@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OXYR_HUMAN: (2016-01-14 )
MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA
Atome Classification :
(20 SA)
.........10......--..20........30...------.....40........50........60........70........80......-..90........100...-....110.......120.......130.......140..--..---...--150.---.---.....160.......170.......180....-----...---..190-...--.---....200.......210.......220.......230-----...---------------------------......240-..------------------------------.----------.------------------..------.-----------------250-------.---------------------------------------------------.------------------------------------------------------------..-----------.---------------..-.--.--------------260....---...270.......280.......290----......-------------..300...----------....310....------------------------...320.......330.......340.......350...-....360.......370.......380.......----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEGALAANWSAEAANAS--AAPPGAEGNRTAGPPR
R
------
N
E
A
L
A
R
V
E
V
A
V
L
C
L
I
L
L
L
ALSGN
A
C
V
L
L
A
L
RT
T
R
Q
K
H
S
R
L
F
F
F
M
K
H
L
S
I
A
D
L
V
-
V
A
V
F
Q
V
L
P
Q
L
L
W
D
I
T
F
RF-Y
G
P
D
L
L
C
R
L
V
K
Y
L
Q
V
V
G
M
F
A
S
T
Y
L
L
L
L
M
S
L
D
R
C
L
A
I
C
Q
P
--
L
R
---
S
L
R
--
R
R
T
D
---
R
---
L
A
V
L
A
T
W
L
G
C
L
VASAP
Q
V
H
I
F
S
L
R
E
V
--A
D
G
V
-----
F
D
C
---
W
A
V
F
--IQP--W---GP
K
A
Y
I
T
W
I
T
L
A
V
Y
I
V
P
V
I
V
L
A
A
C
Y
G
L
I
S
F
K
I
W
Q
N-------LRL---------------------------KTAAAAAAE-AP------------------------------E----------G------------------AA------A-----------------G---------D---------------------------------------------------G------------------------------------------------------------
G
R
-----------
V
---------------
A
L
-
A
--
R
--------------
V
S
S
V
K
L
I
---
S
KA
K
I
R
T
V
K
M
T
F
I
I
V
L
A
F
I
V
CW
T
P
F
-----
F
F
V
Q
M
W
-------------
S
V
WDANAP----------K
E
A
S
A
F
I
I
V
M
L
------------------------
L
A
S
L
N
S
C
C
N
P
W
I
Y
M
L
F
T
G
H
L
F
H
E
L
V
Q
R
F
L
CCS
A
S
Y
LKGR-RLGETSASKKSNSS
S
F
V
L
SHRSSSQRSCSQPSTA----------
30
HHSearch
83.03
22%
-151
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[12-443]
--------------------------------------------------
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
-
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
S
K
W
-
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
--
L
R
---
Y
L
K
--
Y
R
T
K
---
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
H
-------
R
R
E
-----
D
K
C
---
E
T
D
F
--
Y
D
--------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
-------
C
N
I
---------------------------
F
E
M
L
R
I
D
E
G
-
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
-----
N
----------
A
A
K
S
E
L
D
K
A
I
---------
G
R
NTNGVI
T
-----------------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
------------------------------------------------------------
Q
K
-----------
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
--
R
A
K
R
V
I
T
T
F
R
TG---
T
W
D
A
Y
L
H
---
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
-----
F
I
F
F
M
V
-------------
I
A
F
C
K
N
C
C
-----------
N
E
H
L
H
M
F
T
I
W
------------------------
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
-
F
K
K
T
F
K
R
I
L
H
I
-----------------------------------------------------
27
HHSearch
82.98
21%
-144
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
-----------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
-
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
--
F
K
---
Y
Q
S
--
L
L
T
K
---
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--
H
Q
E
A
-----
I
N
C
---
Y
A
E
E
TC
C
D
F
--
F
---
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-------
L
N
I
---------------------------
F
E
M
L
R
I
D
E
G
-
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
----------
L
------------------
D
K
A
I
GR--
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
---------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
-
Q
------------------------------------------------------------
K
R
W
D
E
A
A
V
N
L
A
K
S
R
---------------
W
Y
N
Q
--
T
P
N
R
A
K
R
V
I
T
T
F
R
TG
T
W
D
A
Y
K
F
---
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-----
F
I
V
N
I
V
-------------
H
V
I
Q
D
N
L
-----------
I
R
K
E
V
Y
I
L
L
N
W
------------------------
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
-
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------------------
26
HHSearch
81.46
22%
-144
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-----------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
-
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
-
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
--
L
T
---
Y
P
V
--
K
R
T
T
K
M
A
G
---
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
VR
T
V
E
D
-----
G
E
C
---
Y
I
Q
F
--
F
--------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
-------
I
N
I
---------------------------
F
E
M
L
R
I
D
E
G
-
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN
G
------------------
V
I
------
T
-----------------
K
---------
D
---------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
-----------
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
-
P
N
R
A
K
R
V
I
T
T
F
R
TG----
T
W
D
A
Y
P
P
---
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
-----
N
V
M
V
L
I
-------------
N
T
F
C
A
P
C
-----------
I
P
N
T
V
W
T
I
G
Y
W
------------------------
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
-
F
K
K
T
F
K
H
L
L
M
------------------------------------------------------
45
Fugue
80.27
21%
-117
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GV
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
----------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
F
G
E
N
H
A
---
I
---
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
QC
S
C
G
I
D
Y
---
Y
T
P
---
H
E
E
--
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
---------------
L
V
F
---------------------------
T
V
K
E
A
A
A
S
A
-
T
T
------------------------------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
--------
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
