@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6K2_HUMAN: (2016-01-14 )
MESPNRTTIQEFIFSAFPYSWVKSVVCFVPLLFIYAFIVVGNLVIITVVQLNTHLHTPMYTFISALSFLEIWYTTATIPKMLSSLLSERSISFNGCLLQMYFFHSTGICEVCLLTVMAFDHYLAICSPLHYPSIMTPKLCTQLTLSCCVCGFITPLPEIAWISTLPFCGSNHLEHIFCDFLPVLRLACTDTRAIVMIQVVDVIHAVEIITAVMLIFMSYDGIVAVILRIHSAGGRRTAFSTCVSHFIVFSLFFGSVTLMYLRFSATYSLFWDIAIALAFAVLSPFFNPIIYSLRNKEIKEAIKKHIGQAKIFFSVRPGTSSKIF
Atome Classification :
(20 SA)
----------.--.....-----...-----10..---......20--.........30........40---........50........60........70......-..80....-....-90........100.......110.------......120.......130..-.....140.....-..150....-.-..---160..-...-----...170........180.......190--.......200.......210..------.....220.......230--------------------...---------------....240.......250.......260.-----------...-------.---.---.-------270--........280.......290.......300.......310.......320..---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------M--ESP
N
R
-----
T
T
I
-----
Q
E
F
I
---
F
SAF
P
Y
S
---
W
V
K
S
V
V
C
F
V
P
L
L
F
I
Y
A
F
I
V
VG---
N
L
V
I
I
T
V
V
Q
LNTHLH
T
P
M
Y
T
F
I
S
A
L
S
F
L
E
I
W
Y
TTA
T
-
I
P
K
M
L
S
S
L
-
L
S
ER-SISFN
G
C
L
L
Q
M
Y
F
FHST
G
I
C
E
V
C
L
------
L
T
V
M
A
F
D
H
Y
L
A
I
CSPLHYPSI-M
T
P
K
L
C
T
Q
L
T
L
S
C
-
C
V
C
G
FITPL-P-E
I
---
A
W
-
I
S-TLP-----FCGS
N
-
H
L
E
H
I
F
C
D
F
L
P
V
L
R
L
ACTDT
R
--
A
I
V
M
I
Q
V
V
D
V
I
H
A
V
E
I
I
T
A
V
M
L
------
I
F
MSY
D
G
I
V
A
V
I
L
R
I
HSA--------------------GGR---------------
R
T
A
F
S
T
C
V
S
H
F
I
V
F
S
L
F
F
G
S
V
T
L
M
Y
L
R
F
-----------S
A
T
-------
Y
---
S
---
L
-------
F
W
---
D
I
A
I
A
L
A
F
A
V
L
S
P
F
F
N
P
I
I
Y
S
L
R
N
K
E
I
K
E
A
I
K
K
HIGQ
A
K
I
F
F
S
VRPGTSSKIF---------
42
Fugue
86.39
17%
-130
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFY
V
--
P
F
S
N
K
-----
T
G
V
-----
V
R
S
P
---
F
E
A
P
Q
Y
Y
---
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
-
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
------
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
A
L
A
C
A
A
P
-
P
-
L
V
---
G
W
-
S
R
-
Y
I
P
E
GMQC
S
C
G
I
---------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
--
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
------
L
V
F
T
V
K
E
A
A
A
S
A
T
T
Q
K
A
E
--------------------
K
E
V
---------------
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
-----------
Q
G
S
-------
D
---
F
---
G
-------
P
I
---
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A------
6
PsiBlast_PDB
83.72
19%
-163
- C3 -
3PWH
1
?
