@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR9A1_HUMAN: (2016-01-14 )
MLGNYSSATEFFLLGFPGSQEVCRILFATFFLLYAVTVMGNVVIIITVCVDKCLQSPIYFFLGHLCVLEILITSTAVPFMLWGLLLPSTQIMSLTACAAQLYLYLSLGTLELALMGVMAVDRYVAVCNPLRYNIIMNSSTFIWVIIVSWVLGFLSEIWPVYATFQLTFCKSSVLDHFYCDRGQLLKVSCEDTLFREFILFLMAVFIIIGSLIPTIVSYTYIISTNLKIPSASGWRKSFSTCASHFTYVVIGYGSCLFLYVKPK
Atome Classification :
(20 SA)
------------------------.........10..--------------....--.----.20........30....-------....40.--------------.......-------50........60........70.....-...80........90........-100..---.....110.....-----..120.......130---.-----------....---....140.......150..----------.....---------------------160----------------------------.........-170...-....180.....-----------..--190--..--.......200.......210.......220.......230------------------.....------....240......----------.250.......260.-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------MLGNYSSA
T
E
F
F
L
--------------LGFP--
G
----
S
Q
E
V
C
R
I
L
F
A
T
F
F
L
L
Y
A
-------
V
T
V
MG
N
V
--------------
V
I
I
I
T
V
C
-------
V
D
K
C
L
QS
P
I
Y
F
F
L
G
H
L
C
V
L
E
I
L
ITST
A
-
V
P
F
M
L
W
G
L
LLPS
T
Q
I
M
S
L
T
A
C
A
A
-
Q
L
Y
L
Y
---
L
S
L
G
T
L
E
L
A
L
M
G
V
-----
M
A
V
D
R
Y
V
A
VCN
P
L
-----
R
-----------
Y
N
I
I
---MNSS
T
F
I
W
V
I
I
V
S
W
V
L
G
F
L
----------
S
E
I
W
P
---------------------
V
------------------------------
Y
A
T
F
Q
L
T
F
C
-
K
S
S
V
L
D
-
H
FYCDRG
Q
L
L
K
V-----------SC--
E
----
D
T
--
L
F
R
E
F
I
L
F
L
M
A
V
F
I
I
I
G
S
L
I
P
T
I
V
S
Y
T
Y
I
I
ST
N
L
KIPS--------------------AS
G
W
R
------
K
S
F
S
T
C
A
S
H
F
T
Y
V
----------
V
I
GYG
S
C
L
F
L
Y
VKPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
89.55
17%
-142
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
--------------
A
P
Q
Y
YL
A
----
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
-------
L
G
F
P
I
N
F
--------------
L
T
L
Y
V
T
V
-------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
---
T
L
G
G
E
I
A
L
W
S
L
V
V
-----
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
------------
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
----------
C
A
A
P
P
---------------------
L
V
GW
S
R
Y
I
P
E
GMQC
S
C
G
I
DYYTPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
-
V
I
F
F
C
Y
G
Q
L
V
F
T
VKEAAAQQQES
A
T
--
T
----
Q
K
--
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
----
Q
--------------------
G
S
D
F
G
------
P
I
F
M
T
I
P
A
F
F
A
K
T
----------
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
TETSQVAPA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
88.05
18%
-158
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
SNKTGVVRSPFEAP
Q
Y
Y
L
--
A
----
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
-------
L
G
F
P
I
N
F
--------------
L
T
L
Y
V
T
V
-------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
---
T
L
G
G
E
I
A
L
W
S
L
V
V
-----
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
-----------
E
N
H
A
---
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
VGW-------
S
R
Y
I
P
E
GMQC
S
C
G
I
DYYTPHEETN
N
E
S
------------------------------
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
-
V
I
F
F
C
Y
G
Q
L
V
F
T
-----------
V
K
--
E
AAAS
A
T
--
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
-
A
F
Y
I
F
T
H
Q
--------------------
G
S
D
F
G
------
P
I
F
M
T
I
P
A
F
F
A
K
T
----------
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPSTTVSKTETS
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
86.62
15%
-150
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
-------
A
I
V
F
G
N
V
--------------
L
V
I
T
A
I
A
-------
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
---
V
L
C
V
T
A
S
I
E
T
L
C
V
-----
I
A
V
D
R
Y
F
A
I
T
S
P
F
-----
K
-----------
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
----------
T
S
F
L
P
---------------------
I
------------------------------
Q
M
H
W
Y
-----
R
A
T
H
Q
E
-
A
I
N
C
Y
A
E
E
T
--------------
C
C
--
D
----
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
