@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6X1_HUMAN: (2016-01-14 )
MRNGTVITEFILLGFPVIQGLQTPLFIAIFLTYILTLAGNGLIIATVWAEPRLQIPMYFFLCNLSFLEIWYTTTVIPKLLGTFVVARTVICMSCCLLQAFFHFFVGTTEFLILTIMSFDRYLTICNPLHHPTIMTSKLCLQLALSSWVVGFTIVFCQTMLLIQLPFCGNNVISHFYCDVGPSLKAACIDTSILELLGVIATILVIPGSLLFNMISYIYILSAILRIPSATGHQKTFSTCASHLTVVSLLYGAVLFMYLRPTAHSSFKINKVVSVLNTILTPLLNPFIYTIRNKEVKGALRKAMTCPKTGHAK
Atome Classification :
(20 SA)
--------------------------------...--......10------...---------.....------20...----------------.....30........40....-------....50.--.....-----..60.----.......70....-....80........90..------.--.....100----......---.110.......120.......130-.........140.......150.......-160..---.....170........180....------..-----.----.190--........---200.--......210......--.---220.....-..-----------230------------------..---..-.-....240......-------.250.......260.----.---.---.---------.--.--..270---------.........280---------------........290.......300.......310---------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------MRN--
G
T
V
I
T
E
F
I
------
L
L
G
---------
F
P
V
I
Q------GLQT
P
----------------
L
F
I
A
I
F
L
T
Y
I
L
T
LAGN
G
L
I
I
A
-------
T
VWAEPR--LQ
I
P
M
-----
Y
F
F
LC----N
L
S
F
L
E
I
W
Y
T
T
T
V
-
I
P
K
L
L
G
T
F
V
V
A
R
T
V
I
C
M
S
------
C
--
C
L
L
Q
A
F
F
H
----
F
F
VG
T
T
---
E
F
L
I
L
T
I
MSFD
R
Y
L
T
I
CNPLHH---P
T
I
M
T
S
K
L
C
L
Q
L
A
L
S
S
W
V
V
G
F
T
I
V
F
C
Q
T
M
-
L
L
I
QL---PFCG
N
N
V
-
I
S
H
F
YCDVGP-S
L
K
A
------
A
C
-----
I
----
D
T
-
S
--
I
L
E
L
L
G
V
I
---
A
T
I
L
--VI
P
G
S
L
L
F
N
M
I
S
Y
I
Y
--
I
---
L
S
A
I
L
RIP-SA-----------T--------------------GH---
Q
K
-
T
-
F
S
T
C
A
S
H
L
T
V
V
S
L
-------
L
Y
G
A
V
L
F
M
YLRPT-A----H---S---S---------F--
K
--
I
N
K
-----------
V
V
S
V
L
N
T
I
L
T
-
P
---------------
L
L
N
P
F
I
Y
T
IRN
K
E
V
K
G
A
L
R
K
AMTCPKTGHAK---------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
90.39
22%
-150
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[18-301]
--------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
-------
A
V
W
L
N
S
N
--
L
Q
N
V
T
-----
N
Y
F
V
V
----
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
T
G
F
C
A
A
------
C
H
G
C
L
F
I
A
C
F
V
----
L
V
L
A
Q
S
---
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
---
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
GQP-
G
C
G
E
G
Q
-
V
A
C
L
F
E
D
V
V
P
-
M
N
Y
M
V
YFNFF
A
C
-----
V
----
L
V
-
P
--
L
L
L
M
L
G
V
Y
---
L
R
I
F
--
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
-------------
P
L
P
-
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
-
E
-
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
---
A
---
P
---------
L
--
W
--
L
M
Y
-----------
L
A
I
V
L
A
H
T
-
N
-
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
90.31
22%
-151
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[18-301]
--------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
-------
A
V
W
L
N
S
N
--
L
Q
N
V
T
-----
N
Y
F
V
V
----
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
T
G
F
C
A
A
------
C
H
G
C
L
F
I
A
C
F
V
----
L
V
L
A
Q
S
---
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
---
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
GQP-
G
C
G
E
G
Q
-
V
A
C
L
F
E
D
V
V
P
-
M
N
Y
M
V
YFNFF
A
C
-----
V
----
L
V
-
P
--
L
L
L
M
L
G
V
Y
---
L
R
I
F
--
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
-------------
P
L
P
-
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
-
E
-
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
---
A
---
P
---------
L
--
W
--
L
M
Y
-----------
L
A
I
V
L
A
H
T
-
N
-
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
90.01
22%
-148
- C3 -
3REY
1
AA2AR_HUMAN
A:
[18-301]
--------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
-------
A
V
W
L
N
S
N
--
L
Q
N
V
T
-----
N
Y
F
V
V
----
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
T
G
F
C
A
A
------
C
H
G
C
L
F
I
A
C
F
V
----
L
V
L
A
Q
S
---
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
---
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
GQP-
G
C
G
E
G
Q
-
V
A
C
L
F
E
D
V
V
P
-
M
N
Y
M
V
YFNFF
A
C
-----
V
----
L
V
-
P
--
L
L
L
M
L
G
V
Y
---
L
R
I
F
--
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
-------------
P
L
P
-
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
-
E
-
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
---
A
---
P
---------
L
--
W
--
L
M
Y
-----------
L
A
I
V
L
A
H
T
-
N
-
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
89.56
22%
-151
- C3 -
3PWH
1
?
