@TOME V2.3
(Nov 2016)

Ref. - - Doc.
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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : ALK_HUMAN: (2013-07-19 )
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP

Atome Classification :

(68 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......-1110......-1120.......1130.-.....1140--...-....1150...-..-.1160-......1170.-.....1180--........1190.......1200......1210---.----.------..--..-1220--.......1230......1240......1250......1260--......1270......1280.......1290......1300......1310......1320......1330.......1340......1350......1360......1370......1380-........-1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLK-EVPRKNITLI-R-GLGHGAFGEVYEGQ-VSGMPND-P--SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA-SYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
3 PsiBlast_PDB 93.50100%-105 - C1 -3AOX A:[19-334] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STIMTDYNPNYCFAGKTSSISDLK-EVPRKNITLI-R-GLG----GEVYEGQ-VS----------PL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA--------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8 PsiBlast_PDB 92.9599%-101 - C1 -4FOD A:[8-328] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSTIMTDYNPNYSFAGKTSSISDLK-EVPRKNITLI-R-GLGHGAFGEVYEGQ-VS---------SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA--------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEYGPLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 92.7399%-103 - C1 -3LCS A:[30-333] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YCFAGKTSSISDLK-EVPRKNITLI-R-GLGHGAFGEVYEGQ-VSGMPND-P--SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA-GYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23 PsiBlast_CBE 92.49100%-102 - C1 -2XB7 A:[3-309] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYCFAGKTSSISDLK-EVPRKNITLI-R-GLGHGAFGEVYEGQ-VS----------PL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMA---------------AMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7 PsiBlast_PDB 92.4899%-101 - C1 -4DCE ALK_HUMAN A:[16-325] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLK-EVPRKNITLI-R-GLGH---GEVYEGQ-VS------P--SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDF---------------GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2 PsiBlast_PDB 92.1799%-102 - C1 -4FOC A:[36-345] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLK-EVPRKNITLI-R-GLGHGAFGEVYEGQ-VS---------SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYR---------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21 PsiBlast_CBE 91.2799%-104 - C1 -4DCE B:[17-325] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNYSFAGKTSSISDLK-EVPRKNITLI-R-GLGH----EVYEGQ-VS---------SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDF----------------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120 HHSearch 91.2599% -99 - C1 -3L9P A:[50-357] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYCFAGKTSSISDLK-EVPRKNITLI-R-GLGHGAFGEVYEGQ-VSG--------SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA-GYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5 PsiBlast_PDB 90.6599% -99 - C1 -3LCT A:[27-334] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYCFAGKTSSISDLK-EVPRKNITLI-R-GLGHGAFGEVYEGQ-VSGMPND-P--SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA-GYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1 PsiBlast_PDB 90.2699%-102 - C1 -4FOB A:[36-345] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLK-EVPRKNITLI-R-GLGHGAFGEVYEGQ-VS---------SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------S------SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDFGMARDIYRA-------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9 PsiBlast_PDB 90.1599% -99 - C1 -4FNZ A:[10-319] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLK-EVPRKNITLI-R-GLGH---GEVYEGQ-VSG--------SPL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------SQ--PS-SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDF----------------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11 PsiBlast_PDB 88.8799%-104 - C1 -4FNY A:[20-321] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSISDLK-EVPRKNITLI-R-GLGH---GEVYEGQ-VSG---------PL-QVAVKTLPEVC-SE-QDELD-FLMEALIISKF-NHQNIVR----CIGVSLQSLPR-FILLELMAGGDLKSFLRETRP---R----P------S-------LA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG--RVAKIGDF-----------------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE---RIEYCTQD-PDVINTALPIEYGPL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119 