@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TA2R5_HUMAN: (2016-01-15 )
MLSAGLGLLMLVAVVEFLIGLIGNGSLVVWSFREWIRKFNWSSYNLIILGLAGCRFLLQWLIILDLSLFPLFQSSRWLRYLSIFWVLVSQASLWFATFLSVFYCKKITTFDRPAYLWLKQRAYNLSLWCLLGYFIINLLLTVQIGLTFYHPPQGNSSIRYPFESWQYLYAFQLNSGSYLPLVVFLVSSGMLIVSLYTHHKKMKVHSAGRRDVRAKAHITALKSLGCFLLLHLVYIMASPFSITSKTYPPDLTSVFIWETLMAAYPSLHSLILIMGIPRVKQTCQKILWKTVCARRCWGP
Atome Classification :
(20 SA)
-----------.........---------------10.....--...20.....-----...30........40-.........50........60---..-.......70----.----.--......--.80......----..90--.......-..100----........------.110...--....120.......130-------....-----....140----.........-----150.---.-----...------....160------.----.---.---.---.---...170.....------..180.......190.......200.....-----------------------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------210---..------.....220------......-----.230.......240------.....-.-----------.---250.----.......---------.260...-....270.......280.......290.......------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MLS
A
G
L
G
L
L
---------------
M
L
V
A
V
V
E
--
F
L
I
G
LIGNG
S
-----
L
V
V
W
S
F
R
E
W
I
R
KFN--WSS
Y
N
L
I
I
L
G
L
A
G
C
R
F
L
L
Q
W
----
L
I
-
I
L
D
L
S
L
F
P
-----
L
----
F
--QSS
R
W
L
--
R
Y
L
S
I
F
W
V
L
----VS
Q
---
A
S
L
W
F
A
T
-
F
L
S
------
V
F
Y
C
K
KIT------TFDR
P
A
Y
--
L
W
L
KQRAYN
L
S
L
W
C
L
L
--------
G
Y
F
I
-----
I
N
L
L
L
------
T
V
Q
I
G
L
T
F
Y-----H--P---P-----QGN------S
S
I
RYP-------F----E---S---
W
---
Q
---
Y
L
Y
A
F
QLNSGS------Y
L
P
L
V
V
F
L
VSS
G
M
L
I
V
S
L
YTH
H
K
K
M
K
VHSA-----------------------------------------------------------------------------------------------------------------------------------------------------G------------------------------------------------------------------------------------------------------------------------------------------------------R-----------------R
D
V
---
R
A
------
K
A
H
I
T
A
L
K
------
S
L
G
C
F
L
-----
L
L
H
L
V
Y
I
MASPFSI------TSKTY-P-----------P---
D
--
L
----
T
S
V
F
I
W
E
---------
T
L
M
A
A
Y
P
-
S
L
H
S
L
I
L
I
MGI
P
R
V
K
Q
T
C
Q
K
I
L
W
K
T
V
C
A
R
RCWGP------------------
43
Fugue
86.42
18%
-135
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------SFKCA
L
T
K
T
G
F
Q
F
Y
---------------
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
-
S
-----
V
A
I
W
M
F
V
F
H
M
K
P
----
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
--
Y
----
V
L
-
T
L
P
A
L
I
F
Y
-----
Y
----
F
--
N
K
T
D
W
I
FG
D
A
M
C
K
L
Q
R
F
----
I
F
H
---
V
N
L
Y
G
S
I
L
F
L
T
------
C
I
S
A
H
R
Y
S
------
G
V
V
Y
P
K
S
--
L
-
G
R
L
K
K
K
N
A
I
C
I
S
V
L
--------
V
W
L
I
-----
V
V
V
A
I
------
S
P
I
L
F
Y
S
G
T
-----
G
--
V
---
R
-----
K
N
K
------
T
I
T
C
Y
D
-------
T
----
T
---
S
---
D
---
E