A:
[18-301]
--------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
-------
A
V
W
L
N
S
N
--
L
Q
N
V
T
-----
N
Y
F
V
V
----
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
T
G
F
C
A
A
------
C
H
G
C
L
F
I
A
C
F
V
----
L
V
L
A
Q
S
---
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
---
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
GQP-
G
C
G
E
G
Q
-
V
A
C
L
F
E
D
V
V
P
-
M
N
Y
M
V
YFNFF
A
C
-----
V
----
L
V
-
P
--
L
L
L
M
L
G
V
Y
---
L
R
I
F
--
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
-------------
P
L
P
-
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
-
E
-
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
---
A
---
P
---------
L
--
W
--
L
M
Y
-----------
L
A
I
V
L
A
H
T
-
N
-
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.25
20%
-166
- C3 -
2YCW
7
ADRB1_MELGA
A:
[8-299]
-------------------------------------------------------------------
Q
------
Q
W
E
A
G
----------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
-------
A
I
G
S
T
Q
R
--
L
Q
T
L
T
-----
N
L
F
I
T
----
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-----
L
--
C
E
L
W
T
S
L
D
----
V
L
C
V
T
A
---
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
---
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-
M
-----------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
--
G
C
-----
C
----
D
F
-
V
--
T
N
R
A
Y
A
I
A
---
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
---
K
E
Q
I
R
K
I
D
-
R
A
-----------
S
--------------------
K
R
---
K
R
-
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
-------
I
M
G
V
F
T
L
C
W
L
-----------------
P
---------
F
--
F
--
L
V
N
-----------
I
V
N
V
F
N
R
D
L
V
-
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.22
20%
-164
- C3 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
---------------------------------------------------------------------------
W
E
A
G
----------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
-------
A
I
G
S
T
Q
R
--
L
Q
T
L
T
-----
N
L
F
I
T
----
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-----
L
--
C
E
L
W
T
S
L
D
----
V
L
C
V
T
A
---
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
---
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-
M
-----------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP--
G
C
-----
C
----
D
F
-
V
--
T
N
R
A
Y
A
I
A
---
S
S
I
I
SF
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
---
K
E
Q
I
R
---------------------------------------------------
E
H
K
A
L
K
T
L
G
I
-------
I
M
G
V
F
T
L
C
W
L
-----------------
P
---------
F
--
F
--
L
V
N
-----------
I
V
N
V
F
N
R
D
L
V
-
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
NS
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.01
20%
-166
- C3 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
--------------------------------------------------------------------------
Q
W
E
A
G
----------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
-------
A
I
G
S
T
Q
R
--
L
Q
T
L
T
-----
N
L
F
I
T
----
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-----
L
--
C
E
L
W
T
S
L
D
----
V
L
C
V
T
A
---
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
---
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-
M
-----------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP--
G
C
-----
C
----
D
F
-
V
--
T
N
R
A
Y
A
I
A
---
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
---
K
E
Q
I
R
K
I
D
-
R
A
-----------
S
--------------------
K
R
---
K
R
-
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
-------
I
M
G
V
F
T
L
C
W
L
-----------------
P
---------
F
--
F
--
L
V
N
-----------
I
V
N
V
F
N
R
D
L
V
-
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.41
20%
-164
- C3 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
---------------------------------------------------------------------------
W
E
A
G
----------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
-------
A
I
G
S
T
Q
R
--
L
Q
T
L
T
-----
N
L
F
I
T
----
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-----
L
--
C
E
L
W
T
S
L
D
----
V
L
C
V
T
A
---
