@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FER_HUMAN: (2013-07-20 )
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
Atome Classification :
(102 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..----.----.--...----480.......490......-----.500------.......510-.--.....-..520.......530....-..--------.-------540.--.----..---...-----550-----------....-----.....560.....-.-.570.......580--.----.-.---.-...590.......600..-.....610.......620.......630........640.......650.-.-.---.-..-..660.......670.......680.......690.......700......--.710.....-..720.......730.......740.......750.......760...-....770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELL----K----K--QGD----FLVRESHGKPGEYVLSVYS-----DGQR------RHFIIQYV-D-N--MYRFE-GTGFSNIPQLIDHHYTTKQ-VI--------T-------KKSG--V----VL---LNP-----I-------------PKDK-----KWILSHEDVILGE-L-LGKGNFGEVYKGTL--K----D-K---T-SVAVKTCKEDLPQELKIK-FLQEAKILKQYDHPNIVKLIGVCTQR-QPVYIIMELVSGGDFLTFLRR-K-K-D---E-LK-LKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQ--EDGGVYSSS-GLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMT-NQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
1
PsiBlast_PDB
94.67
66%
-89
- C2 -
3BKB
9
A:
[4-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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--
113
HHSearch
83.99
42%
-86
- C2 -
1OPK
3
ABL1_MOUSE
A:
[100-478]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
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-----
A
PKRNKPTIYGVSP
N
Y
D
------
K
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-
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---
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---
21
PsiBlast_CBE
83.30
40%
-88
- C2 -
1OPL
1
ABL1_HUMAN
B:
[141-512]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
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--------
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TLHYPAP-----------------------------------------
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W
N
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S
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A
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A
F
--------
4
PsiBlast_PDB
83.16
40%
-84
- C2 -
1OPL
2
ABL1_HUMAN
A:
[141-512]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
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TLHYPAP
K
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--
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---
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-----
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A
F
--------
3
PsiBlast_PDB
82.93
40%
-83
- C2 -
2FO0
4
ABL1_HUMAN
A:
[99-470]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
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K
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--
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---
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-----
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F
A
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A
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--------
86
PsiBlast_CBE
80.43
38%
-88
- C2 -
3VRY
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
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A
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L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
-
D
-
N
G
G
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
W
EKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
-------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
9
PsiBlast_PDB
80.03
40%
-84
- C2 -
1Y57
1
SRC_HUMAN
A:
[53-435]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
NAE
N
----
P
--
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
-
S
-----
D
F
D
N
AK
G
L
N
V
K
H
Y
K
I
R
K
L
-
D
-
S
GG
F
Y
I
T
S
-
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
--------
C
-------
H
R
L
T
--
T
----
V
C
---
P
T
S
-----
K
-------------
P
Q
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
-
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
----
G
-
T
---
T
-
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
---
K
Y
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--
I
E
D
N
E
Y
T
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
71
PsiBlast_CBE
79.73
38%
-86
- C2 -
3VS6
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
-------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
82
PsiBlast_CBE
79.66
38%
-84
- C2 -
3VS0
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
77
PsiBlast_CBE
79.65
38%
-83
- C2 -
3VS3
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
-
D
-
N
G
G
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
-------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
84
PsiBlast_CBE
79.60
38%
-84
- C2 -
3VRZ
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
-----G-
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
-------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
93
PsiBlast_CBE
79.52
38%
-85
- C2 -
2C0I
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
90
PsiBlast_CBE
79.36
38%
-87
- C2 -
2C0O
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
73
PsiBlast_CBE
79.34
38%
-85
- C2 -
3VS5
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
-----G-
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
91
PsiBlast_CBE
79.31
38%
-82
- C2 -
2C0O
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
116
HHSearch
79.23
40%
-79
- C2 -
1QCF
1
HCK_HUMAN
A:
[65-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
APG
N
----
M
--
L
G
S
----
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
------
K
H
Y
K
I
R
T
L
-
D
N
G
G
-
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
VP
C
----
M
S
SKP
Q
K
P
-----
W
-------------
E
K
D
------
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
P
G
S
--
M
S
V
E
A
-
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
G
-
S
---
K
-
Q
P
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
E
D
N
E
Y
T
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
--
76
PsiBlast_CBE
79.19
38%
-84
- C2 -
3VS3
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
-------
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
E
-----------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
88
PsiBlast_CBE
79.08
38%
-81
- C2 -
2C0T
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
-----G-
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
83
PsiBlast_CBE
78.97
38%
-82
- C2 -
3VS0
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
------G-
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
112
HHSearch
78.78
36%
-83
- C2 -
2OZO
1
ZAP70_HUMAN
A:
[155-600]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
----
Y
SGAQ
T
--
D
G
K
----
F
L
L
R
P
R
-
K
E
Q
G
T
Y
A
L
S
L
I
Y
-----
G
K
T
V
------
Y
H
Y
L
I
S
Q
D
K
A
-
G
--
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
-
G
L
IYCLKEAC
P
-------
N
------MDTS
V
F
---
E
S
P
FSDPE
E
-------------
L
K
D
K
-----
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
-
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
M
RK-
K
-
Q
