@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PD2R2_HUMAN: (2016-01-14 )
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
Atome Classification :
(20 SA)
.........10........20........30........40........50....-..--..-60.-.------......70........80...-....--.90..-......100.......110.......120.......130.......140---.......150.......160.......-170...--....180.......190.......200---........210.......220...--....230.--------.--------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------------------------------------------------------------------------.-----..---------------------240------------------------------------------------.......250.....----..260..------.....270.------.-.-----.------...280...---....290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSANATL
K
P
L
C
P
I
L
E
Q
M
S
R
L
Q
SHSNT
S
I
R
Y
I
D
H
A
A
V
L
L
H
G
L
A
S
L
L
G
L
VEN
G
V
I
L
F
-
V
V--GC-R
M
R
-
Q
------
T
V
V
T
T
W
V
L
H
L
A
L
S
D
L
L
A
SAS
L
-
P
F
F
T
--
Y
F
L
A
V-GHSWE
L
G
T
T
F
C
K
L
H
S
S
I
F
F
L
N
M
F
AS
G
F
L
L
S
A
I
S
L
D
R
C
L
Q
V
V
R
P
V
W
AQNH---
R
T
V
A
A
A
H
K
V
C
L
V
L
W
A
L
A
V
L
N
TV
P
Y
F
V
F
-
R
D
T
I
S
R--LDG
R
I
M
C
Y
Y
N
V
L
L
LNPGPDRDATCNS----
R
Q
V
A
L
A
V
S
K
F
L
L
A
F
L
V
P
L
A
I
I
ASS--H
A
A
V
S
L
R
L
--------
Q
--------H-----------------------------------------------------------------------------------------------------------------------------------------------------------------R------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----RR---------------------RP
G
------------------------------------------------
R
F
V
R
L
V
A
A
V
V
A
A
F
A
L
----CW
G
P
Y
H
V
------
F
S
L
L
E
A
R
AH------A-N-----P------GLR
P
L
V
WRG---
L
P
F
V
T
S
L
A
F
F
N
SVAN
P
V
L
Y
V
LT
C
P
D
M
L
R
K
L
R
R
S
L
R
T
V
L
E
S
V
LVDDSELGGAGSSRRRRTSSTARSASP
L
A
LCSRPEEPR
G
P
A
R
L
L
G
W
L
L
G
S
CAASPQTG
P
L
N
R
ALSSTSS
57
Fugue
90.03
24%
-138
- C7 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------
S
F
K
C
A
L
------------
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
-
M
F
--
V
F
-
H
M
K
-
P
W-----
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
--
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
--
K
N
K
T
I
T
C
Y
------
D
T
T
S
D
E
Y
L
R
S
Y
F
----
I
Y
S
M
C
T
T
V
A
M
---
F
C
V
P
L
V
L
I
L
G
C
--
Y
G
L
I
V
R
A
L
--------
I
--------
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-----
K
K
---------------------
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
----
S
Y
I
P
F
H
V
------
M
K
T
M
N
L
R
A
R
------
L
-
D
-----
F
QTPAM
C
A
F
N
D
R
V
Y
A
T
---
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
-----------------------------
A
G
D
T
F
R
R
R
----------------------------------------------------
3
PsiBlast_PDB
89.88
31%
-137
- C7 -
4RWD
6
C562_ECOLX (first)
A:
[128-406]
-------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
--
R
Y
-
T
K
M
-
K
------
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
A
K
Y
L
M
----
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
R
---
D
G
A
V
V
C
----
M
L
Q
F
P
S
P
S
W
-----
Y
----
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
--
Y
G
L
M
L
L
R
L
R
S
V
RLLSG
S
--------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
D
R
---------------------
S
L
R
------------------------------------------------
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
------
F
V
I
V
W
T
L
V
D
------
I
-
D
-----
R
------
R
-
D
P
L
V
V
A
A
---
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------------------------------------------------------------
21
PsiBlast_CBE
89.71
31%
-138
- C7 -
4RWD
5
OPRD_HUMAN
B:
[128-405]
-------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
--
R
Y
-
T
K
M
-
K
------
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
AK
Y
L
M
----
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
R
---
D
G
A
V
V
C
----
M
L
Q
F
P
S
P
S
W
-----
Y
----
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
--
Y
G
L
M
L
L
R
L
RSVRLLSG
S
--------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
D
R
---------------------
S
L
R
------------------------------------------------
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
------
F
V
I
V
W
T
L
V
D
------
I
-
D
-----
R
------
R
-
D
P
L
V
V
A
A
---
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
-----------------------------------------------------------------------------
40
HHSearch
89.08
20%
-133
- C7 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-
A
I
--
A
K
F
E
R
L
-
Q
------
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
--
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
---
Q
E
A
I
N
C
Y
A
E
E
T
----------
C
C
D
F
F---
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
--------
Q
