
R
E
L
R
I
K
I
FS----------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
89.20
19%
-139
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-333]
-------------------------------------
V
Y
Y
S
L
G
I
F
I
G
---
I
--
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
-----
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
--
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
---
T
L
-
E
G
V
L
C
N
C
S
F
D
Y
I
------
S
R
D
-
S
----
T
-
T
-
R
S
N
I
L
C
M
F
I
L
G
F
F
-------
G
P
I
L
------
I
I
F
F
C
Y
F
N
I
V
M
S
-
V
S
N
H
------------------
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
--
F
--------
G
PLE-
W
----
V
T
P
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
88.17
16%
-132
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
----------------------------------------
L
W
A
A
A
Y
T
---
V
--
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
-----
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
--
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-
E
----
T
M
P
S
R
V
V
C
M
I
E
W
P
-
E
H
---
P
N
K
-
I
----
Y
-
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
F
-------
L
P
L
L
------
V
I
G
Y
A
Y
T
V
V
G
I
T
-
L
W
A
S
------------------
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
--
I
--------
N
PD--
L
YLKK
F
I
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
86.10
19%
-133
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
-
P
W
Q
F
S
M
L
A
A
Y
M
F
L
------
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
-----
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
--
V
V
C
K
P
M
S
N
F
R
------------
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
----
T
-
P
-
H
E
E
T
N
N
E
S
F
V
I
Y
M
-------
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
-
V
K
E
A
------------------
A
A
S
-----------
A
--------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--
F
--------
Y
----
I
----
F
T
H
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
80.53
15%
-135
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
---
L
--
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
-----
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
--
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
-
E
E
T
C
C
D
F
F
-
T
----
N
-
Q
-
A
Y
A
I
A
S
S
I
V
S
F
----------
Y
V
P
------
L
V
I
M
V
F
V
Y
S
R
V
F
-
Q
E
A
K
------------------
R
Q
L
-----------
N
--------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
--
T
--------
K
----
S
----
P
S
L
N
A
A
-------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
40
Fugue
80.35
17%
-121
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
-
P
W
Q
F
S
M
L
A
A
Y
M
F
L
------
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
-----
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
--
V
V
C
K
P
M
S
N
F
R
------------
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
-
Y
----
Y
-
T
-
P
H
E
E
T
N
N
E
S
F
V
I
Y
-------
M
F
V
V
------
H
F
I
I
P
L
I
V
I
F
F
C
-
Y
G
Q
L
VFTVKEAAAQQQESA
T
T
Q
K
A
E
-----------
K
--------------------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
--------
S
----
D
----
F
G
P
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
LGDDEA
S
T
T
V
S
K
TETSQVAPA-------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
76.27
13%
-146
- C1 -
4R6Y
2
PHNS_SALTY
A:
[1-317]
-----------------
S
M
E
S
V
V
T
V
Y
S
I
D
G
L
H
D
G
D
N
S
W
Y
Q
V
Q
F
D
A
F
T
K
A
T
G
--
I
T
V
R
Y
V
E
G
G
G
G
V
V
V
E
R
L
A
K
E
R
T
N
P
Q
A
D
V
L
V
T
A
P
P
F
I
Q
R
A
A
A
E
K
------
L
L
A
N
F
-
N
T
D
T
A
S
A
I
P
D
A
N
N
L
Y
S
P
L
V
K
N
Y
L
S
F
I
Y
N
S
K
L
L
K
T
A
P
A
S
W
Q
D
L
L
DG
K
F
K
N
K
L
Q
Y
S
T
P
GQ-
A
A
D
G
T
A
V
M
L
Q
A
F
H
S
F
G
S
K
D
A
G
F
A
Y
L
G
K
L
Q
A
N
N
V
G
P
S
A
S
T
G
K
L
T
A
L
V
N
K
G
-
E
I
Y
V
A
N
G
D
-
L
----
Q
-
M
-
N
L
A
Q
M
E
R
N
P
N
V
K
I
F
W
P
A
N
DK
G
E
R
S
------
A
L
A
I
P
Y
V
I
G
L
V
Q
G
A
P
Q
S
------------------
E
N
G
-----------
K
--------------------
K
L
I
N
F
L
L
S
K
E
A
Q
T
R
V
S
E
L
S
W
G
M
P
V
R
S
D
V
T
P
S
--
D
--------
E
----
H
----
Y
K
A
A
T
A
-------
A
L
E
G
V
Q
S
W
Q
-
P
N
W
D
D
V
A
V
S
L
S
A
D
I
S
R
W
H
K
V
T
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
72.04
15%
-119
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-326]
---------------------------------------
S
M
L
A
A
Y
M
F
---
L
--
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
-----
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
--
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
---
I
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
-
T
P
---
H