---
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
MF
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
I
Y
N
PEDGDPDNGVNPGTD-----------------------------------------------------------------------------------------------------------------------------------
F
-----------------
K
D
I
---
V
C
PLCGVG
K
D
Q
F
E
E
V
E
------
E
P
L
R
R
K
-----
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
-
N
-----------
L
---
R
--
A
----
R
L
D
F
Q
T
P
---------
A
M
C
A
F
N
D
-
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------
41
Fugue
83.33
19%
-123
* C2 *
19HC
15
CYC9_DESDA
A:
[1-292]
-----------
A
A
L
E
P
T
D
S
G
---------------
A
P
S
A
I
V
M
--
F
P
V
G
E
K
P
N
P
K
GAAMK
P
V
V
F
N
H
L
I
H
E
K
K
--------------
I
A
D
C
E
T
C
H
H
T
----
G
D
-
P
V
S
C
S
T
C
H
-----
T
----
V
--
E
G
K
A
E
G
--
D
Y
I
T
L
D
R
A
M
----
H
A
T
DIA
A
R
A
K
G
N
T
-
P
T
S
------
C
V
S
C
H
Q
S
E
------
T
K
E
R
R
E
C
A
G
C
H
A
I
T
T
P
K
D
D
E
A
W
C
A
T
--------
C
H
D
I
-----
T
P
-------------
S
M
T
P
S
-----
E
--
M
---
Q
-----
K
G
I
------
A
G
T
L
L
P
-------
G
----
D
---
N
---
E
---
A
---
L
A
A
E
T
V
L
A
E
A
T
------
V
A
P
V
S
P
M
L
A
P
Y
K
V
V
I
D
A
L
A
D
K
Y
E
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
---
T
H
------
R
R
H
L
T
S
L
M
E
S
I
K
DD
K
L
A
Q
A
F
H
DKPE
I
L
C
A
T
C
H
H
R
S
P
L
S
L
------
T
-----
P
-----------
P
---
K
--
C
----
G
S
C
H
T
K
E
IDAADPGRP
N
L
M
A
A
Y
H
L
E
C
M
G
C
H
K
G
M
A
V
A
R
P
R
D
T
D
C
T
T
C
H
K
A
A
A
-------------------------
26
HHSearch
79.39
14%
-133
- C3 -
3EML
13
ENLYS_BPT4
A:
[23-472]
------------------
V
Y
---------------
I
T
V
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
-----
V
C
W
A
V
W
L
N
---
S
N
L
--
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
----
L
A
-
I
P
F
A
I
T
I
S
-----
T
----
G
FC
A
A
C
H
G
C
--
L
F
I
A
C
F
V
L
V
----
L
T
Q
---
S
S
I
F
S
L
L
-
A
I
A
------
I
D
R
Y
I
A
I
R
------
I
P
L
R
-
Y
N
--
G
L
V
T
G
---
T
R
A
K
G
------------
I
I
A
-----
I
C
W
V
L
------
S
F
A
I
G
L
T
P
M
LG---
W
--
N
---
N
CGQ-----------
S
Q
G
C
G
E
GQVACLF
E
----
D
---
V
V--
P
M
--
N
---
Y
M
V
Y
F
N
F
F
A
C
V
------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------
Y
R
S
---
T
L
------
Q
K
E
V
H
A
A
K
------
S
L
A
I
I
V
-----
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
DCS--------
H
---
A
--
P
L
---
W
L
M
Y
L
A
I
---------
V
L
S
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------------------
28
HHSearch
79.03
14%
-136
* C3 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------
Y
---------------
A
L
S
Y
C
A
L
--
I
L
A
I
V
F
G
N
G
L
-----
V
C
M
A
V
L
K
E
---
R
A
L
--
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
----
L
V
-
M
P
W
V
V
Y
L
E
V
T
GGV
W
----
N
--
F
S
R
I
C
C
--
D
V
F
V
T
L
D
V
M
----
M
C
T
---
A
S
I
W
N
L
C
-
A