HHSearch 68.3143% -89 - C1 -4AOJ NTRK1_HUMAN A:[33-322] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH-HIKRRDIVLK-W-ELGEGAFGKVFLAE-CHNLLP------KM-LVAVKALKE-A-SE-SARQD-FQREAELLTML-QHQHIVR----FFGVCTEGRPL-LMVFEYMRHGDLNRFLRSHGP---D---------------PG-PLG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG---QG--LVVKIGDFG-----------------TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQ-LSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQA-PP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50 PsiBlast_CBE 67.5340% -85 - C1 -4AOJ C:[33-322] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH-HIKRRDIVLK-W-ELGEGAFGKVFLAE-CHNLLP--Q--DKM-LVAVKALKE-A-SE-SARQD-FQREAELLTML-QHQHIVR----FFGVCTEGRPL-LMVFEYMRHGDLNRFLRSHGP---D----------------G-PLG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQG--LVVKIGDFGM-----------------MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQ-LSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQA-PP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39 PsiBlast_CBE 66.3345% -82 - C1 -3LW0 IGF1R_HUMAN A:[6-285] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP-------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42 PsiBlast_CBE 66.3043% -75 - C1 -3ETA INSR_HUMAN A:[12-305] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLL-R-ELGQGSFGMVYEGN-ARDIIKG-E--AET-RVAVKTVNESA-SL-RERIE-FLNEASVMKGF-TCHHVVR----LLGVVSKGQPT-LVVMELMAHGDLKSYLRSLRP---EAENNP------GR--PP-P-T---LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---AHD--FTVKIGDFGMTRDIYET-DYYRKG-KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG-LSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVN---LLK-------DDLHPSFP-EVSFFHSEENK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51 PsiBlast_CBE 66.1040% -85 - C1 -4AOJ NTRK1_HUMAN B:[33-324] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH-HIKRRDIVLK-W-ELGEGAFGKVFLAE-CHNLLP------KM-LVAVKALKE-A-SE-SARQD-FQREAELLTML-QHQHIVR----FFGVCTEGRPL-LMVFEYMRHGDLNRFLRSHGP---D----------------G-PLG---LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQG--LVVKIGDF--------------------LPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQ-LSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA---RLQALAQA-PPVY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38 PsiBlast_CBE 65.7345% -82 - C1 -3LW0 IGF1R_HUMAN B:[6-285] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP-------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127 HHSearch 65.6244% -86 - C1 -3CBL A:[106-373] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDKW-VLNHEDLVLG-E-QIGRGNFGEVFSGR-LRA--------DNT-LVAVKSCRETL-PP-DLKAK-FLQEARILKQY-SHPNIVR----LIGVCTQKQPI-YIVMELVQGGDFLTFLRTEG---------------------A-RLR---VKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVT---EK--NVLKISDFGMSREEADG-VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN-LSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQ---ELQSIR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26 PsiBlast_CBE 65.5344% -80 - C1 -1JQH IGF1R_HUMAN B:[6-289] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP-------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMT--------YYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36 PsiBlast_CBE 65.3745% -83 - C1 -3LW0 D:[6-285] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP-------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99 PsiBlast_CBE 65.1938% -83 - C1 -2I0V A:[10-329] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKYQV---RWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFG-K-TLGAGAFGKVVEAT-AFGLGKE-D--AVL-KVAVKMLKSTA-HA-DEKEA-LMSELKIMSHLGQHENIVN----LLGACTHGGPV-LVITEYCCYGDLLNFLRRKR-----------------------QLS---SRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT---NG--HVAKIGDFGLARDIMND-SNYIVKG-ARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICS---FLQEQAQE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31 PsiBlast_CBE 65.1545% -81 - C1 -3NW7 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP---E----M------EN--NP-VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41 PsiBlast_CBE 64.7643% -75 - C1 -3ETA