@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : new_query: (2013-07-20 )
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
Atome Classification :
(71 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.....---..720.-----......730......-.-740.......750.......760.......770.......780.....---..-790.........800.......810-.---...--...820.......830.......840.......850...----....860.......870.......880---.......890.......900.......910.......920---........930......------.940.......950.......960.......970..--------.....980.......990.......1000......1010-.........1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETE---LKRVKV-----LGSGAFGTVYKGIWV-P-EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVC---LS-P--TIQLVTQLMPHGCLLEYVHEHK-D---NIG--SQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPN----HVKITDFGLARLLEGDEKEYNADGGKM---PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY----DGIPTREIPDLLEKGER------LPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEF--------SRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDE----EDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
11
PsiBlast_PDB
74.28
100%
-126
- C5 -
2R4B
1
ERBB4_HUMAN
A:
[16-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
---
L
K
R
V
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
N
------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
---
L
S
-
P
--
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
---
N
I
G
--
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
----
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
D
G
G
K
M
---
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
----
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
--------
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
74.18
100%
-121
- C5 -
3BCE
2
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
---
L
K
R
V
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
N
E
T
T
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
---
L
S
-
P
--
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
---
N
I
G
--
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
----
H
V
K
I
T
D
F
G
L
A
R
L
L
E
-
D
E
K
E
Y
N
A
D
G
-
K
M
---
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
----
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
--------
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
73.52
100%
-125
- C5 -
2R4B
1
B:
[16-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
---
L
K
R
V
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
-------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
---
L
S
-
P
--
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
---
N
I
G
--
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
----
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
D
G
G
K
M
---
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
----
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
--------
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
73.46
77%
-118
- C5 -
3W2O
1
A:
[7-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
--------------------
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.33
100%
-129
- C5 -
3BBT
1
ERBB4_HUMAN
B:
[7-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
R
I
L
K
E
T
E
---
L
K
R
V
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
N
E
--
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
---
L
S
-
P
--
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
---
N
I
G
--
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
----
H
V
K
I
T
D
F
G
L
A
R
L
L
-----------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
----
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
--------
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
-
D
D
R
M
K
L
P
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
72.63
77%
-110
- C5 -
3W32
1
A:
[9-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
72.57
77%
-117
- C5 -
3W2P
1
A:
[7-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
72.03
100%
-130
- C5 -
3BBT
1
D:
[8-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
R
I
L
K
E
T
E
---
L
K
R
V
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
---
E
T
V
K
I
P
V
A
I
K
I
L
N
E
---
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
---
L
S
-
P
--
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
---
N
I
G
--
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
----
H
V
K
I
T
D
F
G
L
A
R
-------------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
----
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
--------
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
71.82
77%
-122
- C5 -
3VJN
1
A:
[9-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
S
S
---
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.82
77%
-121
- C5 -
3POZ
1
A:
[6-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-----
V
K
I
P
V
A
I
K
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
-------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
----------
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
71.77
77%
-121
- C5 -
3W33
1
A:
[9-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
--------
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
71.75
77%
-116
- C5 -
3W2Q
2
A:
[7-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
------------------
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
71.72
77%
-121
- C5 -
3POZ
1
A:
[6-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-----
V
K
I
P
V
A
I
K
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
-------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
----------
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
71.70
77%
-119
- C5 -
4JR3
1
?
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
71.60
77%
-126
- C5 -
2RGP
1
A:
[1-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-----
V
K
I
P
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
--------
N
F
Y
R
A
L
M
D
----------
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
71.56
77%
-119
- C5 -
3W2S
1
A:
[9-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
71.53
77%
-114
- C5 -
4I23
1
A:
[2-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
---
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
-------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
71.49
77%
-108
- C5 -
3IKA
1
EGFR_HUMAN
A:
[5-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
---------------
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
71.36
77%
-118
- C5 -
2ITN
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
-----------
L
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
71.15
77%
-117
- C5 -
1M17
1
A:
[7-330]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
71.11
77%
-111
- C5 -
2GS6
1
A:
[4-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
-----------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.04
77%
-118
- C5 -
4JQ8
1
?
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
71.04
77%
-121
- C5 -
4JRV
1
?
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
71.00
77%
-115
- C5 -
2ITU
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
----------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
----------
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
70.96
77%
-124
- C5 -
1XKK
1
A:
[32-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-----
V
K
I
P
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-------
S
N
F
Y
R
A
L
M
D
E
---------
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
70.85
77%
-117
- C5 -
2ITV
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
---------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
70.85
77%
-116
- C5 -
4JQ7
1
?