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
---
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-
M
-----------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP--
G
C
-----
C
----
D
F
-
V
--
T
N
R
A
Y
A
I
A
---
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
---
K
E
Q
I
R
--
D
-
R
A
-----------
S
--------------------
K
R
---
K
R
-
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
-------
I
M
G
V
F
T
L
C
W
L
-----------------
P
---------
F
--
F
--
L
V
N
-----------
I
V
N
V
F
N
R
D
L
V
-
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.16
20%
-169
- C3 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
--------------------------------------------------------------------------
Q
W
E
A
G
----------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
-------
A
I
G
S
T
Q
R
--
L
Q
T
L
T
-----
N
L
F
I
T
----
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-----
L
--
C
E
L
W
T
S
L
D
----
V
L
C
V
T
A
---
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
---
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-
M
-----------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP--
G
C
-----
C
----
D
F
-
V
--
T
N
R
A
Y
A
I
A
---
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
---
K
E
Q
I
R
K
I
D
-
R
A
-----------
S
--------------------
K
R
---
K
R
-
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
-------
I
M
G
V
F
T
L
C
W
L
-----------------
P
---------
F
--
F
--
L
V
N
-----------
I
V
N
V
F
N
R
D
L
V
-
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
82.28
17%
-133
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------------------
M
N
--
G
T
E
G
P
N
F
Y
------
V
P
F
---------
S
N
K
T
G
------
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-------
V
T
V
Q
H
K
K
--
L
R
T
P
L
-----
N
Y
I
L
L
----
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
--
C
N
L
E
G
F
F
A
----
T
L
G
G
E
I
---
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
---
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---------
A
P
---
P
L
V
G
----
W
S
R
Y
I
P
E
----
G
M
Q
C
------
S
C
-----
G
I
---
D
Y
Y
T
--
P
H
E
E
T
N
N
E
---
S
F
V
I
--
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
--
F
---
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
--------------------
A
A
---
S
A
-
T
-
T
Q
K
A
E
K
E
V
T
R
M
V
I
-------
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
----
G
---
V
---
A
---------
F
--
Y
--
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
-
A
---------------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
81.35
15%
-150
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-333]
--------------------------------------------------------------------------
A
V
Y
Y
S
----------------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
-------
L
F
T
K
T
K
S
--
L
Q
T
P
A
-----
N
M
F
I
I
----
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
------
A
--
C
K
V
Y
G
F
I
G
----
G
I
F
G
F
M
---
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
---
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
G
A
Y
---
T
L
----
E
-
G
V
L
C
N
C
S
F
D
Y
-
I
S
--------------------
R
D
-
S
--
T
T
R
S
N
I
L
C
---
M
F
I
L
--
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
--
I
---
V
M
S
V
S
N
H
E
-
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
---
M
R
-
L
-
A
K
I
S
I
V
I
V
S
Q
F
L
L
-------
S
W
S
P
Y
A
V
V
A
L
L
A
Q
-
F
----
G
PLE
W
---
V
---------
T
--
P
--
Y
A
A
-----------
Q
L
P
V
M
F
A
K
A
S
-
A
---------------
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
80.14
16%
-143
* C3 *
2KS9
1
NK1R_HUMAN
A:
[34-325]
------------------------------------------------------------------------------
L
----------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
-------
I
I
L
A
H
K
R
--
M
R
T
V
T
-----
N
Y
F
L
V
----
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
------
Y
--
C
K
F
H
N
F
F
P
----
I
A
A
V
F
A
---
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
---
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-
Y
S
T
T
----
E
T
----
M
-
P
S
R
V
V
C
M
I
E
W
-
P
E
H
P
------------------
N
K
-
I
--
Y
E
K
V
