@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR8I2_HUMAN: (2016-01-14 )
MAGNNFTEVTVFILSGFANHPELQVSLFLMFLFIYLFTVLGNLGLITLIRMDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVNFQSNRRSISFVGCFVQMYFFVGLVCCECFLLGSMAYNRYIAICNPLLYSVVMSQKVSNWLGVMPYVIGFTSSLISVWVISSLAFCDSSINHFFCDTTALLALSCVDTFGTEMVSFVLAGFTLLSSLLIITVTYIIIISAILRIQSAAGRQKAFSTCASHLMAVTIFYGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVIHRKLFP
Atome Classification :
(20 SA)
.........10.....-------------...20........30........40........50........60........70......-..--80.....-...90........-100.......110..--.....120.......130........140.......150.......160--.....-...--170.......180.......-------190.--......200........210.......220.--....-------..230------------------.........240.......250.......260--...---.---..-.--270.......280........290.......300.......310----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGNN
F
T
E
V
T
V
F
I
LSG-------------FANHP
E
L
Q
V
S
L
F
L
M
F
L
F
I
Y
L
F
T
V
LGNL
G
L
I
T
L
I
RMDSQLH
T
P
M
Y
F
F
L
SNL
A
F
I
D
I
F
YSSTV-
T
P
--
K
A
L
V
NFQ-SNR
R
S
I
S
F
V
G
C
F
V
-
Q
M
Y
F
F
V
G
L
V
C
C
E
C
F
L
--
L
G
S
M
A
YN
R
Y
I
A
I
C
N
P
L
L
-
Y
S
V
V
M
S
Q
K
V
S
N
W
L
G
V
M
P
Y
V
I
G
F
T
S
S
L
I
S
V
W
---
V
I
S
S
L
-
A
F
C
--DSSIN
H
F
FC
D
T
T
A
L
L
A
L
S
C
V
-------
D
T
F
G
--
T
E
M
V
S
F
V
L
-
A
G
F
T
L
L
S
S
L
L
I
I
T
V
T
Y
I
I
I
I
S
A
--
I
L
R
I
-------
Q
SA--------------------AG
R
Q
K
A
F
S
T
C
A
S
H
L
M
A
V
T
I
F
Y
G
S
L
I
F
T
Y
LQPD--NTS---
S
---
L
T
-
Q
--
A
Q
V
A
S
V
F
Y
T
I
V
I
-
P
M
L
N
P
L
I
Y
S
L
RNK
D
V
K
N
A
L
L
R
V
I
H
R
KLFP------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
90.37
14%
-149
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
TGVVRSPFEAPQY
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
--
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
---------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
-
A
C
A
--
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
--
N
E
S
F
V
I
Y
M
-
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
--
V
K
E
A
AASATTQ
K
A
E
--------------------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
S
D
---
F
---
G
P
-
I
--
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
87.37
15%
-138
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
--
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
-
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
--
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
-
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
---
Y
S
T
T
-------
E
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
----------
N
K
I
Y
--
E
K
V
Y
H
I
C
V
-
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
--
L
W
A
S
-------
E
I
P
GDSSDRYH
E
Q
V
---------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
--
I
N
P
---
D
LYL
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
-
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
87.32
16%
-133
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-333]
-----------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
--
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
-
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
-
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
---
G
W
G
A
Y
------
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
S
T
--
T
R
S
N
I
L
C
M
-
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
--
V
S
N
H
-------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
--
F
G
P
LEW
V
---
T
P
-
Y
--
A
A
Q
L
P
V
M
F
A
K
A
S
-
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
82.37
14%
-109
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
TGVVRSPFEAPQY
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
--
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
-----
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
-------
I
Y
M
F
--
V
V
H
F
I
I
P
L
-
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
ES
A
T
T
Q
-------
K
A
E
--------------------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
S
D
---
F
---
G
P
-
I
--
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
LGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
82.12
15%
-123
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-328]
-------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
--
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
---------
E
T
N
N
--
E
S
F
V
I
Y
M
F
--
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
--
V
K
E
A
-------
A
A
Q
QQESA
T
T
Q
------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