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
70.76
77%
-111
- C5 -
3VJO
1
A:
[8-330]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
--
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
---
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
70.75
77%
-126
- C5 -
3BEL
1
A:
[1-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-----
V
K
I
P
V
A
I
K
E
L
------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
---------
N
F
Y
R
A
L
M
-----------
V
V
D
A
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
70.70
77%
-119
- C5 -
2GS7
1
B:
[9-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
---
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
70.64
77%
-118
- C5 -
2ITT
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
---------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
70.59
77%
-118
- C5 -
2GS7
1
EGFR_HUMAN
A:
[11-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
----
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------
D
V
V
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
70.58
77%
-118
- C5 -
3UG2
2
A:
[9-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
S
S
---
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
-------------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
70.50
77%
-116
- C5 -
3GT8
1
EGFR_HUMAN
C:
[7-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
----
E
D
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
70.47
77%
-119
- C5 -
4G5P
1
EGFR_HUMAN
A:
[4-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
--------------------------
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
70.42
77%
-109
- C5 -
2J6M
1
A:
[2-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
70.21
77%
-111
- C5 -
2ITX
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
----
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
70.15
77%
-113
- C5 -
2ITQ
1
A:
[2-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
--------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
70.08
77%
-114
- C5 -
2ITO
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
------------
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
70.07
77%
-118
- C5 -
2ITY
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
----------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
-------------
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
69.65
77%
-112
- C5 -
3UG1
1
A:
[9-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
S
S
---
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
69.64
77%
-113
- C5 -
2ITP
1
A:
[2-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-----------------
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
69.51
74%
-112
- C5 -
3PP0
1
ERBB2_HUMAN
A:
[5-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
L
R
K
V
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
---
R
L
G
--
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
----
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
--
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
----
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
--------
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
69.41
77%
-119
- C5 -
4HJO
1
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-----
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
69.36
77%
-107
- C5 -
4G5J
3
A:
[4-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
----
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
----------
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
----
E
D
M
D
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
69.25
74%
-111
- C5 -
3PP0
1
B:
[5-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
L
R
K
V
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
---
R
L
G
--
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
----
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
--
G
K
V
---
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
----
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
--------
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
-------
P
L
D
S
T
F
Y
R
S
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
69.17
79%
-122
- C5 -
3LZB
1
EGFR_HUMAN
B:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
----------------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
68.92
79%
-123
- C5 -
3LZB
1
EGFR_HUMAN
A:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
----------------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
68.75
77%
-114
- C5 -
4I24
1
EGFR_HUMAN
A:
[7-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
----
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
68.67
77%
-123
* C5 *
3LZB
1
EGFR_HUMAN
A:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
----------------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
68.65
76%
-112
- C5 -
4I22
1
A:
[7-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
R
A
K
L
L
-------------
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
----
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
68.30
79%
-120
- C5 -
3LZB
1
EGFR_HUMAN
D:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
----------------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
68.16
79%
-121
- C5 -
3LZB
1
EGFR_HUMAN
C:
[9-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
-----
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
----------------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
67.56
77%
-108
- C5 -
4I24
1
B:
[7-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
K
K
I
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
---
N
I
G
--
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
----
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-----------
K
V
---
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
----
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
--------
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
----
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
67.51
62%
-120
- C5 -
3LMG
1
ERBB3_HUMAN
A:
[23-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
---
L
R
K
L
K
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
-
P
-
E
G
E
S
I
K
I
P
V
C
I
K
V
I
E
D
K
---
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
---
P
G
-
S
--
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
-
G
---
A
L
G
--
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
----
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
---------
T
---
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
----
A
G
L
R
L
A
E
V
P
D
L
L
E
K
G
E
R
------
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
--------
T
R
M
A
R
D
P
P
R
Y
L
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
67.14
62%
-122
- C5 -
3LMG
1
B:
[23-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
---
L
R
K
L
K
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
-
P
--
G
E
S
I
K
I
P
V
C
I
K
V
I
E
D
K
S
--
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
---
P
G
-
S
--
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
-
G
---
A
L
G
--
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
----
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
K
------------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
----
A
G
L
R
L
A
E
V
P
D
L
L
E
K
G
E
R
------
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
--------
T
R
M
A
R
D
P
P
R
Y
L
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
65.65
74%
-110
- C5 -
3RCD
1
ERBB2_HUMAN
C:
[9-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
L
R
K
V
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
---
R
L
G
--
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
----
H
V
K
I
T
D
F
G
L
-----------------
V
---
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
----
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
--------
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
---------
L
D
S
T
F
Y
R
S
L
L
E
D
----
D
---
D
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
65.26
74%
-111
- C5 -
3RCD
1
ERBB2_HUMAN
A:
[9-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
L
R
K
V
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
---
L
T
-
S
--
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
---
R
L
G
--
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
----
H
V
K
I
T
D
F
G
L
-----------------
V
---
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
----
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
------
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
--------
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
---------
L
D
S
T
F
Y
R
S
L
L
E
D
----
D
---
D
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
64.43
64%
-119
- C5 -
3KEX
1
ERBB3_HUMAN
A:
[8-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
K
E
T
E
---
L
R
K
L
K
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
-
P
-
E
G
E
S
I
K
I
P
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
---
P
G
-
S
--
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
-
G
---
A
L
G
--
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
----
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
K
Q
L
L
-----
T
---