Y
H
I
C
---
V
T
V
L
--
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
--
V
---
G
I
T
L
W
A
S
E
-
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
---
R
K
-
V
-
V
K
M
M
I
V
V
V
C
T
F
A
I
-------
C
W
L
P
F
H
I
F
F
L
L
P
Y
-
I
----
N
PD-
L
YL-
K
---------
K
FI
Q
--
Q
V
Y
-----------
L
A
I
M
W
L
A
M
S
S
-
T
---------------
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
78.70
13%
-131
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------------------------------------
D
E
------
V
W
V
V
G
----------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-------
A
I
A
K
F
E
R
--
L
Q
T
V
T
-----
N
Y
F
I
T
----
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
------
W
--
C
E
F
W
T
S
I
D
----
V
L
C
V
T
A
---
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
-
M
----------
H
W
Y
R
-
A
T
H
Q
E
A
I
N
C
Y
-
A
E
E
T
------
C
C
D----
F
----
F
T
-
N
--
Q
A
Y
A
I
A
S
S
---
I
V
S
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------
Q
E
A
K
R
Q
L
N
-
I
F
-----------
E
--------------------
M
L
---
R
I
-
D
-
E
G
L
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-
P
----
S
---
L
---
N
---------
A
--
A
--
K
S
E
-----------
L
D
K
A
I
G
R
N
T
N
G
V
---------------
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
41
Fugue
77.12
16%
-132
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--------------------------------
M
N
G
--
T
E
G
P
N
F
Y
V
------
P
F
S
NKTGVVRSP
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-------
V
T
V
Q
H
K
K
--
L
R
T
P
L
-----
N
Y
I
L
L
----
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
--
C
N
L
E
G
F
F
A
----
T
L
G
G
E
I
---
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
------------
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
A
P
---
P
L
V
G
----
W
S
R
Y
I
P
E
----
G
M
Q
C
------
S
C
G
I
DYY
T
----
P
H
-
E
--
E
T
N
N
E
S
F
V
---
I
Y
M
F
--
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
A
-
A
Q
-----------
Q
--------------------
Q
E
---
S
A
-
T
-
T
Q
K
A
E
K
E
V
T
R
M
V
I
-------
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
----
G
---
V
---
A
---------
F
--
Y
--
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
-
A
---------------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
76.96
14%
-132
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-327]
-----------------------------------------------------------------------------
S
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-------
V
T
V
Q
H
K
K
--
L
R
T
P
L
-----
N
Y
I
L
L
----
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
--
C
N
L
E
G
F
F
A
----
T
L
G
G
E
I
---
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
---
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
---
I
---
P
-
E
-
G
M
Q
C
S
C
G
I
D
Y
-
Y
T
P
--------------
H
----
E
E
-
T
--
N
N
E
S
F
V
I
Y
---
M
F
V
V
--
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
--
L
---
V
F
T
V
K
E
A
A
-
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
---
K
E
-
V
-
T
R
M
V
I
I
M
V
I
A
F
L
I
-------
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-
T
H
Q--
G
S--
D
---
F
---------
G
--
P
--
I
F
M
-----------
T
I
P
A
F
F
A
K
T
S
-
A
---------------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
71.52
16%
-145
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
---------------------------------------------------------------------------
N
K
Y
V
----------------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
-------
V
I
L
Y
S
R
V
--
G
R
S
V
T
-----
D
V
Y
L
L
----
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
------
L
--
C
K
V
V
S
L
L
K
----
E
V
N
F
Y
S
---
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
---
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-
F
R
Q
A
Y
---
H
--
P
--
N
-
N
S
S
P
V
C
Y
E
V
L
-
G
----------------
N
----
D
T
-
A
K-
W
R
M
V
L
R
I
L
---
P
H
T
F
--
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
--
T
---
L
R
T
L
F
K
A
H
-
M
------------
G
--------------------
Q
K
---
H
R
-
A
-
M
R
V
I
F
A
V
V
L
I
F
L
L
-------
C
W
L
P
Y
N
L
V
L
L
A
D
T
-
L
M
RTQ
V
IQE
S
C
E
R
R
---------
N
--
N
I
G