---
D
F--
G
P
-
I
--
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.50
24%
-151
- C2 -
4IB4
10
5HT2B_HUMAN (first)
A:
[34-240]
-----------------------------------------
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
--
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
-
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
--
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
-
A
N
Q
Y
N
S
R
A
T
A
--------
F
I
K
I
T
----
V
V
W
---
L
I
S
I
G
-
I
A
I
--
P
V
P
I
K
G
I
E
T
---
N
P
N
N
I
T
C
V
LTK----
E
R
F
G
--
D
F
M
L
F
G
S
L
-
A
A
F
--
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
--
L
Q
K
---------
K
A
--------------------
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
--
M
R
A
---
A
---
A
L
-
D
--
A
Q
K
K
D
F
R
H
G
F
D
I
-
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.63
24%
-171
- C2 -
4GPO
-
ADRB1_MELGA
A:
[9-207]
----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
------
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
L
M
T
R
A
R
A
K
-------
V
I
-----
I
C
T
V
W
---
A
I
S
A
L
-
V
S
F
--
L
P
I
M
M
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
-------
Q
D
P
G
--
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
-------
Y
R
E
--------------------
A
K
E
Q
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
--
L
V
N
---
I
---
V
N
-
V
--
F
N
R
D
L
V
P
D
W
L
F
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.27
24%
-177
- C2 -
2VT4
8
ADRB1_MELGA
A:
[10-207]
-----------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
------
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
L
M
T
R
A
R
A
K
-------
V
I
-----
I
C
T
V
W
---
A
I
S
A
L
-
V
S
F
--
L
P
I
M
M
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
-------
Q
D
P
G
--
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
-------
Y
R
E
--------------------
A
K
E
Q
I
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
--
I
V
N
---
V
---
F
N
-
R
--
D
L
V
P
D
W
L
F
V
A
F
N
-
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
76.07
15%
-131
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
-
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
---
M
H
W
Y
R
-
A
T
H
--
Q
E
A
I
N
C
Y
A
E
E
T
C
------
C
D
-------
F
F
T
N
--
Q
A
Y
A
I
A
S
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
--
K
R
Q
L
-------
N
I
F
--------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
--
P
S
L
---
N
---
A
A
-
K
--
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
13
PsiBlast_PDB
75.89
24%
-172
- C2 -
2YCX
3
ADRB1_MELGA
A:
[9-207]
----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
------
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
L
M
T
R
A
R
A
K
-------
V
I
-----
I
C
T
V
W
---
A
I
S
A
L
-
V
S
F
--
L
P
I
M
M
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
-------
Q
D
P
G
--
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
-------
Y
R
E
--------------------
A
K
E
Q
I
R
K
I
D
R
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
--
M
G
V
---
F
---
T
L
-
C
--
W
L
P
F
F
L
V
N
I
V
N
V
-
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.74
24%
-173
- C2 -
2YCW
7
ADRB1_MELGA
A:
[9-207]
----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
------
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
L
M
T
R
A
R
A
K
-------
V
I
-----
I
C
T
V
W
---
A
I
S
A
L
-
V
S
F
--
L
P
I
M
M
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
-------
Q
D
P
G
--
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
-------
Y
R
E
--------------------
A
K
E
Q
I
R
K
I
D
R
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
--
M
G
V
---
F
---
T
L
-
C
--
W
L
P
F
F
L
V
N
I
V
N
V
-
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.31
24%
-170
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[9-207]
----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
------
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
L
M
T
R
A
R
A
K
-------
V
I
-----
I
C
T
V
W
---
A
I
S
A
L
-
V
S
F
--
L
P
I
M
M
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
-------
Q
D
P
G
--
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
-------
Y
R
E
--------------------
A
K
E
Q
I
R
K
I
D
R
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
--
M
G
V
---
F
---
T
L
-
C
--
W
L
P
F
F
L
V
N
I
V
N
V
-
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.31
24%
-174
- C2 -
2YCY
6
ADRB1_MELGA
A:
[10-207]
-----------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
------
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
L
M
T
R
A
R
