@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AURKA_HUMAN: (2013-07-19 )
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Atome Classification :
(89 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.---......160.......170.......180......-.190.......200.......210.......220.....-..230.......240.......250........260.......---270......--.280.--......-..290.......300.......310.......320.......330.......340......--.350-........360.......370-----.-----.------.-....380.......---390.......400.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREK---QSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL-RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-FDEQRTATYITELANALSYCHSK-RVIHRDIKPENLLLGSAGE---LKIADFGWS--VH--A--PSSRRT-TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF--PDF--VTEGARDLISRLLKHNPSQRP-----M-----L------R-EVLEHPWITANSSK---PSNCQNKESASKQS
22
PsiBlast_CBE
91.44
100%
-128
- C1 -
3EFW
1
AURKA_HUMAN
A:
[126-388]
-----------------------------------------------------------------------------------------------------------------------------
R
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-
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N
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S
------------------
125
HHSearch
91.34
100%
-115
- C1 -
3FDN
1
AURKA_HUMAN
A:
[4-272]
-----------------------------------------------------------------------------------------------------------------------------
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---
P
S
N
C
Q
---------
60
PsiBlast_CBE
91.32
100%
-128
- C1 -
2X81
1
AURKA_HUMAN
A:
[8-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
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I
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---
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N
V
Y
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A
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-----
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------
R
-
E
V
L
E
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W
I
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A
N
S
S
------------------
16
PsiBlast_PDB
90.46
99%
-111
- C1 -
3UOD
3
AURKA_HUMAN
A:
[2-267]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
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-
E
V
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W
I
T
A
N
S
S
K
-----------------
36
PsiBlast_CBE
90.31
99%
-113
- C1 -
3UP2
3
AURKA_HUMAN
A:
[2-267]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
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---
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I
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K
-----------------
72
PsiBlast_CBE
90.11
99%
-120
- C1 -
3H0Z
1
AURKA_HUMAN
A:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------
W
A
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V
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A
N
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S
------------------
14
PsiBlast_PDB
90.03
99%
-113
- C1 -
3UO5
1
AURKA_HUMAN
A:
[2-268]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
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W
A
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65
PsiBlast_CBE
89.66
100%
-117
- C1 -
3O50
1
AURKA_HUMAN
A:
[2-264]
-----------------------------------------------------------------------------------------------------------------------------
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A
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------------------
43
PsiBlast_CBE
89.41
99%
-115
- C1 -
3K5U
1
AURKA_HUMAN
A:
[4-272]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
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K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
N
C
Q
---------
54
PsiBlast_CBE
89.15
99%
-118
- C1 -
3LAU
1
AURKA_HUMAN
A:
[2-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
------------
31
PsiBlast_CBE
89.10
99%
-106
- C1 -
4DEE
1
AURKA_HUMAN
A:
[2-272]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
N
C
Q
---------
66
PsiBlast_CBE
89.06
99%
-122
- C1 -
3P9J
1
AURKA_HUMAN
A:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
---
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
62
PsiBlast_CBE
88.79
100%
-114
- C1 -
1MQ4
1
AURKA_HUMAN
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
---
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
68
PsiBlast_CBE
88.62
99%
-108
- C1 -
3H10
1
AURKA_HUMAN
B:
[2-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
A
-
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
------------
52
PsiBlast_CBE
88.59
100%
-113
- C1 -
4JAJ
1
?
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
29
PsiBlast_CBE
88.58
99%
-119
- C1 -
4JBQ
1
?