---
I
-
D
V
A
I
K
V
L
K
Q
G
T
E
K
A
D
T
E
E
-
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-
R
-
E
---
E
-
I
P
-
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
--
L
G
-------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
-
78
PsiBlast_CBE
78.76
38%
-86
- C2 -
3VS2
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
70
PsiBlast_CBE
78.39
38%
-85
- C2 -
3VS6
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
-------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
8
PsiBlast_PDB
78.37
40%
-79
- C2 -
2SRC
1
SRC_HUMAN
A:
[53-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
NAE
N
----
P
--
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
-
S
-----
D
F
D
N
AK
G
L
N
V
K
H
Y
K
I
R
K
L
-
D
-
S
G
G
F
Y
I
T
S
-
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
--------
C
-------
H
R
L
T
--
T
----
V
C
---
P
T
S
-----
K
-------------
P
Q
T
Q
GLAKD
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
-
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
----
G
-
T
---
T
-
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
---
K
Y
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--
I
E
D
N
E
Y
T
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
80
PsiBlast_CBE
78.26
38%
-87
- C2 -
3VS1
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
92
PsiBlast_CBE
78.25
38%
-85
- C2 -
2C0I
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
89
PsiBlast_CBE
78.25
38%
-83
- C2 -
2C0T
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
--------
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
85
PsiBlast_CBE
78.17
38%
-84
- C2 -
3VRZ
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
-----G-
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
72
PsiBlast_CBE
78.06
38%
-86
- C2 -
3VS5
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
--------
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
79
PsiBlast_CBE
77.70
38%
-84
- C2 -
3VS2
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
----G-
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
87
PsiBlast_CBE
77.41
38%
-83
- C2 -
3VRY
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
--------
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
-------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
10
PsiBlast_PDB
77.41
40%
-77
- C2 -
1KSW
1
SRC_HUMAN
A:
[53-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
NAE
N
----
P
--
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
-
S
-----
D
F
D
N
AK
G
L
N
V
K
H
Y
K
I
R
K
L
-
D
-
S
GG
F
Y
I
T
S
-
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
--------
C
-------
H
R
L
T
--
T
----
V
C
---
P
T
S
-----
K
-------------
P
Q
T
Q
GLAKD
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
-
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
----
G
-
T
---
T
-
R
V
A
I
K
T
L
K
---
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
---
K
Y
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--
I
E
D
N
E
Y
T
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
69
PsiBlast_CBE
77.33
38%
-83
- C2 -
3VS7
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
-------
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
W
E
K
D-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
98
PsiBlast_CBE
77.26
38%
-86
- C2 -
1AD5
1
HCK_HUMAN
B:
[61-421]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-----------
V
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
97
PsiBlast_CBE
77.25
38%
-84
- C2 -
2HCK
1
HCK_HUMAN
B:
[61-421]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-----------
V
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
81
PsiBlast_CBE
77.24
38%
-78
- C2 -
3VS1
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
-----------
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
--------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
75
PsiBlast_CBE
76.37
38%
-82
- C2 -
3VS4
1
HCK_HUMAN
A:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
--------
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
E
------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
74
PsiBlast_CBE
76.27
38%
-82
- C2 -
3VS4
1
HCK_HUMAN
B:
[67-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
N
MLG
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
P
R
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
--------
C
-------
Q
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
-------------
P
Q
K
P
WEKD-
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
-
H
---
T
-
K
V
A
V
K
T
M
K
---
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
---
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
--
I
-------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
23
PsiBlast_CBE
74.01
44%
-94
- C2 -
3CS9
1
ABL1_HUMAN
B:
[10-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
---
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
96
PsiBlast_CBE
73.79
45%
-90
- C2 -
3DK3
1
ABL1_MOUSE
A:
[5-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
-----
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
F
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
100
PsiBlast_CBE
73.43
45%
-90
- C2 -
3GVU
2
ABL2_HUMAN
A:
[26-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
E
---
E
-
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-----
G
D
T
Y
T
-----
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
--------
129
HHSearch
72.84
42%
-86
- C2 -
2J0J
1
FAK1_CHICK
A:
[384-652]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
-
C
-
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S---
P
-
E
N
P
A
M
-
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
-
F
---
S
-
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
--
M
E
D
-----------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
--
60
PsiBlast_CBE
72.74
45%
-90
- C2 -
2HZ0
1
ABL1_HUMAN
B:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
------
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
-----
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
44
PsiBlast_CBE
72.07
45%
-86
- C2 -
2G2F
1
ABL1_HUMAN
B:
[9-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
-----
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
121
HHSearch
72.03
38%
-82
* C2 *
4AOJ
1
NTRK1_HUMAN
A:
[35-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
-
L
G
E
G
A
F
G
K
V
F
L
A
E
C
--
H
NLLP--
K
---
M
-
L
V
A
V
K
A
L
K
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
-
H
-
G
-
P
DPG
P
-
L
G
-
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
68
PsiBlast_CBE
72.00
45%
-84
- C2 -
2QOH
1
ABL1_MOUSE
A:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
----
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
55
PsiBlast_CBE
71.91
45%
-88
- C2 -
1M52
1
ABL1_MOUSE
A:
[10-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
14
PsiBlast_PDB
71.67
45%
-87
- C2 -
3PYY
1
ABL1_HUMAN
A:
[18-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
-----
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
47
PsiBlast_CBE
71.58
45%
-85
- C2 -
3MS9
2
ABL1_MOUSE
B:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
---
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
66
PsiBlast_CBE
71.55
45%
