@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR8U8_HUMAN: (2016-01-14 )
MAHINCTQATEFILVGLTDHQELKMPLFVLFLSIYLFTVVGNLGLILLIRADTSLNTPMYFFLSNLAFVDFCYSSVITPKMLGNFLYKQNVISFDACATQLGCFLTFMVSESLLLASMAYDRYVAICNPLLYMVVMTPGICIQLVAVPYSYSFLMALFHTILTFRLSYCHSNIVNHFYCDDMPLLRLTCSDTRFKQLWILACAGITFICSVLIVFVSYMFIIFAILRMSSAEGRRKAFSTCSSHMLAVTIFYGTLIFMYLQPSSSHSLDADKMASVFYTVIIPMLNPLIYSLRNKDVKDALKKVIINRNHAFIFLKLRK
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------....-..--------------...10......-..20.....----------------..-----.30........40........50.-.......60..-......70-.......-..80.....-...90-------........-.---100----..---....-.110.-......120......-------.130.-..---....140.....------..150.......160.......170.-...-...180..-.....-------190-----..---.--......200......----.210.......220.......230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------...---------------------.....240..--------.....250...-------------------....260...---.------------.------------.------.270-----------......------------.-280-.....-..290......--..300.-.-.....310---........----------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------MAHI-NC--------------TQA
T
E
F
I
L
V
GL-TD
H
Q
E
LK
M
P
----------------
L
F
-----
V
L
F
L
S
I
Y
L
F
T
V
VGNL
G
L
I
L
L
I
RAD-TSLN
T
P
M
Y
F
F
L
-
S
N
L
A
F
V
D
--
F
C
Y
S
SVI-
T
P
K
M
L
G
N
F
L
-
Y
K
QN--------VI
S
F
D
A
C
A
-
T
---
Q
L
G
----
C
F
---
L
T
F
M
-
V
S
E
S
L
-
L
L
A
S
M
A
Y
D
R
Y
V
A
I
C
N
-------
P
L
L
Y
M
-
V
V
---MTPG
I
C
I
Q
L
V
AV------PY
S
Y
S
F
L
M
A
L
F
H
T
I
L
T
F
R
L
S
Y
C
H
S
N
I
-
V
N
H
-FYCDDM
P
L
-
L
R
L
TC-------S-------DT---
R
--
F
K
Q
L
W
I
L
ACA
G
I
T
F
I
----
C
S
V
L
I
V
F
V
S
Y
M
F
I
I
F
A
I
L
RMSS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------E
G
R
---------------------
R
K
A
F
S
T
CSS
H
--------
M
L
A
V
T
I
F
Y
G
T
L
-------------------
I
F
M
Y
LQPSSS---H------------S------------L------
D
A
D
K
-----------
M
A
S
V
F
Y
------------
T
-
V
I
I
-
P
M
L
N
P
-
L
I
Y
-
S
LRNK
D
V
--
K
D
A
L
K
K
-
V
-
I
INRN
H
A
----
F
I
F
L
K
LRK----------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
95.87
19%
-145
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-----------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
----------------
M
G
-----
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
-
T
S
L
A
C
A
D
--
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
--------
T
F
G
N
F
W
C
E
-
F
---
W
T
S
----
I
D
---
V
L
C
V
-
T
A
S
I
E
-
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-------
P
F
K
Y
Q
-
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
------
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-
R
A
---
T
H
-
Q
E
A
-
I
N
C
Y
A
E
E
-----
T
C
-------
C
-------
D
F
---
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
----
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
---------------------
H
K
A
L
K
T
L
G
I
I
--------
M
G
T
F
T
L
C
W
L
P
F
-------------------
F
I
V
N
I
V
H
V
I
Q
---
D
NL----------
I
------------
R
------
K
E
V
Y
-----------
I
L
L
N
W
I
------------
G
-
Y
V
N
-
S
G
F
N
P
-
L
I
Y
-
C
-
R
S
P
D
F
--
R
I
A
F
Q
E
-
L
-
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
92.41
20%
-148
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
----------------
L
V
-----
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
-
R
K
L
H
T
V
G
N
L
Y
I
-
V
S
L
S
V
A
D
--
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
--------
S
L
G
R
P
L
C
L
-
F
---
W
L
S
----
M
D
---
Y
V
A
S
-
T
A
S
I
F
-
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
-------
P
L
R
Y
L
-
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
------
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
---------
R
R
E
-
D
K
C
E
T
D
F
Y
-
D
----------------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