B:[12-305] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLL-R-ELGQGSFGMVYEGN-ARDIIKG-E--AET-RVAVKTVNESA-SL-RERIE-FLNEASVMKGF-TCHHVVR----LLGVVSKGQPT-LVVMELMAHGDLKSYLRSLRP---EAENNP------GR--PP-P-T---LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---AHD--FTVKIGDFGMTRDIYET-DYYRK--KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG-LSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVN---LLK-------DDLHPSFP-EVSFFHSEENK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121 HHSearch 64.6137% -89 * C1 *4I4E A:[9-278] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-Y-EIQRERIELG-R-CIGEGQFGDVHQGI-YMSP----N--PAL-AVAIKTCKNCT-SD-SVREK-FLQEALTMRQF-DHPHIVK----LIGVITE-NPV-WIIMELCTLGELRSFLQVRK---------------------Y-SLD---LASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSN-----DCVKLGDF--------------------LPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQG-VKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKA---QLSTILEE-E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32 PsiBlast_CBE 64.3845% -83 - C1 -3NW6 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP---E----M------EN--NP-VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37 PsiBlast_CBE 64.3645% -81 - C1 -3LW0 IGF1R_HUMAN C:[6-285] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP-------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98 PsiBlast_CBE 64.2838% -81 - C1 -2I0Y A:[14-329] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V---RWKIIESYE--SYTFI--------EKWEFPRNNLQFG-K-TLGAGAFGKVVEAT-AFGLGKE-D--AVL-KVAVKMLKSTA-HA-DEKEA-LMSELKIMSHLGQHENIVN----LLGACTHGGPV-LVITEYCCYGDLLNFLRRKR-----------------------QLS---SRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT---NG--HVAKIGDFGLARDIMND-SNYIVKG-ARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICS---FLQEQAQE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33 PsiBlast_CBE 64.1345% -84 - C1 -3NW5 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP---E----M------EN--NP-VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83 PsiBlast_CBE 63.9137% -90 - C1 -2PWL FGFR2_HUMAN B:[31-314] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFPRDKLTLG-K-PLGEGAFGQVVMAE-AVGIDKD-KPKEAV-TVAVKMLKDDA-TE-KDLSD-LVSEMEMMKMIGKHKNIIH----LLGACTQDGPL-YVIVEYASKGNLREYLRARRP---P----G------------EQMT---FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT---EN--NVMKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG-IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24 PsiBlast_CBE 63.7449% -91 - C1 -3ZBF ? A:[24-306] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IENLP-AFPREKLTLR-L-LLGS---GEVYEGTAVDILGVG-S--GEI-KVAVKTLKKGS-TD-QEKIE-FLKEAHLMSKF-NHPNILK----QLGVCLLNEPQ-YIILELMEGGDLLTYLRKARM---A----T------FY--GP-LLT---LVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY-------------LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPA-HSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQD---QLQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65 PsiBlast_CBE 63.3939% -92 - C1 -4F65 B:[16-299] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGAFGQVVLAE-AIGLD---P--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARRP----------------------QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADF-------HI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34 PsiBlast_CBE 63.1245% -80 - C1 -2OJ9 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP---E---------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35 PsiBlast_CBE 62.9845% -85 - C1 -3I81 A:[9-288] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP---E-----------EN--NP-VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYR-----LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135 HHSearch 62.8935% -81 - C1 -4FL3 KSYK_HUMAN A:[360-632] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKEV-YLDRKLLTLE-DKELGSGNFGTVKKGY-YQMK----K--VVK-TVAVKILKNEANDP-ALKDE-LLAEANVMQQL-DNPYIVR----MIGICE-AESW-MLVMEMAELGPLNKYLQQNR-----------------------HVK---DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ-----HYAKISDFGLSKALRA-------------PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVEL---RLRNYYYD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73 PsiBlast_CBE 62.6139% -89 - C1 -1FGI