-85
- C2 -
3KF4
1
ABL1_MOUSE
A:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
------
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
29
PsiBlast_CBE
71.54
45%
-83
- C2 -
3UE4
1
ABL1_HUMAN
B:
[8-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
--
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
65
PsiBlast_CBE
71.45
45%
-85
- C2 -
3KF4
1
ABL1_MOUSE
B:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
---
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
40
PsiBlast_CBE
71.43
45%
-85
- C2 -
2G2I
1
ABL1_HUMAN
B:
[7-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
----
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
13
PsiBlast_PDB
71.18
45%
-87
- C2 -
3IK3
1
ABL1_MOUSE
A:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
99
PsiBlast_CBE
71.17
45%
-81
- C2 -
3HMI
1
ABL2_HUMAN
A:
[26-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
E
---
E
-
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
--------
6
PsiBlast_PDB
71.09
44%
-83
- C2 -
3CS9
1
ABL1_HUMAN
A:
[10-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
-----
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
54
PsiBlast_CBE
71.05
45%
-84
- C2 -
1M52
3
ABL1_MOUSE
B:
[10-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
42
PsiBlast_CBE
71.01
45%
-86
- C2 -
2G2H
1
ABL1_HUMAN
B:
[8-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
67
PsiBlast_CBE
70.90
45%
-84
- C2 -
2QOH
1
ABL1_MOUSE
B:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
----
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
24
PsiBlast_CBE
70.89
44%
-88
- C2 -
2HZI
1
ABL1_HUMAN
B:
[10-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
-----
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
12
PsiBlast_PDB
70.89
45%
-86
- C2 -
2Z60
1
ABL1_MOUSE
A:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
----
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
20
PsiBlast_PDB
70.86
45%
-82
- C2 -
3QRK
1
ABL1_HUMAN
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
95
PsiBlast_CBE
70.67
45%
-89
- C2 -
3DK3
1
ABL1_MOUSE
B:
[5-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
-----
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
F
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
46
PsiBlast_CBE
70.65
45%
-82
- C2 -
2F4J
1
ABL1_HUMAN
A:
[4-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
27
PsiBlast_CBE
70.62
45%
-84
- C2 -
3IK3
1
ABL1_MOUSE
B:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
48
PsiBlast_CBE
70.52
45%
-84
- C2 -
3MS9
2
ABL1_MOUSE
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
-------
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
----
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
36
PsiBlast_CBE
70.51
45%
-80
- C2 -
2HYY
1
ABL1_HUMAN
C:
[6-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
-
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
---
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
19
PsiBlast_PDB
70.43
45%
-86
- C2 -
3QRI
1
ABL1_HUMAN
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
28
PsiBlast_CBE
70.42
45%
-94
- C2 -
3PYY
3
ABL1_HUMAN
B:
[19-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
-------
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
35
PsiBlast_CBE
70.31
45%
-84
- C2 -
2HYY
1
ABL1_HUMAN
D:
[6-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
---
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
41
PsiBlast_CBE
70.27
45%
-79
- C2 -
2G2I
1
ABL1_HUMAN
A:
[5-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
---
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
58
PsiBlast_CBE
70.20
45%
-81
- C2 -
1FPU
1
ABL1_MOUSE
B:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-------
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
122
HHSearch
70.07
42%
-86
- C2 -
4I4E
1
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
-
C
-
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
---
P
-
N
P
A
-
L
-
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
-
Y
---
S
-
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
---
52
PsiBlast_CBE
70.05
45%
-85
- C2 -
1OPJ
2
ABL1_MOUSE
B:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
16
PsiBlast_PDB
70.05
45%
-80
- C2 -
3UE4
1
ABL1_HUMAN
A:
[8-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
5
PsiBlast_PDB
70.03
44%
-83
- C2 -
2HZI
1
ABL1_HUMAN
A:
[10-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
49
PsiBlast_CBE
69.93
45%
-83
- C2 -
3K5V
2
ABL1_MOUSE
B:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
----
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
50
PsiBlast_CBE
69.90
45%
-82
- C2 -
3K5V
2
ABL1_MOUSE
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
--
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
64
PsiBlast_CBE
69.87
45%
-83
- C2 -
3KFA
1
ABL1_MOUSE
A:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
26
PsiBlast_CBE
69.87
45%
-77
- C2 -
3OY3
1
ABL1_MOUSE
B:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
25
PsiBlast_CBE
69.85
45%
-79
- C2 -
3QRJ
1
ABL1_HUMAN
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
63
PsiBlast_CBE
69.81
45%
-82
- C2 -
3KFA
1
ABL1_MOUSE
B:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
43
PsiBlast_CBE
69.70
45%
-78
- C2 -
2G2H
1
ABL1_HUMAN
A:
[8-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
38
PsiBlast_CBE
69.49
45%
-78
- C2 -
2HIW
1
ABL1_HUMAN
B:
[5-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
37
PsiBlast_CBE
69.47
45%
-80
- C2 -
2HYY
1
ABL1_HUMAN
B:
[6-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
-
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
123
HHSearch
69.43
40%
-86
- C2 -
4FYO
1
A:
[11-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
-
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
----
M
K
K
V
V
-
K
-
T
V
A
V
K
I
L
-----
P
A
L
K
D
E
-
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
-
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
-----
H
-
V
K
-
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
-----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
--
11
PsiBlast_PDB
69.36
45%
-77
- C2 -
3OY3
1
ABL1_MOUSE
A:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
57
PsiBlast_CBE
69.35
45%
-83
- C2 -
1IEP
1
ABL1_MOUSE
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
53
PsiBlast_CBE
69.27
45%
-81
- C2 -
1OPJ
2
ABL1_MOUSE
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
39
PsiBlast_CBE
69.27
45%
-82
- C2 -
2HIW
1
ABL1_HUMAN
A:
[5-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
15
PsiBlast_PDB
69.16
45%
-79
- C2 -
2G1T
1
ABL1_HUMAN
A:
[7-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
32
PsiBlast_CBE
69.15
45%
-76
- C2 -
2G1T
1
ABL1_HUMAN
B:
[5-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
22
PsiBlast_CBE
69.05
44%
-81
- C2 -
3CS9
1
ABL1_HUMAN
D:
[10-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
---------------
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
103
Fugue
68.92
44%
-93
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
-
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG-----------
N
-
K
V
A
V
K
C
I
K
-----
N
D
A
Q
A
-
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