----
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
---------------------
R
K
A
A
K
Q
L
G
F
I
--------
M
A
A
F
I
L
C
W
I
P
Y
-------------------
F
I
F
F
M
V
I
A
F
C
---
K
NC----------
C
------------
N
------
E
H
L
H
-----------
M
F
T
I
W
L
------------
G
-
Y
I
N
-
S
T
L
N
P
-
L
I
Y
-
P
L
C
N
E
N
F
--
K
K
T
F
K
R
-
I
-
L
H
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
90.35
19%
-144
* C1 *
2Z73
5
OPSD_TODPA
A:
[31-336]
--------------------------------------------------------------------------------------------------------------------------------------------------
D
A
V
Y
Y
S
----------------
L
G
-----
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
-
K
S
L
Q
T
P
A
N
M
F
I
-
I
N
L
A
F
S
D
--
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
--------
I
F
G
F
A
A
C
K
-
V
---
Y
G
F
----
I
G
---
G
I
F
G
-
F
M
S
I
M
-
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------
P
M
A
A
S
-
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
------
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
----
Y
T
L
E
-
G
V
L
-
C
N
C
S
F
D
Y
I
-
S
R
-------------------
D
---
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
----
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
---------------------
M
R
L
A
K
I
S
I
V
I
--------
V
S
Q
F
L
L
S
W
S
P
Y
-------------------
A
V
V
A
L
L
A
Q
F
G
---
P
LEW---------
V
------------
T
------
P
Y
A
A
-----------
Q
L
P
V
M
F
------------
A
-
K
A
S
-
A
I
H
N
P
-
M
I
Y
-
S
V
S
H
P
K
F
--
R
E
A
I
S
Q
-
T
-
F
P
W
V
L
T
C
----
C
Q
F
D
D
K
E
T
----------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
88.27
19%
-149
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------
V
V
F
----------------
I
V
-----
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
-
R
H
L
Q
T
V
N
N
Y
F
L
-
F
S
L
A
C
A
D
--
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
--------
P
L
G
P
V
V
C
D
-
L
---
W
L
A
----
L
D
---
Y
V
V
S
-
N
A
S
V
M
-
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
-------
P
L
T
Y
P
-
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
------
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
--
G
V
R
T
-
V
E
D
-
G
E
C
Y
I
Q
F
F
-----------------------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
----
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
---------------------
K
K
V
T
R
T
I
L
A
I
--------
L
L
A
F
I
I
T
W
A
P
Y
-------------------
N
V
M
V
L
I
N
T
F
C
---
A
PC----------
I
------------
P
------
N
T
V
W
-----------
T
I
G
Y
W
L
------------
C
-
Y
I
N
-
S
T
I
N
P
-
A
C
Y
-
A
L
C
N
A
T
F
--
K
K
T
F
K
H
-
L
-
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
87.85
15%
-151
- C1 -
3EML
13
ENLYS_BPT4
A:
[21-472]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
----------------
Y
I
-----
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
--
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
--------
C
A
A
C
H
G
C
L
-
F
---
I
A
C
----
F
V
---
L
V
L
T
-
Q
S
S
I
F
-
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-------
P
L
R
Y
N
-
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
------
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
--------
S
-
Q
G
C
G
E
G
Q
V
----
A
C
-------
L
-------
F
E
---
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
---------------------
V
H
A
A
K
S
L
A
I
I
--------
V
G
L
F
A
L
C
W
L
P
L
-------------------
H
I
I
N
C
F
T
F
F
C
---
P
DCSH--------
A
------------
P
------
L
W
L
M
-----------
Y
L
A
I
V
L
------------
S
-
H
T
N
-
S
V
V
N
P
-
F
I
Y
-
A
Y
R
I
R
E
F
--
R
Q
T
F
R
K
-
I
-
I
R
S
H
V
L
R
----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
83.95
16%
-144
- C1 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
----------------
W
A
-----
