@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR7A5_HUMAN: (2016-01-14 )
MEPGNDTQISEFLLLGFSQEPGLQPFLFGLFLSMYLVTVLGNLLIILATISDSHLHTPMYFFLSNLSFADICVTSTTIPKMLMNIQTQNKVITYIACLMQMYFFILFAGFENFLLSVMAYDRFVAICHPLHYMVIMNPHLCGLLVLASWTMSALYSLLQILMVVRLSFCTALEIPHFFCELNQVIQLACSDSFLNHMVIYFTVALLGGGPLTGILYSYSKIISSIHAISSAQGKYKAFSTCASHLSVVSLFYGAILGVYLSSAATRNSHSSATASVMYTVVTPMLNPFIYSLRNKDIKRALGIHLLWGTMKGQFFKKCP
Atome Classification :
(20 SA)
------------.--........10...-.....20.......-----------.30........40--..------...--------....50........60........70.--.....-..80......----..90....-----------------....100..------.....------110.......120.......--130.......140.......150...------....160---....------...170.......180.-------.......-------190-----...--......200..--.....210.......220.--......230-------------------.--------.----...-----...240.......250...----..-..260..-.--.------------.------..-------270-----------........280.........--------290..----......300.....--------.------------.310--.......--------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------M--EPGN
D
T
Q
I
S
E
F
L
L
-LGFSQEPGL
Q
P
F
L
F
-----------
G
L
F
L
S
M
Y
L
V
T
V
L
---
G
N
------
L
L
I
--------
I
L
A
TISDSHLH
T
P
M
Y
F
F
L
SNL
S
F
A
D
I
C--VTST
T
-
I
P
K
M
L
M
N
IQT----Q
N
K
V
I
T
Y
I
-----------------
A
C
L
M
Q
M
Y
F
F
------
I
L
F
A
G
------
F
E
N
F
L
L
S
V
M
A
Y
D
R
F
V
A
I
CHP--
L
H
Y
M
V
I
MNP
H
L
C
G
L
L
V
L
A
S
W
T
M
S
A
L
Y
------
S
L
L
Q
I
L
M
---
V
V
R
L
------
S
F
C
T
ALE
I
P
H
F
F
C
E
-
L
N
-------
Q
V
I
Q
L
AC-------
S
-------
D
S
F
--
L
N
H
M
V
I
Y
F
T
V
A
--
L
LGGG
P
L
T
G
I
L
Y
S
Y
S
K
I
I
S
--
S
I
H
A
I
SSA--------------------Q--------G----
K
Y
K
-----
A
F
S
T
C
A
S
H
L
S
V
V
S
L
F
Y
G
A
I
----
L
G
-
V
Y
L
S
S
AA-T--R------------N------SH-------SS------------
A
T
A
S
V
M
Y
T
V
--
V
T
P
M
L
N
P
F
I
--------
Y
-
S
L
R----N
K
D
I
K
R
A
L
G
I
H
L
L
W
--------
G
------------TMK
G
--
Q
F
FKKCP--------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
93.38
18%
-112
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
-
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
LAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
---
I
N
------
F
L
T
--------
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
----
G
Y
F
V
F
G
P
T
-----------------
G
C
N
L
E
G
F
F
A
------
T
L
G
G
E
------
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
------
A
A
P
P
L
V
G
---
W
S
R
-------------
Y
I
P
E
G
M
---------------
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
--
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
--
T
V
K
E
A
A
A
S
--------------------
A
--------
T
----
T
Q
K
-----
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
----
W
L
-
P
Y
A
G
V
A
F
-
Y
--
I
------------
F
------
T
H
QGSDFGP
I
F
------------
M
T
I
P
A
F
F
A
K
--
T
S
A
V
Y
N
P
V
I
--------
Y
-
I
M
M
----
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
--------
G
------------
K
N
P
S
--
T
T
V
S
K
T
E
TS
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
88.01
18%
-135
- C4 -
2Z73
5
OPSD_TODPA
A:
[33-337]
-------------------------------------
V
Y
Y
S
L
G
-----------
I
F
I
G
I
C
G
I
I
G
C
G
---
G
N
------
G
I
V
--------
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
--
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
----
K
K
W
I
F
G
F
A
-----------------
A
C
K
V
Y
G
F
I
G
------
G
I
F
G
F
------
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
--
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
------
A
I
G
P
I
F
G
---
W
G
A
Y
------
T
L
----
E
G
V
L
C
N
C
S
-
F
D
-------
Y
I
S
-------------------
R
D
S
--
T
T
R
S
N
I
L
C
M
F
I
--
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
--
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
----
E
M
R
-----
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
----
A
V
-
V
A
L
L
A
Q
F
-
G
--
P
LEW---------
V
------
T
P
-------
Y
A
------------
A
Q
L
P
V
M
F
A
K
--
A
S
A
I
H
N
P
M
I
--------
Y
-
S
V
S
----
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
--------
V
------------
L
T
C
C
--
Q
F
D
D
K
E
T
--------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
85.48
17%
-124
- C4 -
1U19
14
OPSD_BOVIN
A:
[36-331]
----------------------------------
E
P
W
Q
F
S
M
L
A
-----------
A
Y
M