-
G
R
S
---
V
-
L
G
-
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
31
PsiBlast_CBE
68.69
45%
-76
- C2 -
2G1T
1
ABL1_HUMAN
C:
[7-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
56
PsiBlast_CBE
68.59
45%
-80
- C2 -
1IEP
1
ABL1_MOUSE
B:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
30
PsiBlast_CBE
68.34
45%
-76
- C2 -
2G1T
1
ABL1_HUMAN
D:
[5-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
45
PsiBlast_CBE
68.27
45%
-81
- C2 -
2G2F
1
ABL1_HUMAN
A:
[7-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
17
PsiBlast_PDB
68.20
45%
-82
- C2 -
2HYY
1
ABL1_HUMAN
A:
[8-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
-
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
34
PsiBlast_CBE
68.14
45%
-83
- C2 -
2HZ4
1
ABL1_HUMAN
B:
[6-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
-----
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
59
PsiBlast_CBE
68.01
45%
-80
- C2 -
1FPU
1
ABL1_MOUSE
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
61
PsiBlast_CBE
66.00
45%
-71
- C2 -
2HZ0
1
ABL1_HUMAN
A:
[6-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
51
PsiBlast_CBE
64.44
45%
-77
- C2 -
2HZN
1
ABL1_MOUSE
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-----
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
---
G
E
V
Y
E
G
V
W
--
K
----
K
-
Y
---
S
L
T
V
A
V
K
T
L
--
D
T
-
M
E
V
E
-
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
---
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
M
T
G
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
Add PDB User Result:
(48 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
133
-
100%
-96
- C2 -
U133
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
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S
H
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K
P
G
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Y
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L
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--
M
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L
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A
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K
---
P
Q
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L
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L
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-
R
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P
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Y
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M
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L
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G
G
D
F
L
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F
L
R
R
K
K
D
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L
K
L
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L
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F
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L
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A
A
A
G
M
L
Y
L
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S
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N
C
I
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L
A
A
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C
L
V
G
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N
N
V
L
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D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
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T
F
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L
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C
P
Y
P
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N
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A
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G
Y
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A
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I
M
M
K
C
W
D
Y
K
P
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N
R
P
K
F
S
E
L
Q
K
----------
134
-
99%
-94
- C2 -
U134
1
A:
[551-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
D
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
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K
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N
F
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K
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C
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L
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-----
K
F
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A
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L
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L
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L
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L
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C
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L
A
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G
G
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Y
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L
K
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K
W
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A
P
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A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
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T
F
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L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
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Q
V
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R
G
Y
R
M
S
A
P
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H
C
P
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I
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I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
135
-
100%
-95
- C2 -
U135
1
A:
[449-820]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
E
K
P
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
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S
H
G
K
-
G
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Y
V
L
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V
Y
S
D
G
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R
R
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F
I
I
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Y
V
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N
M
Y
R
F
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G
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N
I
P
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L
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-
W
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L
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A
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Y
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L
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Y
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L
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F
L
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K
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D
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L
