@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR7AA_HUMAN: (2016-01-14 )
MKSWNNTIILEFLLLGISEEPELQAFLFGLFLSMYLVTVLGNLLIILATISDSHLHTPMYFFLSNLSFVDICFVSTTVPKMLVNIQTHNKVITYAGCITQMCFFLLFVGLDNFLLTVMAYDRFVAICHPLHYMVIMNPQLCGLLVLASWIMSVLNSMLQSLMVLPLPFCTHMEIPHFFCEINQVVHLACSDTFLNDIVMYFAVALLGGGPLTGILYSYSKIVSSIRAISSAQGKYKAFSTCASHLSVVSLFYGTCLGVYLSSAATHNSHTGAAASVMYTVVTPMLNPFIYSLRNKHIKGAMKTFFRGKQ
Atome Classification :
(20 SA)
-----------.........10.......----------.--20........30...-....---.40........50........60........70......-..80........90.....--...100.......110.......120.......130.......140.......150.......160-..---.....170...---.---...180---.......190.-..-.----...200.......210.......220........230-------------------..----......240.......250.......260.--..-------.-----.--..270------........----280.......290.......300.......-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MKSWN
N
T
I
I
L
E
F
L
L
LGIS----------E--
E
P
E
L
Q
A
F
L
F
G
L
F
L
S
M
-
Y
L
V
T
---
V
L
G
N
L
L
I
I
L
A
TISDSHLH
T
P
M
Y
F
F
L
SNL
S
F
V
D
I
C
F
VSTT-VP
K
M
L
V
N
I
QTHN
K
V
I
T
Y
A
G
--
C
I
T
Q
M
C
F
F
L
L
F
V
G
L
D
N
F
L
L
T
V
M
A
Y
D
R
F
V
A
I
CHP
L
H
Y
M
V
I
MNP
Q
L
C
G
L
L
V
L
A
S
W
I
M
S
V
L
N
S
M
L
Q
S
L
M
-VL---PLPFCTHME
I
P
---
H
---
F
F
C
E
I
N
---
Q
V
V
H
LAC
S
D
T
F
-
L
N
-
D
----
I
V
M
Y
F
A
V
A
L
LGGG
P
L
T
G
I
L
Y
S
Y
S
K
I
-
V
S
S
I
R
A
I
S
SA--------------------QG----
K
Y
K
A
F
S
T
C
A
S
H
L
S
V
V
S
L
F
Y
G
T
C
L
G
V
Y
L
S
SA--AT-------H-----N--SHT
G
-------
A
A
A
S
V
M
Y
T
----
V
V
T
P
M
L
N
P
F
I
Y
S
L
R
N
K
H
I
K
G
A
M
K
T
F
FRGKQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
89.28
19%
-127
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
----------
Y
LA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
-
I
M
L
G
---
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-----------
P
P
L
V
G
W
S
R
Y
I
P
---
E
GMQ
C
S
C
G
I
D
---
Y
Y
T
P
---
H
E
E
T
-
N
N
-
E
----
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
A
A
A
S
--------------------
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--
F
Y
-------
I
-----
F
--
T
H
Q
G
SDFGPIF
M
T
I
P
A
F
F
A
----
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
NPSTTVSKTETS
Q
V
A
P
A------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
87.29
17%
-132
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-323]
------------------------------------------------
L
W
A
A
A
Y
T
V
I
-
V
V
T
S
---
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
--
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
----
T
T
E
T
----
M
P
S
---
R
---
V
V
C
M
I
E
---
W
P
E
H
P
---
N
K
I
-
Y
E
-
K
----
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
---------
S
A
----
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
--
I
N
-------
P
DLYL-
K
KF
I
Q
Q
V
-------
Y
L
A
I
M
W
L
A
----
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
86.75
19%
-130
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--------MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYL
A
--
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
-
I
M
L
G
---
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-------
P
---
P
L
V
G
W
S
R
Y
-
I
P
E
GM
Q
---
C
S
C
G
I
D
---
Y
Y
T
P
---
H
E
E
T
-
N
N
-
E
----
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
A
A
A
Q
--------------------
Q
Q
ESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--
F
Y
-------
I
-----
F
--
T
H
Q
G
SDFGPIF
M
T
I
P
A
F
F
A
----
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
NPLGDDEA
S
T
T
V
S
K
TETSQVAPA------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
83.58
18%
-138
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-332]
---------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
-
G
I
I
G
---
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
--
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
---
A
Y
T
L
----
E
G
V
---
L
---
C
N
C
S
F
D
---
Y
I
S
R
-----
D
S
-
T
T
-
R
----
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
----
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
--
F
G
-------
P
LEW--
V
--
T
P
Y
A
-------
A
Q
L
P
V
M
F
A
----
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
76.60
17%
-127
- C3 -
1U19
14
OPSD_BOVIN
A:
[37-325]
-------------------------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
-
I
M
L
G
---
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
---
R
Y
I
P
----
E
G
M
---
Q
---
C
