@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYR1A_HUMAN: (2013-07-20 )
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150...-.-.-..160.......170......-.180-........190----.---......200.......210----........220.......230-----.-------.......240.-......250--.......260-........270.......280.......290...---.--------..-----------------.-------------300-.......310..---.....320.......330..-.-.-.-..340.......350....-----------...360-----....-------....370.......380........--390..-.....400.......410--........420.........430.......440.......450------.........460.......-----470.......480--------.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKW-M-D-RYEIDSLIGKGSFGQVVKAYD-RV-E-QEWVAIKIIKN----K---KAFLNQAQIEVRLLELMN-----KHDTEMKYYIVHLKRHFMFR------N-------HLCLVFEMLSY-NLYDLLRNT--NFRGVSLNL--TRKFAQQMCTALLFLATPELSIIHCDLKPENILL---C--------NP-----------------K-------------RSA-IKIVDFGSSCQL---GQRIYQYIQSRFYRSPEVLL-G-M-P-YDLAIDMWSLGCILVEMHT-----------GEPLF------SGAN-------EVDQMNKIVEVLGIPP-AHILDQAP--KARKF-FEKLPDGTWNLKKTKDG---KREYKPPGT--RKLHNILGVETGGPGGRRAGESGHTVADYL--------KFKDLILRMLDYDPKTRIQ-----PYYALQHSFFKKT--------ADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
53
HHSearch
85.37
33%
-107
- C1 -
1Z57
1
CLK1_HUMAN
A:
[2-336]
------------------------------------------------------------------------------------------------------------------------------------------------
M
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F
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L
--------
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.04
30%
-117
- C1 -
2VAG
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------------------------------------------------------
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-------------------K
R
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I-----
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F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.79
30%
-97
- C1 -
3RAW
1
CLK3_HUMAN
A:
[31-369]
------------------------------------------------------------------------------------------------------------------------------------
R
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EHKS
C
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E
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-------------
N
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1
PsiBlast_PDB
81.18
30%
-96
- C1 -
2WU6
7
CLK3_HUMAN
A:
[31-369]
------------------------------------------------------------------------------------------------------------------------------------
R
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2
PsiBlast_PDB
80.56
30%
-95
- C1 -
2WU7
1
CLK3_HUMAN
A:
[32-369]
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6
PsiBlast_PDB
79.01
30%
-97
- C1 -
3NR9
1
CLK2_HUMAN
A:
[16-356]
--------------------------------------------------------------------------------------------------------------------------------------------
E
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TD
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I
L
-
E
-
L
-
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
-----------
G
F
T
L
F
------
Q
T
H
D
-------
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-
S
R
M
I
R
K
T
R
--
K
Q
K
Y
F
-
Y
R
G
R
L
D
--
W
D
-
E
N
T
S
A
G
---
R
--
Y
V
R
E
N
C
--
K
P
L
R
R
Y
L
T
S
E
---------
A
E
E
H
H
Q
L
F
--------------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
-----
L
G
E
A
L
Q
H
P
F
F
A
R
L
--------
R
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
77.63
30%
-119
- C1 -
3N9X
2
?
A:
[22-371]
--------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
V
-
P
-
D
-
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
-
K
N
-
T
-
E
K
N
V
A
I
K
K
V
N
R
----
M
FED
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
-----------
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
DLLKF-
D
-------
E
L
Y
I
V
L
E
I
A
D
S
-
D
L
K
K
L
F
K
T
P
----
I
F
L
T
E
E
H
--
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
--
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
---
N
--------
Q
D
--------------------------------
C
S
-
V
K
V
C
D
F
G
L
A
R
T
I
---------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
-
E
-
N
-
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
------
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
-
E
D
D
L
K
N
I
N
K
P
E
V
I
K
Y
-
I
K
L
F
P
H
--------------------
R
K
P
--
I
N
L
K
Q
K
Y
P
S
I
------------------
S
D
--------
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
-----
I
D
Q
A
L
D
H
P
Y
L
K
D
V
--------
R
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
72.17
34%
-118
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[52-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
E
-
V
-
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
-
S
-
G
E
L
V
A
I
K
K
V
L
Q
----
D
---
K
R
F
K
N
---
R
E
L
Q
I
M
R
K
L
D
-----------
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
G
EKKD
E
V
-
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
--
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---
D
--------
P
------------------
D
-------------
T
A
V
-
L
K
L
C
D
F
G
S
A
K
Q
L
V
R-
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
T
D
-