A:
[14-301]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
-
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
------
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
T
G
T
R
A
A
G
I
I
A
I
C
-
W
V
L
S
F
A
I
G
L
T
P
-
M
L
---
G
W
-
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
--------------------
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
FCP
D
C
S
-------
H
---
A
---
P
-------
L
W
---
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
8
PsiBlast_PDB
83.52
19%
-162
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[14-301]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
-
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
------
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
T
G
T
R
A
A
G
I
I
A
I
C
-
W
V
L
S
F
A
I
G
L
T
P
-
M
L
---
G
W
-
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
--------------------
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
FCP
D
C
S
-------
H
---
A
---
P
-------
L
W
---
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
10
PsiBlast_PDB
83.29
19%
-164
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[14-301]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
-
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
------
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
T
G
T
R
A
A
G
I
I
A
I
C
-
W
V
L
S
F
A
I
G
L
T
P
-
M
L
---
G
W
-
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
--------------------
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
FCP
D
C
S
-------
H
---
A
---
P
-------
L
W
---
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
9
PsiBlast_PDB
83.18
19%
-161
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[14-301]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
-
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
------
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
T
G
T
R
A
A
G
I
I
A
I
C
-
W
V
L
S
F
A
I
G
L
T
P
-
M
L
---
G
W
-
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
--------------------
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
FCP
D
C
S
-------
H
---
A
---
P
-------
L
W
---
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
7
PsiBlast_PDB
83.09
19%
-162
- C3 -
3REY
1
AA2AR_HUMAN
A:
[14-301]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
-
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
------
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
T
G
T
R
A
A
G
I
I
A
I
C
-
W
V
L
S
F
A
I
G
L
T
P
-
M
L
---
G
W
-
N
N
C
G
Q
P
--------------------------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
--------------------
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
FCP
D
C
S
-------
H
---
A
---
P
-------
L
W
---
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
35
HHSearch
80.49
16%
-156
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-333]
--------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
------
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
-
M
S
H
R
R
A
F
I
M
I
I
F
V
-
W
L
W
S
V
L
W
A
I
-
G
-
P
I
---
F
G
-
W
G
-
A
Y
T
-----
L
-----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
D
S
--
T
T
R
S
N
I
L
C
--
M
F
I
L
G
F
F
G
P
I
L
I
------
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
---------------
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
-----------
Q
F
G
-------
P
LEW
V
---
T
-------
P
Y
---
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
---------
41
Fugue
79.44
16%
-115
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------
M
N
G
T
E
G
P
N
-----
F
Y
V
PFSNK
T
G
V
V
---
R
S
P
F
E
A
P
QYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
-
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
------
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
A
L
A
C
A
A
P
-
P
-
L
V
---
G
W
-
S
R
-
Y
I
P
E
GMQC
S
C
G
I
---------
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
--
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
------
L
V
F
T
V
K
E
A
A
A
---
Q
Q
Q
E
S
--------------------
A
T
T
---------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-----------
A
F
Y
-------
I
---
F
---
T
H
QGSDFG
P
I
---
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
30
HHSearch
76.22
15%
-155
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-326]
-----------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
------
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
---
S
A
T
A
T
K
V
V
I
C
V
I
-
W
V
L
A
L
L
L
A
F
-
P
-
Q
G
---
Y
Y
-
S
T
-
T
E
T
-----------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
K
I
--
Y
E
K
V
Y
H
I
C
--
V
T
V
L
I
Y
F
L
P
L
L
V
------
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
---------
S
A
K
---------------
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
-----------
Y
I
N
-------
P
---
D
LYL
K
-------
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
---------
46
Fugue
74.99
15%
-133
- C2 -
3PVT
2
PAAA_ECOLI
A:
[1-304]
----------
M
--
R
S
T
Q
E
-----
E
R
F
-----
E
Q
R
I
A
Q
E
T
A
I
E
P
Q
D
---
W
M
P
-----------------
D
---
A
Y
R
K
T
L
I
R
Q
I
G
Q
H
A
H
S
E
I
V
G
M
L
P
E
G
N
W
I
T
R
A
P
T
L
R
R
-
K
A
I
L
L
A
K
V
-
Q
D
E
A
-
G
H
G
-----
L
Y
L
Y
S
A
A
E
T
L
G
C
A
R
E
D
------
I
Y
Q
K
M
L
D
G
R
M
K
Y
S
S
I
F
N
Y
P
T
L
S
W
A
D
I
G
V
I
G
W
L
V
D
G
-
A
A
I
V
N
Q
V
A
L
-
C
-
R
T
SY
G
P
Y
-
A
R
-
A
M
V
-----
K
I
C
K
E
-
E
S
F
H
Q
R
Q
G
F
E
A
C
M
A
L
A
Q
G
S
E
A
--
Q
K
Q
M
L
Q
--
D
A
I
N
R
F
W
W
P
A
L
M
M
F
GPNDDN
S
P
N
S
A
R
S
L
T
W
K
I
K
R
F
T
N
D
--------------------
E
L
R
---------------
Q
R
F
V
D
N
T
V
P
Q
V
E
M
L
G
M
T
V
P
D
P
D
L
H
F
D
T
E
-----------
S
G
H
-------
Y
---
R
-----------
F
G
---
E
I
D
W
Q
E
F
N
E
V
I
N
G
------
R
G
I
C
N
Q
E
R
L
D
A
K
R
K
A
W
E
E
G
T
W
V
R
E
A
A
L
A
H
A
Q
K
-----------
29
HHSearch
73.81
14%
-144
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
--------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
---
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
------
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
--
Q
K
R
H
L
V
K
F
V
C
L
G
C
-
W
G
L
S
M
N
L
S
L
-
P
-
F
F
---
L
F
-
R
Q
-
A
Y
H
-----
P
-----
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
----
T
A
K
--
W
R
M
V
L
R
I
L
--
P
H
T
F
G
F
I
V
P
L
F
V
------
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
M
---------------------
G
Q
K
---------------
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
-----------
T
L
M
RTQVIQE
S
---
C
E
R
R
N
-------
N
I
G
R
-
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------
33
HHSearch
73.02
15%
-132
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-328]
----------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
------
