@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : VN1R4_HUMAN: (2016-01-15 )
MASRYVAVGMILSQTVVGVLGSFSVLLHYLSFYCTGCRLRSTDLIVKHLIVANFLALRCKGVPQTMAAFGVRYFLNALGCKLVFYLHRVGRGVSIGTTCLLSVFQVITVSSRKSRWAKLKEKAPKHVGFSVLLCWIVCMLVNIIFPMYVTGKWNYTNITVNEDLGYCSGGGNNKIAQTLRAMLLSFPDVLCLGLMLWVSSSMVCILHRHKQRVQHIDRSDLSPRASPENRATQSILILVSTFVSSYTLSCLFQVCMALLDNPNSLLVNTSALMSVCFPTLSPFVLMSCDPSVYRFCFAWKR
Atome Classification :
(20 SA)
-----......----------------------...10-..------------......20........30.....--..-.-40.........50......---..60.---------.......--70...-.....80........90.-----------.......100---------..----......--110.......120.......130.--......140.......150......----------.160..-------....----.170.---..---.-...180....-.-.-.190.......200.......210..-...-------.-----------------------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------------------------------------------------------------220.......230.......240.....--..250.......260---------.-----------.-----.......270.......280.......290.......300--------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MAS
R
Y
V
----------------------
A
V
G
M
I
-
L
S
------------
Q
T
V
V
G
V
L
G
S
F
S
V
L
L
H
Y
L
S
F
Y
CTG--CR-L-R-
S
T
D
L
I
V
K
H
L
I
V
A
N
F
L
A
L
---RCKGV---------
P
Q
T
M
A
A
F
--
G
V
R
Y
F
-
L
N
A
L
G
C
K
L
V
F
Y
L
H
R
VGRG-----------V
S
I
G
T
T
C
L
L
----------
S
V
----
F
Q
V
I
TV--S
S
R
K
S
R
W
A
K
L
K
E
KAP
K
H
V
G
F
S
V
L
L
--
C
W
I
V
C
M
L
V
N
I
IF
P
M
Y
V
TGKW
N
Y
T
N
I
----------
T
V
NEDL-------GYCS----GGGN
N
---
K
I
---
A
-
Q
T
L
R
A
M
L
L
S
F
-
P
-
D
-
V
L
C
L
G
L
M
L
W
V
SS
S
M
V
C
I
L
H
R
H
K
Q
R
V
Q
-
H
I
D
-------R-----------------------------------------------------------------------------------------------------------------------------------------------------S------------------------------------------------------------------------------------------------------------------------------------------------------DLSPRASPENRA
T
Q
S
I
L
I
L
V
S
T
F
V
S
S
Y
T
--
L
S
C
L
F
Q
V
C
M
A
L
LD-----------N-----------P-----N
S
L
L
V
N
T
S
A
L
M
S
V
C
F
PTLS
P
F
V
L
MSCD
P
S
V
Y
R
F
C
FAWKR---------------------------
23
HHSearch
90.46
15%
-119
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-471]
----------------------------------
Y
A
L
S
Y
C
A
------------
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
----
V
L
K
E
--
R
A
-
L
Q
T
-
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
---
T
L
V
-
M
---------
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
-
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
-----------
A
S
I
W
N
L
C
A
I
----------
S
I
D
R
--
Y
T
A
V
V
---
M
P
V
H
Y
Q
-
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
--
V
W
V
L
A
F
A
V
S
C
P
L
L
-
F
G
F
N
T
------------------
T
G
D
P
-------
T
V
C
S
----
I
S
N
P
D
-------------
F
V
I
Y
S
S
V
-
V
-
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
-
F
E
M
-------
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
---------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW--------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
--
P
F
F
L
T
H
V
L
N
T
H
C
Q
-----------
T
CH---------
V
-----
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
---------------------------
34
Fugue
90.03
14%
-106
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
P
N
F
Y
V
PFSNKTGVVRSPFEAPQYYLAE
P
W
Q
F
S
-
M
L
------------
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
---
F
G
-
G
F
---------
T
T
T
L
Y
T
S
--
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
-----------
I
A
L
W
S
L
V
V
L
----------
A
I
----
E
R
Y
V
V
V
--
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
