@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYRK4_HUMAN: (2013-07-20 )
MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120..-.-....130.......140.......150.......160.-------......170.....------..180.......190....--...200.......210.......220..-.....230.....--------.----.240----------------------.-----------------..--------------.....250....--...260.......270.......-280.......290.......300..-....-----.310.......320.......330.......340.......350.......360...----.---.-------..370-------.......380.......390.......400.......410-.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDH-K-NNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNT-------YNVVHMKDFFYFRN------HFCITFELLGINLYELMKN--NNFQGFSLSIVRRFTLSVLKCLQMLSVE-KIIHCDLKPENIV--------L----YQK-----------------------G-----------------QA--------------SVKVIDFGSSCY--EHQKVYTYIQSRFYRSPEVILGH-PYDVAIDMWSLGCITAELYTGYPLF-PGEN-----EVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMV----L---K-------TYDTS-------FLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRP-QTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
1
PsiBlast_PDB
84.07
33%
-105
- C1 -
2WU6
7
CLK3_HUMAN
A:
[31-377]
---------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
F
H
G
------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
----
Y
N
E
-----------------------
H
-----------------
K
S
C
E
E
K
S
V
KNT-----
S
I
R
V
A
D
F
G
S
A
T
F
--
D
H
E
H
H
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T
I
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Y
R
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P
E
V
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E
L
-
G
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A
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D
V
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I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
----
M
LQD
S
-------
L
E
H
V
Q
-------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.89
33%
-106
- C1 -
2WU7
1
CLK3_HUMAN
A:
[32-377]
----------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
F
H
G
------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
----
Y
N
E
-----------------------
H
-----------------
K
S
C
E
E
K
S
V
KNT-----
S
I
R
V
A
D
F
G
S
A
T
F
--
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
----
M
LQD
S
-------
L
E
H
V
Q
-------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.13
33%
-105
- C1 -
3RAW
1
CLK3_HUMAN
B:
[33-377]
-----------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
F
H
G
------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
FVNS
E
F
E
T
L
----
Y
N
E
-----------------------
H
-----------------
K
S
C
E
E
K
S
V
KNT-----
S
I
R
V
A
D
F
G
S
A
T
F
--
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
----
M
LQD
S
-------
L
E
H
V
Q
-------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.56
33%
-115
- C1 -
1Z57
1
CLK1_HUMAN
A:
[10-329]
-------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
------
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
----
V
Q
S
-----------------------
D
-----------------
Y
T
E
A
Y
NR
D
E
R
T
L
INP-
D
I
K
V
V
D
F
G
S
A
T
Y
--
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
----
M
---
L
-------
S
Q
D
V
E
H
E
R
----
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.27
33%
-103
- C1 -
3RAW
1
CLK3_HUMAN
A:
[31-377]
---------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
-
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
F
H
G
------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
--
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
FVNS
E
F
E
T
L
----
Y
N
E
-----------------------
H
-----------------
K
S
C
E
E
K
S
V
KNT-----
S
I
R
V
A
D
F
G
S
A
T
F
--
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
K
Y
F
Y
K
G
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
----
M
LQD
S
-------
L
E
H
V
Q
-------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.27
31%
-110
- C1 -
3NR9
1
CLK2_HUMAN
A:
[17-356]
-------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
------
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
--
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
----
V
N
S
-----------------------
D
Y
E
L
TD
E
R
S
V
K-------
S
T
--------------
A
V
R
V
V
D
F
G
S
A
T
F
--
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
---
L
D
W
D
E
N
T
S
A
G
R
Y
--
V
R
E
N
C
K
P
----
L
---
R
-------
R
Y
L
T
S
EA
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
--------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.81
31%
-113
- C1 -
3NR9
1
CLK2_HUMAN
B:
[17-354]
-------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
------
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
--
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
----
V
N
S
-----------------------
D
Y
E
L
T
Y
NLEKK
R
D
E
R
S
V
K
S
T
--------------
A
V
R
V
V
D
F
G
S
A
T
F
--
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
---
L
D
W
D
E
N
T
S
A
G
R
Y
--
V
R
E
N
C
K
P
----
L
---
R
-------
R
Y
L
T
S
EA
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.22
33%
-113
- C1 -
2VAG
1
CLK1_HUMAN
A:
[10-329]
-------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
-
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
------
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
--
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
----
V
Q
S
-----------------------
D
-----------------
Y
T
E
A
Y
NK
R
D
E
R
T
L
INP
D
I
K
V
V
D
F
G
S
A
T
Y
--
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
K
Y
F
H
H
D
R
L
D
W
D
E
H
S
S
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
----
M
---
L
-------
S
Q
D
V
E
H
E
R
----
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
79.06
31%
-110
- C1 -
3NR9
1
CLK2_HUMAN
C:
[17-355]
-------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
-
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
------
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
--
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
----
V
N
S
-----------------------
D
YELTYNLEKKRDERSVK
S
T
--------------
A
V
R
V
V
D
F
G
S
A
T
F
--
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
Y
F
Y
R
G
R
---
L
D
W
D
E
N
T
S
A
G
R
Y
--
V
R
E
N
C
K
P
----
L
---
R
-------
R
Y
L
T
S
EAEEHHQ
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---------------------------------------------------------------------------------------------------------------------
44
HHSearch
78.29
35%
-101
- C1 -
3LLT
1
?