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
-
K
R
M
R
T
V
T
N
Y
F
L
-
V
N
L
A
F
A
E
--
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
--------
Y
Y
G
L
F
Y
C
K
-
F
---
H
N
F
----
F
P
---
I
A
A
V
-
F
A
S
I
Y
-
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
-------
P
L
Q
P
R
-
L
-----
S
A
T
A
T
K
V
V
I
C
V
------
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-----
E
T
M
-
P
S
R
-
V
V
C
M
I
E
W
P
-
E
H
P
-----------------
N
K
---
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
----
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
---------------------
R
K
V
V
K
M
M
I
V
V
--------
V
C
T
F
A
I
C
W
L
P
F
-------------------
H
I
F
F
L
L
P
Y
I
N
---
P
------------
D
------------
L
YLKKFI
Q
Q
V
Y
-----------
L
A
I
M
W
L
------------
A
-
M
S
S
-
T
M
Y
N
P
-
I
I
Y
-
C
C
L
N
D
R
F
--
R
L
G
F
K
H
-
A
-
F
R
C
C
P
F
I
----
S
A
G
D
Y
E
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
78.65
17%
-135
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
E
V
W
V
V
G
----------------
M
G
-----
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
-
T
S
L
A
C
A
D
--
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
--------
T
F
G
N
F
W
C
E
-
F
---
W
T
S
----
I
D
---
V
L
C
V
-
T
A
S
I
E
-
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-------
P
F
K
Y
Q
-
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
------
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
--------
T
H
-
Q
E
A
I
N
C
Y
A
-
E
E
T
C
C
-------
D
-------
F
F
---
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
----
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
L
---------------------
R
I
D
E
G
L
R
L
K
I
--------
Y
K
D
T
E
G
Y
Y
T
I
G
-------------------
I
G
H
L
L
T
K
S
P
S
---
L
------------
N
------------
A
------
A
K
S
E
-----------
L
D
K
A
I
G
------------
R
-
N
T
N
G
V
I
T
K
D
-
E
A
E
-
K
L
F
N
Q
D
V
--
D
A
A
V
R
G
-
I
-
L
R
N
A
K
L
K
----
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
28
HHSearch
78.47
16%
-136
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-499]
--------------------------------------------------------------------------------------------------------------------------------------------------
N
F
N
K
I
F
----------------
L
P
-----
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
-
K
K
L
R
S
M
T
D
K
Y
R
-
L
H
L
S
V
A
D
--
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
--------
Y
F
G
N
F
L
C
K
-
A
---
V
H
V
----
I
Y
---
T
V
N
L
-
Y
S
S
V
W
-
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
-------
A
T
N
S
Q
-
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
------
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
-----
S
E
A
-
D
D
R
-
Y
I
C
D
R
F
Y
P
-
N
D
-----------------------
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
----
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
---------------------
R
K
A
L
K
T
T
V
I
L
--------
I
L
A
F
F
A
C
W
L
P
Y
-------------------
Y
I
G
I
S
I
D
S
F
I
---
L
L
EI
I
K
Q
G
C
E
F
E
N
T
------------
V
------
H
K
W
I
-----------
S
I
T
E
A
L
------------
A
-
F
F
H
-
C
C
L
N
P
-
I
L
Y
-
A
F
L
G
A
K
F
--
K
T
S
A
Q
H
-
A
-
L
T
S
G
R
P
L
----
E
V
L
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
76.91
13%
-151
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
-----
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
-
R
A
L
Q
T
T
T
N
Y
L
V
-
V
S
L
A
V
A
D
--
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
--------
N
F
S
R
I
C
C
D
-
V
---
F
V
T
----
L
D
---
V
M
M
C
-
T
A
S
I
W
-
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
-------
P
V
H
Y
Q
-
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
------
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
-------
T
-
G
D
P
-
T
V
C
S
I
S
N
------------------------------
P
--
D