B:[17-300] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGAFGQVVLAE-AIGL----P--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARR-----------------------QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLA-------DYYKK---GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84 PsiBlast_CBE 62.5337% -88 - C1 -2PWL FGFR2_HUMAN A:[31-314] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFPRDKLTLG-K-PLGEGAFGQVVMAE-AVGIDKD-KPKEAV-TVAVKMLKDDA-TE-KDLSD-LVSEMEMMKMIGKHKNIIH----LLGACTQDGPL-YVIVEYASKGNLREYLRARRP---------------------EQMT---FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT---EN--NVMKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG-IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79 PsiBlast_CBE 62.4439% -90 - C1 -3C4F B:[9-292] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGAFGQVVLAE-AIGLDKDKP--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARRPP------------------EE-QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25 PsiBlast_CBE 62.3743% -88 - C1 -3LVP IGF1R_HUMAN A:[39-317] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP---E----M------E----P-VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIY--------GGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29 PsiBlast_CBE 61.9945% -80 - C1 -3QQU IGF1R_HUMAN B:[3-282] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLR--------------------------PS-LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64 PsiBlast_CBE 61.9139% -85 - C1 -3JS2 FGFR1_HUMAN A:[24-307] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGAFGQVVLAE-AIGLDKDKP--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARRPPGL-------------HNPEE-QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43 PsiBlast_CBE 61.8445% -78 - C1 -1I44 A:[9-283] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEW-EVSREKITLL-R-ELGQGSFGMVYEGN-ARDIIKG-E--AET-RVAVKTVNESA-SL-RERIE-FLNEASVMKGF-TCHHVVR----LLGVVSKGQPT-LVVMELMAHGDLKSYLRSLRP---EAENNP------GR--PP-P-T---LQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---AHD--FTVKIGDFGMT-----------------LPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG-LSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102 PsiBlast_CBE 61.7437% -90 - C1 -3B2T FGFR2_HUMAN A:[18-301] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFPRDKLTLG-K-PLGEGCFGQVVMAE-AVGID----PKEAV-TVAVKMLKDDA-TE-KDLSD-LVSEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLRARRP---P------------------QMT---FKDLVSCTYQLARGMEYLASQKCIHRDLTARNVLVT---EN--NVMKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG-IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57 PsiBlast_CBE 61.3838% -79 - C1 -3GQL FGFR1_HUMAN B:[24-317] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGAFGQVVLAE-AIGLDKDKP--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARRPP----------------P-EE-QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLAR-----------------PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN-QE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30 PsiBlast_CBE 60.9845% -83 - C1 -3QQU IGF1R_HUMAN A:[6-282] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLR--------------------------PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 60.7545% -84 - C1 -3QQU D:[4-282] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP---E----M--------------LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45 PsiBlast_CBE 60.6145% -81 - C1 -3EKN A:[9-284] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVSREKITLL-R-ELGQGSFGMVYEGN-ARDIIKG-E--AET-RVAVKTVNESA-SL-RERIE-FLNEASVMKGF-TCHHVVR----LLGVVSKGQPT-LVVMELMAHGDLKSYLRSLRP---EAENNP------GR--PP-P-T---LQEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMV---AHD--FTVKIGDFGMTRDIYET-DYYRKG---LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG-LSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68 PsiBlast_CBE 60.0139% -92 - C1 -4F64 FGFR1_HUMAN A:[16-299] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PL-----GQVVLAE-AIGL----P--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARRPP------------------EE-QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58 PsiBlast_CBE 59.9838% -79 - C1 -3GQL FGFR1_HUMAN A:[24-326] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGAFGQVVLAE-AIGLDKDKP--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARRPP-------------------E-QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLAR-------------NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN-QEYLDLSMPLD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 