F
L
L
I
M
L
G
F
P
---
I
N
------
F
L
T
--------
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
----
G
Y
F
V
F
G
P
T
-----------------
G
C
N
L
E
G
F
F
A
------
T
L
G
G
E
------
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
------
A
A
P
P
L
V
G
---
W
S
R
Y
------
I
---
P
-
E
G
M
Q
C
S
C
G
-
I
D
-------
Y
Y
T
P
----------
H
-------
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
--
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
--
T
V
K
E
A
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
----
E
K
E
-----
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
----
A
G
-
V
A
F
Y
I
F
T
H
Q
GS
D
------------
F
------
G
P
-------
I
F
------------
M
T
I
P
A
F
F
A
K
--
T
S
A
V
Y
N
P
V
I
--------
Y
-
I
M
M
----
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
--------
G
------------
K
N
P
L
--
G
D
D
E
A
S
T
--------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
82.71
17%
-121
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
--
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
-----------
A
Y
M
F
L
L
I
M
L
G
F
P
---
I
N
------
F
L
T
--------
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
----
G
Y
F
V
F
G
P
T
-----------------
G
C
N
L
E
G
F
F
A
------
T
L
G
G
E
------
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
----------------
S
N
F
R
F
G
E
N
H
------
A
I
M
G
V
A
F
---
T
W
V
M
------
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-------
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
--
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
--
T
V
K
E
A
A
A
Q
--------------------
Q
--------
Q
ESA
T
T
Q
K
-----
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
----
W
L
-
P
Y
A
G
V
A
F
-
Y
--
I
------------
F
------
T
H
QGSDFGP
I
F
------------
M
T
I
P
A
F
F
A
K
--
T
S
A
V
Y
N
P
V
I
--------
Y
-
I
M
M
----
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
--------
G
KNPLGDDEA
S
T
T
V
S
K
T
--
E
T
S
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
80.45
15%
-127
* C4 *
2KS9
1
NK1R_HUMAN
A:
[34-328]
----------------------------------------
L
W
A
-----------
A
A
Y
T
V
I
V
V
T
S
V
V
---
G
N
------
V
V
V
--------
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
--
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
----
N
E
W
Y
Y
G
L
F
-----------------
Y
C
K
F
H
N
F
F
P
------
I
A
A
V
F
------
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
--
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
------
A
F
P
Q
G
Y
Y
---
S
T
T
E
------
T
-----
M
P
S
R
V
V
C
M
-
I
E
-------
W
P
E
H
P
N
-----------------
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
--
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
--
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
----
K
R
K
-----
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
----
H
I
-
F
F
L
L
P
Y
I
-
N
--
P
------------
D
LYLKKF
I
Q
-------
Q
V
------------
Y
L
A
I
M
W
L
A
M
--
S
S
T
M
Y
N
P
I
I
--------
Y
-
C
C
L
----
N
D
R
F
R
L
G
F
K
H
A
F
R
C
--------
C
------------
P
F
I
S
--
A
G
D
Y
E
G
L
--------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
75.95
15%
-117
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------
D
E
V
W
V
V
G
M
G
-----------
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
------
V
L
V
--------
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
----
K
M
W
T
F
G
N
F
-----------------
W
C
E
F
W
T
S
I
D
------
V
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
--
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
------
S
F
L
P
I
Q
M
HWY
R
A
T
H
------
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
-
F
F
TN
Q
A
Y
A
I
A
S
S
I
V
S
F
-------
Y
-------
V
P
L
--
V
I
M
V
F
V
Y
S
R
V
F
--
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
--
R
L
K
I
Y
K
D
T
--------------------
E
--------
G
----
Y
Y
T
-----
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
----
L
D
-
K
A
I
G
R
N
T
-
N
--
G
------------
V
------
I
T
-------
K
D
------------
E
A
E
K
L
F
N
Q
D
--
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
-
D
S
L
----
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
--------
M
------------
G
E
T
G
--
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL----------------
48
Fugue
75.65
16%
-156
* C5 *
4RDQ
9
?