--
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
---------------------------
C
S
C
G
I
DYY
T
P
H
E
E
---
T
N
---
N
-
E
S
F
V
I
Y
M
F
V
V
-
H
-
F
-
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-----------
D
-----------
F
-----
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
TETSQVAPA
24
HHSearch
85.50
13%
-101
- C2 -
2Z73
5
OPSD_TODPA
A:
[34-331]
---------
Y
Y
----------------------
S
L
G
I
F
I
G
I
------------
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
----
F
T
K
T
--
K
S
L
Q
-
T
-
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
---
L
V
N
G
F
---------
P
L
M
T
I
S
C
F
-
L
K
K
W
I
-
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
-----------
M
S
I
M
T
M
A
M
I
----------
S
I
D
R
--
Y
N
V
I
G
---
R
P
M
A
A
S
----
K
K
M
S
H
R
R
A
F
I
M
I
I
F
--
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
---------------
E
G
V
L
-------
C
N
C
S
----
F
D
Y
I
S
---
R
D
---
S
T
T
R
S
N
I
L
C
M
F
I
-
L
G
F
-
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
-
A
M
A
K
RLNAKE
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
--
P
Y
A
V
V
A
L
L
A
Q
F
G
P
-----------
L
EW---------
V
-----
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
---------------------------
18
HHSearch
82.93
16%
-104
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[43-476]
----------------------------------
M
G
I
V
M
S
L
------------
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
----
I
A
K
F
--
E
R
-
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
---
L
A
V
-
V
---------
P
F
G
A
A
H
I
L
-
M
K
M
W
T
-
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
-----------
A
S
I
E
T
L
C
V
I
----------
A
V
D
R
--
Y
F
A
I
T
---
S
P
F
K
Y
Q
----
S
L
L
T
K
N
K
A
R
V
I
I
L
M
--
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----------
I
N
C
Y
A
E
-------
E
T
C
C
----
D
F
F
T
-----------
N
Q
A
Y
A
I
A
S
S
I
-
V
-
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
-
M
L
R
-------
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT-
W
------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
--
P
F
F
I
V
N
I
V
H
V
I
Q
D
-----------
N
L----------
I
-----
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
---------------------------
17
HHSearch
82.52
15%
-118
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-442]
----------
M
----------------------
P
L
V
V
V
L
S
T
------------
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
----
V
R
S
E
--
R
K
-
L
H
T
-
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
---
A
V
V
-
M
---------
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
-
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
-----------
A
S
I
F
S
V
F
I
L
----------
C
I
D
R
--
Y
R
S
V
Q
---
Q
P
L
R
Y
L
----
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
--
A
W
F
L
S
F
L
W
V
I
P
I
L
--
G
W
N
H
-------------------
R
R
E
-------
D
K
C
E
----
T
D
F
Y
D
---
V
T
-------
W
F
K
V
M
T
A
I
-
I
N
F
-
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
-
M
L
R
-------
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
--
P
Y
F
I
F
F
M
V
I
A
F
C
K
-----------
N
C----------
C
-----
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
---------------------------
16
HHSearch
81.72
12%
-106
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[26-456]
----------------------------------
I
V
L
V
A
G
S
------------
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
----
I
K
V
N
--
R
H
-
L
Q
T
-
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
---
V
F
S
-
M
---------
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
-