I
S
------
I
D
R
Y
T
A
V
V
------
M
P
V
H
-
Y
Q
--
H
G
T
G
Q
S
S
C
R
R
----
V
A
--------
L
M
I
T
-----
A
V
W
V
L
------
A
F
A
V
S
C
P
L
L
-----
F
--
G
FN-
T
-----
T
G
D
------
P
T
V
C
S
I
-------
S
----
N
-------
P
---
D
---
F
-
V
I
Y
S
S
V
V
S
F
------
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
-----------
A
K
R
V
I
T
T
F
R
T
GTW------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------
A
Y
G
---
V
P
------
L
R
E
K
K
A
T
Q
------
M
V
A
I
V
L
-----
G
A
F
I
V
C
W
L
P
F
F
L
T
H
------
V
L
N
T
H
C
Q
-----------
T
CHV
S
--
P
----
E
L
Y
S
A
T
T
---------
W
L
G
Y
V
N
S
-
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------
34
HHSearch
77.20
12%
-124
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-334]
---------------
V
Y
Y
S
L
---------------
G
I
F
I
G
I
C
--
G
I
I
G
C
G
G
N
G
I
-----
V
I
Y
L
F
T
K
T
K
---
S
L
--
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
----
V
N
G
F
P
L
M
T
I
S
C
-----
F
L
KKW
I
--
F
G
F
A
A
C
--
K
V
Y
G
F
I
G
G
I
----
F
G
F
---
M
S
I
M
T
M
A
-
M
I
S
------
I
D
R
Y
N
V
I
G
------
R
P
M
A
-
A
S
--
K
K
M
S
H
R
---
R
A
F
I
------------
M
I
I
-----
F
V
W
L
W
------
S
V
L
W
A
I
G
P
I
FGW
G
A
Y
--
T
---
L
-----
E
G
V
------
L
C
N
C
S
F
-------
D
----
Y
ISR
D
S
T
-
T
---
R
---
S
N
I
L
C
M
F
I
L
G
F
------
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
----------------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------
A
Q
A
---
G
A
------
N
A
E
M
R
L
A
K
------
I
S
I
V
I
V
-----
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
------
L
L
A
Q
F
-
G
-----------
P
LEW
V
T-
P
----
Y
A
A
Q
L
P
V
---------
M
F
A
K
A
S
A
-
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
------------------
44
Fugue
73.15
13%
-123
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
RSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
--
Y
M
F
L
L
I
M
L
G
F
-----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
KL
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
-----
F
----
V
--
F
G
P
T
G
C
--
N
L
E
G
F
F
A
T
L
----
G
G
E
---
I
A
L
W
S
L
V
-
V
L
A
------
I
E
R
Y
V
V
V
C
KPMS
N
F
R
F
G
E
N
H
A
--
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------
P
P
L
V
GW
S
R
Y
I
P
E
G
M
------
Q
C
S
C
G
I
D
Y
Y
--------------------
T
------
P
H
E
E
T
N
-------
N
----
E
---
S
---
F
V
--
I
---
Y
M
F
V
V
H
F
----------
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------
K
A
E
---
K
E
------
V
T
R
M
V
I
I
M
------
V
I
A
-
F
L
-----
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
------
T
H
Q
G
S
-
D
-----------
F
---
G
-------
P
I
F
M
T
I
P
---------
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA
31
HHSearch
72.53
16%
-135
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
---------------
N
K
Y
V
V
---------------
