@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR7C1_HUMAN: (2016-01-14 )
METGNQTHAQEFLLLGFSATSEIQFILFGLFLSMYLVTFTGNLLIILAICSDSHLHTPMYFFLSNLSFADLCFTSTTVPKMLLNILTQNKFITYAGCLSQIFFFTSFGCLDNLLLTVMAYDRFVAVCHPLHYTVIMNPQLCGLLVLGSWCISVMGSLLETLTVLRLSFCTEMEIPHFFCDLLEVLKLACSDTFINNVVIYFATGVLGVISFTGIFFSYYKIVFSILRISSAGRKHKAFSTCGSHLSVVTLFYGTGFGVYLSSAATPSSRTSLVASVMYTMVTPMLNPFIYSLRNTDMKRALGRLLSRATFFNGDITAGLS
Atome Classification :
(20 SA)
----------------.........10........20...----------------.....--30.-.......---40.........50........60..----------......70......-..80........90---........100......--.110....-------...120.......130.......140...----....150.......160.......170.......180......----..-------190-----......-------...200.....--..210---.....---..220...---------------....230----------.--------------------.......240-------........250.......260..-..---.-------..-------270.......280----.........290.......300...--....310.......320--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------METG
N
Q
T
H
A
Q
E
F
L
L
L
GFSAT
S
E
I
Q
----------------
F
I
L
F
G
--
L
F
L
-
S
M
Y
L
V
T
F---T-G
N
L
L
I
I
L
A
ICSDSHLH
T
P
M
Y
F
F
L
----------SNLS
F
A
D
L
CFTST
T
-
V
P
K
M
L
L
N
I
LTQNKF---
I
T
Y
A
G
C
L
S
Q
I
F
F
F
T
S
F
G
--
C
L
D
N
L
L
L
T
-------
V
M
A
Y
D
R
F
V
A
V
CHP
L
H
Y
T
V
I
MNPQ
L
C
G
L
L
V
----
L
G
S
W
C
I
S
V
M
G
S
L
L
E
T
L
T
V
L
R
L
S
F
CTEME
I
P
H
F
F
C
D
L
-
L
E
V
L
K
L
----
A
C-------S-------D
T
F
IN
N
-------
V
V
I
Y
FA
T
G
V
L
G
--
V
I
S
F
T
---
G
I
F
F
S
---
Y
Y
K
I
V
F
S
I
---------------
L
R
I
SSA-----------G--------------------RKH
K
A
F
S
T
C--------GS
H
L
S
V
V
T
L
F
YGTG
F
G
V
Y
L
SSAA-TP---
S
-------
S
R
-------
T
S
L
V
A
S
V
M
Y
T
M
------
V
T
P
M
L
N
P
F
I
Y
S
LRN
T
D
M
K
R
A
L
G
R
L
L
--
S
R
A
TFFNGDITAGLS----------
45
Fugue
86.26
19%
-120
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
--
Y
M
F
-
L
L
I
M
L
G
F
---
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
----------
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
---
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
--
E
I
A
L
W
S
L
V
-------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-------
Y
I
P
E
G
--------
M
Q
C
----
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
-------
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
---
V
I
F
F
C
---
Y
G
Q
L
V
F
T
V
---------------
K
E
A
A
A
S
-----------
A
--------------------
T
T
Q
K
A
E
K
E
V
--------
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
---
F
-------
T
H
QGSDFGP
I
F
M
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A----
5
PsiBlast_PDB
84.05
23%
-131
- C3 -
4GBR
1
ADRB2_HUMAN
A:
[1-284]
------------------------------------
D
E
V
W
----------------
V
V
G
M
G
--
I
V
M
-
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
----------
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
--
K
T
---
W
T
F
G
N
F
W
C
E
--
F
W
T
S
-----
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
----
L
M
V
W
I
V
S
G
L
T
S
F
L
P
----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
-
E
E
--------
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
---
R
V
F
Q
E
---
A
K
R
Q
L
Q
K
I
---------------
D
K
F
C
L
---------------------------------
K
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
---------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
-----------------------
2
PsiBlast_PDB
83.10
24%
-136
- C3 -
4LDL
3
ADRB2_HUMAN
A:
[176-461]
----------------------------------
A
A
D
E
V
W
----------------
V
V
G
M
G
--
I
V
M
-
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
----------
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
--
K
T
---
W
T
F
G
N
F
W
C
E
--
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
-----
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
----
L
M
V
W
I
V
S
G
L
T
S
F
L
P
----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
-
E
E
T
--------
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
---
R
V
F
Q
E
---
A
K
R
Q
L
Q
------------------
K
F
--
A
-----------
L
--------------------
K
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
---------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
-----------------------
3
PsiBlast_PDB
82.28
24%
-137
- C3 -
4LDO
3
A:
[176-461]
----------------------------------
A
A
D
E
V
W
----------------
V
V
G
M
G
--
I
V
M
-
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
----------
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
--
K
T
---
W
T
F
G
N
F
W
C
E
--
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
-----
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
----
L
M
V
W
I
V
S
G
L
T
S
F
L
P
----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
-
E
E
T
--------
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
---
R
V
F
Q
E
---
A
K
R
Q
L
Q
------------------
K
F
--
A
-----------
L
--------------------
K
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
---------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
-----------------------
1
PsiBlast_PDB
81.44
24%
-136
- C3 -
4LDE
3
A:
[176-461]
----------------------------------
A
A
D
E
V
W
----------------
V
V
G
M
G
--
I
V
M
-
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
----------
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
--
K
T
---
W
T
F
G
N
F
W
C
E
--
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
-----
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
----
L
M
V
W
I
V
S
G
L
T
S
F
L
P
----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
-
E
E
T
--------
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
---
R
V
F
Q
E
---
A
K
R
Q
L
Q
------------------
K
F
--
A
-----------
L
--------------------
K
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
---------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
-----------------------
12
PsiBlast_PDB
81.06
25%
-116
- C3 -
2YCX
3
ADRB1_MELGA
A:
[13-294]
------------------------------------------------------------
G
--
M
S
L
-
L
M
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
----------
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
---