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
-----------
A
S
V
M
N
L
L
I
I
----------
S
F
D
R
--
Y
F
C
V
T
---
K
P
L
T
Y
P
----
V
K
R
T
T
K
M
A
G
M
M
I
A
A
--
A
W
V
L
S
F
I
L
W
A
P
A
I
-
L
F
W
Q
F
I
V
G
V
R
-------------
T
V
E
D
-------
G
E
C
Y
----
I
Q
F
F
S
---
N
-------
A
A
V
T
F
G
T
A
I
-
A
A
F
-
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
-
M
L
R
-------
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
-------------------------------------------------------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW------------------------------------------------------
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
--
P
Y
N
V
M
V
L
I
N
T
F
C
A
-----------
P
C----------
I
-----
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------
26
HHSearch
79.24
11%
-109
- C2 -
1U19
14
OPSD_BOVIN
A:
[43-322]
----------------------------------
L
A
A
Y
M
F
L
------------
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
----
T
V
Q
H
--
K
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
---
F
G
G
-
F
---------
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
-
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
-----------
I
A
L
W
S
L
V
V
L
----------
A
I
E
R
--
Y
V
V
V
C
---
K
P
M
S
N
F
----
R
-
F
G
E
N
H
A
I
M
G
V
A
F
--
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
---------------
E
G
M
Q
-------
C
S
C
G
----
I
D
Y
Y
T
PHE
E
T
---
N
-
N
E
S
F
V
I
Y
M
F
V
-
V
-
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
-
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
--
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
GS---------
D
-----------
F
-----
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
---------------------------
21
HHSearch
76.92
14%
-105
- C2 -
3EML
13
ENLYS_BPT4
A:
[23-466]
---------------------------------
V
Y
I
T
V
E
L
A
------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
----
V
W
L
N
--
S
N
-
L
Q
N
-
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
---
V
L
A
-
I
---------
P
F
A
I
T
I
S
--
T
-
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
-----------
S
S
I
F
S
L
L
A
I
----------
A
I
D
R
--
Y
I
A
I
R
---
I
P
L
R
Y
N
----
G
L
V
T
G
T
R
A
K
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
G
W
N
N
C
G
Q
------------------
S
QGCGEGQ
V
A
C
L
----
F
E
D
V
V
---
P
------
M
N
Y
M
V
Y
F
N
F
F
-
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
-
M
L
R
-------
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
--
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
CSH--------
A
-----
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
---------------------------
15
HHSearch
74.87
14%
-110
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[48-492]
---------
K
I
----------------------
F
L
P
T
I
Y
S
I
------------
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
----
M
G
Y
Q
--
K
K
-
L
R
S
-
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
---
I
--
T
L
---------
P
F
W
A
V
D
A
--
V
A
N
W
Y
-
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
-----------
S
S
V
W
I
L
A
F
I
----------
S
L
D
R
--
Y
L
A
I
V
---
H
A
T
N
S
Q
----
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
--
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
-
S
-
E
---------------
A
D
D
R
-------
Y
I
C
D
----
R
F
Y
P
N
---
D
L
---
W
-
V
V
V
F
Q
F
Q
H
I
M
-
V
-
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
-
E
M
L
-------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
--
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
-----------
T
-----
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
---------------------------