E
E
-
T
----
N
-
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
-------
I
P
L
I
------
V
I
F
F
C
Y
G
Q
L
V
F
T
-
V
K
E
A
------------------
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--------
G
S---
D
----
F
G
P
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
70.26
15%
-123
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[35-323]
----------------------------------
E
T
L
N
K
Y
V
V
I
I
A
Y
A
---
L
--
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
-----
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
--
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
--
Y
-
H
P
N
-
N
S
S
P
V
C
Y
E
V
L
G
----
N
-
D
T
A
-
K
----
W
-
R
-
M
V
L
R
I
L
P
H
T
F
G
F
I
-------
V
P
L
F
------
V
M
L
F
C
Y
G
F
T
L
R
T
-
L
F
K
A
------------------
H
M
------------
G
--------------------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
--
L
M
RTQVIQE
S
C
E
R
R
N
----
N
I
G
R
A
L
-------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
67.96
20%
-156
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
---------------------------------------
V
G
M
G
I
V
M
S
---
L
--
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
-----
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
--
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
----
Q
E
A
I
N
C
Y
A
-----
E
E
T
C
C
D
F
-
F
----
T
-
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
-------
V
P
L
V
------
I
M
V
F
V
Y
S
R
V
F
Q
E
-
A
K
R
Q
------------------
L
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
--------
P
----
S
----
L
N
A
A
K
S
-------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
66.31
19%
-160
- C2 -
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
---------------------------------------
V
F
I
V
L
V
A
G
---
S
--
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
-----
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
--
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
--
G
V
R
T
V
E
D
G
E
-----------
C
Y
I
Q
-
F
----
F
S
N
-
A
A
V
T
F
G
T
A
I
A
A
F
Y
-------
L
P
V
I
------
I
M
T
V
L
Y
W
H
I
S
R
A
-
S
K
S
R
------------------
I
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
--------
P
----
S
----
L
N
A
A
K
S
-------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
65.94
18%
-172
- C2 -
3EML
8
ENLYS_BPT4
A:
[22-221]
---------------------------------------
S
V
Y
I
T
V
E
L
---
A
--
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
-----
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
--
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
----
Q
V
A
C
L
F
E
-
D
----
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-------
V
P
L
L
------
L
M
L
G
V
Y
L
R
I
F
L
A
-
A
R
R
Q
------------------
L
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
--------
P
----
S
----
L
N
A
A
K
S
-------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
61.59
16%
-173
- C2 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-226]
-----------------------------------------
Y
A
L
S
Y
C
---
A
--
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
-----
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
--
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
---
T
T
----
G
D
P
T
V
-----------
C
S
I
S
-
N
----
P
----
D
F
V
I
Y
S
S
V
V
S
F
Y
-------
L
P
F
G
------
V
T
V
L
V
Y
A
R
I
Y
V
V
-
L
K
Q
R
------------------
R
R
K
-----------
N
--------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
--
T
--------
K
----
S
----
P
S
L
N
A
A
-------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.25
27%
-168
- C2 -
4IAR
1
C562_ECOLX
A:
[22-146]
----------------------------------------
L
L
V
M
L
L
A
---
L
--
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
-
T
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
-----
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
--
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
F
F
W
R
Q
A
S
E
C
V
V
N
T
D
H
I
L
Y
T
V
Y
S
T
V
G
-
A
F
Y
F
P
T
L
L
-
L
----
I
-
A
-
L
Y
G
R
I
Y
V
E
A
R
S
R
I
-------
A
D
L
E
------
D
N
W
E
T
L
N
D
N
L
K
V
-
I
E
K
A
------------------
D
N
A
-----------
A
--------------------
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
--
P
--------
E
----
M
----
K
D
F
R
H
G
-------
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
60.66
27%
-163
- C2 -
4IAQ
1
5HT1B_HUMAN (first)
A:
[22-146]
----------------------------------------
L
L
V
M
L
L
A
---
L
--
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
-
T
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
-----
