@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYRK3_HUMAN: (2013-07-20 )
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
Atome Classification :
(19 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......-230.-......-------.240.---......250.......260----........270.......280-----.------.......290.......300-........310.......320.......-330.......340-----------.-----------------..-----------------------..-------------..----350.......360-........370.......380.-.-.....390.......400..-----------.....410.-------..----....420.......430.....--.--.440......-.450.......460.......470.......480......-------...490.......500.......510.......520.......530.......540.......550.......560.......570.......580......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-K-LR-QYVALK-------MVRNE---KRFHRQAAEEIRILEHLK-----KQDKTGSMNVIHMLESFTFR------N------HVCMAFELLSIDLYELIKK--NKFQGFSVQLVRKFAQSILQSLDALHKN-KIIHCDLKPENIL-----------L-----------------KH-----------------------HG-------------RS----STKVIDFGSSCF--EYQKLYTYIQSRFYRAPEIILG-S-RYSTPIDIWSFGCILAELLT-----------GQPLFPGED-------EG----DQLACMMELLGMPPPKLLEQSK--R--AKYFINSKGI-PRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS--KDWGTA-------LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
126
HHSearch
82.62
37%
-93
- C1 -
1Z57
1
CLK1_HUMAN
A:
[2-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
A
G
G
-
R
H
V
A
V
K
-------
I
V
K
N
V
---
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
-----
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
------
G
------
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
-----------
F
-----------------
V
Q
-----------------------
S
D
Y
T
E
A
Y
NR
D
E
R
T
L
I
N
P
----
D
I
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V
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F
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A
T
Y
--
D
D
E
H
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S
T
R
H
Y
R
A
P
E
V
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A
-
L
-
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W
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Q
P
C
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V
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S
I
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C
I
L
I
E
Y
Y
L
-----------
G
F
T
V
F
P
T
H
D
-------
S
K
----
E
H
L
A
M
M
E
R
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P
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P
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T
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--
K
--
R
K
Y
F
H
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D
R
L
D
W
D
E
H
S
S
-----
A
G
R
Y
V
S
---
R
A
C
K
-------
P
L
--
K
E
F
M
L
S
-------
Q
D
V
-
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
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L
R
E
A
L
K
H
P
F
F
D
L
L
---------------------------------------------------------------
123
HHSearch
80.42
34%
-112
- C1 -
3N9X
2
?
A:
[20-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
V
H
V
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
-
N
-
T
E
-
K
N
V
A
I
K
-------
K
V
N
R
M
FED
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
-----------
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
DLLKF-
D
------
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
T
--
P
--
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
-
G
I
I
H
R
D
L
K
P
A
N
C
L
-----------
L
-----------------
N
Q
-----------------------
D
C
-------------------
S
V
K
V
C
D
F
G
L
A
R
T
--
I
------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
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E
-
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
----
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
--
K
P
E
V
I
K
Y
I
K
L
--
F
-
P
H
---------------------------
R
K
P
--
I
N
L
K
Q
K
-------
Y
P
S
I
-
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
---------------------------------------------------------------
7
PsiBlast_PDB
79.79
30%
-102
- C1 -
3NR9
1
CLK2_HUMAN
A:
[17-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
-
R
G
G
A
R
V
A
L
K
-------
I
I
K
N
V
---
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
-----
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
------
G
------
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
--
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
-----------
F
VNS
D
Y
E
L
T----------------------------------
D
E
-------------
R
S
V
KST
A
V
R
V
V
D
F
G
S
A
T
F
--
D
H
E
H
H
S
