@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6C1_HUMAN: (2016-01-13 )
MRNHTEITEFILLGLTDDPNFQVVIFVFLLITYMLSITGNLTLITITLLDSHLQTPMYFFLRNFSILEISFTTVSIPKFLGNIISGDKTISFNNCIVQLFFFILLGVTEFYLLAAMSYDRYVAICKPLHCLSIMNRRVCTLLVFTSWLVSFLIIFPALMLLLKLHYCRSNIIDHFTCDYFPLLQLACSDTKFLEVMGFSCAAFTLMFTLALIFLSYIYIIRTILRIPSTSQRTKAFSTCSSHMVVVSISYGSCIFMYIKPSAKDRVSLSKGVAILNTSVAPMMNPFIYSLRNQQVKQAFINMARKTVFFTST
Atome Classification :
(20 SA)
--------------------.........10......---------------..20.----------------..-----.....30.......-------------.40........-----50........60........------70....-....--80...-.....90..-......100.......-----------------110.......120....-...130.---......140.......150.......160.......170.......180-.....-----.-------.190.......----..200.......210--.......--.220-----....-....230---------.----------------..-----......240.......250.--------.....----.260.----.--.---.---.-.-------.-------.--.--270.......280---........290.......300.-----------------......310---------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------MR
N
H
T
E
I
T
E
F
I
L
L
GLTD---------------DPNF
Q
----------------
V
V
-----
I
F
V
F
L
L
I
T
Y
M
L
S
IT-------------G
N
L
T
L
I
T
I
T
L
L
-----
D
S
HL
Q
T
P
M
Y
F
F
L
RN
F
S
I
L
E
I
------
S
F
T
TV
S
-
I
P
K
F
--
L
G
N
I
I-SGD
K
T
I
S
F
N
-
N
C
I
V
Q
L
F
F
F
I
L
L
G
V
T
E
-----------------
F
Y
L
L
A
A
MSYDR
Y
V
A
I
C
K
-
P
L
H
C
L
S
I
---
M
N
RR
V
C
T
L
L
V
F
T
S
W
L
V
S
F
L
I
I
F
P
A
L
M
L
L
L
K
L
H
Y
C
R
S
N
I
I
D
HFTC
D
Y
F
P
L
-
L
Q
L
AC-----S-------DT--
K
F
L
E
V
MG----F
S
C
A
A
F
T
L
M
F
T
L
A
L
---
I
F
L
S
Y
I
Y
--
I
I
R
------
T
I
L
R-IPSTS-----------
Q
----------------
R
T
-----
K
A
F
STCSS
H
M
V
V
V
S
ISYG
S
C
--------
I
F
M
Y
I----KP--S----A--K---D---
R
-
V
-------S-------L--S--K
G
V
A
I
L
NT
S
V
A
-
P
---
M
M
N
P
F
I
Y
S
L
R
N
Q
Q
V
K
Q
A
F
I
N
M
A
-----------------
R
K
T
V
F
FTST---------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
93.46
21%
-144
- C3 -
4UG2
3
?
A:
[18-307]
-----------------------------------------------------------------------------------------
V
L
A
I
L
-------------
G
N
V
L
V
C
W
A
V
W
L
-----
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
------
L
V
G
V
L
A
-
I
P
F
A
--
I
A
--
I
-
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
-----------------
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
---
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
-
G
Q
V
A
C
LF---
E
-------
D
V
--
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
--
Q
L
----------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
--
D
----
C
--
S
---
H
---
A
-
P
-------
L
-------
W
--
L
--
M
Y
L
A
I
V
L
S
H
T
N
-
S
---
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-----------------
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.49
21%
-143
- C3 -
2YDV
6
?