A:
[1-366]
--------TVTY
T
--
N
R
V
A
D
A
R
L
G
T
F
S
Q
-
L
L
L
Q
W
K
G
S
I
Y
K
L
L
Y
-----------
S
E
F
L
-
I
F
I
S
L
Y
F
---
A
I
------
S
L
V
--------
Y
R
L
I
L
S
E
S
Q
R
L
M
F
E
K
L
A
L
Y
C
N
S
Y
A
E
L
I
--
P
V
S
F
V
-
L
G
F
Y
V
S
L
V
V
S
R
W
W
A
Q
Y
E
S
I
P
W
P
-----------------
D
R
I
M
N
L
V
S
C
------
N
V
--------------------
D
G
E
D
E
Y
G
R
L
--
L
R
R
T
L
M
R
Y
S
N
L
C
S
V
L
I
L
R
S
V
S
T
A
V
Y
K
------
R
F
P
S
M
E
H
---
V
V
R
A
------
G
L
M
T
P
E
E
H
K
K
F
E
S
L
-
N
S
-------
P
H
N
K
F
W
I
-------
P
-------
C
V
W
--
F
S
N
L
A
V
K
A
R
N
E
GR
I
R
D
S
V
L
L
Q
G
I
L
N
E
L
N
T
L
R
S
--
Q
C
G
R
L
Y
G
Y
--------------------
D
W
-------
I
----
S
I
P
-----
L
V
Y
T
Q
V
V
T
V
A
V
Y
S
F
F
L
A
C
L
----
I
G
R
Q
F
L
D
P
E
K
-
A
--
Y
------------
P
------
G
H
-------
E
L
DLFVP
V
F
T
F
L
Q
F
F
F
Y
A
G
W
L
K
V
--
A
E
Q
L
I
N
P
F
G
--------
E
-
D
D
D
DFE
T
N
W
L
I
D
R
N
L
Q
V
S
L
M
A
V
D
E
MHQDL
P
------------
I
L
E
K
--
D
L
Y
W
N
E
P
D
P
Q
P
P
Y
T
AATAEYKRPSFLGSTFDIS------------------------------------------------------------------------------------------------------------------
34
HHSearch
74.68
17%
-124
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
-----------------------------------
T
L
N
K
Y
V
V
I
-----------
I
A
Y
A
L
V
F
L
L
S
L
L
---
G
N
------
S
L
V
--------
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
--
F
A
L
T
--
L
P
I
W
A
A
S
K
-
V
----
N
G
W
I
F
G
T
F
-----------------
L
C
K
V
V
S
L
L
K
------
E
V
N
F
Y
------
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
--
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
------
S
L
P
F
F
L
F
---
R
Q
A
Y
------
H
----
P
N
N
S
S
P
V
C
Y
-
E
V
-------
L
G
N
D
------------------
T
A
K
--
W
R
M
V
L
R
I
L
P
H
T
--
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
--
T
L
F
K
A
H
M
---------------------
G
--------
Q
----
K
H
R
-----
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
----
N
L
-
V
L
L
A
D
T
L
-
M
--
R
TQVIQE
S
C
E
R
R
N
N
------
I
G
-------
R
A
------------
L
D
A
T
E
I
L
G
F
--
L
H
S
C
L
N
P
I
I
--------
Y
-
A
F
I
----
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
--------
H
------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
73.03
15%
-135
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
----------------
P
C
F
R
E
E
N
A
N
F
-----------
N
K
I
F
L
P
-----------
T
I
Y
S
I
I
F
L
T
G
I
V
---
G
N
------
G
L
V
--------
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
--
F
V
I
T
--
L
P
F
W
A
V
D
A
V
A
----
N
W
-
Y
F
G
N
F
-----------------
L
C
K
A
V
H
V
I
Y
------
T
V
N
L
Y
------
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
--
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
------
T
I
P
D
F
I
F
---
A
N
V
S
E
A
DD
R
Y
I
C
D
R
F
Y
P
N
D
L
W
V
V
V
-
F
Q
-------
F
Q
H
I
M
V
G
-------
L
-------
I
L
P
--
G
I
V
I
L
S
C
Y
C
I
I
--
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
--------------------
E
--------
G
----
Y
Y
T
I
GIGH
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNT
N
G
-
V
I
T
K
D
E
A
-
E
--
K
------------
L
------
F
N
-------
Q
D
------------
V
D
A
A
V
R
G
I
L
--
R
N
A
K
L
K
P
V
Y
--------
D
-
S
L
D
------
A
V
R
R
A
A
L
I
N
M
V
F
--------
Q
MG
E
T
--------
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
28
HHSearch
71.48
22%
-162
- C4 -
3EML
8
ENLYS_BPT4
A:
[22-222]
---------------------------------------
S
V
Y
I
-----------
T
V
E
L
A
I
A
V
L
A
I
L
---
G
N
------
V
L
V
--------
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
------
G
F
C
A
A
C
H
-----------------
G
C
L
F
I
A
C
F
V
------
L
V
L
T
Q
------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
--
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
------
G
L
T
P
M
L
G
---
W
N
N
C