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I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
-----------
G
F
T
L
F
Q
T
H
D
-------
N
R
----
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
--
K
--
Q
K
Y
F
Y
R
G
-----
R
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
R
Y
-------------
L
T
-------
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
-------------------------------------------------------------
2
PsiBlast_PDB
79.06
34%
-101
- C1 -
2VAG
1
CLK1_HUMAN
A:
[10-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
-
A
G
G
R
H
V
A
V
K
-------
I
V
K
N
V
---
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
-----
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
------
G
------
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQS
D
Y
T
E
A
Y
N------------------
K
R
-----------------------
D
E
-------------
R
T
L
INP
D
I
K
V
V
D
F
G
S
A
T
Y
--
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
-----------
G
F
T
V
F
P
T
H
D
-------
S
K
----
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
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T
R
--
K
--
R
K
Y
F
H
H
D
-----
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
----------
S
R
A
C
K
P
L
--
K
E
F
M
L
S
-------
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
-----------------------------------------------------------------
3
PsiBlast_PDB
78.07
32%
-93
- C1 -
2WU6
7
CLK3_HUMAN
A:
[35-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
-
S
Q
V
A
L
K
-------
I
I
R
N
V
---
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
-----
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
------
G
------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
-----------
F
VNS
E
F
E
T
L
Y
NEHKS
C
E
E
K
S
-----------------------
V
K
-------------
N
T
----
S
I
R
V
A
D
F
G
S
A
T
F
--
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
Q
T
H
E
-------
N
R
----
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
--
K
--
Q
K
Y
F
Y
K
G
G
L
V
-
W
D
----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
--------
P
L
K
S
--
Y
M
L
Q
D
S
-------
L
E
H
V
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
119
HHSearch
77.96
33%
-98
- C1 -
3LLT
1
?
A:
[20-360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
-
D
-
N
K
-
K
Y
Y
A
V
K
-------
V
V
R
N
I
---
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
-----
N
-
D
D
I
N
N
N
N
I
V
K
Y
H
G
K
F
M
Y
Y
------
D
------
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
--
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
-
S
L
T
H
T
D
L
K
P
E
N
I
L
-----------
L
-----------------
D
D
PYF
E
K
S
L
I
T
V
R
R
VTDG
K
K
I
Q
I
Y
R
T
K
-------------
S
T
----
G
I
K
L
I
D
F
G
C
A
T
F
--
K
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
-
L
-
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
-----------
G
S
L
L
F
R
T
H
E
-------
H
M
----
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
--
K
--
T
N
G
--------
S
K
Y
V
N
---------------
K
D
E
L
K
L
A
W
P
E
N
A
SS
I
N
S
I
K
H
V
K
K
CLP
L
Y
K
I
I
K
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
-----------------------------------------------------------------
5
PsiBlast_PDB
77.42
32%
-90
- C1 -
3RAW
1
CLK3_HUMAN
A:
[35-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
-
S
Q
V
A
L
K
-------
I
I
R
N
V
---
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
-----
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
------
G
------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
-----------
F
VNS
E
F
E
T
L
Y
N
EHKS
C
E
E
K
S
-----------------------
V
K
-------------
N
T
----
S
I
R
V
A
D
F
G
S
A
T
F
--
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
Q
T
H
E
-------
N
R
----
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
--
K
--
Q
K
Y
F
Y
K
G
G
L
V
-
W
D
----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
--------
P
L
K
S
--
Y
M
L
Q
D
S
-------
L
E
H
V
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
4
PsiBlast_PDB
77.19
32%
-94
- C1 -
2WU7
1
CLK3_HUMAN
A:
[35-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
-
S
Q
V
A
L
K
-------
I
I
R
N
V
---
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
-----
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
------
G
------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
-----------
F
VNS
E
F
E
T
L
Y
NEHKS
C
E
E
K
S
-----------------------
V
K
-------------
N
T
----
S
I
R
V
A
D
F
G
S
A
T
F
--
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
Q
T
H
E
-------
N
R
----
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
--
K
--
Q
K
Y
F
Y
K
G