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
----
A
G
L
R
L
A
E
V
P
D
L
L
E
K
G
E
R
------
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
--------
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
60.87
37%
-100
- C5 -
4AOJ
1
NTRK1_HUMAN
A:
[38-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
---
I
V
L
K
W
E
-----
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
-
N
L
L
P
---
K
M
L
V
A
V
K
A
L
K
E
A
-
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
---
T
E
-
G
R-
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
-
P
DPG
P
L
G
--
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
----
V
V
K
I
G
D
F
G
----------------
T
M
L
---
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
----
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
------
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
--------
Q
A
L
A
Q
A
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
60.70
39%
-103
- C5 -
2J0J
1
FAK1_CHICK
A:
[383-654]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
Q
R
E
R
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
-
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
---
T
E
-
N
--
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
-
F
---
S
L
D
--
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
----
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
-
D
----------
L
---
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
----
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
------
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
--------
S
T
I
L
E
E
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
60.66
39%
-110
- C5 -
3PXK
1
FAK1_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
-
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
---
T
E
-
N
--
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
-
Y
---
S
L
D
--
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
----
C
V
K
L
G
D
F
G
------------------
L
---
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
----
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
------
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
--------
S
T
I
L
E
E
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
60.48
39%
-107
- C5 -
3PXK
1
B:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
-
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
---
T
E
-
N
--
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
-
Y
---
S
L
D
--
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
----
C
V
K
L
G
D
F
G
L
-----------------
L
---
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
----
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
------
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
--------
S
T
I
L
E
E
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
60.31
39%
-104
- C5 -
4EBW
1
A:
[31-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
----
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
---
T
E
-
N
--
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
-
Y
---
S
L
D
--
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
----
C
V
K
L
G
D
F
G
L
----------------
K
L
---
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
----
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
------
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
--------
S
T
I
L
E
E
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
60.30
39%
-101
- C5 -
1MQB
1
B:
[35-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
PSC
V
T
R
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
-----
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
---
S
K
Y
K
--
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
-
G
---
E
F
S
--
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
----
V
C
K
V
S
D
F
G
L
S
R
V
L
------------
K
I
---
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
----
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
------
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
--------
D
K
L
I
R
A
P
D
S
L
K
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
60.14
39%
-105
- C5 -
4EBV
3
A:
[31-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
-
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
---
T
E
-
N
--
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
-
Y
---
S
L
D
--
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
----
C
V
K
L
G
D
F
G
L
----------------
K
L
---
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
----
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
------
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
--------
S
T
I
L
E
E
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
58.97
39%
-99
- C5 -
1MQB
1
EPHA2_HUMAN
A:
[38-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
T
R
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
---
S
K
Y
K
--
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
-
G
---
E
F
S
--
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
----
V
C
K
V
S
D
F
G
L
----------------
K
I
---
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
----
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
------
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
--------
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
58.81
39%
-103
- C5 -
4I4F
2
A:
[10-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
-
S
-
P
----
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
---
T
E
-
N
--
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
-
Y
---
S
L
D
--
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
----
C
V
K
L
G
D
F
G
L
S
---------------
K
L
---
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
----
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
------
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
--------
S
T
I
L
E
E
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
57.80
42%
-108
- C5 -
4FYO
1
A:
[23-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
-----
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
-
M
---
K
K
V
V
K
T
V
A
V
K
I
L
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
---
E
A
-
E
--
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
--
R
---
H
V
K
--
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
----
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
---
K
W
---
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
----
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
------
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
--------
R
N
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Fugue
55.47
38%
-101
- C5 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
---
L
K
L
L
Q
T
-----
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G--------
N
K
V
A
V
K
C
I
K
-----
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
---
V
---EE
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
S
---
V
L
G
--
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
----
V
A
K
V
S
D
F
G
-----------------
L
L
---
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
----
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
------
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
--------
E
H
I
K
T
H
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Fugue
39.97
18%
-48
- C5 -
4EUT
1
TBK1_HUMAN
A:
[2-387]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
S
T
S
N
H
L
---
W
L
L
S
D
I
-----
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
-
K
-
T
G
D
----
L
F
A
I
K
V
F
N
N
I
S
F
L
R
P
V
D
V
Q
M
R
E
F
E
V
L
K
K
L
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
-
R
--
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
-
N
---
A
Y
G
LP
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
DG
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
V
S
L
Y
G
T
E
E
YLH
P
D
M
Y
E
R
A
V
L
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
-
G
S
L
P
F
RPFE
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
SGAISG
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
EADQEKC
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
YNT
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Add PDB User Result:
(17 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
137
-
100%
-125
- C5 -
U137
1
A:
[694-991]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
E
G
E
T
V
K
I
P
V
A
I
K
I
L
N
------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
D
G
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
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K
F
K
E
L
A
A
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F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
-
100%
-121
- C5 -
U138
1
A:
[703-1025]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
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M
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H
V
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I
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F
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L
A
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L
L
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G
D
----------
M
P
I
K
W
M
A
L
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C