A:
[18-307]
-----------------------------------------------------------------------------------------
V
L
A
I
L
-------------
G
N
V
L
V
C
W
A
V
W
L
-----
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
------
L
V
G
V
L
A
-
I
P
F
A
--
I
A
--
I
-
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
-----------------
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
---
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
-
G
Q
V
A
C
LF---
E
-------
D
V
--
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
--
Q
L
K
------
Q
M
E
S
-
Q
----------------------------------S
T
L
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
--
D
----
C
--
S
---
H
---
A
-
P
-------
L
-------
W
--
L
--
M
Y
L
A
I
V
L
S
H
T
N
-
S
---
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-----------------
R
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
90.53
18%
-130
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
---------------
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
-----
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-------------
I
N
F
L
T
L
Y
V
T
V
Q
-----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
------
F
M
V
F
G
G
-
F
T
T
T
--
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
-
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----------------
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-----
G
W
S
R
----------
Y
I
P
E
G
M
Q
C
S
C
-----
G
I
DYYTPH
E
E
--
T
N
N
E
S
F
V
----
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
---
I
F
F
C
Y
G
Q
--
L
V
F
------
T
V
K
E
-
A
A
A
S
A
-----------
T
----------------
T
Q
-----
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
----
G
V
--
A
----
F
--
Y
---
I
---
F
-
T
-------
H
QGSDFGP
I
--
F
--
M
T
I
P
A
F
F
A
K
T
S
-
A
---
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-----------------
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.33
21%
-143
- C3 -
2YDO
3
?
A:
[18-307]
-----------------------------------------------------------------------------------------
V
L
A
I
L
-------------
G
N
V
L
V
C
W
A
V
W
L
-----
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
------
L
V
G
V
L
A
-
I
P
F
A
--
I
A
--
I
-
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
-----------------
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
---
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
-
G
Q
V
A
C
LF---
E
-------
D
V
--
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
--
Q
L
K
------
Q
M
E
S
------------------------------------T
L
Q
--
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
--
D
----
C
--
S
---
H
---
A
-
P
-------
L
-------
W
--
L
--
M
Y
L
A
I
V
L
S
H
T
N
-
S
---
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-----------------
R
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.22
21%
-150
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[18-307]
-----------------------------------------------------------------------------------------
V
L
A
I
L
-------------
G
N
V
L
V
C
W
A
V
W
L
-----
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
------
A
V
G
V
L
A
-
I
P
----
F
A
I
T
I
-
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-----------------
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
---
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
-
G
Q
V
A
C
L
F
---
E
-------
D
V
--
V
P
M
N
Y
M
V
YFNF
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
--
Q
L
K
------
Q
M
E
S
-
Q
P
L
P
G
-----------
E
----------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
--
D
----
C
--
S
---
H
---
A
-
P
-------
L
-------
W
--
L
--
M
Y
L
A
I
V
L
S
H
T
N
-
S
---
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-----------------
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.00
21%
-151
- C3 -
3VG9
8
?
A:
[18-307]
-----------------------------------------------------------------------------------------
V
L
A
I
L
-------------
G
N
V
L
V
C
W
A
V
W
L
-----
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
------
A
V
G
V
L
A
-
I
P
----
F
A
I
T
I
-
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-----------------
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
---
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
-
G
Q
V
A
C
L
F
---
E
-------
D
V
--
V
P
M
N
Y
M
V
YFNF
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
--
Q
L
K
------
Q
M
E
S
-
Q
P
L
P
G
-----------
E
----------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
--
D
----
C
--
S
---
H
---
A
-
P
-------
L
-------
W
--
L
--
M
Y
L
A
I
V
L
S
H
T
N
-
S
---
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-----------------
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.80
21%
-146