I
I
A
Y
A
L
V
--
F
L
L
S
L
L
G
N
S
L
-----
V
M
L
V
I
L
Y
S
---
R
V
G
--
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
----
T
L
-
P
-
I
W
A
A
S
K
V
N
G--
W
----
I
--
F
G
T
F
L
C
--
K
V
V
S
L
L
K
E
V
----
N
F
Y
---
S
G
I
L
L
L
A
-
C
I
S
------
V
D
R
Y
L
A
I
V
------
H
A
T
R
-
T
L
----
T
Q
K
R
--
H
L
V
----
K
--------
F
V
C
L
-----
G
C
W
G
L
------
S
M
N
L
S
L
P
F
F
LF---
R
--
Q
A--
Y
HP---
N
N
S
------
S
P
V
C
Y
E
-------
V
LG--
N
---
D
T--
A
---
K
WRM
V
L
R
I
L
P
H
T
F
G
F
------
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
G
Q
K
H
R
A
M
R
------
V
I
F
A
V
V
-----
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
------
L
A
D
T
L
M
R
TQVIQE
S
C
E
R
-
R
---
N
N
I
G
----
R
A
L
D
A
T
E
---------
I
L
G
F
L
H
S
-
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------
25
HHSearch
72.27
13%
-131
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
------------------
G
M
---------------
G
I
V
M
S
L
I
--
V
L
A
I
V
F
G
N
V
L
-----
V
I
T
A
I
A
K
F
---
E
R
L
--
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
----
A
V
-
V
P
F
G
A
A
H
I
L
M
KM-
W
----
T
--
F
G
N
F
W
C
--
E
F
W
T
S
I
D
V
L
----
C
V
T
---
A
S
I
E
T
L
C
-
V
I
A
------
V
D
R
Y
F
A
I
T
------
S
P
F
K
-
Y
Q
--
S
L
L
T
K
---
N
K
A
R
V
------------
I
I
L
-----
M
V
W
I
V
------
S
G
L
T
S
F
L
P
I
Q
M
HW-
Y
RA
T
---
H
-----
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
-------
F
--------
T
---
N
---
Q
---
A
Y
A
I
A
S
S
I
V
S
F
------
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
--------------
R
A
K
R
V
I
T
T
F
R
TGTW-----------------------------------------------------------------------------------------------------------------------------------------
D
-----------------
A
Y
K
---
F
C
------
L
K
E
H
K
A
L
K
------
T
L
G
I
I
M
-----
G
T
F
T
L
C
W
L
P
F
F
I
V
N
------
I
V
H
V
I
-
Q
-----------
D
NLI
R
--
K
----
E
V
Y
I
L
L
N
---------
W
I
G
Y
V
N
S
-
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------
42
Fugue
72.19
16%
-123
- C2 -
4R1D
-
?
B:
[1-301]
-----------
M
D
K
T
G
W
------------------
I
T
H
C
F
G
R
--
F
L
I
D
L
-
P
P
D
A
-----
V
I
N
A
G
Y
Y
L
W
G
D
R
I
E
--
Y
L
D
D
K
P
T
E
L
A
A
R
V
D
R
L
E
Q
E
W
----
R
T
-
Q
R
H
K
S
K
G
N
-----
M
----
F
--
L
R
K
I
D
F
--
G
N
E
S
V
G
L
L
S
WSSE
V
A
S
---
K
T
Y
L
L
D
T
-
Y
V
T
S
K
P
T
W
H
V
Y
R
W
K
G
K
V
------
S
V
D
R
E
Q
H
--
A
V
E
I
S
R
A
L
A
R
N
L
R
S
R
A
PKEIPS
E
P
G
F
C
I
-----
D
H
A
Y
I
AGDSFQ
V
E
R
F
G
V
G
V
T
-----
F
--
P
---
E
-----
H
P
G
------------------------------------------
A
R
F
E
F
R
S
S
T
------
G
A
E
L
N
S
L
L
E
R
V
D
G
F
V
Q
N
M
L
S
T
F
A
G
M
E
T
L
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------
H
P
V
GSL
P
G
------
E
E
Y
L
V
A
G
S
------
D
K
G
--------------
Q
R
G
Y
T
F
M
W
------
E
V
Q
G
K
-
E
-----------
E
---
S