F
V
I
Y
S
S
V
V
S
F
Y
----
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
---------------------
K
K
A
T
Q
M
V
A
I
V
--------
L
G
A
F
I
V
C
W
L
P
F
-------------------
F
L
T
H
V
L
N
T
H
C
---
Q
TCH---------
V
------------
S
------
P
E
L
Y
-----------
S
A
T
T
W
L
------------
G
-
Y
V
N
-
S
A
L
N
P
-
V
I
Y
-
T
T
F
N
I
E
F
--
R
K
A
F
L
K
-
I
-
L
S
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
76.48
15%
-120
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------------------------------------------------------------------------------------------------------
M
-
N
G
--------------
T
E
G
P
N
F
Y
V
P
F
S
-
N
K
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
-----
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
--------
V
F
G
P
T
G
C
N
-
L
---
E
G
F
----
F
A
---
T
L
G
G
-
E
I
A
L
W
-
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------
P
M
--------------------
S
------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
V
-
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
---
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
----
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
---------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------------------
F
Y
I
F
T
H
Q
G
S
D
---
F
------------
G
------------
P
------
I
F
M
T
-----------
I
P
A
F
F
A
------------
K
-
T
S
A
-
V
-
Y
N
P
-
V
I
Y
-
I
M
M
N
K
Q
F
--
R
N
C
M
V
T
-
T
-
L
C
C
G
K
N
P
----
S
T
T
V
S
K
T
E
TS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
75.28
16%
-140
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
--------------------------------------------------------------------------------------------------------------------------------------------------
E
N
S
I
K
L
----------------
T
S
-----
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
-
K
K
F
H
R
P
M
Y
Y
F
I
-
G
N
L
A
L
S
D
--
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
--------
K
L
T
P
A
Q
W
F
-
L
---
R
E
G
----
S
M
---
F
V
A
L
-
S
A
S
V
F
-
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-------------------
N
N
F
R
L
F
L
L
I
S
A
------
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
-------
I
-
S
A
L
-
S
S
C
S
T
V
L
P
-
L
---------------------------
Y
H
K
H
Y
-
I
L
F
C
T
T
V
F
T
----
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
---------------------
V
A
L
L
K
T
V
I
I
V
--------
L
S
V
F
I
A
C
W
A
P
L
-------------------
F
I
L
L
L
L
D
V
G
C
---
K
------------
V
KTC
D
--------
I
------
L
F
R
A
-----------
E
Y
F
L
V
L
------------
A
-
V
L
N
-
S
G
T
N
P
-
I
I
Y
-
T
L
T
N
K
E
M
--
R
R
A
F
I
R
-
I
-
M
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
74.25
14%
-119
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----------------------------------------------------------------------------------------------------------------
M
-
N
G
--------------
T
E
G
P
N
F
Y
V
P
F
S
-
N
K
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
-----
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
--------
V
F
G
P
T
G
C
N
-
L
---
E
G
F
----
F
A
---
T
L
G
G
-
E
I
A
L
W
-
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------
P
M
--------------------
S
------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
V
-
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
---
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
----
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
---------------------
S
A
T
T
Q
K
A
E
K
E
--------
V
T
R
M
V
I
I
M
V
I
A
-------------------
F
L
I
C
W
L
P
Y
A
G
---
V
------------
A
------------
F
------
Y
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
------------
A
-
K
T
S
-
A
V
Y
N
P
-
V
I
Y
-
I
M
M
N
K
Q
F
--
R
N
C
M
V
T
-
T
-
L
C
C
G
K
N
P
----
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
72.29