25
HHSearch
74.66
11%
-107
- C2 -
2KS9
1
NK1R_HUMAN
A:
[35-321]
----------------------------------
W
A
A
A
Y
T
V
------------
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
----
I
L
A
H
--
K
R
-
M
R
T
-
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
---
A
F
N
-
T
---------
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
-
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
-----------
A
S
I
Y
S
M
T
A
V
----------
A
F
D
R
--
Y
M
A
I
I
---
H
P
L
Q
P
R
----
L
--
S
A
T
A
T
K
V
V
I
C
V
--
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
--
E
T
---------------
M
P
S
R
-------
V
V
C
M
----
I
E
W
P
E
---
H
P
NKI
Y
-
E
K
V
Y
H
I
C
V
T
V
-
L
-
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
-
S
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
--
P
F
H
I
F
F
L
L
P
Y
I
N
P
-----------
D
-----------
L
YLKKF
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
---------------------------
22
HHSearch
74.63
11%
-116
* C2 *
3V2Y
1
ENLYS_BPT4
A:
[63-492]
---------
I
K
----------------------
L
T
S
V
V
F
I
L
------------
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
----
I
W
K
T
--
K
K
-
F
H
R
-
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
---
V
A
Y
-
T
---------
A
N
L
L
L
S
G
--
A
T
T
Y
K
-
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
-----------
A
S
V
F
S
L
L
A
I
----------
A
I
E
R
--
Y
I
T
M
L
---
K
------------
N
N
F
R
L
F
L
L
I
S
A
--
C
W
V
I
S
L
I
L
G
G
L
P
I
M
-
G
W
N
C
------------------
I
S
A
L
-------
S
S
C
S
----
T
V
L
P
L
---
Y
H
------
K
H
Y
I
L
F
C
T
T
-
V
-
F
-
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
-
L
R
I
-------
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
A
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
--
P
L
F
I
L
L
L
L
D
V
G
C
K
-----------
V
KTC--------
D
-----
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
---------------------------
27
HHSearch
73.57
17%
-111
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[41-321]
---------------------------------
V
V
I
I
A
Y
A
L
------------
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
----
I
L
Y
S
--
R
V
-
G
R
S
-
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
---
L
T
--
L
---------
P
I
W
A
A
S
K
--
V
N
G
W
I
-
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
-----------
S
G
I
L
L
L
A
C
I
----------
S
V
D
R
--
Y
L
A
I
V
---
H
A
T
R
T
L
----
T
Q
-
K
R
H
L
V
K
F
V
C
L
G
--
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-
F
R
Q
A
Y
H
P
---------------
N
N
S
S
-------
P
V
C
Y
----
E
V
L
G
N
---
D
T
AK-
W
-
R
M
V
L
R
I
L
P
H
T
-
F
G
F
-
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
--
P
Y
N
L
V
L
L
A
D
T
L
M
R
-----------
T
QVIQE
S
C
E
R
R
N
N
-----
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
---------------------------
41
Fugue
62.36
13%
-107
- C3 -
1PQZ
-
?
A:
[5-242]
------------------------------------------------------------
G
S
E
S
G
L
R
Y
A
Y
T
L
V
V
D
G
--
T
A
-
N
-
T
-
A
R
C
F
G
T
G
H
V
D
G
E
A
F
V
G
Y
S
NN
K
T
H
G
I
---------
G
R
W
V
N
A
S
--
H
V
E
E
E
-
N
K
E
F
V
R
Q
C
K
E
L
Q
A
E
L
D
K
M
-----------
Q
N
N
S
A
V
I
G
V
----------
K
T
----
V
Q
L
D
V
G
CT
S
K
I
E
K
H
Y
A
Y
D
G
N
E
T
E
D
D
T
A
T
S
A
S
E
--
R
A
R
D
C
Q
K
K
L
T
E
Y
R
K
L
V
L
A
S
A
V
S
P
Q
L
----------
E
V
E
R
R
S
-------
S
----------
G
R
---
E
G
---
G
-
M
R
L
R
C
F
A
R
D
Y
Y
P
-
A
-
D
L
---
E
I
R
W
W
K
D
D
------
G
G
G
G
A
L
P
-
Q
T
S
-------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
D
P
L
P
S
G
Q
G
L
Y
Q
K
H
I
D
V
Y
V
D
G
G
-
L
E
H
V
--
Y
S
C
R
V
K
--------------------------------------------------------
G
I
A
T
G
L
E
L
