@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OXER1_HUMAN: (2016-01-14 )
MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90...-.....100.......110.......120.......130.......140..-......150.......160.......170.......180.......190.......200.---......210.....-----.-.220......---------.-230..-----.--------..-..240---.------..------....250...----....260.....-..270---------.....----....280---.--------------------------------------..-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------..-------..290..--------.....300.......310-.........320.----.---...---..330.-......340.......350.......360.......370.......380.......390.......400.......410.......420.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLCHRG
G
Q
L
I
V
P
IIPLCPEHSC
R
G
R
R
L
Q
N
L
LSGPWPKQP
M
E
LHNLSSPSPSLSSSVLPPSFSPSPSSAP
S
A
F
T
TVGGSSGGPCHP
T
S
S
S
L
V
S
A
F
-
L
A
P
I
L
A
L
E
F
V
L
G
L
VGN
S
L
A
L
F
I
F
C
IHTRPWTSN
T
V
F
L
V
S
L
V
A
A
D
F
L
L
-IS-NLPL
R
V
D
Y
Y
L
L
H
E
T
WRFGA
A
A
C
K
V
N
L
F
M
L
STNR
T
A
S
V
V
F
L
T
A
I
A
L
N
R
Y
L
K
V
VQ
P
H
H
V
L
S
R
---ASVG
A
A
A
R
VAG
G
L
W
-----
V
-
G
I
L
L
LN
G
H
L
L
---------
L
-
S
TFSG-----P--------
S
C
-
L
S
Y
RV---G------TK------PSA
S
L
R
W
H
Q
A
----
L
Y
L
L
E
F
F
L
P
L
A
L
-
I
L
F
-----------
A
I
V
S
I
----
G
L
T
I
RN----R--------------------------------------GL-----------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------GQ-------A
G
P
Q
R
A
M
--------
R
V
L
A
M
V
V
A
V
Y
T
I
C
F
L
P
---
S
I
I
F
G
M
A
S
M
V
A
F
W
----
L
---
S
A
C
---
R
S
L
D
L
C
-
T
Q
L
FHG
S
L
A
F
T
Y
L
N
S
V
L
D
P
V
L
Y
C
FSSP
N
F
L
H
Q
S
R
A
L
L
G
LTRGRQGPVSDESSYQP
S
R
Q
W
R
Y
R
E
AS
R
K
A
E
A
I
G
K
L
K
V
Q
G
E
V
S
L
EKEGSSQG
43
Fugue
90.51
24%
-146
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------------------------------------------------------------------
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
-
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
-
T
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
-
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
-----
L
-
I
V
V
V
A
I
S
P
I
L
---------
F
-
Y
S
G
T
G
-----
V
R
KNKTI--
T
C
-
Y
D
T
T
S
---
D
------
E
Y
------
L
R
S
Y
F
I
Y
S
M
C
----
T
T
V
A
M
F
C
V
P
L
V
L
-
I
L
G
-----------
C
Y
G
L
I
----
V
R
A
L
I
Y
----
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLC
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
Q
F
E
E
V
EE
P
L
R
R
K
S
I
--------
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
---
F
H
V
M
K
T
M
N
L
R
A
R
L
DFQT
P
---
A
M
C
---
A
F
N
D
R
V
-
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------------------------
35
HHSearch
87.86
22%
-141
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
-
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
-----
V
-
L
A
F
A
V
S
C
P
L
L
---------
F
-
G
F
N
T
T
-----
G
DPT-----
V
C
-
S
I
S
N
-----------------------
P
D
F
V
I
Y
----
S
S
V
V
S
F
Y
L
P
F
G
V
-
T
V
L
-----------
V
Y
A
R
I
----
Y
V
V
L
K
Q
----
R
--------------------------------------
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
P
-------
L
R
E
K
K
A
T
--------
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
---
F
F
L
T
H
V
L
N
T
H
C
Q
T
----
C
------------
H
V
S
-
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------------------------------------------------
28
HHSearch
81.86
22%
-138
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------------------------------------------------------
P
-
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
-
G
A
V
V
M
P
M
N
I
L
Y
L
-
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
-----
F
-
L
S
F
L
W
V
I
P
I
L
---------
G
-
W
N
H
--RRE--
D
--------
K
C
-
E
T
D
F
Y
---
D
-----------------
V
T
W
F
K
V
M
----
T
A
I
I
N
F
Y
L
P
T
L
L
-
M
L
W
-----------
F
Y
A
K
I
----
Y
K
A
V
R
Q
----
H