S
C
G
I
D
---
Y
Y
T
P
---
H
E
E
T
-
N
N
-
E
----
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
A
A
A
Q
QQESA
T
T
Q
------------
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S------
D
-----
F
--
G
P
I
F
-------
M
T
I
P
A
F
F
A
----
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
76.11
16%
-113
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
-
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-
H
W
YRA
T
H
Q
E
A
I
N
C
Y
A
E
---
E
---
T
C
C
D
F
F
TN
Q
A
Y
A
I
A
S
S
I
V
S
F
-
Y
V
-
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
-
G
L
R
L
K
I
Y
K
D
T
--------------------
E
G
----
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
--
T
N
-------
G
-----
V
--
I
T
K
D
-------
E
A
E
K
L
F
N
Q
----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL-------------------------------------
12
PsiBlast_PDB
71.37
25%
-139
- C3 -
4LDL
3
ADRB2_HUMAN
A:
[186-376]
---------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
--
I
-
Q
M
---
H
W
Y
R
A
T
H
Q
E
------------
A
I
N
---
C
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
----
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
Q
K
--------------------
F
A
----
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
--
H
V
-------
I
-----
Q
--
D
N
L
I
-------
R
K
E
V
Y
I
L
L
----
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.28
24%
-137
- C3 -
4GBR
1
ADRB2_HUMAN
A:
[2-199]
----------------------------------------------
E
V
W
V
V
G
M
G
I
V
M
-
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
------
H
W
Y
R
A
T
H
Q
E
------------
A
I
N
---
C
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
----
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
Q
K
--------------------
I
D
----
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
--
N
I
-------
V
-----
H
--
V
I
Q
D
-------
N
L
I
R
K
E
V
Y
----
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
70.97
15%
-124
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------P
C
F
R
E
E
N
A
N
F
--------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
-
F
L
T
G
---
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
A
N
W
-
Y
F
G
N
F
L
--
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
--------
A
N
V
S
E
A
D
D
R
---
Y
---
I
C
D
R
F
Y
---
P
N
D
L
W
V
V
V
F
Q
F
-
Q
H
-
I
----
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
--------------------
E
G
----
L
R
L
K
I
Y
K
D
T
E
G
------
Y
Y
T
I
G
I
G
H
L
L
T
K
S
--
P
S
-------
L
-----
N
--
A
A
K
S
-------
E
L
D
K
A
I
G
R
NTNG
V
I
T
---
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
LK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
13
PsiBlast_PDB
70.97
25%
-138
- C3 -
4LDO
3
A:
[186-376]
---------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
--
I
-
Q
M
---
H
W
Y
R
A
T
H
Q
E
------------
A
I
N
---
C
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
----
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
Q
K
--------------------
F
A
----
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
--
H
V
-------
I
-----
Q
--
D
N
L
I
-------
R
K
E
V
Y
I
L
L
----
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.81
25%
-136
- C3 -
4LDE
3
A:
[186-376]
---------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
--
I
-
Q
M
---
H
W
Y
R
A
T
H
Q
E
------------
A
I
N
---
C
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
----
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
Q
K
--------------------
F
A
----
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
--
H
V
-------
I
-----
Q
--
D
N
L
I
-------
R
K
E
V
Y
I
L
L
----
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
70.03
23%
-141
* C3 *
2RH1
6
ADRB2_HUMAN (first)
A:
[41-235]
-----------------------------------------------
V
G
M
G
I
V
M
S
L
I
-
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
--
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
---
R
A
T
H
Q
-----
E
---
A
---
I
N
C
Y
A
-------
E
E
T
C
C
D
F
F
-
T
N
-
Q
----
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
N
I
--------------------
F
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-------
S
-----
L
--
N
A
A
K
-------
S
E
L
D
K
A
I
G
----
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
69.68
16%
-125
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
-
F
L
L
S
---
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
--
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
---
A
Y
H
P