15%
-124
- C1 -
1U19
14
OPSD_BOVIN
A:
[37-328]
--------------------------------------------------------------------------------------------------------------------------------------------------
P
W
Q
F
S
M
----------------
L
A
-----
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
--
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
--------
V
F
G
P
T
G
C
N
-
L
---
E
G
F
----
F
A
---
T
L
G
G
-
E
I
A
L
W
-
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------
P
M
S
N
F
-
R
F
----
G
E
N
H
A
I
M
G
V
A
F
------
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
--
Y
--
I
P
E
-
G
M
Q
-
C
S
C
G
I
D
Y
Y
-
T
P
H
-----------------
E
E
---
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
----
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
---------------------
K
E
V
T
R
M
V
I
I
M
--------
V
I
A
F
L
I
C
W
L
P
Y
-------------------
A
G
V
A
F
Y
I
F
T
H
QGS
D
------------
F
------------
G
------
P
I
F
M
-----------
T
I
P
A
F
F
------------
A
-
K
T
S
-
A
V
Y
N
P
-
V
I
Y
-
I
M
M
N
K
Q
F
--
R
N
C
M
V
T
-
T
-
L
C
C
G
K
N
P
----
L
G
D
D
E
A
S
T
----------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
68.68
15%
-125
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[36-322]
--------------------------------------------------------------------------------------------------------------------------------------------------
T
L
N
K
Y
V
----------------
V
I
-----
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
-
R
V
G
R
S
V
T
D
V
Y
L
-
L
N
L
A
L
A
D
--
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
--------
I
F
G
T
F
L
C
K
-
V
---
V
S
L
----
L
K
---
E
V
N
F
-
Y
S
G
I
L
-
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
-------
A
T
R
T
L
-
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
------
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
--
Y
--
H
P
N
-
N
S
S
-
P
V
C
Y
E
V
L
G
-
N
D
------------------
T
A
---
K
--
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
----
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
---------------------
H
R
A
M
R
V
I
F
A
V
--------
V
L
I
F
L
L
C
W
L
P
Y
-------------------
N
L
V
L
L
A
D
T
L
M
---
R
------------
T
QVIQE
S
C
E
R
R
N
N
I
------
G
R
A
L
-----------
D
A
T
E
I
L
------------
G
-
F
L
H
-
S
C
L
N
P
-
I
I
Y
-
A
F
I
G
Q
N
F
--
R
H
G
F
L
K
-
I
-
L
A
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
65.78
18%
-107
- C1 -
4OWT
-
INT3_HUMAN
A:
[1-466]
-------------------------------------------------------------------------------------------GGRL
L
L
S
T
SLDAKD
E
L
E
E
R
L
E
R
C
M
S
I
V
T
S
M
T
AGVS
E
R
E
A
N
D
A
L
N
A
Y
V
C
K
G
L
-
P
Q
H
E
E
I
C
L
G
----------------
L
F
-----
T
L
I
L
T
E
P
A
Q
A
Q
K
C
Y
R
D
L
A
L
V
S
R
D
G
M
N
I
V
L
N
K
I
N
Q
I
L
M
E
K
--
Y
L
K
--
L
Q
D
T
C
R
T
-
Q
L
V
W
L
V
R
E
L
-
V
K
S
G
--------
V
L
G
A
D
G
V
C
M
T
F
M
K
Q
I
A
GGDV
T
A
---
K
N
I
W
-
L
A
E
S
V
-
L
D
I
L
T
E
Q
R
E
W
V
-
L
K
S
-------
S
I
L
I
A
M
A
V
---
Y
T
---
Y
L
R
L
I
V
D
------
H
H
G
T
A
Q
L
Q
A
L
R
Q
K
E
V
D
F
C
I
S
L
L
R
E
R
F
M
E
C
L
M
I
G
R
D
L
V
R
L
-
L
Q
N
V
A
-------
R
-------
I
P
---
E
--
F
E
L
L
W
K
D
I
I
H
N
P
Q
A
L
SPQF
T
G
I
L
Q
L
L
Q
S
R
T
S
R
K
F
L
A
C
R
L
T
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
K
L
L
F
M
T
S
RVRFGQQ
K
R
Y
Q
D
W
F
Q
R
Q
Y
L
S
T
P
D
S
Q
--------
S
L
R
C
D
L
I
R
Y
I
C
GV
V
H
P
S
N
E
V
L
S
SDILP
R
W
A
I
I
G
W
L
L
T
T
C
T
---
S
------------
N
------------
V
------
A
A
S
N
-----------
A
K
L
A
L
F
Y
DWLFFSPDKDS
I
M
N
I
E
-
P
A
I
L
V
M
H
H
S
M
K
P
H
P
A
I
T
--
A
T
L
L
D
F
M
C
R
I
I
P
N
F
Y
P
----
P
L
E
G
H
V
R
Q
G
V
F
S
S
L
N
H
I
V
E
K
RVLAHL
A
P
L
F
D
NPKLD
K
E
L
R
A
M
L
R
E
K
FPEFCS--------------------------------------------------------------------------------------------------------
48
Fugue
65.50
18%
-154
- C1 -
4IWS
-
?