--------------------------------------
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
M
-------
N
R
E
R
K
A
A
--------
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
---
Y
F
I
F
F
M
V
I
A
F
C
K
N
-----------------
C
C
N
-
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
---------------------------------------------------
23
HHSearch
81.65
20%
-133
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[42-498]
-------------------------------------------------------------------------------------
E
N
A
N
F
N
K
I
F
-
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
-
V
I
-
T
L
P
F
W
A
V
D
A
-
V
-
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
-----
I
-
P
A
L
L
L
T
I
P
D
F
---------
I
-
F
A
N
V
S
-----
E
A
DD
R
Y
---
I
C
-
D
R
F
Y
P
---
N
------
D
L
--------
W
V
V
V
F
Q
F
Q
----
H
I
M
V
G
L
I
L
P
G
I
V
-
I
L
S
-----------
C
Y
C
I
I
----
I
S
K
L
S
H
----
S
--------------------------------------
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-------
H
Q
K
R
K
A
L
--------
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
---
Y
Y
I
G
I
S
I
D
S
F
I
L
L
----
E
I
I
K
Q
G
C
---
E
F
E
N
T
V
-
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
------------------------------------------
44
Fugue
81.23
21%
-112
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
--------------------------------
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
-----------------------
E
P
W
Q
F
S
M
-
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-----
M
-
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
----
I
-
P
E
G
M
Q
-----
C
--------
S
C
G
I
D
Y
Y
T
---
P
------
H
E
------
E
T
N
N
E
S
F
V
I
Y
----
M
F
V
V
H
F
I
I
P
L
I
V
-
I
F
F
-----------
C
Y
G
Q
L
----
V
F
T
V
K
E
----
A
--------------------------------------
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
ES-----
A
T
T
Q
K
A
E
--------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
-----
I
C
W
L
P
Y
A
G
V
A
F
Y
----
I
---
F
T
H
---
Q
G
S
D
F
G
-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
------
E
T
S
Q
V
A
P
A
--------------------
45
Fugue
79.79
20%
-115
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
-------------------------
F
S
N
K
T
G
V
V
R
S
P
F
E
------------------------------
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
-
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-----
M
-
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
-
Q
C
S
C
G
-----
I
--------
D
Y
-
Y
T
------
P
------
H
E
------
E
T
N
N
E
S
F
V
I
Y
----
M
F
V
V
H
F
I
I
P
L
I
V
-
I
F
F
-----------
C
Y
G
Q
L
----
V
F
T
V
K
E
----
A
--------------------------------------
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
---------
T
Q
K
A
E
--------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
-----
I
C
W
L
P
Y
A
G
V
A
F
Y
----
I
---
F
T
H
---
Q
G
S
D
F
G
-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------------
27
HHSearch
79.76
20%
-136
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
-----------------------------------------------------------------------------------------
V
W
V
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
-
G
L
A
V
V
P
F
G
A
A
H
I
-
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
-----
I
-
V
S
G
L
T
S
F
L
P
I
---------
Q
M
H
W
Y
R
A
TH
Q
E
A
I
--------
N
C
-
Y
A
E
E
T
---
C
------
C
D
------
F
F
T
N
Q
A
Y
A
I
A
----
S
S
I
V
S
F
Y
V
P
L
V
I
-
M
V
F
-----------
V
Y
S
R
V
----
F
Q
E
A
K
R
----
Q
--------------------------------------
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
C
-------
L
K
E
H
K
A
L
--------
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
---
F
F
I
V
N
I
V
H
V
I
Q
D
N
-----------------
L
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------------
10
PsiBlast_PDB
79.69
27%
-141
- C2 -
5C1M
7
?