A
K
-------
V
I
-----
I
C
T
V
W
---
A
I
S
A
L
-
V
S
F
--
L
P
I
M
M
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
-------
Q
D
P
G
--
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
--
A
L
R
V
-------
Y
R
E
--------------------
A
K
E
Q
I
R
D
R
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
--
V
F
T
---
L
---
C
W
-
L
--
P
F
F
L
V
N
I
V
N
V
F
N
-
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.38
24%
-150
- C2 -
4NC3
12
C562_ECOLX
A:
[34-240]
-----------------------------------------
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
--
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
-
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
--
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
-
A
N
Q
Y
N
S
R
A
T
A
--------
F
I
K
I
T
----
V
V
W
---
L
I
S
I
G
-
I
A
I
--
P
V
P
I
K
G
I
E
T
-
V
D
N
P
N
N
I
T
C
V
LTK----
E
R
F
G
--
D
F
M
L
F
G
S
L
-
A
A
F
--
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
--
L
Q
K
---------
K
A
--------------------
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
--
M
R
A
---
K
---
D
F
-
R
--
H
G
F
D
I
L
V
G
Q
I
D
D
-
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.56
21%
-147
- C2 -
3NY9
4
ADRB2_HUMAN (first)
A:
[42-237]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
-
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
---
M
H
W
Y
R
-
A
T
H
--
Q
E
A
I
N
C
Y
A
E
E
T
-------
C
C
-------
D
F
F
T
--
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
--
Y
S
R
V
-------
F
Q
E
--------------------
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
--
I
G
H
---
L
---
L
T
-
K
--
S
P
S
L
N
A
A
K
S
E
L
D
-
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.43
21%
-149
- C2 -
3D4S
6
ENLYS_BPT4
A:
[42-237]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
-
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
---
M
H
W
Y
R
-
A
T
H
--
Q
E
A
I
N
C
Y
A
E
E
T
-------
C
C
-------
D
F
F
T
--
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
--
Y
S
R
V
-------
F
Q
E
--------------------
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
--
I
G
H
---
L
---
L
T
-
K
--
S
P
S
L
N
A
A
K
S
E
L
D
-
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
72.00
21%
-163
- C2 -
3EML
8
ENLYS_BPT4
A:
[21-221]
------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
-
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
-
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
---
G
W
N
N
C
-
G
Q
--------
S
Q
G
C
G
E
G
Q
---
V
A
C
L
-------
F
E
D
V
VP
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
--
A
R
R
Q
-------
L
N
I
--------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
S
---
L
---
N
A
-
A
--
K
S
E
L
D
K
A
I
G
R
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
71.89
21%
-145
- C2 -
3NYA
3
ADRB2_HUMAN (first)
A:
[42-237]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
-
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
---
M
H
W
Y
R
-
A
T
H
--
Q
E
A
I
N
C
Y
A
E
E
T
-------
C
C
-------
D
F
F
T
--
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
--
Y
S
R
V
-------
F
Q
E
--------------------
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
--
I
G
H
---
L
---
L
T
-
K
--
S
P
S
L
N
A
A
K
S
E
L
D
-
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.85
21%
-147
- C2 -
3NY8
7
ENLYS_BPT4
A:
[42-237]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
-
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
---
M
H
W
Y
R
-
A
T
H
--
Q
E
A
I
N
C
Y
A
E
E
T
-------
C
C
-------
D
F
F
T
--
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
--
Y
S
R
V
-------
F
Q
E
--------------------
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
--
I
G
H
---
L
---
L
T
-
K
--
S
P
S
L
N
A
A
K
S
E
L
D
-
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.17
20%
-147
- C2 -
4LDE
3
A:
[183-378]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
-
T
--
K
T
W
T
F
G
N
F
W
C
-
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
-
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
---
M
H
W
Y
R
-
A
T
H
--
Q
E
A
I
N
C
Y
A
E
E
T
-------
C
C
-------
D
F
F
T
--
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
--
Y
S
R
V
-------
F
Q
E
--------------------
A
K
R
Q
L
Q
K
F
A
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
--
F
F
I
---
V
---
N
I
-
V
--
H
V
I
Q
D
N
L
I
R
K
E
V
-
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
------------------------------------------------------------------------------------------------------------------------------------------------------------