--
L
----
T
E
P
N
L
T
A
---------
G
L
A
V
L
E
R
-
S
N
E
N
G
K
P
P
P
P
A
F
K
S
D
K
E
A
L
E
-
L
W
D
T
I
V
D
S
I
R
V
R
P
TS----------------
33
HHSearch
70.99
11%
-129
- C3 -
1U19
14
OPSD_BOVIN
A:
[42-327]
------------------
M
L
---------------
A
A
Y
M
F
L
L
--
I
M
L
G
F
P
I
N
F
L
-----
T
L
Y
V
T
V
Q
H
---
K
K
L
--
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
----
G
G
-
F
T
T
T
L
Y
T
S
L
H
GY-
F
----
V
--
F
G
P
T
G
C
--
N
L
E
G
F
F
A
T
L
----
G
G
E
---
I
A
L
W
S
L
V
-
V
L
A
------
I
E
R
Y
V
V
V
C
------
K
P
M
S
-
N
F
--
R
-
F
G
E
N
H
A
I
M
---------------
G
V
A
-----
F
T
W
V
M
------
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
--
I
---
P
-----
E
G
M
------
Q
C
S
C
G
I
-------
D
YYTP
H
---
E
ETN
N
---
E
---
S
F
V
I
Y
M
F
V
V
H
F
------
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
---
T
Q
------
K
A
E
K
E
V
T
R
------
M
V
I
I
M
V
-----
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
------
F
Y
I
F
T
H
Q
-----------
G
SDF
G
--
P
----
I
F
M
T
I
P
A
---------
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
------------------
23
HHSearch
70.62
12%
-132
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-----------------
M
P
L
---------------
V
V
V
L
S
T
I
--
C
L
V
T
V
G
L
N
L
L
-----
V
L
Y
A
V
R
S
E
---
R
K
L
--
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
----
V
V
-
M
P
M
N
I
L
Y
L
L
M
SK-
W
----
S
--
L
G
R
P
L
C
--
L
F
W
L
S
M
D
Y
V
----
A
S
T
---
A
S
I
F
S
V
F
-
I
L
C
------
I
D
R
Y
R
S
V
Q
------
Q
P
L
R
-
Y
L
--
K
Y
R
T
K
---
T
R
A
S
------------
A
T
I
L
-----
G
A
W
F
L
------
S
F
L
W
V
I
P
I
L
G----
W
--
N
H---------
R
R
------
E
D
K
C
E
T
-------
D
----
F
---
Y
---
D
V--
T
---
W
F
K
V
M
T
A
I
I
N
F
------
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
Y
L
---
H
M
------
N
R
E
R
K
A
A
K
------
Q
L
G
F
I
M
-----
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
------
M
V
I
A
F
-
C
K----------
N
CC-
N
--
E
----
H
L
H
M
F
T
I
---------
W
L
G
Y
I
N
S
-
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------
24
HHSearch
69.92
14%
-116
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-499]
---------------
N
K
I
F
L
---------------
P
T
I
Y
S
I
I
--
F
L
T
G
I
V
G
N
G
L
-----
V
I
L
V
M
G
Y
Q
---
K
K
L
--
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
----
T
L
--
P
F
W
A
V
D
A
V
AN--
W
----
Y
--
F
G
N
F
L
C
--
K
A
V
H
V
I
Y
T
V
----
N
L
Y
---
S
S
V
W
I
L
A
-
F
I
S
------
L
D
R
Y
L
A
I
V
------
H
A
T
N
-
S
Q
--
R
P
R
K
L
---
L
A
E
K
V
------------
V
Y
V
-----
G
V
W
I
P
------
A
L
L
L
T
I
P
D
F
IF---
A
--
N
---
V
S
E
---
A
D
D
------
R
Y
I
C
D
R
-------
F
----
Y
---
P
N--
D
L
W
V
V
---
V
F
Q
F
Q
H
I
M
V
G
L
------
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
-----------------
Y
G
S
---
K
G
------
H
Q
K
R
K
A
L
K
------