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[18-307]
-----------------------------------------------------------------------------------------
V
L
A
I
L
-------------
G
N
V
L
V
C
W
A
V
W
L
-----
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
------
L
V
G
V
L
A
-
I
P
F
A
--
I
A
--
I
-
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
-----------------
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
---
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
-
G
Q
V
A
C
LF---
E
-------
D
V
--
V
P
M
N
Y
M
V
YFNF
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
--
Q
L
K
------
Q
M
E
S
-
Q
P
L
P
G
-----------
E
----------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
--
D
----
C
------
H
---
A
-
P
-------
L
-------
W
--
L
--
M
Y
L
A
I
V
L
S
H
T
N
-
S
---
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-----------------
R
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
84.32
17%
-142
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-325]
-------------------------------------------------------------------------
V
L
-----
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
-------------
G
N
V
V
V
M
W
I
I
L
A
-----
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
------
S
M
A
A
F
N
-
T
V
V
N
--
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
-
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
-----------------
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
-
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
-----
M
P
S
R
V
V
C
M
I
E
W
P
-
E
H
P
---------------
N
K
--
I
Y
E
K
V
Y
H
----
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
---
I
G
Y
A
Y
T
V
--
V
G
I
------
T
L
W
A
-
S
E
I
P
G
DSSDRYH
E
Q
V
S
A
----------------
K
R
-----
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
--------
H
I
F
F
L
----
L
P
--
Y
----
I
NP
D
---
L
---
Y
L
K
-------
K
F------
I
Q
Q
V
--
Y
L
A
I
M
W
L
A
M
S
S
-
T
---
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-----------------
R
C
C
P
F
I
S
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
82.16
17%
-122
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
----------------
S
M
-----
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-------------
I
N
F
L
T
L
Y
V
T
V
Q
-----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
------
F
M
V
F
G
G
-
F
T
T
T
--
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
-
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----------------
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-----
G
W
S
R
----------
Y
I
P
E
G
M
Q
C
S
C
G
I
DYY
T
-------
P
H
--
E
E
T
N
N
E
S
----
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
---
I
V
I
F
F
C
Y
G
Q
L
V
F
------
T
V
K
E
-
A
A
A
Q
Q
-----------
Q
ESA
T
------------
T
Q
-----
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
----
G
V
--
A
----
F
--
Y
---
I
---
F
-
T
H
QGSDFG
P
-------
I
--
F
--
M
T
I
P
A
F
F
A
K
T
S
-
A
---
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
82.05
17%
-122
- C3 -
1U19
14
OPSD_BOVIN
A:
[38-328]
------------------------------------------------------
W
Q
F
----------------
S
M
-----
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-------------
I
N
F
L
T
L
Y
V
T
V
Q
-----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
------
F
M
V
F
G
G
-
F
T
T
T
--
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
-
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----------------
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
-
T
P
--------
H
-------
E
E
--
T
N
N
E
S
F
V
----
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
---
I
F
F
C
Y
G
Q
--
L
V
F
------
T
V
K
E
-
A
A
A
Q
Q
-----------
Q
ESA
T
------------
T
Q
-----
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
----
Q
--
G
S--
D
---
F
-
G
-------
P
-------
I
--
F
--
M
T
I
P
A
F
F
A
K
T
S
-
A
---
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-----------------
C
C
G
K
N
P
L
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
81.86
17%
-139
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-------------------------------------------------------
V
Y
----------------
Y
S
-----
L
G
I
F
I
G
I
C
G
I
I
G
C
G
-------------
G
N
G
I
V
I
Y
L
F
T
K
-----
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
------
T
F
S
L
V
N
G
F
P
L
M
--
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
-
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
-----------------
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
-
S
-----------------
R
D
--
S
T
T
R
S
N
I
----
L
C
M
F
I
L
G
F
F
G
P
I
L
I
---
I
F
F
C
Y
F
N
--
I
V
M
------
S
V
S
N
-
H
E
K
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
--------
W
S
P
Y
A
V
V
A
L
L
A
--
Q
----
F
G-
P
LE-
W
---
V