G
L
V
-
W
D
----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
--------
P
L
K
S
--
Y
M
L
Q
D
S
-------
L
E
H
V
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
21
PsiBlast_CBE
76.63
32%
-91
- C1 -
3RAW
1
CLK3_HUMAN
B:
[35-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
-
S
Q
V
A
L
K
-------
I
I
R
N
V
---
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
-----
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
------
G
------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
-----------
F
VNS
E
F
E
T
L
Y
N
EHKS
C
E
E
K
S
-----------------------
V
K
-------------
N
T
----
S
I
R
V
A
D
F
G
S
A
T
F
--
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
Q
T
H
E
-------
N
R
----
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
--
K
--
Q
K
Y
F
Y
K
G
G
L
V
-
W
D
----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
--------
P
L
K
S
--
Y
M
L
Q
D
S
-------
L
E
H
V
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
132
HHSearch
74.84
36%
-126
* C1 *
2FST
3
MK14_HUMAN
X:
[26-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
-
K
-
T
G
-
L
R
V
A
V
K
-------
K
L
S
R
P
FQS
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
-----------
H
E
N
V
I
G
L
L
D
V
F
T
P
A
RSLEEF
N
------
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
----------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
-
D
I
I
H
R
D
L
K
P
S
N
L
A
-----------
V
-----------------
N
E
-----------------------
D
C
-------------------
E
L
K
I
L
D
-----------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
----
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
SE
S
--
A
R
N
Y
I
Q
S
L
---
T
Q
M
---------------------------
P
K
--
M
N
F
A
N
V
-------
F
I
G
A
-
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
---------------------------------------------------------------
131
HHSearch
73.69
33%
-110
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[53-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
-
S
G
-
E
L
V
A
I
K
-------
K
V
L
Q
D
---
K
R
F
K
N
---
R
E
L
Q
I
M
R
K
L
D
-----------
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
G
EKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
-
G
I
C
H
R
D
I
K
P
Q
N
L
L
-----------
L
-----------------
D
P
-----------------------
D
T
--------------
A
----
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
----
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
---------------
N
-
P
N
Y
T
E
F
-
K
F
P
-----------------
Q
-
I
K
A
--
H
P
W
T
K
V
-------
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
---------------------------------------------------------------
15
PsiBlast_PDB
71.02
30%
-88
- C1 -
1Q99
2
SKY1_YEAST
A:
[20-361]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
-
N
N
-
T
H
V
A
M
K
-------
I
V
R
G
D
---
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
DNT
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
------
G
PN
G
V
--
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
--
Y
E
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
-----------
M
-----------------
E
I
VDSP-------------------
E
N
-------------
L
I
----
Q
I
K
I
A
D
L
G
N
A
C
W
--
Y
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
-----------
G
D
F
L
F
E
------------T
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
--
Y
--
T
R
T
F
F
N
S
--
L
-
L
R
N
I
S
K
L
K
F
W
P
L
E
D
V
L
T
---------
E
K
Y
K
F
S
--
K
D
E
A
K
E
-------
I
S
--------
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
----------
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
--------------------------------
79
PsiBlast_CBE
68.42
31%
-101
- C1 -
4EHV
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
-
K
-
T
G
-
L
R
V
A
V
K
K
L
S
RPFQ
S
I
I
H
A
---
K
R
T
Y
R
----
E
L
R
L
L
K
H
M
K
-----
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
E
F
------
N
------
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
--
Q
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
-
D
I
I
H
R
D
L
K
P
S
N
L
A
-----------
V
-----------------
N
E
-----------------------
D
---------------
C
----
E
L
K
I
L
D
F
G
L
-------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
----
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----------
I
S
S
E
S
A
-
R
N
Y
I
Q
S
L
T
Q
M
--------------------
P
K
--
M
N
F
A
N
V
-------
F
I
G
A
N
P
-
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
35
PsiBlast_CBE
67.58
31%
-107
- C1 -
3HV3
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
-
K
-
T
G
-
L
R
V
A
V
K
K
L
S
RPFQ
S
I
I
H
A
---
K
R
T
Y
R
----
E
L
R
L
L
K
H
M
K
-----
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
