@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYR1B_HUMAN: (2013-07-20 )
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
Atome Classification :
(51 SA)
.........10........20........30........40........50........60........70........80........90........100......-.110.......120.......130...-.....140...---....150.......160.......170---.........180.------.------.....190...-....200.--......210.----......220.......230.......240.....---.--------.250---------------..-.---------......260...--.--...270.......280....-.-.-.290.......300......-----------.310.------....-------..320.......330.....-..340-.....-.--..350.......360.........370--.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWL-ERYEIDSLIGKGSFGQVVKAYDH-QTQ-ELVAIKIIKNK---KAFLNQAQIELRLLELMNQHDTEMK-----YYIVHLKRHFMFR------N------HLCLVFELLSY-NLYDLLRN--THFRGVSLNL----TRKLAQQLCTALLFLATPELSIIHCDLKPENILL---C--------NP-----------------KR-S---------AIKIVDFGSSCQ--L--GQRIYQYIQSRFYRSPEVLL-G-T-PYDLAIDMWSLGCILVEMHT-----------GEPLF------SGSN-------EVDQMNRIVEVLGIPPAAML-DQAP--KARKY-F--ERLPGGGWTLRRT--KELRKDYQGPGT--RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
2
PsiBlast_PDB
81.92
32%
-120
- C1 -
1Z57
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
-
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-
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I
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V
---
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-----
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------
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-
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--
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----
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A
Y
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---
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QS
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A
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N
----------------------R
D
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INP
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-----------
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V
F
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-------
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-
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--
A
---
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F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.68
32%
-118
- C1 -
2VAG
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
Q
S
G
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---
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-----
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------
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------
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-
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--
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F
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----
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--
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I
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---
V
QS
D
Y
T
E
A
Y
N
---------------------
K
R
D
E
R
T
L
INP
D
I
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V
V
D
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--
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--
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E
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-----------
G
F
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V
F
------
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T
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-------
S
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A
M
M
E
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P
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--
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--
R
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R
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Y
-
F
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D
R
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---
D
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S
S
--
A
---
G
R
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V
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A
C
--
K
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E
F
M
L
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Q
---------------
D
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A
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A
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H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.64
32%
-99
- C1 -
3NR9
1
CLK2_HUMAN
A:
[16-356]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
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Y
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-
R
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A
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---
E
K
Y
K
E
A
A
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I
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E
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P
D
N
K
-----
N
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M
F
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W
F
D
Y
H
------
G
------
H
M
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I
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L
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G
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-
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--
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Y
P
I
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----
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A
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E
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F
---
V
--------
N
S
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Y
E
L
TD
E
R
S
V
-------
K
S
-
T
---------
A
V
R
V
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D
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G
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A
T
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--
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--
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E
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-
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I
I
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E
Y
Y
V
-----------
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F
T
L
F
------
Q
T
H
D
-------
N
R
E
H
L
A
M
M
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I
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I
-
R
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T
R
--
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-
Q
K
Y
-
F
--
Y
R
-------------
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R
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D
E
N
T
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A
G
--
R
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R
E
-----
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C
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R
Y
L
T
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E
A
---
E
E
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A
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F
F
A
R
L
R
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
81.12
32%
-101
- C1 -
3NR9
1
CLK2_HUMAN
B:
[16-354]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
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I
Y
H
V
G
D
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-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
---
E
K
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K
E
A
A
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I
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V
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N
K
-----
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H
------
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M
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-
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--
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E
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---
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--------
N
S
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Y
E
L
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Y
NLEKK
R
D
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R
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S
-
T
---------
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-----------
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-------
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--
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A
---
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F
A
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
80.50
32%
-100
- C1 -
3NR9
1
CLK2_HUMAN
C:
[16-355]
--------------------------------------------------------------------------------------------
E
D
D
A
E
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-
R
R
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---
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Y
H
------
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------
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M
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-
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--
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T
--
H
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K
P
E
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---
V
--------
N
S
DYELTYNLEKKRDERSV
K
S
-
T
---------
A
V
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V
V
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A
T
F
--
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--
H
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V
-----------
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F
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-------
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A
---
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R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
HHSearch
80.04
32%
-130
- C1 -
3N9X
2
?