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
--
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
----
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
-
F
V
T
N
-------
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
---
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
---------------
R
K
I
D
R
A
-----------
S
K
R
K
R
V
M
L
M
------------
R
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
---------------------
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
------------------------------
44
Fugue
80.69
18%
-112
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
----------------
F
S
M
L
A
--
A
Y
M
F
L
L
I
M
L
G
F
---
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
----------
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
---
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
--
E
I
A
L
W
S
L
V
-------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
--------------
I
-
P
E
G
M
Q
C
----
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
-------
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
---
V
I
F
F
C
---
Y
G
Q
L
V
F
T
V
---------------
K
E
A
A
A
Q
QQES-------
A
--------------------
T
T
Q
K
A
E
K
E
V
--------
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
---
F
T
H
QGSDF
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
11
PsiBlast_PDB
80.36
25%
-120
- C3 -
2YCW
7
ADRB1_MELGA
A:
[13-298]
------------------------------------------------------------
G
--
M
S
L
-
L
M
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
----------
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
---
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
--
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
----
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
-
F
V
T
N
-------
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
---
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
---------------
R
K
I
D
R
A
-----------
S
KRKR
V
M
L
M
------------
R
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
---------------------
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
F
-----------------------
13
PsiBlast_PDB
80.21
25%
-121
- C3 -
2YCZ
2
ADRB1_MELGA
A:
[13-298]
------------------------------------------------------------
G
--
M
S
L
-
L
M
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
----------
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
---
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
--
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
----
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
-
F
V
T
N
-------
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
---
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
---------------
R
K
I
D
R
A
-----------
S
K
R
K
R
V
M
L
M
------------
R
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
---------------------
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
F
-----------------------
10
PsiBlast_PDB
80.00
25%
-126
- C3 -
2VT4
8
ADRB1_MELGA
A:
[13-298]
------------------------------------------------------------
G
--
M
S
L
-
L
M
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
----------
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
---
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
--
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
----
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
-
F
V
T
N
-------
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
---
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
---------------
R
--------------------------------------
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
---------------------
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
------------------------
14
PsiBlast_PDB
79.92
25%
-123
- C3 -
2YCY
6
ADRB1_MELGA
A:
[13-298]
------------------------------------------------------------
G
--
M
S
L
-
L
M
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
----------
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
---
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
--
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
----
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
-
F
V
T
N
-------
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
---
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
---------------
R
--
D
R
A
-----------
S
KR
K
R
V
M
L
M
------------
R
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
---------------------
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
F
-----------------------
19
PsiBlast_PDB
79.81
24%
-129
- C3 -
2Y02
13
ADRB1_MELGA
A:
[13-300]
------------------------------------------------------------
G
--
M
S
L
-
L
M
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
----------
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
---
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
--
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
----
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
-
F
V
T
N
-------
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
---
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------S
R
V
M
L
M
--------------
R
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
---------------------
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
------------------------
17
PsiBlast_PDB
79.64
24%
-123
- C3 -
2Y00
13
ADRB1_MELGA
A:
[13-300]
------------------------------------------------------------
G
--
M
S
L
-
L
M
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
----------
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
---
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
--
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
----
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
-
F
V
T
N
-------
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
---
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------S
R
V
M
L
M
--------------
R
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
---------------------
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
------------------------
4
PsiBlast_PDB
79.38
24%
-139
- C3 -