--------------------
F
E
M
L
R
------
I
D
E
G
L
R
L
K
I
Y
K
D
T
----------
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
PS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
34
HHSearch
85.76
16%
-177
- C4 -
2Z73
5
OPSD_TODPA
A:
[33-282]
-----------------------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
-------
I
G
C
G
G
N
G
--------------
I
V
I
Y
L
F
T
-------
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
K
W
I
F
G
F
A
A
C
K
V
-
Y
G
F
I
G
---
G
I
F
G
F
M
S
I
M
T
M
A
M
-----
I
S
I
D
R
Y
N
V
I
G
R
P
M
-----
A
-----------
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
----------
W
A
I
G
P
---------------------
I
------------------------------
F
G
W
G
A
Y
T
L
-----
E
G
V
-
L
C
N
C
S
F
D
Y
I
S
R
----------------------
D
--
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
------
R
L
A
K
I
S
I
V
I
V
S
Q
F
----------
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
85.24
18%
-160
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-269]
--------------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
-------
T
S
V
V
G
N
V
--------------
V
V
M
W
I
I
L
-------
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
-
N
E
W
Y
Y
G
L
F
Y
C
K
F
-
H
N
F
F
P
---
I
A
A
V
F
A
S
I
Y
S
M
T
A
-----
V
A
F
D
R
Y
M
A
I
I
H
P
L
-----
Q
-----------
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
----------
L
A
F
P
Q
---------------------
G
------------------------------
Y
Y
S
T
T
-
E
-----
T
M
P
S
-
R
V
V
C
M
I
E
W
P
E
H
P
--------------------
N
K
--
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
---------
V
S
A
K
R
------
K
V
V
K
M
M
I
V
V
V
C
T
F
----------
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
79.73
18%
-146
* C4 *
1U19
10
OPSD_BOVIN
A:
[41-272]
-------------------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
-------
L
G
F
P
I
N
F
--------------
L
T
L
Y
V
T
V
-------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
---
T
L
G
G
E
I
A
L
W
S
L
V
V
-----
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
-----------
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
----------
C
A
A
P
P
---------------------
L
------------------------------
V
G
W
S
R
Y
I
-----
P
E
G
M
-
Q
C
S
C
G
I
D
Y
Y
T
P
H
--------------------
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
QQQESA
T
T
------------
Q
K
A
E
K
------
E
V
T
R
M
V
I
I
M
V
I
A
F
----------
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
79.14
20%
-172
- C4 -
3EML
8
ENLYS_BPT4
A:
[22-221]
-------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
-------
L
A
I
L
G
N
V
--------------
L
V
C
W
A
V
W
-------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
-
I
A
C
F
V
---
L
V
L
T
Q
S
S
I
F
S
L
L
A
-----
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
-----------
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
----------
I
G
L
T
P
---------------------
M
------------------------------
L
G
W
N
N
C
G
Q
---------
S
Q
G
C
G
E
G
Q
---
V
-----------
A
C
--
L
----
F
E
DV
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
--------------------
I
F
E
M
L
------
R
I
D
E
G
L
R
L
K
I
Y
K
D
----------
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.38
24%
-142
- C4 -
4EIY
19
AA2AR_HUMAN (first)
A:
[44-204]
--------------------------------------------------------------------------------------
L
A
I
L
G
N
V
--------------
L
V
C
W
A
V
W
-------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
------
T
I
S
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-----
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
-----------
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
----------
I
G
L
T
P
---------------------
M
------------------------------
L
G
W
N
N
C
G
Q
P
-
K
E
G
K
N
H
-
S
Q
G
C
G
E
G
Q
---
V
-----------
A
C
LF
E
----
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
A
--------------------
D
L
E
D
N
------
W
E
T
L
N
D
N
L
K
V
I
E
K
----------
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