A:
[4-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
------------
70
PsiBlast_CBE
88.54
99%
-121
- C1 -
3H0Z
1
AURKA_HUMAN
C:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
59
PsiBlast_CBE
88.50
100%
-117
- C1 -
3MYG
2
AURKA_HUMAN
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
----------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
73
PsiBlast_CBE
88.35
99%
-120
- C1 -
3H0Y
1
AURKA_HUMAN
A:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
69
PsiBlast_CBE
87.98
99%
-106
- C1 -
3H10
1
AURKA_HUMAN
A:
[2-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
A
-
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
------------
21
PsiBlast_CBE
87.96
100%
-122
- C1 -
3EFW
1
AURKA_HUMAN
B:
[126-389]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
------------------------
L
D
Y
L
P
P
E
M
I
E
-----
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
57
PsiBlast_CBE
87.66
100%
-115
- C1 -
2W1E
1
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
33
PsiBlast_CBE
87.57
99%
-110
- C1 -
4DEB
3
AURKA_HUMAN
A:
[3-266]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
84
PsiBlast_CBE
87.55
94%
-117
- C1 -
3DJ7
1
AURKA_MOUSE
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------------
74
PsiBlast_CBE
87.55
99%
-117
- C1 -
4DHF
1
AURKA_HUMAN
B:
[8-269]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
-----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
83
PsiBlast_CBE
87.28
97%
-114
- C1 -
3COH
1
AURKA_HUMAN
A:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
---------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
6
PsiBlast_PDB
87.18
100%
-116
- C1 -
2X6D
1
AURKA_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
----
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
-----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
30
PsiBlast_CBE
87.05
99%
-109
- C1 -
4JBO
1
?
A:
[4-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
T
-
D
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
------------
76
PsiBlast_CBE
87.04
99%
-113
- C1 -
3R22
1
AURKA_HUMAN
A:
[6-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
58
PsiBlast_CBE
87.04
100%
-118
- C1 -
2W1D
1
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
77
PsiBlast_CBE
87.03
99%
-117
- C1 -
3R21
1
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
11
PsiBlast_PDB
87.02
98%
-115
- C1 -
2WTW
1
AURKA_HUMAN
A:
[10-271]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
34
PsiBlast_CBE
86.89
99%
-110
- C1 -
4DEA
4
AURKA_HUMAN
A:
[2-267]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
78
PsiBlast_CBE
86.87
99%
-117
- C1 -
2W1G
1
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
82
PsiBlast_CBE
86.78
97%
-115
- C1 -
3COH
1
AURKA_HUMAN
B:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
---------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
75
PsiBlast_CBE
86.64
99%
-114
- C1 -
4DHF
1
AURKA_HUMAN
A:
[8-269]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
-----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
56
PsiBlast_CBE
86.52
99%
-115
- C1 -
2XNE
1
AURKA_HUMAN
A:
[7-268]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
-------
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
N
F
G
W
S
--
V
H
--
A
--
P
----------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
49
PsiBlast_CBE
86.44
99%
-111
- C1 -
3NRM
1
AURKA_HUMAN
A:
[6-268]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
A
-
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
45
PsiBlast_CBE
86.43
99%
-115
- C1 -
2C6E
1
AURKA_HUMAN
B:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
-----------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
13
PsiBlast_PDB
86.22
99%
-110
- C1 -
3UO4
4
AURKA_HUMAN
A:
[2-267]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
40
PsiBlast_CBE
86.13
99%
-109
- C1 -
3UOH
3
AURKA_HUMAN
B:
[4-267]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
63
PsiBlast_CBE
86.11
100%
-126
- C1 -
3O51
1
AURKA_HUMAN
A:
[2-264]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
17
PsiBlast_PDB
86.02
99%
-109
- C1 -
3UOH
4
AURKA_HUMAN
A:
[4-267]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
71
PsiBlast_CBE
85.92
99%
-119
- C1 -
3H0Z
1
AURKA_HUMAN
B:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
------
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
88
PsiBlast_CBE
85.85
94%
-116
- C1 -
3D15
1
AURKA_MOUSE
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