4QKX
2
ADRB2_HUMAN
A:
[176-461]
----------------------------------
A
A
D
E
V
W
----------------
V
V
G
M
G
--
I
V
M
-
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
----------
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
T
--
K
T
---
W
T
F
G
N
F
W
C
E
--
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
-----
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
----
L
M
V
W
I
V
S
G
L
T
S
F
L
P
----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
-
E
E
T
--------
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--
V
F
V
Y
S
---
R
V
F
Q
E
---
A
K
R
Q
L
Q
------------------
K
F
--
A
-----------
L
--------------------
K
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
---------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
-----------------------
20
PsiBlast_PDB
79.11
24%
-125
- C3 -
2Y03
9
ADRB1_MELGA
A:
[13-300]
------------------------------------------------------------
G
--
M
S
L
-
L
M
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
----------
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
---
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
--
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
----
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
-
F
V
T
N
-------
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
---
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
---------------
R
-----------------S
R
V
M
L
M
--------------
R
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
---------------------
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
------------------------
38
HHSearch
79.09
18%
-131
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-332]
--------------------------------------
V
Y
----------------
Y
S
L
G
I
--
F
I
G
-
I
C
G
I
I
G
C
---
G
-
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
----------
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
---
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
--
F
M
S
I
M
T
M
A
-------
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
----
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
-
D
Y
I
S
-----------------------
R
D
S
T
T
R
-------
S
N
I
L
C
M
F
I
L
G
F
--
F
G
P
I
L
---
I
I
F
F
C
---
Y
F
N
I
V
M
S
V
---------------
S
N
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
--------
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
-
G
P
LEW
V
-------
T
P
-------
Y
A
A
Q
L
P
V
M
F
A
K
------
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
----------
18
PsiBlast_PDB
79.03
24%
-123
- C3 -
2Y01
12
ADRB1_MELGA
A:
[13-300]
------------------------------------------------------------
G
--
M
S
L
-
L
M
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
----------
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
---
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
--
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
----
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
-
F
V
T
N
-------
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
---
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------S
R
V
M
L
M
--------------
R
E
H
K
A
L
K
T
L
--------
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
---------------------
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--
A
------------------------
35
HHSearch
78.97
18%
-120
- C3 -
1U19
14
OPSD_BOVIN
A:
[40-330]
---------------------------------------
F
----------------
S
M
L
A
A
--
Y
M
F
-
L
L
I
M
L
G
F
---
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
----------
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
---
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
--
E
I
A
L
W
S
L
V
-------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
----
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---
P
-
E
G
M
Q
C
S
C
G
I
-
D
Y
Y
T
P
--------------
H
-------
E
E
T
N
N
E
-------
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
---
V
I
F
F
C
---
Y
G
Q
L
V
F
T
V
---------------
K
E
A
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
K
E
V
T
R
M
V
--------
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S--
D
F------
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
----------
33
HHSearch
74.25
14%
-126
* C3 *
2KS9
1
NK1R_HUMAN
A:
[34-328]
---------------------------------------------------------
L
W
A
A
--
A
Y
T
-
V
I
V
V
T
S
V
---
V
-
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
----------
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
---
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
--
F
A
S
I
Y
S
M
T
-------
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
----
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
-----
M
P
S
R
V
V
C
M
I
-
E
W
P
E
H
P
---------------------
N
K
I
Y
E
K
-------
V
Y
H
I
C
V
T
V
L
I
Y
--
F
L
P
L
L
---
V
I
G
Y
A
---
Y
T
V
V
G
I
T
L
---------------
W
A
S
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
R
K
V
V
K
M
M
--------
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
-
N
P
---
D
LYLKKF-
I
Q
-------
Q
V
Y
L
A
I
M
W
L
A
M
------
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
--
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
----------
47
Fugue
72.19
17%
-153
* C2 *
4L9B
5
?
A:
[2-393]
VLKGINFP
E
N
E
A
S
I
L
D
L
A
M
Q
N
R
S
G
V
L
D
G
M
T
I
D
I
L
N
T
T
S
N
Q
----------------
L
A
L
F
H
G
T
A
V
L
-
Q
G
Y
G
I
E
I
---
T
-
G
A
P
D
V
L
V
D
T
T
G
Q
S
N
E
T
M
L
L
C
L
T
I
D
LN
Q
V
N
V
PSG
T
A
V
D
Y
K
Q
I
R
L
E
F
L
D
-
V
P
T
L
L
K
Q
Y
W
R
D
H
S
L
HDL
I
D
P
R
R
V
I
S
M
P
L
Y
W
I
T
F
G
--
Q
T
G
T
T
P
L
Y
-------
E
Q
I
K
S
N
Y
I
D
N
S
G
N
P
A
Y
G
I
A
A
R
C
E
N
F
N
H
F
I
N
KVA
V
Q
S
I
P
I
N
G
V
A
N
R
P
V
S
S
T
A
S
Q
L
T
N
Y
K
V
W
R
N
P
-
Y
L
C
S
Q
-
D
P
R
D
K
F
----
A
P
-------
D
-------
N
L
V
I
E
E
DG-----
I
Y
R
I
D
I
S
G
S
I
N
--
I
A
N
Y
T
F
PA
R
V
G
G
R
---
Y
F
Q
I
V
C
A
R
N
SSANNLAEFGAE
Q
H
L
P
P
S
G
V
-----------
W
--------------------
T
R
R
V
L
V
G
E
Y
TAGMT
E
Q
A
F
S
S
V
A
T
I
S
L
F
K
G
D
N
F
F
L
Q
F
E
T
G
--
T
N
---
T
-------
S
R
-------
D
S
A
Y
N
N
G
Y
G
T
S
------
G
T
H
L
R
N
-
F
S
Y
T
L
E
R
V
G
------
D
L
N
--
G
T
A
Y
Y
D
N
G
T
F
---------------