59.8845% -79 - C1 -3QQU IGF1R_HUMAN C:[4-282] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEW-EVAREKITMS-R-ELGQGSFGMVYEGV-AKGVVKD-E--PET-RVAIKTVNEAA-SM-RERIE-FLNEASVMKEF-NCHHVVR----LLGVVSQGQPT-LVIMELMTRGDLKSYLRSLRP---E----M-------------VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---AED--FTVKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS---SIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46 PsiBlast_CBE 59.7345% -83 - C1 -3EKK A:[9-284] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEW-EVSREKITLL-R-ELGQGSFGMVYEGN-ARDIIKG-E--AET-RVAVKTVNESA-SL-RERIE-FLNEASVMKGF-TCHHVVR----LLGVVSKGQPT-LVVMELMAHGDLKSYLRSLRP---EAENNP------GR--PP-P-T---LQEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMV---AHD--FTVKIGDF-------------------LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG-LSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67 PsiBlast_CBE 59.7039% -89 - C1 -4F64 B:[16-299] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGAFGQVVLAE-AIGL----P--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARR-----------------------QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLA-------DYYKK---GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80 PsiBlast_CBE 59.5939% -89 - C1 -3C4F FGFR1_HUMAN A:[9-292] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGAFGQVVLAE-AIGLDKDKP--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARRPP------------------EE-QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48 PsiBlast_CBE 59.5842% -79 - C1 -4AT4 A:[7-277] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQ-HIKRHNIVLK-R-ELGEGAFGKVFLAE-CYNLC-------KI-LVAVKTLKD-A-SD-NARKD-FHREAELLTNL-QHEHIVK----FYGVCVEGDPL-IMVFEYMKHGDLNKFLRAHGP---D----AVLMA---P--PT-ELT---QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GEN--LLVKIGDFGMSRDVYST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQ-LSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70 PsiBlast_CBE 59.2239% -91 - C1 -4F63 FGFR1_HUMAN A:[16-299] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PL-----GQVVLAE-AIGL----P--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARRPP------------------EE-QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47 PsiBlast_CBE 59.0842% -78 - C1 -4AT5 A:[7-277] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQ-HIKRHNIVLK-R-ELGEGAFGKVFLAE-CYNL--------KI-LVAVKTLKD-A-SD-NARKD-FHREAELLTNL-QHEHIVK----FYGVCVEGDPL-IMVFEYMKHGDLNKFLRAHGP---D----AVLMAEGNP--PT-ELT---QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GEN--LLVKIGDFGMSRDVYST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQ-LSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132 HHSearch 59.0634% -85 - C1 -2OZO ZAP70_HUMAN A:[328-599] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKL-FLKRDNLLIA-DIELGCGNFGSVRQGV-YRMRK------KQI-DVAIKVLKQGT-EK-ADTEE-MMREAQIMHQL-DNPYIVR----LIGVCQA-EAL-MLVMEMAGGGPLHKFLVGKR---------------------E-EIP---VSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVN---R--HYAKISDFGLSKALG--------------PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK-MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ---RMRACYYS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49 PsiBlast_CBE 59.0142% -77 - C1 -4AT3 A:[7-277] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQ-HIKRHNIVLK-R-ELGEGAFGKVFLAE-CYNLC-------KI-LVAVKTL---A-SD-NARKD-FHREAELLTNL-QHEHIVK----FYGVCVEGDPL-IMVFEYMKHGDLNKFLRAHGP---D----AVLMA--NP--PT-ELT---QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GEN--LLVKIGDFGMSR--YST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQ-LSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101 PsiBlast_CBE 58.9137% -91 - C1 -3B2T B:[18-301] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFPRDKLTLG-K-PL----FGQVVMAE-AVGID---KPKEAV-TVAVKMLKDDA-TE-KDLSD-LVSEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLRARRP---P------------------QMT---FKDLVSCTYQLARGMEYLASQKCIHRDLTARNVLVT---EN--NVMKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG-IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55 PsiBlast_CBE 58.8942% -88 - C1 -3BKB