76.90
19%
-158
- C4 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-200]
--------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
-------
V
T
V
G
L
N
L
--------------
L
V
L
Y
A
V
R
-------
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
-
S
K
W
S
L
G
R
P
L
C
L
F
-
W
L
S
M
D
---
Y
V
A
S
T
A
S
I
F
S
V
F
I
-----
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-----
R
-----------
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
----------
W
V
I
P
I
---------------------
L
-------------------------------
G
W
N
H
---------
R
R
-
E
D
K
C
E
T
D
F
Y
----------------------------
D
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
--------------------
I
F
E
M
L
------
R
I
D
E
G
L
R
L
K
I
Y
K
D
----------
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
75.92
16%
-182
- C2 -
4UZ1
5
NOTUM_HUMAN
A:
[9-375]
NED
L
R
L
H
L
LLNTSVTCNDGS
P
A
G
Y
Y
L
K
E
S
R
G
S
R
R
W
L
L
--------------
F
L
E
G
--
G
W
YCF
N
R
E
N
C
D
S
R
Y
D
T
M
R
R
L
M
S
SRDWPR
T
R
T
G
T
G
I
L
SSQPEENPYWWNAN
M
V
F
I
P
Y
C
SSDVWSG
A
S
S
K
S
E
K
N
E
Y
A
F
M
G
A
L
I
I
Q
E
V
V
R
E
L
L
G
-
R
G
L
S
G
A
K
V
L
L
----
L
A
G
S
S
A
G
G
T
-
G
V
L
L
N
---
V
D
R
V
A
E
Q
L
E
K
L
G
Y
-----
P
A
I
Q
V
R
G
L
A
D
S
G
W
-----
F
LDNKQYRHTDC
V
D
T
I
---
T
C
A
P
T
E
A
I
R
R
G
I
R
Y
W
N
G
V
V
P
E
R
C
R
R
Q
F
QE
G
E
E
W
N
---------------------
C
------------------------------
F
F
G
Y
K
V
Y
P
T
L
R
S
P
V
F
V
V
Q
W
L
F
D
E
A
Q
L
T
V
D
-----------
N
V
--
H
----
L
P
--
V
Q
E
G
L
R
L
Y
I
Q
N
L
G
R
E
L
R
H
T
L
K
D
V
P
A
S
F
A
P
A
C
L
S
H
E
I
I
I
--------------------
R
S
H
W
T
DVQVKG
T
S
L
P
R
A
L
H
C
W
D
R
S
L
HKTPLKGCP
V
H
L
V
D
S
C
P
W
P
H
C
N
P
S
CPTG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.91
24%
-148
- C4 -
3EML
8
ENLYS_BPT4
A:
[34-194]
--------------------------------------------------------------------------------------
L
A
I
L
G
N
V
--------------
L
V
C
W
A
V
W
-------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
------
T
I
S
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-----
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
-----------
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
----------
I
G
L
T
P
---------------------
M
------------------------------
L
G
W
N
N
C
G
Q
---------
S
Q
G
C
G
E
G
Q
---
V
-----------
A
C
LF
E
----
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
--------------------
I
F
E
M
L
------
R
I
D
E
G
L
R
L
K
I
Y
K
D
----------
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.77
24%
-147
- C4 -
4UG2
3
?
A:
[19-179]
--------------------------------------------------------------------------------------
L
A
I
L
G
N
V
--------------
L
V
C
W
A
V
W
-------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
------
A
I
S
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-----
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
-----------
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
----------
I
G
L
T
P
---------------------
M
------------------------------
L
G
W
N
N
C
G
Q
P
-
K
E
G
K
A
H
-
S
Q
G
C
G
E
G
Q
---
V
-----------
A
C
LF
E
----
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
A
--------------------
R
S
T
L
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
----------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
75.42
17%
-161
- C4 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
-------
A
I
V
F
G
N
V
--------------
L
V
I
T
A
I
A
-------
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
---
V
L
C
V
T
A
S
I
E
T
L
C
V
-----
I
A
V
D
R
Y
F
A
I
T
S
P
F
-----
K
-----------
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
----------
T
S
F
L
P
---------------------
I
------------------------------
Q
M
H
W
Y
R
A
T
H
-----
Q
E
-
A
I
N
C
Y
A
----
E
E
-----------
T
C
--
C
----
D
F
--
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
--------------------
I
F
E
M
L
------
R
I
D
E
G
L
R
L
K
I
Y
K
D
----------
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.29
24%
-148
- C4 -
2YDO
3
?