E
F
------
N
------
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
--
Q
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
-
D
I
I
H
R
D
L
K
P
S
N
L
A
-----------
V
-----------------
N
E
-----------------------
D
---------------
S
----
E
L
K
I
L
D
F
G
--------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
----
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----------
I
S
S
E
S
A
-
R
N
Y
I
Q
S
L
T
Q
M
--------------------
P
K
--
M
N
F
A
N
V
-------
F
I
G
A
N
P
-
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
81
PsiBlast_CBE
66.83
31%
-107
- C1 -
4EH8
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
D
T
-
K
-
T
G
-
L
R
V
A
V
K
K
L
S
RPFQ
S
I
I
H
A
---
K
R
T
Y
R
----
E
L
R
L
L
K
H
M
K
-----
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
E
F
------
N
------
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
--
Q
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
-
D
I
I
H
R
D
L
K
P
S
N
L
A
-----------
V
-----------------
N
E
-----------------------
D
---------------
C
----
E
L
K
I
L
D
F
---------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
----
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----------
I
S
S
E
S
A
-
R
N
Y
I
Q
S
L
T
Q
M
--------------------
P
K
--
M
N
F
A
N
V
-------
F
I
G
A
N
P
-
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
34
PsiBlast_CBE
64.62
31%
-100
- C1 -
3IW6
4
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
D
T
-
K
-
T
G
-
L
R
V
A
V
K
K
L
S
RPFQ
S
I
I
H
A
---
K
R
T
Y
R
----
E
L
R
L
L
K
H
M
K
-----
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
E
F
------
N
------
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
--
Q
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
-
D
I
I
H
R
D
L
K
P
S
N
L
A
-----------
V
-----------------
N
E
-----------------------
D
---------------
S
----
E
L
K
I
L
D
F
G
L
-------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
----
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----------
I
S
S
E
S
A
-
R
N
Y
I
Q
S
L
T
Q
M
--------------------
P
K
--
M
N
F
A
N
V
-------
F
I
G
A
N
P
-
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
80
PsiBlast_CBE
64.25
31%
-104
- C1 -
4EH9
2
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
D
T
-
K
-
T
G
-
L
R
V
A
V
K
K
L
S
RPFQ
S
I
I
H
A
---
K
R
T
Y
R
----
E
L
R
L
L
K
H
M
K
-----
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
E
F
------
N
------
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
-----
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
-
D
I
I
H
R
D
L
K
P
S
N
L
A
-----------
V
-----------------
N
E
-----------------------
D
---------------
C
----
E
L
K
I
L
D
F
G
L
-------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
----
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----------
I
S
S
E
S
A
-
R
N
Y
I
Q
S
L
T
Q
M
--------------------
P
K
--
M
N
F
A
N
V
-------
F
I
G
A
N
P
-
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
92
PsiBlast_CBE
64.18
31%
-98
- C1 -
3QUE
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
-
K
-
T
G
-
L
R
V
A
V
K
K
L
S
RPFQ
S
I
I
H
A
---
K
R
T
Y
R
----
E
L
R
L
L
K
H
M
K
-----
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
E
F
------
N
------
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
--
Q
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
-
D
I
I
H
R
D
L
K
P
S
N
L
A
-----------
V
-----------------
N
E
-----------------------
D
---------------
C
----
E
L
K
I
L
D
F
G
L
A
R
H
--
T
D
------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
----
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----------
I
S
S
E
S
A
-
R
N
Y
I
Q
S
L
T
Q
M
--------------------
P
K
--
M
N
F
A
N
V
-------
F
I
G
A
N
P
-
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
93
PsiBlast_CBE
63.69
31%
-97
- C1 -
3QUD
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
-
K
-
T
G
-
L
R
V
A
V
K
K
L
S
RPFQ
S
I
I
H
A
---
K
R
T
Y
R
----
E
L
R
L
L
K
H
M
K
-----
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
E
F
------
N
------
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
--
Q
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
-
D
I
I
H
R
D
L
K
P
S
N
L
A
-----------
V
-----------------
N
E
-----------------------
D
---------------
C
----
E
L
K
I
L
D
F
G
L
A
R
H
--
T
D
------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
----
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-----------
I
S
S
E
S
A
-
R
N
Y
I
Q
S
L
T
Q
M
--------------------
P
K
--
M
N
F
A
N
V
-------
F
I
G
A
N
P
-
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------