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A
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L
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L
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L
A
A
R
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C
L
V
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N
N
V
L
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I
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D
F
G
M
S
R
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D
G
G
V
Y
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S
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L
K
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I
P
I
K
W
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A
P
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A
L
N
Y
G
R
Y
S
S
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S
D
V
W
S
F
G
I
L
L
W
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T
F
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L
G
V
C
P
Y
P
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M
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N
Q
Q
A
R
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R
G
Y
R
M
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A
P
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C
P
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D
I
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I
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M
K
C
W
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K
P
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N
R
P
K
F
S
E
L
Q
K
E
L
T
I
I
K
R
K
--
136
-
100%
-95
- C2 -
U136
1
B:
[555-814]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
-----
Q
E
L
K
-
K
F
L
Q
E
A
K
I
L
K
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Y
D
H
P
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K
L
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A
A
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L
A
A
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L
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N
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L
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R
Q
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D
G
G
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Y
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S
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L
K
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K
W
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A
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A
L
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Y
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Y
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V
W
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F
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L
L
W
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C
P
Y
P
G
M
T
N
Q
Q
A
R
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V
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Y
R
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A
P
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H
C
P
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I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
137
-
100%
-94
- C2 -
U137
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
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S
H
G
K
P
G
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Y
V
L
S
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D
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F
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I
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N
M
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L
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L
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P
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P
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L
L
G
K
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F
G
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K
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L
K
D
K
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S
V
A
V
K
T
C
K
---
P
Q
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L
K
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K
F
L
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A
K
I
L
K
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Y
D
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P
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L
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R
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Y
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G
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L
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R
K
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D
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L
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L
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A
A
A
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L
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L
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I
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A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
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F
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L
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V
C
P
Y
P
G
M
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N
Q
Q
A
R
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R
G
Y
R
M
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A
P
Q
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C
P
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I
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M
K
C
W
D
Y
K
P
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N
R
P
K
F
S
E
L
Q
K
----------
138
-
100%
-94
- C2 -
U138
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
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L
V
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S
H
G
K
P
G
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Y
V
L
S
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Y
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L
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L
L
N
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L
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L
L
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N
F
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K
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K
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A
V
K
T
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K
---
P
Q
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A
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R
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L
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G
D
