@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR7G3_HUMAN: (2016-01-14 )
MKAGNFSDTPEFFLLGLSGDPELQPILFMLFLSMYLATMLGNLLIILAVNSDSHLHTPMYFLLSILSLVDICFTSTTMPKMLVNIQAQAQSINYTGCLTQICFVLVFVGLENGILVMMAYDRFVAICHPLRYNVIMNPKLCGLLLLLSFIVSVLDALLHTLMVLQLTFCIDLEIPHFFCELAHILKLACSDVLINNILVYLVTSLLGVVPLSGIIFSYTRIVSSVMKIPSAGGKYKAFSICGSHLIVVSLFYGTGFGVYLSSGATHSSRKGAIASVMYTVVTPMLNPLIYSLRNKDMLKALRKLISRIPSFH
Atome Classification :
(20 SA)
--------------.........10........20........30........40........50........60........70......-..80........90......--..100.......110.......120.......130.......140.......150.......160-.......170.......180.......-------190-----....-.-....200.......210.......220------......-------..230-------------------.--------.....------------------..240.......250.......260..-.-------.---.--.---.270------........280-.......290.......300.......310-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MKAGNFSDTP
E
F
F
L
L
GLSGDP
E
L
Q
P
I
L
F
M
L
F
L
S
M
Y
L
A
T
M
LG
N
L
L
I
I
L
A
VNSDSHL
H
T
P
M
Y
F
L
L
S
I
L
S
L
V
D
I
CFTSTT-MP
K
M
L
V
N
I
Q
A
QAQSINY
T
G
C
--
L
T
Q
I
C
F
V
L
V
F
V
GLEN
G
I
L
V
M
M
A
Y
D
R
F
V
A
I
CHP
L
R
Y
N
V
IMN
P
K
L
C
G
L
L
L
L
L
S
F
I
V
S
V
L
D
A
L
L
H
T
L
M
-
V
L
Q
L
T
F
C
I
DLE
I
P
H
F
F
C
E
L
A
H
I
L
K
L
A
C
-------
S
-------
D
V
L
I
-
N
-
N
I
L
V
Y
L
V
T
S
L
L
G
VVP
L
S
G
I
I
F
S
Y
T
R
I
-------
V
S
S
V
M
K-------IPSA--------------------G--------GK
Y
K
A
------------------
F
S
ICGS
H
L
I
V
V
S
L
FYGTG
F
G
V
Y
LSSGA-T-------H---S--S---RK
G
-------
A
I
A
S
V
M
Y
T
V
V
T
-
P
M
L
N
P
L
I
Y
S
LR
N
K
D
M
L
K
A
L
R
K
L
I
S
RIPSFH-----------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
89.58
21%
-161
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[14-304]
---------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--
G
C
--
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-------
Q
P
L
P
--------------------
G
--------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
------
T
F
F
C
P
D
C
-
S
-------
H
---
A
--
P
---
L
W
L
-------
M
Y
L
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.55
21%
-160
- C2 -
3PWH
1
?
A:
[14-303]
---------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--
G
C
--
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
LF-----
E
-------
D
V
V
P
-
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
--------------------
G
--------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
------
T
F
F
C
P
D
C
-
S
-------
H
---
A
--
P
---
L
W
L
-------
M
Y
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.71
21%
-159
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--
G
C
--
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
--------------------
G
--------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
------
T
F
F
C
P
D
C
-
S
-------
H
---
A
--
P
---
L
W
L
-------
M
Y
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.71
21%
-161
- C2 -
3REY
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--
G
C
--
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
--------------------
G
--------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
------
T
F
F
C
P
D
C
-
S
-------
H
---
A
--
P
---
L
W
L
-------
M
Y
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
88.50
21%
-159
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--
G
C
--
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
--------------------
G
--------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
------
T
F
F
C
P
D
C
-
S
-------
H
---
A
--
P
---
L
W
L
-------
M
Y
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.32
21%
-157
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--
G
C
--
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
--------------------
G
--------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
------
T
F
F
C
P
D
C
-
S
-------
H
---
A
--
P
---
L
W
L
-------
M
Y
L
A
I
V
L
A
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
87.09
21%
-158
- C2 -
3VG9
8
?