A:
[11-292]
--------------------------------------------------------------------------------------
S
P
S
M
V
T
A
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
-
T
L
P
F
Q
S
V
N
Y
L
M
-
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
-----
I
----
L
S
S
A
I
G
L
---------
P
-
V
M
F
M
A
-----
T
--------
T
---
K
Y
R
Q
---
G
SIDC
T
L
T
F
------
S
H
P
T
W
Y
W
E
N
L
----
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
-----------
I
T
V
C
Y
----
G
L
M
I
L
R
L
K
S
V
R
--------------------------------------
M
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
-------
K
E
K
D
R
N
L
R
R
I
T
----
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
---
I
H
I
Y
V
I
I
K
A
--------
L
---
I
T
I
---
P
E
T
T
F
Q
-
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
---------------------------------------------------------
4
PsiBlast_PDB
79.28
25%
-144
- C2 -
4XT1
15
US28_HCMVA
A:
[23-318]
-------------------------------------------------------------
D
Y
D
E
D
A
T
P
C
V
F
T
D
V
L
N
Q
S
K
P
---------
V
T
L
F
-
L
Y
G
V
V
---
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
-
V
C
-
T
L
P
L
W
M
Q
Y
L
L
D
-------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
R
Y
-------
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
-----
I
F
A
V
I
I
A
I
P
H
F
M
---------
V
-
V
T
K
K
D
-----
N
--------
Q
C
-
M
T
D
Y
D
---
Y
------
L
E
------
V
S
Y
P
I
I
L
N
V
E
----
L
M
L
G
A
F
V
I
P
L
S
V
-
I
S
Y
-----------
C
Y
Y
R
I
----
S
---
R
I
----
V
--------------------------------------
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
-------
R
H
K
G
R
I
V
--------
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
K
W
I
----
S
---
S
S
C
E
F
E
R
S
L
K
R
--
A
L
I
L
T
E
S
L
A
F
C
--
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
F
R
-------------------------------------------------
24
HHSearch
79.02
18%
-144
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
-------------------------------------------------------------------------------------------
V
V
F
-
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
-
G
V
F
S
M
N
L
Y
T
L
Y
T
-
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
-----
V
-
L
S
F
I
L
W
A
P
A
I
---------
L
-
F
W
Q
F
I
-----
V
GVRTVEDG
E
C
-
Y
I
Q
F
F
--------------------
S
N
A
A
V
T
F
G
----
T
A
I
A
A
F
Y
L
P
V
I
I
-
M
T
V
-----------
L
Y
W
H
I
----
S
R
A
S
K
S
----
R
--------------------------------------
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
-------
S
R
E
K
K
V
T
--------
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
---
Y
N
V
M
V
L
I
N
T
F
C
A
P
-----------------
C
I
P
-
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
----------------------------------------------------
3
PsiBlast_PDB
78.85
26%
-132
- C2 -
4N6H
23
C562_ECOLX (first)
A:
[112-408]
-------------------------------------------------------------------------------
G
S
P
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
-
T
L
P
F
Q
S
A
K
Y
L
M
-
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
-----
V
-
L
A
S
G
V
G
V
P
I
M
---------
V
-
M
A
V
T
R
-----
P
--------------
R
D
---
G
------
A
V
VC
M
L
Q
F
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
-
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
L
L
S
----
G
S
K
E
K
D
----
R
--------------------------------------
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
I
T
--------
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
---
I
H
I
F
-----
V
I
V
W
T
L--
V
---
D
I
D
---
R
R
D
P
L
V
-
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
------------------------------------------------
6
PsiBlast_PDB
78.00
27%
-132
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[135-405]
---------------------------------------------------------------------------------------------------------
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
-
T
L
P
F
Q
S
A
K
Y
L
M
-
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
-----
V
-
L
A
S
G
V
G
V
P
I
M
---------
V
-
M
A
V
T
R
-----
P
--------------
R
D
---
G
------
A
V
V
C
M
L
Q
F
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
-
I
T
V
C
Y
G
L
M
LL-------------
G
S
K
E
K
D
----
R
--------------------------------------
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
I
T
--------
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
---
I
H
I
F
-----
V
I
V
W
T
L--
V
---
D
I
D
---
R
R
D
P
L
V
-
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-----------------------------------------------------
5
PsiBlast_PDB
77.92
25%
-138
- C2 -
4XT3
2
US28_HCMVA
A:
[26-316]
----------------------------------------------------------------
E
D
A
T
P
C
V
F
T
D
V
L
N
Q
S
K
P
---------
V
T
L
F
-
L
Y
G
V
V
---
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
-
V
C
-
T
L
P
L
W
M
Q
Y
L
L
D
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
R
Y
-------
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
-----
I
F
A
V
I
I
A
I
P
H
F
M
---------
V
-
V
T
K
K
D
-----
N
--------
Q
C
-
M
T
D
Y
D
---
Y
------
L
E
------
V
S
Y
P
I
I
L
N
V
E
----
L
M
L
G
A
F
V
I
P
L
S
V
-
I
S
Y
-----------
C
Y
Y
R
I
----
S
---
R
I
----
V
--------------------------------------
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
-------
R
H
K
G
R
I
V
--------
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
K
W
I
----
S
---
S
S
C
E
F