A:
[23-515]
M
N
R
S
A
L
D
F
R
H
F
V
D
H
L
R
R
Q
GD
L
V
D
V
HTEVDANL
E
I
G
A
I
T
R
R
V
Y
E
R
RA
P
A
P
L
F
HNIRDSLPG
A
R
V
L
G
APAGLRADRARAH
S
R
L
A
L
H
F
GLPEHSG
P
R
D
I
V
A
M
L
R
A
A
M
R
A
E
P
I
A
P
R
R
L
-
E
R
--------------
G
P
V
Q
E
N
V
W
L
G
E
Q
V
D
L
T
R
F
P
V
P
----------------
L
L
HEQDG
G
R
Y
F
G
T
Y
G
F
H
V
V
Q
------------
T
P
D
G
S
W
D
S
W
S
V
-
G
R
L
M
L
V
D
RN
T
L
A
G
P
T
I
-
P
T
Q
H
I
G
I
I
R
-
E
Q
W
R
R
L
GK
P
T
P
W
A
M
A
L
G
A
P
P
-
A
---
A
L
A
----
A
A
G
MP
L
P
E
G
-
V
S
E
A
G
-
Y
V
G
A
L
V
G
E
P
V
E
V
V
R
T
QTNGLWV
P
A
N
T
E
-
I
V
---
L
E
G
E
I
S
L
D
E
T
A
L
EGPMGE
Y
H
G
Y
S
F
P
I
G
K
P
Q
P
L
F
H
V
H
A
L
S
F
R
D
Q
------------
P
I
-
L
P
I
C
V
-------
A
-------
G
T
---
P
--
P
E
E
N
H
T
I
---
W
G
T
M
I
----
S
A
Q
L
L
D
V
A
Q
N
A
G
L
P
V
D
M
V
W
C
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
T
---------------------
C
W
A
V
L
S
I
D
V
Q
--------
R
L
A
A
L
-------------------------------
G
T
D
A
---
A
------------
A
------------
F
------
A
A
R
V
-----------
A
E
T
V
F
G
------------
S
-
H
A
G
-
H
L
V
P
K
-
L
I
L
-
V
G
N
D
I
D
V
TE
I
D
Q
V
V
W
-
A
-
L
A
T
R
A
H
P
LHDH
F
A
F
P
Q
I
R
D
FPMVPYLD
A
E
D
K
A
R
GSGG
R
L
V
I
N
CLY
P
E
Q
F
A
GQMRAATASFRHAYP
T
A
L
R
R
R
V
E
E
R
W
SDYGF--------------------------------------------------------------------------------------
51
Fugue
61.87
18%
-134
- C1 -
1DKZ
1
A:
[1-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
----------------
L
D
-----
V
T
P
L
S
L
G
I
E
T
M
G
G
--
V
M
T
T
L
I
A
K
N
-
T
T
I
P
T
K
H
S
Q
V
F
-
S
T
-------------------------
A
E
D
N
---------------------
Q
S
A
----
V
S
---
I
H
V
L
-
Q
G
E
R
K
-
R
A
A
D
----------
N
-------
K
S
L
G
Q
-
F
N
---
L
D
-
G
I
N
P
A
P
R
G
M
------
P
-----------------------
Q
I
-
E
V
T
-
F
D
I
D
A
D
G
I
-
L
H
V
S
A
-------
K
-------
D
K
NSG
K
--
E
Q
K
I
T
I
K
A
S
S
G
L
N
-------------------
E
D
E
I
Q
K
M
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
A
---------------------
N
A
E
A
D
R
K
F
E
E
--------
L
V
Q
T
R
N
Q
G
D
H
L
-------------------
L
H
S
T
R
K
Q
V
E
E
---
A
------------
G
---------------------
D
K
-----------
L
P
A
D
D
K
------------
T
-
A
I
E
-
S
A
L
T
A
-
L
E
T
-
A
L
K
G
E
D
K
--
A
A
I
E
A
K
-
M
-
Q
E
L
A
Q
V
S
----
Q
K
L
M
E
I
A
Q
----------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.08
23%
-162
- C1 -
2Y03
5
ADRB1_MELGA
A:
[8-157]
--------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
W
E
A
G
----------------
M
S
-----
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
-
Q
R
L
Q
T
L
T
N
L
F
I
-
T
S
L
A
C
A
D
--
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
-
V
V
R
G
--------
T
W
L
W
G
S
F
L
-
C
---
E
L
W
----
T
S
---
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
-------
P
F
R
Y
Q
-
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