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
--
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
F
F
W
R
Q
A
S
E
C
V
V
N
T
D
H
I
L
Y
T
V
Y
S
T
V
G
-
A
F
Y
F
P
T
L
L
-
L
----
I
-
A
-
L
Y
G
R
I
Y
V
E
A
R
S
R
I
-------
A
D
L
E
------
D
N
W
E
T
L
N
D
N
L
K
V
-
I
N
A
A
------------------
Q
V
K
-----------
D
--------------------
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
--
L
--------
V
----
G
----
Q
I
D
D
A
L
-------
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
L
M
A
A
R
E
R
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
59.95
18%
-156
- C2 -
3RZE
2
ENLYS_BPT4 (first)
A:
[12-200]
------------------------------------------
V
V
V
L
S
---
T
--
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
-----
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
--
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
-
H
--------
R
R
E
D
K
-----------
C
E
T
D
-
F
----
Y
-
D
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
-------
L
P
T
L
------
L
M
L
W
F
Y
A
K
I
Y
K
A
-
V
R
Q
H
------------------
C
N
I
-----------
F
--------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
--------
P
----
S
----
L
N
A
A
K
S
-------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.71
24%
-145
- C2 -
3RZE
2
ENLYS_BPT4 (first)
A:
[20-177]
-------------------------------------------------------
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
-----
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
--
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
----
T
R
A
S
A
T
I
L
G
----
A
W
-
F
L
S
F
L
W
V
I
P
I
L
G
---
W
N
H
-------
R
-
R
E
D
K
C
E
T
D
-
F
YDV
T
W
-
F
-
K
V
M
T
A
I
I
N
F
Y
L
P
T
-------
L
L
M
L
------
W
F
Y
A
K
I
Y
K
A
V
R
Q
-
H
C
N
I
------------------
F
E
M
-----------
L
--------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
--
L
--------
N
----
A
----
A
K
S
E
L
D
-------
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.50
23%
-161
- C2 -
4U15
1
ACM3_RAT
A:
[8-138]
------------------------------------
T
I
W
Q
V
V
F
I
A
F
L
---
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
-----
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
--
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
E
C
F
I
Q
F
L
S
E
-
P
T
I
T
F
G
T
A
-
I
----
A
-
A
-
F
Y
M
P
V
T
I
M
T
I
L
Y
W
-------
R
I
Y
K
------
E
T
E
K
M
N
I
F
E
M
L
R
-
I
D
E
G
------------------
G
G
S
-----------
G
--------------------
G
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
--
L
--------
D
----
A
----
V
R
R
A
A
L
-------
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.38
23%
-172
- C2 -
4U14
1
ENLYS_BPT4
A:
[8-138]
------------------------------------
T
I
W
Q
V
V
F
I
A
F
L
---
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
-----
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
--
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
E
C
F
I
Q
F
L
S
E
-
P
T
I
T
F
G
T
A
-
I
----
A
-
A
-
F
Y
M
P
V
T
I
M
T
I
L
Y
W
-------
R
I
Y
K
------
E
T
E
K
M
N
C
F
E
M
L
R
-
I
D
E
G
------------------
L
R
L
-----------
K
--------------------
I
Y
K
D
C
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
--
K
--------
A
----
I
----
G
R
N
T
N
G
-------
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
58.29
19%
-137
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[63-250]
--------------------------------------
I
K
L
T
S
V
V
F
I
---
L
--
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
-----
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
--
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
-------
I
S
A
L
S
S
C
S
T
V
L
P
--------
L
------
Y
-
H
-
K
H
Y
I
L
-
F
C
T
T
V
F
T
-------
L
L
L
L
------
S
I
V
I
L
Y
C
R
I
Y
S
L
-
V
R
T
R
------------------
N
I
F
-----------
E
--------------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
--
P
--------
S
----
L
----
N
A
A
K
S
E
-------
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
58.15
25%
-149
- C2 -
4LDO
3
A:
[192-308]
-----------------------------------------------------
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
-----
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
--
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
-
F
T
N
Q
A
Y
A
I
-
A
----
S
-
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
F
-------
V
Y
S
R
------
V
F
Q
E
A
K
R
Q
L
Q
K
F
-
A
L
K
E
------------------
H
K
A
-----------
L
--------------------
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
--
R
--------
K
----
E
----
V
Y
I
L
L
N
-------
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------