-
T
-------
P
-------
Y
--
A
--
A
Q
L
P
V
M
F
A
K
A
S
-
A
---
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-----------------
P
W
V
L
T
C
C
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
76.71
15%
-122
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------------
D
E
V
W
V
----------------
V
G
-----
M
G
I
V
M
S
L
I
V
L
A
I
V
F
-------------
G
N
V
L
V
I
T
A
I
A
K
-----
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
------
V
M
G
L
A
V
-
V
P
F
G
--
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
-
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----------------
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
-------
T
H
Q
E
A
I
N
C
Y
A
-
E
E
T
C
C
-----
D
-------
F
F
--
T
N
Q
A
Y
A
I
----
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
---
M
V
F
V
Y
S
R
--
V
F
Q
------
E
A
K
R
Q
L
N
I
F
E
-----------
M
----------------
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
--------
I
G
H
L
L
----
T
K
--
S
----
P
--
S
---
L
---
N
-
A
-------
A
-------
K
--
S
--
E
L
D
K
A
I
G
R
N
T
N
G
V
---
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
-----------------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
29
HHSearch
70.54
16%
-126
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
-----------------------------------------------------
T
L
N
K
----------------
Y
V
-----
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
-------------
G
N
S
L
V
M
L
V
I
L
Y
-----
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
------
L
F
A
L
-
T
-
L
P
I
W
--
A
A
S
K
V
--
N
G
W
I
F
G
T
F
-
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
-----------------
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
-
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
----
P
N
N
S
S
P
V
C
Y
E
V
L
G
-
N
---
D
-------------
T
A
--
K
W
R
M
V
L
R
----
I
L
P
H
T
F
G
F
I
V
P
L
F
V
---
M
L
F
C
Y
G
F
--
T
L
R
------
T
L
F
K
-
A
H
M
G
------------
Q
----------------
K
H
-----
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
--------
N
L
V
L
L
----
A
D
--
T
L
M
RT
Q
--
V
IQE
S
C
E
R
R
-
N
-------
N
-------
I
--
G
R
A
L
D
A
T
E
I
L
G
F
L
H
-
S
---
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
-----------------
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
69.77
20%
-154
* C2 *
1CJD
-
CAPSD_BPPRD
A:
[15-383]
L
R
N
Q
Q
A
M
A
A
N
L
Q
A
R
Q
I
V
L
Q
Q
S
Y
P
V
I
Q
Q
V
E
T
Q
T
F
D
P
A
N
---------------
R
S
V
F
D
----------------
V
T
P
ANVG
I
V
K
G
F
L
V
K
V
T
A
A
I
T
NNHA
T
E
A
V
A
L
T
DF
G
P
A
N
L
V
Q
R
V
I
Y
Y
D
PDN
Q
R
H
T
E
T
S
-
G
W
H
L
H
F
V
N
T
A
K
Q
GAPFL
S
S
M
V
T
D
S
-
P
I
K
Y
GD
V
M
N
V
I
-
D
A
P
A
T
I
A
A
G
A
T
G
E
L
T
M
Y
Y
W
V
P
L
A
Y
S
E
TDLTGAVLANVPQS
K
Q
R
L
K
L
E
F
A
N
N
N
T
A
F
A
A
V
G
A
N
P
L
E
A
--
I
---
Y
Q
G
A
G
A
A
D
C
E
F
E
E
--
I
S
Y
T
V
Y
Q
S
Y
L
D
---
Q
L
P
V
G
Q
N
G
Y
I
-
L
P
L
I
D
L
S
T
L
-
Y
N
L
E
N
-----
S
-------
A
Q
--
A
G
L
T
--------
P
N
V
D
F
V
V
Q
Y
A
N
L
Y
---
R
Y
L
S
T
I
A
--
V
F
D
NGGSFN
A
G
T
D
-
I
N
Y
L
S
-----------
Q
----------------
R
T
-----
A
N
F
S
D
T
R
K
L
D
-------------------
P
K
T
W
----
A
A
--
Q
----
T
--
R
---
R
---
R
-
I
-------
A
TD-----
F
--
P
--
K
G
V
Y
Y
C
D
N
R
D
K
-
P
IYT
L
Q
Y
G
N
V
G
F
V
V
N
P
K
T
V
N
Q
N
A
R
L
L
-----------------
M
G
Y
E
Y
F
T
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
68.94
20%
-162
- C3 -
3EML
8
ENLYS_BPT4
A:
[21-222]
--------------------------------------------------------
S
----------------
S
V
-----
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
-------------
G
N
V
L
V
C
W
A
V
W
L
-----
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
------
A
V
G
V
L
A
-
I
P
F
A
--
I
T
I
S
T
---
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-----------------
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
----
V
A
C
-----
L
-------
F
E
DV
V
P
M
N
Y
M
V
----
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
---
M
L
G
V
Y
L
R
--
I
F
L
------
A
A
R
R
-
Q
L
N
I
F
-----------
E
----------------
M
L
-----
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
--------
G
I
G
H
L
----
L
T
--
K
----
S
--
P
---
S
---
L
-
N
-------
A
-------
A
--
K
--
S
E
L
D
K
A
I
G
R
N
T
-
N
---
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------------
I
L
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
65.94
17%
-147
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
--------------------------------------------------------
V
----------------
V
G
-----
M
G
I
V
M
S
L
I
V
L
A
I
V
F
-------------
G
N
V
L
V
I
T
A
I
A
K
-----
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
------
V
M
G
L
A
V
-
V
P
F
G
--
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
-
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----------------
