@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR9Q1_HUMAN: (2016-01-14 )
MAEMNLTLVTEFLLIAFTEYPEWALPLFLLFLFMYLITVLGNLEMIILILMDHQLHAPMYFLLSHLAFMDVCYSSITVPQMLAVLLEHGAALSYTRCAAQFFLFTFFGSIDCYLLALMAYDRYLAVCQPLLYVTILTQQARLSLVAGAYVAGLISALVRTVSAFTLSFCGTSEIDFIFCDLPPLLKLTCGESYTQEVLIIMFAIFVIPASMVVILVSYLFIIVAIMGIPAGSQAKTFSTCTSHLTAVSLFFGTLIFMYLRGNSDQSSEKNRVVSVLYTEVIPMLNPLIYSLRNKEVKEALRKILNRAKLS
Atome Classification :
(20 SA)
------------.........10........---------------20........30.--.......40---........50..-.-...-..60........70......-..80........90........100.......110-------.......120.......130......-.140.......150.......160.......170.......180.......190------.....---....200--...--.....210.......220------......------.-.230---.------------..---------------------......240.......------------250.......-------260..---.---...---.270------........280.......290.......300.......310-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MAE
M
N
L
T
L
V
T
E
F
L
L
I
A
FTE---------------YPE
W
A
L
P
L
F
L
L
F
L
--
F
M
Y
L
I
T
V
LG---
N
L
E
M
I
I
L
I
L
MDH-Q-LH
A
-
P
M
Y
F
L
L
S
H
L
A
F
M
D
V
C
Y
SSI
T
-
V
P
Q
M
L
A
V
L
L
EHGAA
L
S
Y
T
R
C
A
A
Q
F
F
L
F
T
F
FG
S
I
D
C
-------
Y
L
L
A
L
M
A
Y
D
R
Y
L
A
V
C
Q
P
L
L
Y
V
T
I
L
T
Q
-
Q
A
R
L
S
L
V
A
G
A
Y
V
A
G
L
I
S
A
L
V
R
T
V
S
A
F
T
L
S
FCGTSEI
D
F
I
F
CDLP
P
L
L
K
LTCG--------
E
S
Y
T
Q
---
E
V
L
I
I
M
---
F
A
I
--
F
V
I
P
A
S
M
V
V
I
L
V
S
Y
L
F
I
-------
I
V
A
I
MG------I-PA-----G------------SQ---------------------A
K
T
F
S
T
C
T
S
H
L
T
A
V
S
L
------------
F
F
G
T
L
I
F
M
Y
L
-------RGNSD---Q---SSE---K
N
R
-------
V
V
S
V
L
Y
T
E
V
I
P
M
L
N
P
L
I
Y
S
LR
N
K
E
V
K
E
A
L
R
K
I
L
N
R
AKLS---------------------
14
PsiBlast_PDB
82.36
20%
-157
- C2 -
3DQB
6
GNAT1_BOVIN (first)
A:
[39-325]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----
Q
------------
Q
Q
E--------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
12
PsiBlast_PDB
81.69
20%
-154
- C2 -
3C9L
13
OPSD_BOVIN
A:
[39-325]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----
Q
------------
Q
Q
E--------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
---------------------
17
PsiBlast_PDB
81.66
20%
-157
- C2 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[39-325]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----
Q
------------
Q
Q
E--------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
2
PsiBlast_PDB
81.18
24%
-144
- C2 -
4U14
1
ENLYS_BPT4
A:
[13-289]
-----------------------------------------------------
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
---
N
I
L
V
I
V
A
F
K
V
N
K
-
Q
-
L
K
T
V
N
N
Y
F
L
L
S
-
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
-------
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
T
-
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
--
L
W
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
-------
P
P
------
G
--------
E
C
F
I
Q
FLS
E
P
T
I
T
F
G
T
A
I
A
A
--
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
-------
E
T
E
K
M
N
C
F
E
M
L
R
I
-
D
E
-----
G
------------
L
R
---------------------
L
K
I
Y
K
D
C
E
G
Y
Y
T
---
I
------------
G
I
G
H
L
L
T
K
S
P
-------
S
L
N
A
A
---
K
----
S
E
---
L
D
K
-------
A
I
G
R
N
T
N
G
V
I
T
--
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
---------------------
18
PsiBlast_PDB
80.91
20%
-153
- C2 -
4PXF
8
OPSD_BOVIN
A:
[39-325]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----
Q
------------
Q
Q
E--------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
16
PsiBlast_PDB
80.87
20%
-156
- C2 -
3PXO
5
OPSD_BOVIN
A:
[39-325]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----
Q
------------
Q
Q
E--------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
15
PsiBlast_PDB
80.58
20%
-159
- C2 -
3PQR
10
OPSD_BOVIN
A:
[39-325]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----