R
A
L
-----------
D
A
T
E
I
L
G
F
L
H
-
S
---------------
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
65.93
20%
-164
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-222]
-----------------------------------------------------------------------------
S
V
----------------
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-------
A
V
W
L
N
S
N
--
L
Q
N
V
T
-----
N
Y
F
V
V
----
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
------
G
--
C
L
F
I
A
C
F
V
----
L
V
L
T
Q
S
---
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
---
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
---
G
Q
--------
S
Q
G
C
G
E
G
Q
----
V
------
A
C
-----
L
----
F
E
-
D
VV
P
M
N
Y
M
V
Y
F
---
N
F
F
A
--
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
---
F
L
A
A
R
R
Q
L
-
N
I
-----------
F
--------------------
E
M
---
L
R
-
I
-
D
E
G
L
R
L
K
I
Y
K
D
T
E
-------
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-
S
----
P
---
S
---
L
---------
N
--
A
--
A
K
S
-----------
E
L
D
K
A
I
G
R
N
T
-
N
---------------
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
65.73
18%
-169
- C1 -
3GRE
-
VPS15_YEAST
A:
[1031-1454]
ESIEKFLSTFILPPLRDYKEFGPIQEIVRSPN
M
G
N
LR
G
K
L
I
A
T
L
M
ENEPNS
I
T
S
---------
S
A
V
S
P
------
G
-
E
T
P
----------------
Y
L
I
T
G
S
D
Q
G
V
I
K
I
W
N
L
K
E
I
I
V
GEVYSSS
L
T
Y
D
C
S
S
TV
T
Q
I
T
M
IPNFD
A
F
A
V
S
S
KDG
Q
I
I
V
L
K
V
N
H
Y
Q
Q
E
-
S
E
V
K
F
L
N
C
E
C
I
R
K
I
N
L
K
N
FGKNEY
A
--
V
R
M
R
A
F
V
N
EE
K
S
L
L
V
A
L
T
NLS
R
V
I
I
F
D
I
R
T
L
E
R
L
Q
I
I
E
N
S
P
R
H
GAV
S
S
I
C
I
D
E
E
C
C
V
L
I
L
G
T
-
T
R
G
I
I
D
I
W
D
I
R
F
N
V
L
I
R
S
---
W
S
F
G
D
H
A
P
I
T
H
V
E
V
C
Q
F
Y
-
G
K
N
S
------
V
I
-----
V
V
G
GS
S
K
-
T
--
F
L
T
I
W
N
F
V
KGH
C
Q
Y
A
--
F
I
N
S
D
E
Q
P
S
M
E
H
F
L
P
--
I
EKG
L
E
E
L
N
F
C
G
-
I
R
-----------
S
--------------------
L
N
---
A
L
S
T
-
I
S
V
S
N
D
K
I
L
L
T
D
E
-------
A
T
S
S
I
V
M
F
S
L
N
E
L
-
S
----
S
---
S
---
K
AVISPF
S
D
V
F
--
I
--
P
T
Q
-----------
V
T
A
N
L
T
M
L
L
R
-
K
---------------
M
K
H
D
I
I
N
S
I
S
T
C
E
V
D
E
T
-
P
L
L
V
A
C
D
N
S
G
L
I
G
I
F
Q------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.83
23%
-172
- C3 -
2Y00
9
ADRB1_MELGA
A:
[8-158]
-------------------------------------------------------------------
Q
------
Q
W
E
A
G
----------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
-------
A
I
G
S
T
Q
R
--
L
Q
T
L
T
-----
N
L
F
I
T
----
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-----
L
--
C
E
L
W
T
S
L
D
----
V
L
C
V
T
A
---
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
---
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-
M
-----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
------
C
Y
-----
Q
----
D
P
-
G
--
C
C
D
F
V
T
N
R
---
A
Y
A
I
--
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
--
F
---
V
A
L
R
V
Y
R
E
-
A
K
-----------
E
--------------------
Q
S
---
R
V
-
M
-
L
M
R
E
H
K
A
L
K
T
L
G
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
----
V
---
N
---
I
---------
V
--
N
--
V
F
N
-----------
R
D
L
V
P
D
W
L
F
V
-
A
---------------
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.73
23%
-166
- C3 -
2Y01
9
ADRB1_MELGA
A:
[8-158]
-------------------------------------------------------------------
Q
------
Q
W
E
A
G
----------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
-------
A
I
G
S
T
Q
R
--
L
Q
T
L
T
-----
N
L
F
I
T
----
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
-----
L
--
C
E
L
W
T
S
L
D
----
V
L
C
V
T
A
---
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
---
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
-
M
-----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
------
C
Y
-----
Q
----
D
P
-
G
--
C
C
D
F
V
T
N
R
---
A
Y
A
I
--
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
--
F
---
V
A
L
R
V
Y
R
E
-
A
K
-----------
E
--------------------
Q
S
---
R
V
-
M
-
L
M
R
E
H
K
A
L
K
T
L
G
I
-------
I
M
G
V
F
T
L
C
W
L
P
F
F
-
L
----
V
---
N
---
I
---------
V
--
N
--
V
F
N
-----------
R
D
L
V
P
D
W
L
F
V
-
A
---------------
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------