--------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------------
5
PsiBlast_PDB
85.85
100%
-113
- C1 -
4B0G
1
AURKA_HUMAN
A:
[6-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
----
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
-----------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
------------
86
PsiBlast_CBE
85.81
94%
-126
- C1 -
3DJ5
1
AURKA_MOUSE
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
---
L
K
I
A
D
F
G
W
---------------
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------------
46
PsiBlast_CBE
85.56
99%
-116
- C1 -
2C6E
1
AURKA_HUMAN
A:
[9-271]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
87
PsiBlast_CBE
85.45
94%
-118
- C1 -
3D2I
1
AURKA_MOUSE
A:
[8-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
--------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------------
41
PsiBlast_CBE
85.39
99%
-107
- C1 -
3UO6
3
AURKA_HUMAN
B:
[4-267]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
67
PsiBlast_CBE
85.35
99%
-111
- C1 -
3H10
1
AURKA_HUMAN
D:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
---------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
37
PsiBlast_CBE
85.23
99%
-109
- C1 -
3UOL
8
AURKA_HUMAN
B:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
85
PsiBlast_CBE
85.08
94%
-124
- C1 -
3DJ6
1
AURKA_MOUSE
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
E
---
L
K
I
A
D
F
G
W
---------------
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------------
35
PsiBlast_CBE
85.04
99%
-110
- C1 -
3UP7
1
AURKA_HUMAN
A:
[2-265]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
-------------------
64
PsiBlast_CBE
85.00
100%
-118
- C1 -
3O50
1
AURKA_HUMAN
B:
[2-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
-----------------
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
19
PsiBlast_PDB
84.98
99%
-107
- C1 -
3UOK
1
AURKA_HUMAN
A:
[3-267]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
20
PsiBlast_PDB
84.97
99%
-109
- C1 -
3UOL
6
AURKA_HUMAN
A:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
15
PsiBlast_PDB
84.94
99%
-106
- C1 -
3UO6
3
AURKA_HUMAN
A:
[4-267]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
3
PsiBlast_PDB
84.76
100%
-117
- C1 -
1MUO
1
AURKA_HUMAN
A:
[22-282]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
-----------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
38
PsiBlast_CBE
84.56
99%
-106
- C1 -
3UOK
1
AURKA_HUMAN
B:
[3-267]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
39
PsiBlast_CBE
84.45
99%
-106
- C1 -
3UOJ
1
AURKA_HUMAN
B:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
51
PsiBlast_CBE
84.35
98%
-113
- C1 -
3QBN
1
AURKA_HUMAN
A:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
--------------------
T
L
S
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
32
PsiBlast_CBE
84.33
99%
-107
- C1 -
4DED
4
AURKA_HUMAN
A:
[2-266]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
18
PsiBlast_PDB
84.28
99%
-106
- C1 -
3UOJ
1
AURKA_HUMAN
A:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
12
PsiBlast_PDB
84.28
99%
-107
- C1 -
3UNZ
3
AURKA_HUMAN
A:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
53
PsiBlast_CBE
84.27
100%
-115
- C1 -
4JAI
1
?
A:
[14-278]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
-----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
-------------
42
PsiBlast_CBE
83.98
99%
-108
- C1 -
3UNZ
3
AURKA_HUMAN
B:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
7
PsiBlast_PDB
82.89
100%
-114
- C1 -
2X6E
1
AURKA_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
----------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
90
PsiBlast_CBE
76.30
71%
-112
- C1 -
4AF3
1
AURKB_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------
R
H
F
T
I
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
K
S
H
F
I
V
A
L
K
V
L
F
K
S
Q
I
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
A
H
L
-
H
H
P
N
I
L
R
L
Y
N
Y
F
Y
D
R
R
R
I
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
C
T
-
F
D
E
Q
R
T
A
T
I
M
E
E
L
A
D
A
L
M
Y
C
H
G
K
-
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
L
K
G
E
---
L
K
I
A
D
F
G
-----------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
N
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
N
P
P
F
E
S
A
S
H
N
E
T
Y
R
R
I
V
K
V
D
L
K
F
--
P
A
S
--
V
P
T
G
A
Q
D
L
I
S
K
L
L
R
H
N
P
S
E
R
L
-----
P
-----
L
------
A
-
Q
V
S
A
H
P
W
V
R
A
N
S
R
R
V
L
P
P
S
------------
89
PsiBlast_CBE
75.70
68%
-107
- C1 -
4B8L
1
?