--------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
-----
C
L
---------------------
K
E
H
------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
----
C
W
L
P
F
F
I
------
V
N
I
V
H
V
I
Q
D
------
N
-----------------
L
I
R
K
E
V
---
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------
22
PsiBlast_CBE
88.74
31%
-139
- C7 -
4RWA
1
OPRD_HUMAN
B:
[128-403]
-------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
--
R
Y
-
T
K
M
-
K
------
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
A
K
Y
L
M
----
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
R
---
D
G
A
V
V
C
----
M
L
Q
F
P
S
P
S
W
-----
Y
----
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
--
Y
G
L
M
L
L
R
-G-------
S
--------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
D
R
---------------------
S
L
R
------------------------------------------------
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
------
F
V
I
V
W
T
L
V
D
------
I
-
D
-----
R
------
R
-
D
P
L
V
V
A
A
---
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
-------------------------------------------------------------------------------
2
PsiBlast_PDB
88.27
31%
-138
- C7 -
4RWA
2
C562_ECOLX (first)
A:
[128-406]
-------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
--
R
Y
-
T
K
M
-
K
------
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
A
K
Y
L
M
----
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
R
---
D
G
A
V
V
C
----
M
L
Q
F
P
S
P
S
W
-----
Y
----
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
--
Y
G
L
M
L
L
--G-------
S
--------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
D
R
---------------------
S
L
R
------------------------------------------------
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
------
F
V
I
V
W
T
L
V
D
------
I
-
D
-----
R
------
R
-
D
P
L
V
V
A
A
---
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------------------------------------------------------------
1
PsiBlast_PDB
88.25
31%
-141
- C7 -
4N6H
22
OPRD_HUMAN
A:
[131-410]
-------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
--
R
Y
-
T
K
M
-
K
------
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
A
K
Y
L
M
----
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
R
---
D
G
A
V
V
C
----
M
L
Q
F
P
S
P
S
W
-----
Y
----
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
--
Y
G
L
M
L
L
R
L
R
S
V
RLLSG
S
--------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
D
R
---------------------
S
L
R
------------------------------------------------
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
------
F
V
I
V
W
T
L
V
D
------
I
-
D
------------
R
R
D
P
L
V
V
A
A
---
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
-----------------------------------------------------------------------
47
HHSearch
86.94
23%
-138
- C7 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
-
A
V
--
L
K
E
R
A
L
-
Q
------
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
--
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
T
G
-----
D
P
T
V
C
S
I
S
---------------------
N
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
--------
R
--------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
-----
P
L
---------------------
R
E
K
------------------------------------------------
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
----
C
W
L
P
F
F
L
------
T
H
V
L
N
T
H
C
Q
------
T
-
C
---------------
H
V
S
P
E
L
---
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------------------------------------
38
HHSearch
86.14
23%
-140
- C7 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
-
S
I
--
K
V
N
R
H
L
-
Q
------
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
--
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
G
VR
T
V
E
D
G
E
C
Y
I
Q
F
F
S
------------------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
--------
R
--------
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYP--
P
-----
P
S
---------------------
R
E
K
------------------------------------------------
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
----
T
W
A
P
Y
N
V
------
M
V
L
I
N
T
F
C
A
------
P
-----------------
C
I
P
N
T
V
---
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------------
19
PsiBlast_PDB
85.83
20%
-149
- C7 -
4XNV
15
P2RY1_HUMAN
A:
[56-382]
-------------------------------------
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
-
M
F
--
V
F
-
H
M
K
-
P
W-----
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
--
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
--
K
N
K
T
I
T
C
Y
------------
D
T
T
S
D
E
Y
L
R
-
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
--
Y
G
L
I
V
R
A
L
--------
I
--------