A:
[21-371]
-------------------------------------------------------------------------------------------------------
N
V
H
V
P
-
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
-
N
T
E
-
K
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V
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M
FED
L
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R
L
K
------
S
-----
D
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I
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Y
D
L
I
I
P
D
DLLKF-
D
------
E
L
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I
V
L
E
I
A
D
S
-
D
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K
L
F
K
T
--
P
--
I
F
L
T
E
E
H
----
I
K
T
I
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Y
N
L
L
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E
N
F
I
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--
E
S
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I
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K
P
A
N
C
L
L
---
N
--------
Q
D
--------------------
C
---------
S
V
K
V
C
D
F
G
L
A
R
T
--
I
--------
H
V
V
T
R
W
Y
R
A
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-
E
-
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Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
------
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
-
K
N
I
N
K
P
E
V
I
K
Y
-
I
--
K
L
F
P
H
R
-------------------
K
P
--
I
N
L
K
Q
K
Y
P
S
I
------------------
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.13
31%
-109
- C1 -
3RAW
1
CLK3_HUMAN
B:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
---
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
F
H
------
G
------
H
M
C
I
A
F
E
L
L
G
K
-
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
S
E
F
E
T
L
Y
N
EHKS
C
E
E
K
S
V
K
N
-
T
---------
S
I
R
V
A
D
F
G
S
A
T
F
--
D
--
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
-
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
------
Q
T
H
E
-------
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
--
K
-
Q
K
Y
-
F
--
Y
K
-
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
--
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.90
31%
-110
- C1 -
2WU7
1
CLK3_HUMAN
A:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
---
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
F
H
------
G
------
H
M
C
I
A
F
E
L
L
G
K
-
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
S
E
F
E
T
L
Y
NEHKS
C
E
E
K
S
V
K
N
-
T
---------
S
I
R
V
A
D
F
G
S
A
T
F
--
D
--
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
-
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
------
Q
T
H
E
-------
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
--
K
-
Q
K
Y
-
F
--
Y
K
-
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
--
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.39
31%
-111
- C1 -
2WU6
7
CLK3_HUMAN
A:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
---
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
F
H
------
G
------
H
M
C
I
A
F
E
L
L
G
K
-
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
S
E
F
E
T
L
Y
NEHKS
C
E
E
K
S
V
K
N
-
T
---------
S
I
R
V
A
D
F
G
S
A
T
F
--
D
--
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
-
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
------
Q
T
H
E
-------
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
--
K
-
Q
K
Y
-
F
--
Y
K
-
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
--
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.76
31%
-110
- C1 -
3RAW
1
CLK3_HUMAN
A:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
-
S
Q
V
A
L
K
I
I
R
N
V
---
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
F
H
------
G
------
H
M
C
I
A
F
E
L
L
G
K
-
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
S
E
F
E
T
L
Y
N
EHKS
C
E
E
K
S
V
K
N
-
T
---------
S
I
R
V
A
D
F
G
S
A
T
F
--
D
--
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
-
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
------
Q
T
H
E
-------
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
--
K
-
Q
K
Y
-
F
--
Y
K
-
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
--
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
70.53
35%
-127
* C1 *
1J1B
1
GSK3B_HUMAN
A:
[52-346]
----------------------------------------------------------------------------------------------------------
Q
E
-
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
---
R
E
L
Q
I
M
R
K
L
D
------
H
-----
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
G
EKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
----
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---
D
--------
P
------------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
-
R
E
M
N
----------------
P
N
Y
-----------
T
E
F
K
F
P
Q
I
KA
H
P
W
T
K
V
F
R
P
R
-----------------
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
65.93
33%
-138
- C1 -
1Q99
2
SKY1_YEAST
B:
[20-275]
--------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
N
N
-
T
H
V
A
M
K
I
V
R
G
D
---
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
------
G
PN
G
V
--
H
V
V
M
V
F
E
V
L
G
E
-
N
L
L
A
L
I
K
K
--
Y
E
H
R
G
I
P
L
I
Y
----
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
--------
S
P
-----------------
E
N
L
I
---------
Q
I
K
I
A
D
L
G
N
A
C
W
--
Y
--
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
-
G
-
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
-----------
G
D
F
L
F
E
P
D
E
G
H
S
Y
T
K
-------
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
-
R
N
G
K
--
Y
T