T
T
V
I
L
I
-----
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
------
S
I
D
S
F
-
I
L
L
EI
I
K
Q
G
C
E
F
E
N
--
T
V
-
H
----
K
W
I
S
I
T
E
---------
A
L
A
F
F
H
C
-
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-------------------
32
HHSearch
67.58
10%
-117
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
-------------------
W
---------------
A
A
A
Y
T
V
I
--
V
V
T
S
V
V
G
N
V
V
-----
V
M
W
I
I
L
A
H
---
K
R
M
--
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
----
F
N
-
T
V
V
N
F
T
Y
A
-----
V
H
NEW
Y
--
Y
G
L
F
Y
C
--
K
F
H
N
F
F
P
I
A
----
A
V
F
---
A
S
I
Y
S
M
T
-
A
V
A
------
F
D
R
Y
M
A
I
I
------
H
P
L
Q
-
P
R
----
L
S
A
T
A
T
K
V
---------------
V
I
C
-----
V
I
W
V
L
------
A
L
L
L
A
F
P
Q
G
Y----
Y
--
S
TTE
T
-----
M
P
S
------
R
V
V
C
M
I
-------
E
WPE-
H
---
P
---
N
KIY
E
K
--
V
Y
H
I
C
V
T
V
L
I
Y
------
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
Y
H
E
---
Q
V
------
S
A
K
R
K
V
V
K
------
M
M
I
V
V
V
-----
C
T
F
A
I
C
W
L
P
F
H
I
F
F
------
L
L
P
Y
I
-
N
-----------
P
DLY
L
--
K
KFI
Q
Q
V
Y
L
A
I
M
---------
W
L
A
M
S
S
T
-
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
------------------
22
HHSearch
66.27
12%
-125
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
------------------
F
I
---------------
V
L
V
A
G
S
L
--
S
L
V
T
I
I
G
N
I
L
-----
V
M
V
S
I
K
V
N
---
R
H
L
--
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
----
F
S
-
M
N
L
Y
T
L
Y
T
V
I
GY-
W
----
P
--
L
G
P
V
V
C
--
D
L
W
L
A
L
D
Y
V
----
V
S
N
---
A
S
V
M
N
L
L
-
I
I
S
------
F
D
R
Y
F
C
V
T
------
K
P
L
T
-
Y
P
--
V
K
R
T
T
---
K
M
A
G
M
M
------------
I
A
-----
A
A
W
V
L
------
S
F
I
L
W
A
P
A
I
L
F---
W
--
Q
---
F
I
V
GVR
T
V
E
------
D
G
E
C
Y
I
-------
Q
----
F
---
F
S--
N
---
A
---
A
V
T
F
G
T
A
I
A
A
F
------
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
-----------------
A
Y
P
---
P
P
------
S
R
E
K
K
V
T
R
------
T
I
L
A
I
L
-----
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
------
L
I
N
T
F
C
A
P----------
C
---
I
P-
N
----
T
V
W
T
I
G
Y
---------
W
L
C
Y
I
N
S
-
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------
50
Fugue
62.83
20%
-123
- C3 -
4O6Y
3
ACFR2_ARATH
A:
[10-219]
--------P
I
F
M
V
V
R
V
L
G
F
I
---------------
I
A
A
L
V
L
T
--
W
T
V
H
Y
R
G
G
L
A
-----
L
----------------
S
S
D
N
--------
K
D
H
I
F
N
V
----
H
P
-
V
M
M
V
I
G
L
I
-----
L
----
F
--
N
G
E
A
M
L
--
A
Y
K
S
V
-----------------------------------
Q
G
T
K
------
N
L
K
K
L
V
H
--
L
T
L
Q
L
T
A
F
I
L
S
L
I
G
V
W
--------
A
A
L
K
-----
F
H
I
D
K
------
G
I
E
N
F
-----------------------------------
Y
S
-------
L
----
H
---
S
---
W
---
L
---
G
L
A
C
L
F
L
F
A
F
Q
------
W
A
A
G
F
V
T
Y
W
Y
P
G
G
---
S
R
N
S
R
A
S
L
M
P
W
H
V
F