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-----
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGV
N
P
G
TDFKDIVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
R
---------------------
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
----
S
Y
I
P
F
H
V
------
M
K
T
M
N
L
R
A
R
L
DFQTP
A
-
M
-----
C
------
A
F
N
D
R
V
Y
A
T
---
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------------------------------------------------
20
PsiBlast_PDB
85.14
20%
-145
- C7 -
4XNW
2
RUBR_CLOPA
A:
[56-382]
-------------------------------------
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
-
M
F
--
V
F
-
H
M
K
-
P
W-----
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
--
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
--
K
N
K
T
I
T
C
Y
------------
D
T
T
S
D
E
Y
L
R
-
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
--
Y
G
L
I
V
R
A
L
--------
I
--------
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-----
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGV
N
P
G
TDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
R
-----------------
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
----
S
Y
I
P
F
H
V
------
M
K
T
M
N
L
R
A
R
L
DFQTP
A
-
M
-----
C
------
A
F
N
D
R
V
Y
A
T
---
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------------------------------------------------
7
PsiBlast_PDB
84.54
29%
-145
- C7 -
5C1M
7
?
A:
[23-285]
-------------------------------------
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
-
V
I
--
V
R
-
Y
T
K
M
K
------
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
--
V
N
Y
L
M
-
G
-
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
-
V
M
F
-
M
A
T
T
K
Y
--
R
Q
G
S
I
D
C
--
T
L
T
F
S
H
P
T
W
Y
W
E
N
-----------
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
--
Y
G
L
M
I
L
R
L
--------
K
S
VRMLSGS
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
D
R
---------------------
N
L
R
------------------------------------------------
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
----
C
W
T
P
I
H
I
------
Y
V
I
I
K
A
L
I
T
------
I
P
E
-----
T
------
T
F
Q
T
V
S
W
H
------
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
--------------------------------------------------------------------------------
37
HHSearch
84.47
23%
-127
- C7 -
3ODU
6
CXCR4_HUMAN (first)
A:
[41-498]
------------------------
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
-
V
M
--
G
Y
Q
K
K
L
-
R
------
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
--
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
V
S
E
---
A
D
D
R
Y
I
C
D
R
F
Y
P
N
D
-----------
L
----
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
--------
S
--------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGS
K
-----
G
H
---------------------
Q
K
R
------------------------------------------------
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
----
C
W
L
P
Y
Y
I
------
G
I
S
I
D
S
F
I
L
------
L
-
E
I
I
K
Q
G
C
------
E
F
E
N
T
V
H
K
W
---
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------------------------------------------------------------
5
PsiBlast_PDB
84.40
28%
-145
- C7 -
4XT3
2
US28_HCMVA
A:
[43-314]
---------------------------------
V
T
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
-
T
I
--
T
W
-
R
R
R
I
Q
------
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
L
-
P
L
W
M
--
Q
Y
L
L
D
-
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
----
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
----
V
V
T
K
--
K
D
N
Q
C
M
T
D
Y
D
Y
L
E
V
-----------
S
----
Y
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
--
Y
Y
R
I
S
R
I
V
--------
A
--------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----
S
R
---------------------
H
K
G
------------------------------------------------
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
----
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
K
W
I
S
S
------
S
-
C
-----
E
------
F
E
R
S
L
K
-
R
A
---
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
----
K
F
R
Q
E
L
H
C
L
L
A
E
----------------------------------------------------------------------
41
HHSearch
82.90
22%
-139
- C7 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
----------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
-
A
V
--
R
S
E
R
K
L
-
H
------
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
--
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-
N
H
-------
R
R
E
D
K
C
E
T
D
F
Y
D
------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
--------
H
--------
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
-----
M
N
---------------------
R
E
R
------------------------------------------------