------
G
Q
-------
S
Q
G
C
G
-
E
G
-------
Q
---
V
A
C
-------
L
-------
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
--
A
A
R
R
Q
L
N
I
--------------------
F
--------
E
----
M
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----
G
I
-
G
H
L
L
T
K
S
-
P
--
S
------------
L
------
N
A
-------
A
K
------------
S
E
L
D
K
A
I
G
R
--
N
T
N
G
V
I
T
K
D
--------
E
-
A
E
K
----
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--------
R
------------
N
A
K
L
--
K
P
V
Y
D
S
L
--------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
70.30
22%
-137
- C4 -
2RH1
6
ADRB2_HUMAN (first)
A:
[37-236]
-----------------------------------
E
V
W
V
V
G
M
G
-----------
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
------
V
L
V
--------
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
----
K
M
W
T
F
G
N
F
-----------------
W
C
E
F
W
T
S
I
D
------
V
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
--
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
------
S
F
L
P
I
Q
M
---
H
W
Y
R
------
A
T
----
H
Q
E
A
I
N
C
Y
-
A
E
-----------
E
T
C
-------
C
-------
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
--
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
--
E
A
K
R
Q
L
N
I
--------------------
F
--------
E
----
M
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----
G
I
-
G
H
L
L
T
K
S
-
P
--
S
------------
L
------
N
A
-------
A
K
------------
S
E
L
D
K
A
I
G
R
--
N
T
N
G
V
I
T
K
D
--------
E
-
A
E
K
----
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--------
R
------------
N
A
K
L
--
K
P
V
Y
D
S
L
--------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
70.27
14%
-142
- C2 -
2CE7
1
FTSH_THEMA
A:
[5-457]
------------
Y
--
K
P
S
G
N
K
R
V
T
F
K
D
V
-
G
G
A
E
E
A
I
E
E
L
K
E
V
V
-----------
E
F
L
K
D
P
S
K
F
N
R
I
---
G
A
RMPK
G
I
L
L
V
G
P
P
GTG
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
-
F
F
H
I
S
G
S
D
F
V
E
L
F
VG
V
G
A
A
R
-
V
R
D
L
F
A
Q
A
K
A
----
H
A
P
C
I
V
F
I
D
EIDAVGRHD
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
DSKEG
I
I
V
M
A
A
T
NRPDI
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
N
L
E
I
I
A
K
R
T
PGF
V
G
A
D
L
E
N
---
L
V
N
E
------
A
A
L
L
A
A
R
E
G
R
D
K
I
T
-
M
K
-------
D
F
E
E
A
I
D
-------
R
-------
V
I
L
--
I
S
P
A
E
K
R
I
I
A
Y
--
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
--
R
I
S
I
I
K
Y
L
--------------------
V
--------
S
----
R
N
E
-----
L
L
D
K
L
T
A
L
L
-
G
G
R
A
A
E
E
V
V
----
F
G
-
D
V
T
S
G
A
A
-
N
--
D
------------
I
------
E
R
-------
A
T
------------
E
I
A
R
N
M
V
C
Q
LG
M
S
E
E
L
G
P
L
A
--------
W
G
K
L
R
----
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
--------
K
------------
K
I
V
T
--
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
KETIE
G
D
E
L
R
R
I
L
S-----------------------------------------------------------------------------------------------------------
24
HHSearch
68.39
20%
-142
- C4 -
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
---------------------------------------
V
F
I
V
-----------
L
V
A
G
S
L
S
L
V
T
I
I
---
G
N
------
I
L
V
--------
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
--
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
----
G
Y
W
P
L
G
P
V
-----------------
V
C
D
L
W
L
A
L
D
------
Y
V
V
S
N
------
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
--
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
------
W
A
P
A
I
L
F
---
W
Q
F
I
------
V
--
G
V
R
T
V
E
D
G
E
C
Y
-
I
Q
-------
F
-----------------------
F
--
S
N
A
A
V
T
F
G
T
A
I
--
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
--
A
S
K
S
R
I
N
I
--------------------
F
--------
E
----
M
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----