Q
I
V
R
----
W
K
G
---------------------------
42
Fugue
50.58
8%
-118
- C1 -
2B5W
7
GLCDH_HALMT
A:
[1-357]
--M
K
A
I
A
V
K
R
G
----------------------
E
D
R
P
V
-
V
I
E
K
P
R
P
E
P
E
SG
E
A
L
V
R
T
L
R
V
G
V
C
G
T
D
H
E
V
I
A
G
G
H
G
G
--
F
P
-
E
-
G
-
E
D
H
L
V
L
G
H
E
A
V
G
V
V
V
D
P
---
N
D
T
E
L
EEG
D
I
V
V
P
T
V
R
R
P
P
A
S
--
G
T
N
E
Y
-
F
E
R
D
Q
P
D
M
A
P
D
G
M
Y
F
E
R
G
IVGAHGYMSE
F
F
T
S
P
E
K
Y
L
V
R
I
PRSQAELG
F
L
----
I
E
P
I
S
I
--
T
E
K
A
L
E
H
A
Y
A
S
R
S
A
F
D
W
D
P
S
S
A
F
V
L
G
N
G
S
L
G
L
L
T
L
A
M
L
K
V
D
D
K
G
Y
E
N
L
Y
C
L
G
RRDRPD
P
T
I
D
I
I
E
E
L
-------
D
A
T
Y
----
V
D
S
R
Q
---
T
P
---
V
-
E
D
V
P
D
V
Y
E
Q
M
-
D
-
F
-
I
Y
E
A
T
G
F
P
K
H
A
I
Q
S
V
Q
A
L
A
P
N
G
V
G
A
L
L
G
V
P
-------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------
D
------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
F
E
V
D
A
G
A
F
H
R
E
M
V
L
H
N
K
A
L
V
G
S
V
N
S
H
--
V
E
H
F
E
A
A
T
V
T
F
T
K
-----------
L
-----------
P
--------
K
W
F
L
E
D
L
V
T
G
V
H
P
L
S
E
F
E
A
A
F
D
D
D
D
T
T
I
K
T
A
I
E
F
S
T
V--------------------------
11
PsiBlast_PDB
49.14
23%
-85
- C3 -
2VQ1
2
IGHG3_MOUSE
B:
[146-218]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
G
Y
F
P
E
P
V
T
V
K
W
N
Y
G
A
L
----------
S
---------------------
S
G
V
R
---
T
V
---
S
-
S
V
L
Q
S
G
F
Y
S
L
-
S
-
S
-
L
V
T
V
P
S
S
T
W
P
S
Q
T
V
I
C
N
V
A
H
P
A
S
K
T
E
-
L
I
K
-------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
P
R
-------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.88
23%
-74
- C3 -
3IJY
-
?
B:
[154-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
G
Y
F
P
E
P
V
T
V
K
W
N
Y
G
A
L
----------
S
---------------------
S
G
V
R
---
T
V
---
S
-
S
V
L
Q
S
G
F
Y
S
L
-
S
-
S
-
L
V
T
V
P
S
S
T
W
P
S
Q
T
V
I
C
N
V
A
H
P
A
S
K
T
E
-
L
I
K
-------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
P
R
-------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
48.63
21%
-97
- C2 -
1E68
-
?
A:
[1-70]
-----------------------------------------------------------------------------------------------------------------------------
M
--
A
K
E
F
G
-
I
P
A
A
V
A
G
T
V
L
N
V
V
E
A
G
G
W
-----------
V
T
T
I
V
S
I
L
T
----------
A
V
G
S
G
G
L
S
L
L
A
A
--
A
G
R
E
S
I
K
A
Y
L
K
K
E
I
K
K
K
-
G
K
R
A
V
I
--
A
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
48.50
23%
-66
- C3 -
3IJH
-
?
B:
[154-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
G
Y
F
P
E
P
V
T
V
K
W
N
Y
G
A
L
----------
S
---------------------
S
G
V
R
---
T
V
---
S
-
S
V
L
Q
S
G
F
Y
S
L
-
S
-
S
-
L
V
T
V
P
S
S
T
W
P
S
Q
T
V
I
C
N
V
A
H
P
A
S
K
T
E
-
L
I
K
-------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
P
R
-------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
48.19
23%
-77
- C3 -
3VFG
-
?
H:
[141-213]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
G
Y
F
P
E
P
V
T
V
K
W
N
Y
G
A
L
----------
S
---------------------
S
G
V
R
---
T
V
---
S
-
S
V
L
Q
S
G
F
Y
S
L
-
S
-
S
-
L
V
T
V
P
S
S
T
W
P
S
Q
T
V
I
C
N
V
A
H
P
A
S
K
T
E
-
L
I
K
-------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
P
R
-------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
47.72
23%
-10
- C- -
1UZ6
-
HVM41_MOUSE
F:
[145-217]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
G
Y
F
P
E
P
V
T
V
K
W
N
Y
G
A
L
----------
S
---------------------
S
G
V
R
---
T
V
---
S
-
S
V
L
Q
S
G
F
Y
S
L
-
S
-
S
-
L
V
T
V
P
S
S
T
W
P
S
Q
T
V
I
C
N
V
A
H
P
A
S
K
T
E
-
L
I
K
-------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
P
R
-------------------------------------------------------------------------------------------------------------------------------------