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
--
F
G
E
N
H
A
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
-
P
-
P
L
---
V
G
-
W
S
-
R
Y
I
-----
P
-----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
T
--
N
N
E
S
F
V
I
Y
--
M
F
V
V
H
F
I
I
P
L
I
V
------
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
QQESA
T
T
Q
------------
K
A
E
---------------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
-----------
F
T
H
QG-----
S
---
D
F--
G
-------
P
I
---
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
---------
26
HHSearch
63.90
20%
-150
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-221]
----------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
-
T
-
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
-
V
T
G
T
R
A
K
G
I
I
A
I
C
-
W
V
L
S
F
A
I
G
L
-
T
-
P
M
---
L
G
-
W
N
-
N
C
G
-----
Q
--------
S
Q
G
C
G
E
G
Q
---
V
A
C
L
F
E
D
VV
P
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
L
L
------
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
--------------------
F
E
M
---------------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
-----------
K
S
P
-------
S
---
L
---
N
-------
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
---------
1
PsiBlast_PDB
63.66
25%
-138
- C3 -
4LDE
3
ENLYS_BPT4
A:
[155-342]
-------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
-----
R
T
G
T
---
W
D
A
Y
A
A
D
---
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
-
L
T
-
K
-
T
W
T
F
G
N
F
W
C
E
F
W
----
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
-
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
I
Q
M
---
H
W
-
Y
R
-
A
T
H
-----
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
--
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------
R
Q
L
Q
K
F
A
L
K
E
H
K
A
L
K
T
L
G
--------------------
I
I
M
---------------
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
-----------
Y
I
L
-------
L
---
N
---
W
-------
I
G
---
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------
4
PsiBlast_PDB
63.08
25%
-138
- C3 -
4QKX
2
ADRB2_HUMAN
A:
[155-342]
-------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
-----
R
T
G
T
---
W
D
A
Y
A
A
D
---
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
-
L
T
-
K
-
T
W
T
F
G
N
F
W
C
E
F
W
----
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
-
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
I
Q
M
---
H
W
-
Y
R
-
A
T
H
-----
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
--
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------
R
Q
L
Q
K
F
A
L
K
E
H
K
A
L
K
T
L
G
--------------------
I
I
M
---------------
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
-----------
Y
I
L
-------
L
---
N
---
W
-------
I
G
---
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------
3
PsiBlast_PDB
63.00
25%
-139
- C3 -
4LDO
3
ENLYS_BPT4
A:
[155-342]
-------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
-----
R
T
G
T
---
W
D
A
Y
A
A
D
---
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
-
L
T
-
K
-
T
W
T
F
G
N
F
W
C
E
F
W
----
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
-
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
I
Q
M
---
H
W
-
Y
R
-
A
T
H
-----
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
--
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------
R
Q
L
Q
K
F
A
L
K
E
H
K
A
L
K
T
L
G
--------------------
I
I
M
---------------
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
-----------
Y
I
L
-------
L
---
N
---
W
-------
I
G
---
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------
2
PsiBlast_PDB
62.57
25%
-139
- C3 -
4LDL
3
ADRB2_HUMAN (first)
A:
[155-342]
-------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
-----
R
T
G
T
---
W
D
A
Y
A
A
D
---
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
-
L
T
-
K
-
T
W
T
F
G
N
F
W
C
E
F
W
----
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
-
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
I
Q
M
---
H
W
-
Y
R
-
A
T
H
-----
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
--
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------
R
Q
L
Q
K
F
A
L
K
E
H
K
A
L
K
T
L
G
--------------------
I
I
M
---------------
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
-----------
Y
I
L
-------
L
---
N
---
W
-------
I
G
---
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------
25
HHSearch
61.86
20%
-148
* C3 *
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
---------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
------
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
-
L
T
K
N
K
A
R
V
I
I
L
M
V
-
W
I
V
S
G
L
T
S
F
-
L
-
P
I
---
Q
M
H
W
Y
-
R
A
T
-----
H
------
Q
E
A
I
N
C
Y
A
E
----
E
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
--
S
S
I
V
S
F
Y
V
P
L
V
I
------
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
--------------------
F
E
M
---------------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
-----------
K
S
P
-------
S
---
L
---
N
-------
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
---------
5
PsiBlast_PDB
61.02
25%
-153
- C3 -
3SN6
1
ENLYS_BPT4
R:
[155-342]
-------------
Q
T
P
N
R
AKRVI
T
T
F
-----
R
T
G
T
---
W
D
A
-------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
-
L
T
-
K
-
T
W
T
F
G
N
F
W
C
E
F
W
----
T
S
I
D
V
L
C
V
TASIET
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
-
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
I
Q
M
---
H
W
-
Y
R
---------
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
--
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------
R
Q
L
Q
K
I
D
K
S
E
G
R
C
L
K
E
H
K
--------------------
A
L
K
---------------
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
-----------
L
I
R
-------
K
---
E
---
V
-------
Y
I
---
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
------------------------------
24
HHSearch
59.51
17%
-148
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[9-200]
----------------------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
---
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
K
W
-
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
------
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
-
R
T
K
T
R
A
S
A
T
I
L
G
A
-
W
F
L
S
F
L
W
V
I
-
P
-
I
L
---
G
--
W
N
-
H
--------------
R
R
E
D
K
C
E
T
D
F
Y
-----------
D
V
T
W
F
K
V
M
--
T
A
I
I
N
F
Y
L
P
T
L
L
------
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
--------------------
F
E
M
---------------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
-----------
K
S
P
-------
S
---
L
---
N
-------
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
---------