A:
[20-360]
--------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
-
D
-
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
-
D
I
N
N
-------
N
N
I
V
K
Y
H
G
K
F
M
Y
Y
D
------
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
--
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
-
S
L
T
H
T
D
L
K
P
E
N
I
L
--------
L
----
D
D
P
YF
E
K
S
L
I
T
V
R
R
VTDG
K
K
I
Q
I
Y
R
T
K
-----------------
S
T
--------------
G
I
K
L
I
D
F
G
C
A
T
F
--
K
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
-
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
-
R
T
H
E
-----
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
T
N
-------
G
S
K
Y
V
N
K
D
E
L
K
L
A
W
P
E
N
A
S
S
I
N
S
I
K
H
V
K
---
K
CLP
L
Y
K
I
I
K
H
E
L
-------
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.85
31%
-94
- C1 -
1Q8Y
1
SKY1_YEAST
B:
[20-362]
------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
---
F
S
T
V
W
L
A
K
D
M
-
V
-
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
G
PN
G
V
--
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
--
Y
E
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
E
I
VD
S
P
E
-----------------------
N
-----------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
--
Y
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
E
G
HSYT
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
T
R
T
F
F
N
S
R
G
L
L
R
N
I
S
K
---
L
K
F
W
P
L
E
D
V
L
T
E
K
----
Y
---
K
F------
S
K
D
E
A
K
E
-----
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
73.21
31%
-89
- C1 -
1Q99
2
SKY1_YEAST
B:
[20-362]
------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
-
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
G
PN
G
V
--
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
--
Y
E
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
E
I
VD
S
P
E
-----------------------
N
-----------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
--
Y
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
E
G
HSYT
K
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
T
R
T
F
F
N
S
R
G
L
L
R
N
I
S
K
---
L
K
F
W
P
L
E
D
V
L
T
E
K
----
Y
---
K
F------
S
K
D
E
A
K
E
-----
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.03
31%
-92
- C1 -
1Q99
2
SKY1_YEAST
A:
[20-362]
------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
M
-
V
-
N
N
T
H
V
A
M
K
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
K
E
D
S
M
G
A
N
H
I
L
K
L
L
D
H
F
N
H
K
G
PN
G
V
--
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
--
Y
E
H
R
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
E
I
VD
S
P
E
-----------------------
N
-----------------
L
I
--------------
Q
I
K
I
A
D
L
G
N
A
C
W
--
Y
D
E
H
Y
T
N
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
A
-
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E----T
K
---
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
T
R
T
F
F
N
S
--
L
L
R
N
I
S
K
---
L
K
F
W
P
L
E
D
V
L
T
E
K
----
Y
---
K
F------
S
K
D
E
A
K
E
-----
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
------------------------------------------------------------------------------------------------
57
HHSearch
71.09
32%
-126
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[53-345]
----------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
-
D
-
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
F
K
N
---
R
E
L
Q
I
M
R
K
L
D
------
H
-------
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
EKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
-
G
I
C
H
R
D
I
K
P
Q
N
L
L
--------
L
----
D
P
D
-----------------------
T
------------------
A
--------------
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
-
P
G
D
S
-----
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
---
N
Y
T
E
F
K
F
P
Q
-----------
I
K
A
H
P
W
T
K
V
----
F
---
R
P------
R
T
P
P
E
-------
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
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