@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF2R_HUMAN: (2016-01-14 )
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
Atome Classification :
(20 SA)
-----------.........10........20........30........40........50........60........70........80...-.....90........100.......110.......120.......130.......140....---...150.......160.......170.......180....---.--..190...-...-.200.......210.......220.......230...------------.---.-----------------------------------------------------------------------------------------------------------------------------------------------------------..240.......250.......260.......270......--.280.......290.......300.......310.......320.......330.......340.......350.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MSMNN
S
K
Q
L
V
S
P
A
A
A
L
LSNTTCQTE
N
R
L
S
V
F
F
S
V
I
F
M
T
V
G
I
L
SN
S
L
A
I
A
I
L
M
K
A
Y
Q
R
F
R
Q
KSK
A
S
F
L
L
L
AS
G
L
V
I
T
D
F
F
G
H
L
IN-G
A
I
A
V
F
V
YASDK
E
W
I
R
FDQS
N
V
L
C
S
I
F
G
I
C
M
V
F
SG
L
C
P
L
L
L
G
S
V
M
A
I
E
R
C
IGVTKPIFHSTK---I
T
S
K
H
V
K
M
M
L
S
G
V
C
L
F
A
V
F
I
A
L
L
P
I
LGHR
D
Y
K
I
Q
A
S
R
T
W
C
---
F
--Y
N
T
E
DI
K
D
-
W
E
D
-
R
F
Y
L
L
L
F
S
F
L
G
L
L
A
L
G
V
S
L
L
C
N
A
IT
G
I
T
L
L
R
V
K
FK
S
Q
------------
Q
---
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------RQG
R
S
H
H
L
E
M
V
I
Q
L
L
A
I
M
C
V
S
C
I
CW
S
P
F
L
V
T
M
A
NIGINGNH--
S
L
E
T
C
E
T
T
L
F
A
L
R
M
A
T
W
N
Q
I
L
D
P
W
V
Y
I
L
L
R
K
A
V
L
K
N
L
Y
K
L
A
S
QCC
G
V
H
V
I
S
L
H
I
W
E
L
S
S
I
KNS
L
K
V
A
A
ISESPVAEKSAST
41
Fugue
93.59
18%
-118
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-----
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
----
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
I
D
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-
K
E
A
A
A
S
A
------------
T
---
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
---
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
---------------
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----
40
Fugue
88.84
18%
-101
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
-
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-------
F
T
T
T
L
Y
T
S
L
H
G
Y
--
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
--
Y
-
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
----------
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-
4
PsiBlast_PDB
87.04
20%
-141
- C4 -
3DQB
6
GNAT1_BOVIN (first)
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
---------------------------------
5
PsiBlast_PDB
86.11
20%
-141
- C4 -
3PQR
9
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
---------------------------------
2
PsiBlast_PDB
86.01
20%
-138
- C4 -
3C9L
13
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
D
D
E
------------------------------
8
PsiBlast_PDB
85.98
20%
-135
- C4 -
4PXF
7
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
---------------------------------
20
PsiBlast_PDB
85.57
20%
-134
- C4 -
3C9M
1
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
C
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
P
--------------------------------
7
PsiBlast_PDB
85.49
20%
-137
- C4 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
---------------------------------
6
PsiBlast_PDB
85.43
20%
-139
- C4 -
3PXO
5
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
---------------------------------
1
PsiBlast_PDB
84.90
20%
-139
- C4 -
3CAP
5
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
---------------------------------
32
HHSearch
84.76
16%
-139
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
-----
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
---
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
G
---
D
P
T
V
C
---
S
--
I
S
N
P
D
---------
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
------------
F
---
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDA
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
---
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------
13
PsiBlast_PDB
84.28
20%
-129
- C4 -
2I35
3
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
I
D
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
D
D
E
------------------------------
3
PsiBlast_PDB
83.22
20%
-138
- C4 -
1F88
7
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
I
D
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------
12
PsiBlast_PDB
83.09
20%
-141
- C4 -
2I36
2
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
I
D
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
---------------------------------
14
PsiBlast_PDB
82.40
20%
-141
- C4 -
2I37
1
OPSD_BOVIN
A:
[64-324]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
I
D
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
---------------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
---
R
N
C
M
--
V
T
T
L
C
C
G
K
N
P
L
G
------------------------------
31
HHSearch
82.30
14%
-131
* C4 *
2KS9
1
NK1R_HUMAN
A:
[32-326]
------------------------------------
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
-----
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
-
N
E
W
Y
Y
---
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
T
M
P
S
R
V
V
C
---
M
--
I
E
W
P
E
H
P
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
------------
S
SDR
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
L
YL
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
22
HHSearch
82.05
16%
-134
- C4 -
2Z73
5
OPSD_TODPA
A:
[31-334]
---------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
-----
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
K
W
I
F
---
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
---
S
--
F
D
Y
I
S
R
D
S
-
T
T
R
-
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
---
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
---
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
------------
9
PsiBlast_PDB
80.59
20%
-108
- C4 -
3OAX
16
OPSD_BOVIN
A:
[67-325]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------
18
PsiBlast_PDB
80.41
20%
-112
- C4 -
1L9H
14
OPSD_BOVIN
A:
[67-325]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
I
D
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
P
L
G
D
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------
16
PsiBlast_PDB
80.14
20%
-108
- C4 -
2PED
13
OPSD_BOVIN
A:
[67-325]
------------------------------------------------------------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
F
--
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
---
G
ID
Y
Y
T
P
H
E
E
T
-
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------
E
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
-
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
--
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------