A:[114-370] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDLVLG-E-QIGRGNFGEVFSGR-LRA--------DNT-LVAVKSCRETL-PP-DLKAK-FLQEARILKQY-SHPNIVR----LIGVCTQKQPI-YIVMELVQGGDFLTFLR-------------------TE--GA-RLR---VKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVT---EK--NVLKISDFGMSREEADG-VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN-LSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQ---ELQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69 PsiBlast_CBE 58.7439% -86 - C1 -4F63 B:[16-299] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGA-GQVVLAE-AIGL----P--NRVTKVAVKMLKSDA-TE-KDLSD-LISEMEMMKMIGKHKNIIN----LLGACTQDGPL-YVIVEYASKGNLREYLQARR-----------------------QLS---SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT---ED--NVMKIADFGLA-------DYYKK---GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE---DLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122 HHSearch 58.6235% -90 - C1 -4FYO A:[11-279] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-YLDRKLLTLEDK-ELGSGNFGTVKKGY-YQMK----K--VVK-TVAVKIL-------PALKDE-LLAEANVMQQL-DNPYIVR----MIGICE-AESW-MLVMEMAELGPLNKYLQQNRH-----------------------VK---DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT---Q--HYAKISDFGLSKALRADENYYKA----KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVEL---RLRNYYY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103 PsiBlast_CBE 56.7337% -93 - C1 -3TCP B:[31-310] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDRNLLILG-K-ILGE---GSVMEGN-LK--QED-G--TSL-KVAVKTMK----------------EAACMKDF-SHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL---E-----------TG--PK-HIP---LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLR---DD--MTVCVADF--------------------MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG-VQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRL---QLEKLLESL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53 PsiBlast_CBE 56.6540% -83 - C1 -3V5Q NTRK3_HUMAN A:[6-287] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIHVQ-HIKRRDIVLK-R-EL------KVFLAE-CYNLSPT-K--DKM-LVAVKALPTLA-AR-KD----FQREAELLTNL-QHEHIVK----FYGVCGDGDPL-IMVFEYMKHGDLNKFLRAHGP----------------------ELG---LSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV---GAN--LLVKIGDFGM--DVYST-DYYR----TMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQ-LSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133 HHSearch 56.1140% -82 - C1 -1OPK ABL1_MOUSE A:[212-481] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDKW-EMERTDITMK-H-KLGGGQYGEVYEGV-WKK--------YSL-TVAVKTLKEDT----MEVEE-FLKEAAVMKEI-KHPNLVQ----LLGVCTREPPF-YIITEFMTYGNLLDYLRECNR--------------------Q-EVS---AVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVG---EN--HLVKVADFGLSRLMTGD-T-YTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG-IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ---AFETMFQE-SS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131 HHSearch 55.7339% -85 - C1 -1QCF HCK_HUMAN A:[179-442] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKDAW-EIPRESLKLE-K-KLGAGQFGEVWMAT-YNK---------HT-KVAVKTMKPGS----MSVEA-FLAEANVMKTL-QHDKLVK----LHAVVT-KEPI-YIITEFMAKGSLLDFLKSDEG--------------------S-KQP---LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS---AS--LVCKIADFGLARVIEDN-EYTAREG-AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG-MSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQS---VLDDFYT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104 PsiBlast_CBE 53.9137%-100 - C1 -3TCP MERTK_HUMAN A:[31-312] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDRNLLILG-K-ILG-----SVMEGN-LK--QED-G--TSL-KVAVKTMKLDN-SS-QREIEEFLSEAACMKDF-SHPNVIRLLGVCIE------PKPMVILPFMKYGDLHTYLLYSRL---E-----------TG--PK-HIP---LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLR---DD--MTVCVADF---------------------PVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG-VQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRL---QLEKLLESLPD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105 PsiBlast_CBE 53.5137% -93 - C1 -3BRB B:[31-312] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDRNLLILG-K-ILGEGEFGSVMEGN-LK--QED-G--TSL-KVAVKTMKLDN-SS-QREIEEFLSEAACMKDF-SHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL---E-----------TG--PK-HIP---LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLR---DD--MTVCVADFGL-------------------PVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG-VQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRL---QLEKLLESLPD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------