E
R
S
L
K
R
--
A
L
I
L
T
E
S
L
A
F
C
--
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
---------------------------------------------------
16
PsiBlast_PDB
75.90
22%
-157
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[17-299]
--------------------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
-
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
-
S
F
L
P
I
M
M
H
W
W
RDED
P
Q
A
--
L
-
K
C
Y
Q
D
-----
P
--------
G
C
-
C
D
F
-
V
---
T
------
N
R
------
A
Y
A
I
-----
A
----
S
S
I
I
S
F
Y
I
P
L
L
I
-
M
I
F
-----------
V
A
L
R
V
----
Y
R
E
A
K
E
Q
I
--
R
--------------------------------------
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
-------
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
---
F
F
L
V
N
I
V
N
V
F
------------------
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------
7
PsiBlast_PDB
75.88
27%
-127
- C2 -
4RWD
6
C562_ECOLX (first)
A:
[135-405]
---------------------------------------------------------------------------------------------------------
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
-
T
L
P
F
Q
S
A
K
Y
L
M
-
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
-----
V
-
L
A
S
G
V
G
V
P
I
M
---------
V
-
M
A
V
T
R
-----
P
--------------
R
D
---
G
------
A
V
V
C
M
L
Q
F
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
-
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
L
L
S
----
G
S
K
E
K
D
----
R
--------------------------------------
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
I
T
--------
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
---
I
H
I
F
-----
V
I
V
W
T
L--
V
---
D
I
D
---
R
R
D
P
L
V
-
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-----------------------------------------------------
17
PsiBlast_PDB
75.49
22%
-153
- C2 -
2YCY
6
ADRB1_MELGA
A:
[17-299]
--------------------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
-
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
-
S
F
L
P
I
M
M
H
W
W
RDED
P
Q
A
--
L
-
K
C
Y
Q
D
-----
P
--------
G
C
-
C
D
F
-
V
---
T
------
N
R
------
A
Y
A
I
-----
A
----
S
S
I
I
S
F
Y
I
P
L
L
I
-
M
I
F
-----------
V
A
L
R
V
----
Y
R
E
A
K
E
Q
I
--
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
-------
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
---
F
F
L
V
N
I
V
N
V
F
------------------
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------
32
HHSearch
74.52
23%
-136
- C2 -
2KS9
1
NK1R_HUMAN
A:
[32-326]
-------------------------------------------------------------------------------------------
I
V
L
-
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
-
A
A
F
N
T
V
V
N
F
T
Y
A
-
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
-----
V
-
L
A
L
L
L
A
F
P
Q
G
---------
Y
-
Y
S
T
T
E
-----
T
MPSRV---
V
C
-
M
I
E
W
P
---
E
------
H
P
N-----
K
I
Y
E
K
V
Y
H
I
C
----
V
T
V
L
I
Y
F
L
P
L
L
V
-
I
G
Y
-----------
A
Y
T
V
V
----
G
I
T
L
W
A
----
S
--------------------------------------
E
I
PGDSSDRYH--------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
-------
S
A
K
R
K
V
V
--------
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
---
F
H
I
F
F
L
L
P
Y
I
N
P
D
----
L
---
Y
L
------
K
K
F
I
-
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
---------
31
HHSearch
74.50
20%
-130
- C2 -
3EML
13
ENLYS_BPT4
A:
[21-472]
-------------------------------------------------------------------------------------------
S
S
V
-
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
-
G
V
L
A
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
-----
V
-
L
S
F
A
I
G
L
T
P
M
---------
L
-
G
W
N
N
C
GQS--
Q
--------
G
C
-
G
E
G
Q
V
ACL
F
------
E
D
------
V
V
P
M
N
Y
M
V
Y
F
----
N
F
F
A
C
V
L
V
P
L
L
L
-
M
L
G
-----------
V
Y
L
R
I
----
F
L
A
A
R
R
----
Q
--------------------------------------
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
-------
Q
K
E
V
H
A
A
--------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
---
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
---
S
--------
H
A
P
-
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------------------
14
PsiBlast_PDB
74.22
22%
-158
- C2 -
2YCW
7
ADRB1_MELGA
A:
[17-299]
--------------------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
-
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
-
S
F
L
P
I
M
M
H
W
W
RDED
P
Q
A
--
L
-
K
C
Y
Q
D
-----
P
--------
G
C
-
C
D
F
-
V
---
T
------
N
R
------
A
Y
A
I
-----
A
----
S
S
I
I
S
F
Y
I
P
L
L
I
-
M
I
F
-----------
V
A
L
R
V
----
Y
R
E
A
K
E
Q
I
--
R
--------------------------------------
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
-------
S
K
R
K
R
V
M
L
M
R
E
H
KA
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
---
F
F
L
V
N
I
V
N
V
F
------------------
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------
20
PsiBlast_PDB
74.19
23%
-163
- C2 -
2Y02
13
ADRB1_MELGA
A:
[17-300]
--------------------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-
V
V
P
F
G
A
T
L
-
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
-
S
F
L
P
I
M
M
H
W
W
RDED
P
Q
A
--
L
-
K
C
Y
Q
D
-----
P
--------
G
C
-
C
D
F
-
V
---
T
------
N
R
------
A
Y
A
I
-----
A
----
S
S
I
I
S
F
Y
I
P
L
L
I
-
M
I
F
-----------
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
---
F
F
L
V
N
I
V
N
V
F
------------------
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------