Q
------------
Q
Q
E--------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
10
PsiBlast_PDB
79.89
23%
-151
- C2 -
3PDS
4
ADRB2_HUMAN (first)
A:
[8-290]
-------------------------------------------------
W
V
V
G
M
G
I
V
M
S
--
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
-
R
-
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
M
K
M
W
T
F
G
N
F
W
C
E
-------
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
--------
D
F
F
T
N
---
Q
A
Y
A
I
A
---
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
------
I
-
D
E
-----
G
------------
L
R
---------------------
L
K
I
Y
K
D
T
E
G
Y
Y
T
---
I
------------
G
I
G
H
L
L
T
K
S
P
-------
S
L
N
A
A
---
K
----
S
E
---
L
D
K
-------
A
I
G
R
N
T
N
G
V
I
T
--
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
---------------------
11
PsiBlast_PDB
79.70
20%
-155
- C2 -
3CAP
5
OPSD_BOVIN
A:
[39-325]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----
Q
------------
Q
Q
E--------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
19
PsiBlast_PDB
78.54
20%
-141
- C2 -
3OAX
17
OPSD_BOVIN
A:
[42-326]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----
Q
------------
Q
Q
E--------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
---------------------
6
PsiBlast_PDB
78.35
23%
-155
- C2 -
3D4S
6
ENLYS_BPT4
A:
[40-322]
-------------------------------------------------
W
V
V
G
M
G
I
V
M
S
--
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
-
R
-
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
-------
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
--------
D
F
F
T
N
---
Q
A
Y
A
I
A
---
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLN
I
F
E
M
L
R
------
I
-
D
E
-----
G
------------
L
R
---------------------
L
K
I
Y
K
D
T
E
G
Y
Y
T
---
I
------------
G
I
G
H
L
L
T
K
S
P
-------
S
L
N
A
A
---
K
----
S
E
---
L
D
K
-------
A
I
G
R
N
T
N
G
V
I
T
--
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
---------------------
9
PsiBlast_PDB
78.24
23%
-154
- C2 -
3NYA
3
ADRB2_HUMAN (first)
A:
[40-322]
-------------------------------------------------
W
V
V
G
M
G
I
V
M
S
--
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
-
R
-
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
-------
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
--------
D
F
F
T
N
---
Q
A
Y
A
I
A
---
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
------
I
-
D
E
-----
G
------------
L
R
---------------------
L
K
I
Y
K
D
T
E
G
Y
Y
T
---
I
------------
G
I
G
H
L
L
T
K
S
P
-------
S
L
N
A
A
---
K
----
S
E
---
L
D
K
-------
A
I
G
R
N
T
N
G
V
I
T
--
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
---------------------
20
PsiBlast_PDB
77.92
20%
-142
- C2 -
1GZM
15
OPSD_BOVIN
A:
[42-326]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----
Q
------------
Q
Q
E--------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
---------------------
8
PsiBlast_PDB
77.89
23%
-150
- C2 -
3NY9
4
ADRB2_HUMAN (first)
A:
[40-322]
-------------------------------------------------
W
V
V
G
M
G
I
V
M
S
--
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
-
R
-
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
-------
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
--------
D
F
F
T
N
---
Q
A
Y
A
I
A
---
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
------
I
-
D
E
-----
G
------------
L
R
---------------------
L
K
I
Y
K
D
T
E
G
Y
Y
T
---
I
------------
G
I
G
H
L
L
T
K
S
P
-------
S
L
N
A
A
---
K
----
S
E
---
L
D
K
-------
A
I
G
R
N
T
N
G
V
I
T
--
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
---------------------
7
PsiBlast_PDB
77.60
23%
-152
- C2 -
3NY8
7
ENLYS_BPT4
A:
[40-322]
-------------------------------------------------
W
V
V
G
M
G
I
V
M
S
--
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
-