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----------------
I
S
I
---
Y
A
------
L
A
L
V
T
A
T
T
------
G
I
L
E
K
V
-----
T
F
L
Q
V
N
Q
V
I
T
R
Y
S
-----------------------------------------------------
T
E
A
M
L
V
N
-
T
M
G
V
L
I
L
I
L
G
G
F
V
I
L
G
V
V
T
---------------------------------
29
HHSearch
62.67
9%
-134
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[63-495]
----------------
I
K
L
T
---------------
S
V
V
F
I
L
I
--
C
C
F
I
I
L
E
N
I
F
-----
V
L
L
T
I
W
K
T
---
K
K
F
--
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
----
A
Y
-
T
A
N
L
L
L
S
G
-----
A
TTY-
K
--
L
T
P
A
Q
W
--
F
L
R
E
G
S
M
F
V
----
A
L
S
---
A
S
V
F
S
L
L
-
A
I
A
------
I
E
R
Y
I
T
M
L
------
K
-----------
N
N
---
F
R
L
F
------------
L
L
I
S
-----
A
C
W
V
I
------
S
L
I
L
G
G
L
P
I
MG---
W
--
N
---
C
-----
I
S
A
------
L
S
S
C
S
T
-------
V
----
L
---
P
L--
Y
---
H
---
K
H
Y
I
L
F
C
T
T
V
F
------
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------
Y
A
S
---
R
S
------
S
E
N
V
A
L
L
K
------
T
V
I
I
V
L
-----
S
V
F
I
A
C
W
A
P
L
F
I
L
L
------
L
L
D
V
G
C
K
-----------
V
KT-
C
D
I
L
----
F
R
A
E
Y
F
L
---------
V
L
A
V
L
N
S
-
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
--------------------------
5
PsiBlast_PDB
45.56
39%
23
- C1 -
3UGJ
-
PUR4_SALTY
A:
[1204-1244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
V
E
V
---
R
D
------
D
A
H
L
A
A
L
E
------
S
K
G
--------
L
V
A
L
R
Y
V
--
D
N
F
G
K
------
V
T
E
T
Y
-
P
-----------
A
---
N
--
P
----
N
G
S
P
N
G
I
---------
T
A
V
T
T
E
N
-
G
R
V
T
I
M
M
P
H
P
E
R
V
F
R
T
V
A
N
S
W
H
P
E
N
W
G
E
D
S
P
W
M
R
------------------
8
PsiBlast_PDB
42.19
39%
61
- C1 -
4R7G
1
PUR4_SALTY
A:
[1206-1244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
V
E
V
---
R
D
------
D
A
H
L
A
A
L
E
------
S
K
G
--------
L
V
A
L
R
Y
V
--
D
N
F
G
K
------
V
T
E
T
Y
-
P
-----------
A
---
N
--
P
----
N
G
S
P
N
G
I
---------
T
A
V
T
T
E
N
-
G
R
V
T
I
M
M
P
H
P
E
R
V
F
R
T
V
A
N
S
W
H
P
E
N
W
G
E
D
S
P
W
M
R
------------------
1
PsiBlast_PDB
41.18
39%
59
- C1 -
1T3T
1
PUR4_SALTY
A:
[1206-1244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
V
E
V
---
R
D
------
D
A
H
L
A
A
L
E
------
S
K
G
--------
L
V
A
L
R
Y
V
--
D
N
F
G
K
------
V
T
E
T
Y
-
P
-----------
A
---
N
--
P
----
N
G
S
P
N
G
I
---------
T
A
V
T
T
E
N
-
G
R
V
T
I
M
M
P
H
P
E
R
V
F
R
T
V
A
N
S
W
H
P
E
N
W
G
E
D
S
P
W
M
R
------------------
3
PsiBlast_PDB
40.33
39%
70
- C1 -
3UMM
-
PUR4_SALTY
A:
[1206-1244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
V
E
V
---
R
D
------
D
A
H
L
A
A
L
E
------
S
K
G
--------
L
V
A
L
R
Y
V
--
D
N
F
G
K
------
V
T
E
T
Y
-
P
-----------
A
---
N
--
P
----
N
G
S
P
N
G
I
---------
T
A
V
T
T
E
N
-
G
R
V
T
I
M
M
P
H
P
E
R
V
F
R
T
V
A
N
S
W
H
P
E
N
W
G
E
D
S
P
W
M
R
------------------