G
I
-
G
H
L
L
T
K
S
-
P
--
S
------------
L
------
N
A
-------
A
K
------------
S
E
L
D
K
A
I
G
R
--
N
T
N
G
V
I
T
K
D
--------
E
-
A
E
K
----
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--------
R
------------
N
A
K
L
--
K
P
V
Y
D
S
L
--------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
68.09
21%
-138
- C4 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-201]
----------------------------------------
P
L
V
-----------
V
V
L
S
T
I
C
L
V
T
V
G
---
L
N
------
L
L
V
--------
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
--
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
----
S
K
W
S
L
G
R
P
-----------------
L
C
L
F
W
L
S
M
D
------
Y
V
A
S
T
------
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
--
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
------
V
I
P
I
L
G
W
----
N
H
--------------
R
R
E
D
K
C
E
-
T
D
-------
F
Y
-------------------------
D
V
T
W
F
K
V
M
T
A
I
--
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
--
A
V
R
Q
H
C
N
I
--------------------
F
--------
E
----
M
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----
G
I
-
G
H
L
L
T
K
S
-
P
--
S
------------
L
------
N
A
-------
A
K
------------
S
E
L
D
K
A
I
G
R
--
N
T
N
G
V
I
T
K
D
--------
E
-
A
E
K
----
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--------
R
------------
N
A
K
L
--
K
P
V
Y
D
S
L
--------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.49
28%
-157
- C4 -
4AMI
3
ADRB1_MELGA
A:
[8-149]
--------------------------------------
Q
Q
W
E
A
-----------
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
------
V
L
V
--------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
--
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
----
G
T
W
L
W
G
S
F
-----------------
L
C
E
L
W
T
S
L
D
------
V
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
--
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
------
S
F
L
P
I
M
M
---
H
W
W
R
------
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
-
C
C
-------
D
F
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
L
M
R
--
E
H
K
A
L
K
T
L
--------------------
G
--------
I
----
I
M
G
-----
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
----
R
D
-
L
V
P
D
W
L
F
-
V
--
A
------------
F
------
N
W
-------
L
G
------------
Y
A
N
S
A
M
N
P
I
--
I
Y
C
R
S
P
D
F
R
--------
K
-
A
F
K
----
R
L
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.11
28%
-160
- C4 -
4AMJ
6
ADRB1_MELGA
A:
[8-149]
--------------------------------------
Q
Q
W
E
A
-----------
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
------
V
L
V
--------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
--
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
----
G
T
W
L
W
G
S
F
-----------------
L
C
E
L
W
T
S
L
D
------
V
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
--
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
------
S
F
L
P
I
M
M
---
H
W
W
R
------
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
-
C
C
-------
D
F
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
S
R
V
--
M
L
M
R
E
H
K
A
--------------------
L
--------
K
----
T
L
G
-----
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
----
N
V
-
F
N
R
D
L
V
P
-
D
--
W
------------
L
------
F
V
-------
A
F
------------
N
W
L
G
Y
A
N
S
A
--
M
N
P
I
I
Y
C
R
S
--------
P
-
D
F
R
----
K
A
F
K
R
L
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.08
28%
-159
- C4 -
2Y00
7
ADRB1_MELGA
A:
[8-149]
--------------------------------------
Q
Q
W
E
A
-----------
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
------
V
L
V
--------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
--
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