-
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
--------------
A
P
A
------------
47
Fugue
79.16
20%
-148
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------------------
S
F
K
C
A
L
T
K
------
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
-
F
G
-
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
KS
L
G
---
R
L
K
--
K
K
N
A
---
I
---
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
--
K
N
K
T
-----
I
T
C
---
Y
D
T
T
--
S
D
E
Y
L
R
---
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
-------
M
K
K
---------------------------
Y
T
C
T
V
C
G
Y
I
Y
N
P
------------------------------
E
----------
D
------------------
G
D
------
P
-----------------
D
---------
N
---------------------------------------------------
G
------------------------------------------------------------
V
N
PGTDFKDIV--
C
---------------
P
L
-
C
--
G
--------------
V
G
K
D
Q
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
-----
H
V
M
K
T
M
-------------
N
L
R
A
R
L
D
F
QTPAM
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
------------------------
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
--------------------------
G
D
T
F
R
R
R
-----------------------------------
48
Fugue
77.64
19%
-131
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------------------
P
C
F
R
E
E
N
--------------
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
-
F
V
--
I
T
L
P
F
W
A
V
D
A
V
A
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
--
T
N
S
Q
R
P
R
K
--
L
L
A
E
---
K
---
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
---
A
D
D
R
-----
Y
I
C
---
D
R
F
Y
--
P
N
D
--
L
---
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
GSN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKS
P
S
L
N
A
A
K
S
E
-
L
D
------------------------------
K
----------
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
------
D
-----------------
V
---------
D
---------------------------------------------------
A
------------------------------------------------------------
A
V
-----------
R
---------------
G
I
-
L
--
R
--------------
N
A
K
L
K
P
V
---
Y
D
S
-
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
----------
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
SGRPLEVLFQ
44
Fugue
77.00
20%
-120
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
----------
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
PQYYLA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
F
G
E
N
H
A
---
I
---
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
G
I
D
Y
Y
T
P
--
H
E
E
--
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
----------------
V
---------------------------
F
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
---
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
-
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------
17
PsiBlast_PDB
76.00
22%
-141
- C2 -
2PED
14
OPSD_BOVIN
A:
[45-345]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
P
L
-
G
D
-
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------
6
PsiBlast_PDB
75.82
22%
-156
- C2 -
3PQR
10
OPSD_BOVIN
A:
[42-326]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
--------------------------------------------------
4
PsiBlast_PDB
75.65
22%
-141
- C2 -
1F88
7
OPSD_BOVIN
A:
[42-344]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
---------------------------------------------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
P
--------
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------
10
PsiBlast_PDB
75.58
22%
-142
- C2 -
3OAX
17
OPSD_BOVIN
A:
[45-345]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
P
L
-
G
D
-
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------
20
PsiBlast_PDB
75.57
22%
-138
- C2 -
1U19
14
OPSD_BOVIN
A:
[45-345]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
P
L
-
G
D
-
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------
9
PsiBlast_PDB
75.29
22%
-153
- C2 -
4PXF
8
OPSD_BOVIN
A:
[42-326]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
--------------------------------------------------
18
PsiBlast_PDB
75.25
22%
-139
- C2 -
2G87
14
OPSD_BOVIN
A:
[45-345]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
P
L
-
G
D
-
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------
16
PsiBlast_PDB
75.24
22%
-139
- C2 -
2HPY
14
OPSD_BOVIN
A:
[45-345]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
P
L
-
G
D
-
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------
19
PsiBlast_PDB
74.88
22%
-145
- C2 -
1L9H
14
OPSD_BOVIN
A:
[45-345]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
----------------------------------------------------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
P
L
-
G
D
----
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------
13
PsiBlast_PDB
74.78
22%
-159
- C2 -
2I36
2
OPSD_BOVIN
A:
[42-326]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
--------------------------------------------------
5
PsiBlast_PDB
74.57
22%
-154
- C2 -
3DQB
6
GNAT1_BOVIN (first)
A:
[42-326]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
--------------------------------------------------
12
PsiBlast_PDB
74.28
22%
-144
- C2 -
1HZX
14
OPSD_BOVIN
A:
[45-345]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
----------------------------------------------------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
P
L
-
G
D
----
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------
3
PsiBlast_PDB
74.25
22%
-165
- C- -
3C9L
13
OPSD_BOVIN
A:
[42-332]
---------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--
M
S
---
N
F
R
--
F
G
E
N
---
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
-
R
Y
I
--
P
E
G
M
Q----
C
S
C
---
G
I
D
Y
--
Y
T
P
--
H
EET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------------------------------------------
T
V
K
E
A
A
A
Q
-
Q
Q
------------------------------
E
----------
S
------------------
A
T
------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-------------
I
F
T
H
Q
G
S
D
----------
F
G
P
I
F
M
T
I
P
A
F
------------------------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
C
G
K
N
----
D
-
D
E
------------------------------------------