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L
T
F
L
R
R
K
K
D
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L
K
L
K
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L
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F
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L
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A
A
A
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M
L
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L
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A
A
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C
L
V
G
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N
N
V
L
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D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
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A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
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T
F
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L
G
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C
P
Y
P
G
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N
Q
Q
A
R
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R
G
Y
R
M
S
A
P
Q
H
C
P
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D
I
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K
I
M
M
K
C
W
D
Y
K
P
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N
R
P
K
F
S
E
L
Q
K
----------
139
-
99%
-94
- C2 -
U139
1
A:
[551-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
D
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
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K
G
T
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K
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K
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A
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K
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C
K
E
E
L
K
-----
K
F
L
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A
K
I
L
K
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D
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K
L
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F
L
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K
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L
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L
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L
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L
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A
A
A
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L
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L
A
A
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K
W
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A
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A
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Y
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Y
S
S
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S
D
V
W
S
F
G
I
L
L
W
E
T
F
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L
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C
P
Y
P
G
M
T
N
Q
Q
A
R
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Q
V
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R
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Y
R
M
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A
P
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H
C
P
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K
I
M
M
K
C
W
D
Y
K
P
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N
R
P
K
F
S
E
L
Q
K
E
L
--------
140
-
99%
-94
- C2 -
U140
1
A:
[551-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
D
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
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Y
K
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L
K
D
K
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A
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L
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-----
K
F
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A
K
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L
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P
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K
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A
P
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A
L
N
Y
G
R
Y
S
S
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S
D
V
W
S
F
G
I
L
L
W
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F
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L
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C
P
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P
G
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T
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Q
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A
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A
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C
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M
K
C
W
D
Y
K
P
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N
R
P
K
F
S
E
L
Q
K
E
L
--------
141
-
100%
-96
- C2 -
U141
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
I
I
Q
Y
---
M
Y
R
F
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G
T
G
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N
I
P
Q
L
I
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H
H
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T
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L
L
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K
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K
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L
L
G
K
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N
F
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K
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A
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K
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---
P
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K
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L
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L
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K
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L
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L
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L
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F
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L
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A
A
A
G
M
L
Y
L
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K
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C
I
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L
A
A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
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Q
V
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R
G
Y
R
M
S
A
P
Q
H
C
P
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D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
142
-
100%
-98
- C2 -
U142
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
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F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