R
-
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
-------
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
--------
D
F
F
T
N
---
Q
A
Y
A
I
A
---
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
------
I
-
D
E
-----
G
------------
L
R
---------------------
L
K
I
Y
K
D
T
E
G
Y
Y
T
---
I
------------
G
I
G
H
L
L
T
K
S
P
-------
S
L
N
A
A
---
K
----
S
E
---
L
D
K
-------
A
I
G
R
N
T
N
G
V
I
T
--
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
---------------------
13
PsiBlast_PDB
77.38
20%
-150
- C2 -
1F88
7
OPSD_BOVIN
A:
[39-325]
-------------------------------------------------------
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
DYYTPHE
E
T
N
N
E
---
S
F
V
I
Y
M
---
F
V
V
H-
F
I
I
P
--
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
-----------------------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-------
H
Q
G
S
D
-------
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
---------------------
42
Fugue
77.31
18%
-149
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
TGVVRSPFEAPQYYL
A
E
P
W
Q
F
S
M
L
A
A
Y
M
--
F
L
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---------
G
W
S
R
------
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH-
E
E
T
N
N
---
E
S
F
V
I
Y
---
M
F
V
--
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
A
A
S
-----
A
------------
T
T
---------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
------------
A
F
L
I
C
W
L
P
Y
A
-------
G
V
A
F
Y
---
I
---
F
T
H
---
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A------
36
HHSearch
75.09
16%
-160
- C2 -
2Z73
5
OPSD_TODPA
A:
[34-333]
--------------------------------------------------
Y
Y
S
L
G
I
F
I
G
--
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
-
S
-
L
Q
T
-
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
-------
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
-
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
---
T
-
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------------
R
D
S
T
T
---
R
S
N
I
L
C
---
M
F
I
--
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-------
V
M
S
V
S
N
------
H
-
E
K
-----
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
------------
S
W
S
P
Y
A
V
V
A
L
-------
L
A
Q
F
G
PLE
W
---
V
T
P
---
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
---------------------
43
Fugue
73.58
17%
-128
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
---------------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
--
F
L
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---------
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH-
E
E
T
N
N
---
E
S
F
V
I
Y
---
M
F
V
--
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
------
A
-
A
A
QQQES
A
------------
T
T
---------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
------------
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
---
D
---
F
G
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
LGDDEA
S
T
T
V
S
K
TETSQVAPA
34
HHSearch
73.54
14%
-153
* C2 *
2KS9
1
NK1R_HUMAN
A:
[35-324]
-----------------------------------------------------
W
A
A
A
Y
T
--
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
-
R
-
M
R
T
-
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
-------
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
-
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
T
----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------
N
K
I
Y
E
---
K
V
Y
H
I
C
---
V
T
V
--
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-------
G
I
T
L
W
A
------
S
-
E
I
-----
P
GDSSDRYH
E
Q
V
S
A
K
---------------------
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
------------
C
W
L
P
F
H
I
F
F
L
-------
L
P
Y
I
N
---
P
DLY
L
K
K
FI
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
---------------------