A:
[14-304]
---------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
--
G
C
--
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-------
Q
P
L
P
--------------------
G
--------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
------
T
F
F
C
P
D
C
-
S
-------
H
---
A
--
P
---
L
W
L
-------
M
Y
L
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
84.04
18%
-143
- C2 -
2Z73
5
OPSD_TODPA
A:
[34-332]
-------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
--
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------------------
R
D
S
T
-
T
-
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-------
V
M
S
V
S
N
-------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
M
R
L
------------------
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
-
G
-------
P
LEW
V
--
T
---
P
Y
A
-------
A
Q
L
P
V
M
F
A
K
A
S
-
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
82.42
17%
-144
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
--
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
-------
V
G
W
S
R
Y
I
P
E
G
---
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
-
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
-------
A
A
A
S
--------------------
A
--------
T
T
Q
K
A
------------------
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
-------
I
---
F
--
T
---
H
Q
G
SDFGPIF
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
79.04
17%
-137
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
--
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-
H
W
Y
-------
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
-------
F
F
T
N
-
Q
-
A
Y
A
I
A
S
S
I
V
S
F
-
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-------
F
Q
E
A
K
R
Q
------
L
N
I
F
--------------------
E
--------
M
L
R
I
D
------------------
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
-
S
-------
L
---
N
--
A
---
A
K
S
-------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
41
Fugue
76.34
17%
-129
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
--
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
-------
V
G
W
S
R
Y
I
P
E
G
---
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
-
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
-------
A
A
A
Q
QQES----------------
A
--------
T
T
Q
K
A
------------------
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
-------
I
---
F
--
T
---
H
Q
G
SDFGPIF
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
74.75
14%
-146
- C2 -
2KS9
1
NK1R_HUMAN
A:
[35-325]
----------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
--
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
T
-----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------------
N
K
I
Y
-
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-------
G
I
T
L
W
A
-------
S
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
R
K
V
------------------
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
-
N
PD-----
L
YL-
K
KF
I
---
Q
Q
V
-------
Y
L
A
I
M
W
L
A
M
S
S
-
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
74.37
18%
-130
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
----------------------------------
T
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
--
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
A
Y
H
---
P
-
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
------------------
T
A
K
W
-
R
-
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-------
L
R
T
L
F
K
-------
A
H
M
---------------------
G
--------
Q
K
H
R
A
------------------
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
-
M
RTQVIQE
S
C
--
E
R
-
R
N
N
I
G
R
A
-------
L
D
A
T
E
I
L
G
F
L
H
-
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
74.01
15%
-139
- C2 -
1U19
14
OPSD_BOVIN
A:
[40-326]
-------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
--
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
----------
H
-------
E
E
T
N
-
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
-------
A
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
E
K
E
V
------------------
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
GS-----
D
---
F
--
G
---
P
I
F
-------
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
68.27
21%
-162
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[42-236]
---------------------------------------
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
--
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
-----
Q
E
A
I
N
C
Y
A
----
E
E
T
C
-------
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-------
F
Q
E
A
K
R
-------
Q
L
N
I
--------------------
F
--------
E
M
L
R
I
------------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-
P
-------
S
---
L
--
N
---
A
A
K
-------
S
E
L
D
K
A
I
G
R
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.14
22%
-154
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[52-235]
-------------------------------------------------
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
---
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
------
E
T
C
-------
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-------
F
Q
E
A
K
R
-------
Q
L
N
I
--------------------
F
--------
E
M
L
R
I
------------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-
P
-------
S
---
L
--
N
---
A
A
K
-------
S
E
L
D
K
A
I
G
R
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
65.89
24%
-171
- C2 -
3EML
8
ENLYS_BPT4
A:
[23-222]
---------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
--
T
G
F
C
A
A
C
H
G
C
--
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
---
V
A
C
-------
L
-------
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
L
A
A
R
R
-------
Q
L
N
I
--------------------
F
--------
E
M
L
R
I
------------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-
P
-------
S
---
L
--
N
---
A
A
K
-------
S
E
L
D
K
A
I
G
R
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.28
22%
-152
- C2 -
4QKX
2
ADRB2_HUMAN
A:
[194-377]
-------------------------------------------------
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
---
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
------
E
T
C
-------
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-------
F
Q
E
A
K
R
-------
Q
L
Q
K
--------------------
F
--------
A
L
K
E
H
------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
-
V
-------
I
---
Q
--
D
---
N
L
I
-------
R
K
E
V
Y
I
L
L
N
W
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.92
22%
-154
- C2 -
4LDO
3
A:
[194-377]
-------------------------------------------------
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
---
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
------
E
T
C
-------
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-------
F
Q
E
A
K
R
-------
Q
L
Q
K
--------------------
F
--------
A
L
K
E
H
------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
-
V
-------
I
---
Q
--
D
---
N
L
I
-------
R
K
E
V
Y
I
L
L
N
W
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
63.58
22%
-156
- C2 -
4LDL
3
ADRB2_HUMAN
A:
[194-377]
-------------------------------------------------
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
---
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
------
E
T
C
-------
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-------
F
Q
E
A
K
R
-------
Q
L
Q
K
--------------------
F
--------
A
L
K
E
H
------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
-
V
-------
I
---
Q
--
D
---
N
L
I
-------
R
K
E
V
Y
I
L
L
N
W
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------