R
T
F
-
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
65.78
33%
-142
- C1 -
1Q8Y
1
SKY1_YEAST
B:
[20-275]
--------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
---
F
S
T
V
W
L
A
K
D
M
-
V
N
N
-
T
H
V
A
M
K
I
V
R
G
D
---
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
------
G
PN
G
V
--
H
V
V
M
V
F
E
V
L
G
E
-
N
L
L
A
L
I
K
K
--
Y
E
H
R
G
I
P
L
I
Y
----
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
--------
S
P
-----------------
E
N
L
I
---------
Q
I
K
I
A
D
L
G
N
A
C
W
--
Y
--
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
-
G
-
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
-----------
G
D
F
L
F
E
P
D
E
G
H
S
Y
T
K
-------
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
-
R
N
G
K
--
Y
T
R
T
F
-
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
64.91
32%
-140
- C1 -
2FST
3
MK14_HUMAN
X:
[27-320]
----------------------------------------------------------------------------------------------------------
V
P
-
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
-
K
T
G
-
L
R
V
A
V
K
K
L
S
R
P
FQS
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
------
H
-----
E
N
V
I
G
L
L
D
V
F
T
P
A
RSLEEF
N
------
D
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
----------
Q
K
L
T
D
D
H
----
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---
N
--------
E
D
--------------------
C
---------
E
L
K
I
L
D
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
------
P
G
T
D
-------
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
-
K
K
I
S
SE
S
A
R
N
Y
-
I
--
Q
S
L
T
Q
M
-------------------
P
K
--
M
N
F
A
N
V
F
I
G
A
------------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
64.49
31%
-147
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[13-277]
-------------------------------------------------------------------------------------------------------
A
E
D
I
R
-
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
-
R
T
Q
-
K
L
V
A
I
K
C
I
A
----------
S
M
E
N
E
I
A
V
L
H
K
I
K
------
H
-----
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
------
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
--
K
--
G
F
Y
T
E
R
D
----
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
--
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
---
Y
--------
S
L
D----------------
E
D
-
S
---------
K
I
M
I
S
D
F
G
L
S
K
M
--
E
D
P
G
--------
T
P
G
Y
V
A
P
E
V
L
A
-
Q
-
K
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-----------
G
Y
P
P
F
------
Y
D
E
N
-------
D
A
K
L
F
E
Q
I
L
K
A
---------------------------------------------
E
Y
E
F
D
S
P
--
Y
W
-----
D
----------------
D
I
--
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.80
33%
-138
- C1 -
1Q99
2
SKY1_YEAST
A:
[20-275]
--------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
N
N
-
T
H
V
A
M
K
I
V
R
G
D
---
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
------
G
PN
G
V
--
H
V
V
M
V
F
E
V
L
G
E
-
N
L
L
A
L
I
K
K
--
Y
E
H
R
G
I
P
L
I
Y
----
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
E
I
V
D
--------
S
P
-----------------
E
N
L
I
---------
Q
I
K
I
A
D
L
G
N
A
C
W
--
Y
--
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
-
G
-
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
-----------
G
D
F
L
F
E-------
T
K
-------
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
-
R
N
G
K
--
Y
T
R
T
F
-
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
60.46
31%
-107
- C1 -
4ACD
1
GSK3B_HUMAN
A:
[101-390]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
60.14
31%
-105
- C1 -
1PYX
1
GSK3B_HUMAN
B:
[58-347]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
-----
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
--------
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
60.11
31%
-105
- C1 -
3L1S
1
GSK3B_HUMAN
B:
[50-339]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
--
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
-------------------
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
60.01
31%
-102
- C1 -
2JLD
1
GSK3B_HUMAN
B:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
-
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
59.85
31%
-105
- C1 -
3M1S
1
GSK3B_HUMAN
B:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
-
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
59.84
31%
-101
- C1 -
3PUP
1
GSK3B_HUMAN
B:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
-
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
-
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
59.76
31%
-96
- C1 -
1H8F
2
GSK3B_HUMAN
A:
[22-311]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
G
---
K
A
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
-----------------------------
T
R
E
Q
I
--
R
E
M
N
P
N
Y
----------
T
E
F
A
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
----
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
59.76
31%
-106
- C1 -
4ACD
1
GSK3B_HUMAN
B:
[101-390]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
59.59
31%
-100
- C1 -
3PUP
1
GSK3B_HUMAN
A:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
-
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
-
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
59.58
31%
-101
- C1 -
3I4B
1
GSK3B_HUMAN
B:
[50-339]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
59.37
31%
-105
- C1 -
4ACC
3
GSK3B_HUMAN
A:
[101-390]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
59.27
31%
-103
- C1 -
1J1C
1
GSK3B_HUMAN
A:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
58.94
31%
-98
- C1 -
1J1B
1
GSK3B_HUMAN
B:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.91
31%
-105
- C1 -
1PYX
1
GSK3B_HUMAN
A:
[58-347]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
-----
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
------
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
58.89
31%
-107
- C1 -
2O5K
1
GSK3B_HUMAN
A:
[35-324]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
58.85
31%
-96
- C1 -
1H8F
2
GSK3B_HUMAN
B:
[22-311]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
G
---
K
A
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
-----------------------------
T
R
E
Q
I
--
R
E
M
N
P
N
Y
----------
T
E
F
A
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
----
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
58.85
31%
-105
- C1 -
4ACG
1
GSK3B_HUMAN
B:
[101-390]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
58.69
31%
-101
- C1 -
4IQ6
1
GSK3B_HUMAN
B:
[62-351]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
------
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
----------
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
58.60
31%
-101
- C1 -
1J1C
1
GSK3B_HUMAN
B:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
58.54
31%
-101
- C1 -
2JLD
1
GSK3B_HUMAN
A:
[56-345]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
-
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
-
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
58.27
31%
-103
- C1 -
4ACG
1
GSK3B_HUMAN
A:
[101-390]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
57.99
31%
-100
- C1 -
4B7T
1
GSK3B_HUMAN
A:
[22-311]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
57.96
31%
-103
- C1 -
3I4B
1
GSK3B_HUMAN
A:
[50-339]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
57.76
31%
-104
- C1 -
1Q3W
1
GSK3B_HUMAN
A:
[60-349]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
----
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
----K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
57.44
31%
-100
- C1 -
3Q3B
1
GSK3B_HUMAN
B:
[60-349]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
---
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
-------K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
57.44
31%
-102
- C1 -
1Q3D
1
GSK3B_HUMAN
A:
[60-349]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
------
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--------
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
57.18
31%
-103
- C1 -
1Q3D
1
GSK3B_HUMAN
B:
[60-349]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
----
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--------
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
56.90
31%
-103
- C1 -
1Q3W
1
GSK3B_HUMAN
B:
[60-349]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
---
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
-------K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.13
31%
-100
- C1 -
3DU8
1
GSK3B_HUMAN
A:
[58-347]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
------
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--------
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
55.84
31%
-102
- C1 -
3DU8
1
GSK3B_HUMAN
B:
[58-347]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
------
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--------
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
55.64
31%
-103
- C1 -
1Q4L
1
GSK3B_HUMAN
A:
[60-349]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
---
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
---------
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
55.08
31%
-103
- C1 -
4IQ6
1
GSK3B_HUMAN
A:
[62-351]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
--------
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
------------------
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
54.82
31%
-101
- C1 -
3Q3B
1
GSK3B_HUMAN
A:
[60-349]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
E
----
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
----K
F
--
P
Q
I
K
A
H
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
53.92
31%
-99
- C1 -
1Q4L
1
GSK3B_HUMAN
B:
[60-349]
---------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
D
---
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
-----
F
Y
S
S
G
---
D
E
V
Y
L
------
N
---------
L
V
L
D
Y
V
P
E
-
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
P
-----------------
D
T
-
A
---------
V
L
K
L
C
D
F
G
S
A
K
Q
--
L
VR
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
A
T
-
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
------
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
-----------
P
W
----
T
--
K
V
F
R
-----
P
R
T
-----------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
51.89
35%
-131
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-236]
-----------------------------------------------------------------------------------------------------------
M
-
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
-
E
T
H
-
E
I
V
A
I
K
K
F
K
----------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
--------
N
I
V
E
L
K
E
A
F
R
R
R
------
G
------
K
L
Y
L
V
F
E
Y
V
E
K
-
N
M
L
E
L
L
E
E
--
M
P
-
N
G
V
P
P
E
K
----
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
--
I
V
H
R
D
I
K
P
E
N
L
L
I
---
S
--------
H
-------------------
N
-
D
---------
V
L
K
L
C
D
F
G
F
A
R
N
--
L
--
S
E
-------
T
R
W
Y
R
S
P
E
L
L
L
-
G
-
A
-
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
------
P
G
E
S
-------
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------