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
Q
I
R
E
M
N
--------------
P
N
Y
------------
T
E
F
K
F
P
Q
I
KA
H
P
W
T
K
V
F
R
P
R
-----------------
T
P
P
--------
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
-----
P
L
E
A
C
A
H
S
F
F
D
E
L
--------
R
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.63
30%
-102
- C1 -
4ACC
3
GSK3B_HUMAN
A:
[101-404]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
-
S
-
G
E
L
V
A
I
K
K
V
L
Q
----
D
---
K
R
F
K
N
------
R
E
L
Q
I
M
R
-----
K
L
D
---
H
C
N
I
V
R
L
-
R
Y
F
F
Y
S
------
S
G
EKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
--
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
-------------
T
A
V
-
L
K
L
C
D
F
G
S
A
K
Q
L
VR-
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
-
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
P
Q
I
K
A
H
P
W
T
-----
K
V
---
F
R
P
R
T
P
P
E
A
--
I
A
L
C
S
----------------------------------------
R
L
L
E
Y
T
P
T
A
R
L
T
-----
P
L
E
A
C
A
H
S
F
F
D
E
L
--------
R
D
P
N
V
K
L
P
N
G
R
D
T
-
P
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.43
30%
-100
- C1 -
4ACD
1
GSK3B_HUMAN
A:
[101-404]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
-
S
-
G
E
L
V
A
I
K
K
V
L
Q
----
D
---
K
R
F
K
N
------
R
E
L
Q
I
M
R
-----
K
L
D
---
H
C
N
I
V
R
L
-
R
Y
F
F
Y
S
------
S
G
E
KKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
--
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
-------------
T
A
V
-
L
K
L
C
D
F
G
S
A
K
Q
L
VR-
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
-
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
P
Q
I
K
A
H
P
W
T
-----
K
V
---
F
R
P
R
T
P
P
E
A
--
I
A
L
C
S
----------------------------------------
R
L
L
E
Y
T
P
T
A
R
L
T
-----
P
L
E
A
C
A
H
S
F
F
D
E
L
--------
R
D
P
N
V
K
L
P
N
G
R
D
T
-
P
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
66.17
34%
-137
- C1 -
1Q8Y
1
SKY1_YEAST
B:
[13-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
P
Y
-
K
-
D
A
R
Y
I
L
V
R
K
L
G
---
F
S
T
V
W
L
A
K
D
-
M
V
-
N
-
N
T
H
V
A
M
K
I
V
R
G
----
D
---
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
DNT
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
------
G
PN
G
V
---
H
V
V
M
V
F
E
V
L
G
E
-
N
L
L
A
L
I
K
K
Y
--
E
H
R
G
I
P
L
I
Y
--
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
--------
S
P
-----------------
E
-------------
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
---
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
-
G
-
A
-
P
-
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
-----------
G
D
F
L
F
E
P
D
E
G
H
S
Y
T
K
-------
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
-
S
Y
L
L
R
N
G
K
--
Y
T
R
T
F
-
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
66.08
30%
-103
- C1 -
4ACH
1
GSK3B_HUMAN
A:
[101-404]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
-
S
-
G
E
L
V
A
I
K
K
V
L
Q
----
D
---
K
R
F
K
N
------
R
E
L
Q
I
M
R
-----
K
L
D
---
H
C
N
I
V
R
L
-
R
Y
F
F
Y
S
------
S
G
E
KKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
--
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
-------------
T
A
V
-
L
K
L
C
D
F
G
S
A
K
Q
L
VR-
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
-
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
P
Q
I
K
A
H
P
W
T
-----
K
V
---
F
R
P
R
T
P
P
E
A
--
I
A
L
C
S
----------------------------------------
R
L
L
E
Y
T
P
T
A
R
L
T
-----
P
L
E
A
C
A
H
S
F
F
D
E
L
--------
R
D
P
N
V
K
L
P
N
G
R
D
T
-
P
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
66.05
34%
-133
- C1 -
1Q99
2
SKY1_YEAST
B:
[13-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
P
Y
-
K
-
D
A
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
V
-
N
-
N
T
H
V
A
M
K
I
V
R
G
----
D
---
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
DNT
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
------
G
PN
G
V
---
H
V
V
M
V
F
E
V
L
G
E
-
N
L
L
A
L
I
K
K
Y
--
E
H
R
G
I
P
L
I
Y
--
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
--------
S
P
-----------------
E
-------------
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
---
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
-
G
-
A
-
P
-
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
-----------
G
D
F
L
F
E
P
D
E
G
H
S
Y
T
K
-------
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
-
S
Y
L
L
R
N
G
K
--
Y
T
R
T
F
-
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.87
30%
-102
- C1 -
4ACG
1
GSK3B_HUMAN
A:
[101-404]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
-
S
-
G
E
L
V
A
I
K
K
V
L
Q
----
D
---
K
R
F
K
N
------
R
E
L
Q
I
M
R
-----
K
L
D
---
H
C
N
I
V
R
L
-
R
Y
F
F
Y
S
------
S
G
EKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
--
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
-------------
T
A
V
-
L
K
L
C
D
F
G
S
A
K
Q
L
VR-
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
-
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
P
Q
I
K
A
H
P
W
T
-----
K
V
---
F
R
P
R
T
P
P
E
A
--
I
A
L
C
S
----------------------------------------
R
L
L
E
Y
T
P
T
A
R
L
T
-----
P
L
E
A
C
A
H
S
F
F
D
E
L
--------
R
D
P
N
V
K
L
P
N
G
R
D
T
-
P
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.98
34%
-133
- C1 -
1Q99
2
SKY1_YEAST
A:
[13-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
P
Y
-
K
-
D