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
----
Q
E
A
I
N
C
Y
A
E
-----
E
T
C
-----
C
-------
D
F
--
F
T
N
Q
A
Y
A
----
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
---
M
V
F
V
Y
S
R
--
V
F
Q
------
E
A
K
R
-
Q
L
N
I
F
-----------
E
----------------
M
L
-----
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
--------
G
I
G
H
L
----
L
T
--
K
----
S
--
P
---
S
---
L
-
N
-------
A
-------
A
--
K
--
S
E
L
D
K
A
I
G
R
N
T
-
N
---
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------------
I
L
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
65.23
18%
-165
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
-------------------------------------------------------------------------
V
F
-----
I
V
L
V
A
G
S
L
S
L
V
T
I
I
-------------
G
N
I
L
V
M
V
S
I
K
V
-----
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
------
I
I
G
V
F
S
-
M
N
L
Y
--
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
-
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
-----------------
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
-
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
-
V
-
R
T
V
E
D
G
E
C
Y
I
Q
----------------------
F
--
F
S
N
A
A
V
T
----
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
---
M
T
V
L
Y
W
H
--
I
S
R
------
A
S
K
S
-
R
I
N
I
F
-----------
E
----------------
M
L
-----
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
--------
G
I
G
H
L
----
L
T
--
K
----
S
--
P
---
S
---
L
-
N
-------
A
-------
A
--
K
--
S
E
L
D
K
A
I
G
R
N
T
-
N
---
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------------
I
L
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
62.00
17%
-153
* C3 *
3PBL
1
DRD3_HUMAN (first)
A:
[41-227]
--------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
-------------
G
N
G
L
V
C
M
A
V
L
K
-----
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
------
L
V
A
T
L
V
-
M
P
W
V
--
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
-
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
-----------------
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
-
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
---
G
----
D
P
T
V
C
S
I
-----------------------
S
--
N
--
P
D
F
V
----
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
---
T
V
L
V
Y
A
R
--
I
Y
V
------
V
L
K
Q
-
R
R
R
K
N
-----------
I
----------------
F
E
-----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
--------
T
I
G
I
G
----
H
L
--
L
----
T
--
K
---
S
---
P
-
S
-------
L
-------
N
--
A
--
A
K
S
E
L
D
K
A
I
G
R
-
N
---
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
-----------------
R
G
I
L
R
N
A
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
61.98
18%
-144
- C3 -
4O6Y
3
ACFR2_ARATH
A:
[10-219]
---------------------------------
P
I
F
M
---------------
V
V
R
V
L
----------------
G
F
-----
I
I
A
A
L
V
L
T
W
T
V
H
Y
R
-------------
G
G
L
A
L
S
-------------------------------------------------------
S
D
N
K
D
H
I
F
N
-
V
H
P
V
M
M
V
I
G
L
I
L
F
N
G
E
-----------------
A
M
L
A
Y
K
S
V
Q
G
-------------------
T
K
N
L
K
K
L
V
H
L
T
L
Q
L
T
A
F
I
L
S
L
I
G
V
W
A
A
L
K
F
H
I
-
D
K
G
I
E
N
F
Y
S
------------------------------
L
H
S
W
L
G
----
L
A
C
L
-
F
L
F
A
F
Q
W
A
A
---
G
F
V
T
Y
W
Y
-----------------
P
G
G
S
-----------
R
----------------
N
S
-----
R
A
--
S
L
M
P
W
H
V
F
L
G
I
S
I
Y
A
L
--------
A
L
V
T
A
----
T
T
--
G
----
I
--
L
---
E
---
K
-
V
-------
T
-------
F
--
L
--
Q
V
N
Q
V
I
T
R
Y
S
-----------
T
E
A
M
L
V
N
T
M
G
V
L
I
L
I
L
G
-----------------
G
F
V
I
L
G
V
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
61.20
15%
-146
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-201]
--------------------------------------------------------------------------
P
-----
L
V
V
V
L
S
T
I
C
L
V
T
V
G
-------------
L
N
L
L
V
L
Y
A
V
R
S
-----
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
------
I
V
G
A
V
V
-
M
P
M
N
--
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
-
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
-----------------
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
-
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
--------
R
R
E
D
K
C
E
T
D
F
------------------------
Y
D
V
T
W
F
K
----
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
---
M
L
W
F
Y
A
K
--
I
Y
K
------
A
V
R
Q
-
H
C
N
I
F
-----------
E
----------------
M
L
-----
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
--------
G
I
G
H
L
----
L
T
--
K
----
S
--
P
---
S
---
L
-
N
-------
A
-------
A
--
K
--
S
E
L
D
K
A
I
G
R
N
T
-
N
---
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------------
I
L
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------