----
N
N
S
---
S
---
P
V
C
Y
E
V
---
L
G
N
D
----
T
A
K
-
W
R
-
M
----
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-
L
R
T
L
F
K
A
H
M
G
---------------------
Q
----
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
--
L
M
RTQVIQE
S
C
E
R
R
N
N
--
I
G
R
A
-------
L
D
A
T
E
I
L
G
----
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.85
24%
-154
- C3 -
3D4S
6
ENLYS_BPT4
A:
[40-235]
----------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
--
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
--
I
-
Q
M
---
H
W
Y
R
A
T
H
Q
E
------------
A
I
N
---
C
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
----
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
N
I
--------------------
F
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-------
S
-----
L
--
N
A
A
K
-------
S
E
L
D
K
A
I
G
----
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
68.70
24%
-150
- C3 -
3NY8
7
ENLYS_BPT4
A:
[40-235]
----------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
--
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
--
I
-
Q
M
---
H
W
Y
R
A
T
H
Q
E
------------
A
I
N
---
C
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
----
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
N
I
--------------------
F
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-------
S
-----
L
--
N
A
A
K
-------
S
E
L
D
K
A
I
G
----
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.54
24%
-153
- C3 -
3NY9
4
ADRB2_HUMAN (first)
A:
[40-235]
----------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
--
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
--
I
-
Q
M
---
H
W
Y
R
A
T
H
Q
E
------------
A
I
N
---
C
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
----
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
N
I
--------------------
F
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-------
S
-----
L
--
N
A
A
K
-------
S
E
L
D
K
A
I
G
----
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.91
24%
-151
- C3 -
3NYA
3
ADRB2_HUMAN (first)
A:
[40-235]
----------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
--
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
--
I
-
Q
M
---
H
W
Y
R
A
T
H
Q
E
------------
A
I
N
---
C
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
----
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
N
I
--------------------
F
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-------
S
-----
L
--
N
A
A
K
-------
S
E
L
D
K
A
I
G
----
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
65.34
22%
-154
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-221]
-----------------------------------------------
S
V
Y
I
T
V
E
L
A
I
-
A
V
L
A
---
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
--
T
G
F
C
A
A
C
H
G
--
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
Q
----------
S
---
Q
G
C
G
E
G
---
Q
---
V
A
C
L
F
E
D
V
V
P
M
N
----
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
Q
L
N
I
--------------------
F
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-------
S
-----
L
--
N
A
A
K
-------
S
E
L
D
K
A
I
G
----
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
64.23
19%
-139
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[25-215]
------------------------------------------------
F
I
V
L
V
A
G
S
L
-
S
L
V
T
---
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
V
V
--
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
---
F
I
V
G
--
V
R
T
V
E
---
D
---
G
E
C
Y
I
Q
---
F
---------
F
-
S
N
-
A
----
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
-
S
R
A
S
K
S
R
I
N
I
--------------------
F
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-------
S
-----
L
--
N
A
A
K
-------
S
E
L
D
K
A
I
G
----
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
62.17
19%
-133
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[11-200]
-------------------------------------------------
L
V
V
V
L
S
T
I
-
C
L
V
T
---
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
P
L
--
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-
G
-
W
N
---
H
--------
R
R
---
E
---
D
K
C
E
T
D
---
F
Y
----------
D
V
-
T
----
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
-
Y
K
A
V
R
Q
H
C
N
I
--------------------
F
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-------
S
-----
L
--
N
A
A
K
-------
S
E
L
D
K
A
I
G
----
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------