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
----
C
W
I
P
Y
F
I
------
F
F
M
V
I
A
F
C
K
------
N
-
C
----------------
C
N
E
H
L
---
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------------------------------------
4
PsiBlast_PDB
82.79
28%
-157
- C7 -
4XT1
15
US28_HCMVA
A:
[43-314]
---------------------------------
V
T
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
-
T
I
--
T
W
-
R
R
R
I
Q
------
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
L
-
P
L
W
M
--
Q
Y
L
L
D
--------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
----
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
----
V
V
T
K
--
K
D
N
Q
C
M
T
D
Y
D
Y
L
E
V
-----------
S
----
Y
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
--
Y
Y
R
I
S
R
I
V
--------
A
--------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----
S
R
---------------------
H
K
G
------------------------------------------------
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
----
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
K
W
I
S
S
------
S
-
C
-----
E
------
F
E
R
S
L
K
-
R
A
---
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
----
K
F
R
Q
E
L
H
C
L
L
A
E
F
R
--------------------------------------------------------------------
58
Fugue
82.18
16%
-125
- C7 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-
F
L
--
T
L
-
Y
V
T
-
V
Q
H
KKLR
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
--
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
--
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
------------
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
--
Y
G
Q
L
V
F
T
V
--------
K
--------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
ASATT
Q
K
---------------------
A
E
K
------------------------------------------------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
----
C
W
L
P
Y
A
G
------
V
A
F
Y
-
I
F
T
H
------
Q
-
G
-----
S
------
D
F
G
P
I
F
M
T
I
---
P
A
F
F
A
K
T
S
A
---
V
Y
N
P
V
I
Y
I
M
M
--------
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------------------
36
HHSearch
81.57
19%
-142
* C7 *
2Z73
5
OPSD_TODPA
A:
[28-339]
-------------------------
Q
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
-
L
F
--
T
K
T
K
S
L
-
Q
------
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
--
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
--
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
----------
S
----
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
--------
H
--------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
----------------------------------------------------------------------------------------------------------------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
A
N
---------------------
A
E
M
------------------------------------------------
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
----
S
W
S
P
Y
A
V
------
V
A
L
L
A
Q
F
G
P
------
L
-
E
---------------
W
V
T
P
Y
A
---
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
------------------------------------------------
6
PsiBlast_PDB
80.38
29%
-141
- C7 -
4EA3
3
C562_ECOLX (first)
A:
[139-393]
---------------------------------------------
G
L
L
G
N
C
L
V
M
Y
-
V
I
L
R
H
T
-
K
M
K
--------
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
L
-
P
F
Q
G
--
T
D
I
L
L
-
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
--
G
S
A
Q
V
--
E
D
E
E
I
E
C
L
V
E
I
----
P
T
P
Q
-----
D
Y
----
W
G
P
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
--
Y
S
L
M
I
R
R
L
--------
R
--------
G
VRLL-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
S
R
---------------------
E
K
D
------------------------------------------------
R
N
L
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
------
F
V
L
A
Q
G
L
-----------------------
G
V
Q
P
S
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-------------------------------------------------------------------------------
45
HHSearch
78.58
18%
-131
- C7 -
3EML
13
ENLYS_BPT4
A:
[21-472]
-------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-
A
V
--
W
L
N
S
N
L
-
Q
------
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
--
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
G
Q
-----
S
Q
G
C
G
E
G
Q
V
----------
A
C
L
F
EDVV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
--------
Q
--------
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
L
Q
---------------------
K
E
V
------------------------------------------------
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
----
C
W
L
P
L
H
I
------
I
N
C
F
T
F
F
C
P
------
D
-
C
--------------
S
H
A
P
L
W
L
---
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------------------------------------------------------