------
V
W
A
I
S
A
L
V
S
F
L
P
-------------
I
-
M
M
H
-
W
W
R
D
E
D
P
Q
-
A
L
K
C
Y
-------
Q
-------
D
P
---
G
--
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
----
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
I
---------------------
R
S
R
V
M
L
M
R
E
H
--------
K
A
L
K
T
L
G
I
I
M
G
-------------------
V
F
T
L
C
W
L
P
F
F
---
L
------------
V
------------
N
------
I
V
N
V
-----------
F
N
R
D
L
V
------------
P
-
D
W
L
-
F
V
A
F
N
-
W
L
G
-
Y
A
N
S
A
M
N
--
P
I
I
Y
C
R
-
S
-
P
D
F
R
K
A
F
----
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.85
23%
-161
- C1 -
2Y02
9
ADRB1_MELGA
A:
[8-157]
--------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
W
E
A
G
----------------
M
S
-----
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
-
Q
R
L
Q
T
L
T
N
L
F
I
-
T
S
L
A
C
A
D
--
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
-
V
V
R
G
--------
T
W
L
W
G
S
F
L
-
C
---
E
L
W
----
T
S
---
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
-------
P
F
R
Y
Q
-
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
------
V
W
A
I
S
A
L
V
S
F
L
P
-------------
I
-
M
M
H
-
W
W
R
D
E
D
P
Q
-
A
L
K
C
Y
-------
Q
-------
D
P
---
G
--
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
----
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
S
---------------------
R
V
M
L
M
R
E
H
K
A
--------
L
K
T
L
G
I
I
M
G
V
F
-------------------
T
L
C
W
L
P
F
F
L
V
---
N
------------
I
------------
V
------
N
V
F
N
-----------
R
D
L
V
P
D
------------
W
-
L
F
V
-
A
F
N
W
L
-
G
Y
A
-
N
S
A
M
N
P
I
--
I
Y
C
R
S
P
-
D
-
F
R
K
A
F
K
R
----
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.81
23%
-160
- C1 -
4AMJ
8
ADRB1_MELGA
A:
[8-157]
--------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
W
E
A
G
----------------
M
S
-----
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
-
Q
R
L
Q
T
L
T
N
L
F
I
-
T
S
L
A
C
A
D
--
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
-
V
V
R
G
--------
T
W
L
W
G
S
F
L
-
C
---
E
L
W
----
T
S
---
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
-------
P
F
R
Y
Q
-
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
------
V
W
A
I
S
A
L
V
S
F
L
P
-------------
I
-
M
M
H
-
W
W
R
D
E
D
P
Q
-
A
L
K
C
Y
-------
Q
-------
D
P
---
G
--
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
----
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
S
---------------------
R
V
M
L
M
R
E
H
K
A
--------
L
K
T
L
G
I
I
M
G
V
F
-------------------
T
L
C
W
L
P
F
F
L
V
---
N
------------
I
------------
V
------
N
V
F
N
-----------
R
D
L
V
P
D
------------
W
-
L
F
V
-
A
F
N
W
L
-
G
Y
A
-
N
S
A
M
N
P
I
--
I
Y
C
R
S
P
-
D
-
F
R
K
A
F
K
R
----
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------