A:
[19-179]
--------------------------------------------------------------------------------------
L
A
I
L
G
N
V
--------------
L
V
C
W
A
V
W
-------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
------
A
I
S
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-----
I
A
I
D
R
Y
I
A
I
R
I
P
L
-----
R
-----------
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
----------
I
G
L
T
P
---------------------
M
------------------------------
L
G
W
N
N
C
G
Q
P
-
K
E
G
K
A
H
-
S
Q
G
C
G
E
G
Q
---
V
-----------
A
C
LF
E
----
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
--------------------
Q
M
E
S
T
------
L
Q
K
E
V
H
A
A
K
S
L
A
I
----------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.98
26%
-171
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[19-179]
--------------------------------------------------------------------------------------
L
A
I
L
G
N
V
--------------
L
V
C
W
A
V
W
-------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
---------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
---
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-----
R
-----------
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
----------
I
G
L
T
P
---------------------
M
------------------------------
L
G
W
N
N
C
G
Q
P
----------
G
C
G
E
G
Q
---
V
-----------
A
C
L
F
E
----
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
--------------------
Q
M
E
S
Q
------
P
L
P
G
E
R
A
R
S
T
L
Q
K
----------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
74.75
18%
-169
- C4 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-226]
---------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
-------
A
I
V
F
G
N
G
--------------
L
V
C
M
A
V
L
-------
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
-
F
V
T
L
D
---
V
M
M
C
T
A
S
I
W
N
L
C
A
-----
I
S
I
D
R
Y
T
A
V
V
M
P
V
-----
H
-----------
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
----------
V
S
C
P
L
---------------------
L
------------------------------
F
G
F
N
T
T
--------
G
D
-
P
T
V
C
S
I
---------------------------
S
--
N
--
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
--------------------
K
N
I
F
E
------
M
L
R
I
D
E
G
L
R
L
K
I
Y
----------
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.61
26%
-172
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[19-179]
--------------------------------------------------------------------------------------
L
A
I
L
G
N
V
--------------
L
V
C
W
A
V
W
-------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
---------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
---
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-----
R
-----------
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
----------
I
G
L
T
P
---------------------
M
------------------------------
L
G
W
N
N
C
G
Q
P
----------
G
C
G
E
G
Q
---
V
-----------
A
C
L
F
E
----
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
--------------------
Q
M
E
S
Q
------
P
L
P
G
E
R
A
R
S
T
L
Q
K
----------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.40
26%
-172
- C4 -
3PWH
1
?
A:
[19-179]
--------------------------------------------------------------------------------------
L
A
I
L
G
N
V
--------------
L
V
C
W
A
V
W
-------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
---------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
---
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-----
R
-----------
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
----------
I
G
L
T
P
---------------------
M
------------------------------
L
G
W
N
N
C
G
Q
P
----------
G
C
G
E
G
Q
---
V
-----------
A
C
LF
E
----
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
--------------------
Q
M
E
S
Q
------
P
L
P
G
E
R
A
R
S
T
L
Q
K
----------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
74.26
19%
-154
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-239]
-----------------------------------------------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
-------
T
G
I
V
G
N
G
--------------
L
V
I
L
V
M
G
-------
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
-
V
H
V
I
Y
---
T
V
N
L
Y
S
S
V
W
I
L
A
F
-----
I
S
L
D
R
Y
L
A
I
V
H
A
T
-----
N
-----------
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
----------
L
T
I
P
D
---------------------
F
------------------------------
I
F
A
N
V
S
E
------
A
D
D
-
R
Y
I
C
D
R
F
Y
P
N
-----------------------
D
--
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
--------------------
N
I
F
E
M
------
L
R
I
D
E
G
L
R
L
K
I
Y
K
----------
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.28
26%
-169
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[19-179]
--------------------------------------------------------------------------------------
L
A
I
L
G
N
V
--------------
L
V
C
W
A
V
W
-------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
---------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
---
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-----
R
-----------
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
----------
I
G
L
T
P
---------------------
M
------------------------------
L
G
W
N
N
C
G
Q
P
----------
G
C
G
E
G
Q
---
V
-----------
A
C
L
F
E
----
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
--------------------
Q
M
E
S
Q
------
P
L
P
G
E
R
A
R
S
T
L
Q
K
----------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------