----
G
T
W
L
W
G
S
F
-----------------
L
C
E
L
W
T
S
L
D
------
V
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
--
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
------
S
F
L
P
I
M
M
---
H
W
W
R
------
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
-
C
C
-------
D
F
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
S
R
V
--
M
L
M
R
E
H
K
A
--------------------
L
--------
K
----
T
L
G
-----
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
----
N
V
-
F
N
R
D
L
V
P
-
D
--
W
------------
L
------
F
V
-------
A
F
------------
N
W
L
G
Y
A
N
S
A
--
M
N
P
I
I
Y
C
R
S
--------
P
-
D
F
R
----
K
A
F
K
R
L
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.04
28%
-158
- C4 -
4BVN
9
ADRB1_MELGA
A:
[8-149]
--------------------------------------
Q
Q
W
E
A
-----------
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
------
V
L
V
--------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
--
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
----
G
T
W
L
W
G
S
F
-----------------
L
C
E
L
W
T
S
L
D
------
V
L
C
V
T
------
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
--
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
------
S
F
L
P
I
M
M
---
H
W
W
R
------
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
-
C
C
-------
D
F
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
R
K
T
S
R
V
M
L
--------------------
M
--------
R
----
E
H
K
-----
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
----
F
L
-
V
N
I
V
N
V
F
-
N
--
R
------------
D
------
L
V
-------
P
K
------------
W
L
F
V
A
F
N
W
L
--
G
Y
A
N
S
A
M
N
P
--------
I
-
I
L
C
----
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.93
28%
-159
- C4 -
2Y02
7
ADRB1_MELGA
A:
[8-149]
--------------------------------------
Q
Q
W
E
A
-----------
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
------
V
L
V
--------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
--
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
----
G
T
W
L
W
G
S
F
-----------------
L
C
E
L
W
T
S
L
D
------
V
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
--
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
------
S
F
L
P
I
M
M
---
H
W
W
R
------
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
-
C
C
-------
D
F
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
S
R
V
--
M
L
M
R
E
H
K
A
--------------------
L
--------
K
----
T
L
G
-----
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
----
N
V
-
F
N
R
D
L
V
P
-
D
--
W
------------
L
------
F
V
-------
A
F
------------
N
W
L
G
Y
A
N
S
A
--
M
N
P
I
I
Y
C
R
S
--------
P
-
D
F
R
----
K
A
F
K
R
L
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.62
28%
-159
- C4 -
3ZPQ
7
ADRB1_MELGA
A:
[8-149]
--------------------------------------
Q
Q
W
E
A
-----------
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
------
V
L
V
--------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
--
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
----
G
T
W
L
W
G
S
F
-----------------
L
C
E
L
W
T
S
L
D
------
V
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
--
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
------
S
F
L
P
I
M
M
---
H
W
W
R
------
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
-
C
C
-------
D
F
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
S
R
V
--
M
L
M
R
E
H
K
A
--------------------
L
--------
K
----
T
L
G
-----
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
----
N
V
-
F
N
R
D
L
V
P
-
D
--
W
------------
L
------
F
V
-------
A
F
------------
N
W
L
G
Y
A
N
S
A
--
M
N
P
I
I
Y
C
R
S
--------
P
-
D
F
R
----
K
A
F
K
R
L
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------