A
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
V
-
N
-
N
T
H
V
A
M
K
I
V
R
G
----
D
---
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
DNT
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
------
G
PN
G
V
---
H
V
V
M
V
F
E
V
L
G
E
-
N
L
L
A
L
I
K
K
Y
--
E
H
R
G
I
P
L
I
Y
--
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
--------
S
P
-----------------
E
-------------
N
L
I
Q
I
K
I
A
D
L
G
N
A
C
W
Y
---
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
-
G
-
A
-
P
-
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
-----------
G
D
F
L
F
E-------
T
K
-------
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
-
S
Y
L
L
R
N
G
K
--
Y
T
R
T
F
-
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.76
30%
-99
- C1 -
1Q3D
1
GSK3B_HUMAN
A:
[60-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
-
S
-
G
E
L
V
A
I
K
K
V
L
Q
----
D
---
K
R
F
K
N
------
R
E
L
Q
I
M
R
-----
K
L
D
---
H
C
N
I
V
R
L
-
R
Y
F
F
Y
S
------
S
V------
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
--
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
-------------
T
A
V
-
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
-
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
-
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--------
F
P
Q
I
K
A
H
P
W
T
-----
K
V
---
F
R
P
R
T
P
P
E
A
--
I
A
L
C
S
----------------------------------------
R
L
L
E
Y
T
P
T
A
R
L
T
-----
P
L
E
A
C
A
H
S
F
F
D
E
L
--------
R
D
P
N
V
K
L
P
N
G
R
D
T
-
P
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
63.49
30%
-119
- C1 -
4GV1
5
AKT1_HUMAN
A:
[3-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
-
N
-
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
-
K
A
-
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
---
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
-----------
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
------
D
-------
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
V
F
S
E
D
R
--
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
--------
K
D
-----------------
G
---------------
H
-
I
K
I
T
D
F
G
L
C
K
E
G
IKD
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
-
N
-
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
-----------
G
R
L
P
F
------
Y
N
Q
D
-------
H
E
K
L
F
E
L
I
L
M
--------------------------------------------
E
E
I
R
F
P
R
---------------------------
T
L
--
G
P
--------
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
EK
K
L
S
P
P
F
K
P
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
60.84
31%
-136
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[13-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
D
I
-
R
-
D
-
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
-
K
R
-
T
-
Q
K
L
V
A
I
K
C
I
A
--------------
S
M
E
N
E
I
A
V
L
H
K
I
K
-----------
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
-------
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
----
G
F
Y
T
E
R
D
--
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
--
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
---
Y
--------
S
L
D----------------
E
-------------
D
S
K
-
I
M
I
S
D
F
G
L
S
K
M
E
D
P-
G
--------
T
P
G
Y
V
A
P
E
V
L
A
-
Q
-
K
----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-----------
G
Y
P
P
F
------
Y
D
E
N
-------
D
A
K
L
F
E
Q
I
L
K
A
--------------------------------------------
E
Y
E
F
D
S
P
--
Y
---------------------
W
D
D
I
--
S
D
--------
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
60.26
30%
-126
- C1 -
2FST
3
MK14_HUMAN
X:
[27-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
P
-
E
-
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
-
T
K
-
T
-
G
L
R
V
A
V
K
K
L
S
R
----
P
FQS
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
-----------
H
E
N
V
I
G
L
L
D
V
F
T
P
A
RSLEEF
N
-------
D
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
----------
Q
K
L
T
D
D
H
--
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---
N
--------
E
D
--------------------------------
C
E
-
L
K
I
L
D
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
W
M
-
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
------
P
G
T
D
-------
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
-
A
E
L
L
K
K
I
S
SE
S
A
R
N
Y
-
I
Q
S
L
T
Q
--------------------
M
P
K
--
M
N
F
A
N
V
F
I
G
A
------------------
N
P
--------
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
-----
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
--------
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
43.23
34%
-118
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
N
-
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
-
T
-
H
E
I
V
A
I
K
K
F
K
--------------
V
K
E
T
T
L
R
E
L
K
M
L
R
-----
T
L
K
Q
E
---
N
I
V
E
L
K
E
A
F
R
R
R
------
G
-------
K
L
Y
L
V
F
E
Y
V
E
K
-
N
M
L
E
L
L
E
E
M
--
P
-
N
G
V
P
P
E
K
--
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
--
I
V
H
R
D
I
K
P
E
N
L
L
I
---
S
--------
H
--------------------------------
N
D
V
-
L
K
L
C
D
F
G
F
A
R
N
L
---
S
E
-------
T
R
W
Y
R
S
P
E
L
L
L
-
G
-
A
-
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
------
P
G
E
S
-------
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
-
S
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------