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
---
L
K
I
A
D
F
-----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
--
P
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
-----
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L---------------
112
HHSearch
69.25
34%
-109
* C1 *
4GV1
5
AKT1_HUMAN
A:
[3-270]
-----------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
---
I
K
I
T
D
F
G
L
C
--
K
E
GI
K
--
D
G
A
T
M
K
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
--
P
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGS
E
D
A
------
K
-
E
I
M
Q
H
R
F
F
A
G
---------------------
80
PsiBlast_CBE
69.14
99%
-78
- C1 -
3E5A
1
AURKA_HUMAN
A:
[2-266]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
--
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
55
PsiBlast_CBE
68.65
98%
-66
- C1 -
2DWB
1
AURKA_HUMAN
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
---
T
L
C
G
T
L
D
Y
L
P
P
E
-
I
E
G
R
-
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----------
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
128
HHSearch
66.59
35%
-101
- C1 -
1O6L
1
AKT2_HUMAN
A:
[1-266]
------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
---
I
K
I
T
D
F
G
L
C
--
K
E
GI
S
--
D
G
A
T
M
K
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
--
P
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
-----
A
------
K
-
E
V
M
E
H
R
F
F
L
S
---------------------
81
PsiBlast_CBE
66.04
99%
-66
- C1 -
3HA6
1
AURKA_HUMAN
A:
[2-265]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------
79
PsiBlast_CBE
66.00
99%
-65
- C1 -
2W1C
1
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
R
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------
93
PsiBlast_CBE
65.24
37%
-118
- C1 -
3HX4
3
?
A:
[56-309]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
--
F
--
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
------
R
-
D
A
L
D
H
E
W
I
-----------------------
91
PsiBlast_CBE
64.55
38%
-122
- C1 -
3COK
1
PLK4_HUMAN
A:
[10-267]
---------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
---
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
-
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
N
---
I
K
I
A
D
F
G
L
A
T
Q
L
K
---------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
-----
V
V
L
A
D
Y
E
M
--
P
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
-----
L
------
S
-
S
V
L
D
H
P
F
M
S
----------------------
132
HHSearch
63.12
32%
-91
- C1 -
1XJD
1
A:
[16-276]
---------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
-
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
---
I
K
I
A
D
F
G
M
C
--
K
E
--
N
ML
G
D
A
K
T
N
-
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
--
P
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
-----
V
------
R
G
D
I
R
Q
H
P
L
F
R
E
I
--------------------
94
PsiBlast_CBE
61.32
37%
-103
- C1 -
3V5T
1
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
--
F
--
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
------
R
-
D
A
L
D
H
E
W
I
-----------------------
92
PsiBlast_CBE
60.82
37%
-105
- C1 -
3KU2
1
?
A:
[55-308]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
--
F
--
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
------
R
-
D
A
L
D
H
E
W
I
-----------------------
98
PsiBlast_CBE
60.73
37%
-102
- C1 -
3UPX
1
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
--
F
--
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
------
R
-
D
A
L
D
H
E
W
I
-----------------------
126
HHSearch
60.63
34%
-105
- C1 -
3TXO
1
A:
[23-286]
----------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
---
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
-
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
---
C
K
L
A
D
F
G
M
C
--
K
E
--
G
IC----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
--
P
T
W
--
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
-----
S
LTQGG
E
H
-
A
I
L
R
H
P
F
F
K
E
---------------------
99
PsiBlast_CBE
60.61
37%
-102
- C1 -
3T3V
2
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
--
F
--
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
------
R
-
D
A
L
D
H
E
W
I
-----------------------
97
PsiBlast_CBE
60.51
37%
-101
- C1 -
3UPZ
1
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
--
F
--
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
------
R
-
D
A
L
D
H
E
W
I
-----------------------
95
PsiBlast_CBE
59.63
37%
-105
- C1 -
3V5P
1
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
--
F
--
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
------
R
-
D
A
L
D
H
E
W
I
-----------------------
100
PsiBlast_CBE
58.83
37%
-102
- C1 -
3T3U
5
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
--
F
--
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
EL
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
------
R
-
D
A
L
D
H
E
W
I
-----------------------
116
HHSearch
55.74
34%
-98
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[20-287]
------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
-
V
------
D
I
L
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
---
I
K
L
T
D
F
G
L
S
--
K
E
-------
K
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
--
P
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
-----
G
AGPD
G
V
------
E
-
E
I
K
R
H
S
F
F
S
T
---------------------
61
PsiBlast_CBE
50.78
100%
-104
- C1 -
2NP8
1
AURKA_HUMAN
A:
[8-166]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
H
--
A
--
P
S
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------