I
H
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F
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Y
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I
Q
G
D
D
R
M
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L
-------------
D
E
E
D
L
E
D
M
M
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
-
100%
-124
- C5 -
U139
1
A:
[707-1024]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
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G
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A
I
K
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N
-----
K
A
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V
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F
M
D
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A
L
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A
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M
D
H
P
H
L
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L
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L
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P
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L
L
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L
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L
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W
C
V
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M
M
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L
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R
R
L
V
H
R
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L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
------------
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
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V
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N
L
L
D
----
E
D
M
M
D
A
E
E
Y
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
-
100%
-130
- C5 -
U140
1
D:
[709-988]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
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W
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--
E
T
V
K
I
P
V
A
I
K
I
L
N
E
---
P
K
A
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V
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F
M
D
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A
L
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A
S
M
D
H
P
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L
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L
L
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L
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V
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D
F
G
L
A
R
----------------
P
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M
A
R
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P
Q
R
Y
L
V
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
-
100%
-130
- C5 -
U141
1
D:
[709-988]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
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--
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---
P
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L
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L
V
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T
D
F
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L
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----------------
P
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Y
L
V
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
-
100%
-124
- C5 -
U142
1
A:
[702-1025]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
P
N
Q
A
Q
L
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L
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L
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---
T
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I
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G
D
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---------------------
L
E
D
M
M
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
-
100%
-130
- C5 -
U143
1
D:
[709-988]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
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I
L
K
E
T
E
L
K
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K
V
L
G
S
G
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--
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---
P
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----------------
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Y
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V
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
-
100%
-121
- C5 -
U144
1
A:
[702-1025]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
P
N
Q
A
Q
L
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L
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I
Q
G
D
D
---------------------
L
E
D
M
M
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
-
100%
-125
- C5 -
U145
1
A:
[707-1023]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
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-------
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N
L
L
D
------
M
M
D
A
E
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
-
100%
-125
- C5 -
U146
1
A:
[694-991]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
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A
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L
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S
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M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
-
100%
-121
- C5 -
U147
1
A:
[702-1025]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
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L
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Y
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Q
G
D
D
---------------------
L
E
D
M
M
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
-
100%
-124
- C5 -
U148
1
A:
[702-1025]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
P
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Q
A
Q
L
R
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L
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---
T
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Q
G
D
D
---------------------
L
E
D
M
M
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
-
100%
-125
- C5 -
U149
1
A:
[694-991]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
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L
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A
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------
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A
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L
V
I
Q
G
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
-
100%
-125
- C5 -
U150
1
A:
[707-1023]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
L
R
I
L
K
E
T
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L
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R
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K
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L
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----
V
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-------
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------
M
M
D
A
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E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
-
100%
-124
- C5 -
U151
1
A:
[702-1025]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
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Q
A
Q
L
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L
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L
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---
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Q
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D
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---------------------
L
E
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M
M
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A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
-
100%
-121
- C5 -
U152
1
A:
[702-1025]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
P
N
Q
A
Q
L
R
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L
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T
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L
K
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D
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---------------------
L
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M
M
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A
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E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
-
100%
-125
- C5 -
U153
1
A:
[707-1023]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
L
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I
L
K
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T
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------
M
M
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A
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---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------