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R
H
F
I
I
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Y
V
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N
M
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L
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K
K
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G
V
V
L
L
N
P
I
P
K
D
K
K
W
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L
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H
E
D
V
I
L
G
E
L
L
G
K
G
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F
G
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V
Y
K
G
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L
K
D
K
T
S
V
A
V
K
T
C
K
---
P
Q
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L
K
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K
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L
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A
K
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L
K
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-
R
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L
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G
G
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F
L
T
F
L
R
R
K
K
D
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L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
E
S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
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R
G
Y
R
M
S
A
P
Q
H
C
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I
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K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
143
-
99%
-94
- C2 -
U143
1
A:
[551-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
D
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
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V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
E
E
L
K
-----
K
F
L
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A
K
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L
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L
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L
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F
L
R
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K
K
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L
K
L
K
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L
V
K
F
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L
D
A
A
A
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L
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L
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L
A
A
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L
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L
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A
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A
L
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S
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S
D
V
W
S
F
G
I
L
L
W
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F
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L
G
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C
P
Y
P
G
M
T
N
Q
Q
A
R
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R
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S
A
P
Q
H
C
P
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D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
144
-
100%
-95
- C2 -
U144
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
I
I
Q
Y
---
M
Y
R
F
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G
T
G
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N
I
P
Q
L
I
D
H
H
Y
T
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K
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V
L
L
N
P
I
P
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K
K
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L
L
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G
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F
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K
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V
A
V
K
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---
P
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A
K
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L
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R
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G
G
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F
L
T
F
L
R
R
K
K
D
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L
K
L
K
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L
V
K
F
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L
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A
A
A
G
M
L
Y
L
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K
N
C
I
H
R
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L
A
A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
------------
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
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F
G
I
L
L
W
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T
F
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L
G
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C
P
Y
P
G
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Q
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A
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R
G
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R
M
S
A
P
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C
P
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D
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I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
145
-
100%
-94
- C2 -
U145
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
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R
R
H
F
I
I
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Y
V
D
N
M
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G
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F
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N
I
P
Q
L
I
D
H
H
Y
T
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K
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V
I
T
K
K
S
G
V
V
L
L
N
P
I
P
K
D
K
K
W
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L
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H
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V
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L
G
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L
L
G
K
G
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F
G
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K
G
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L
K
D
K
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A
V
K
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---
P
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A
K
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L
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L
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R
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L
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G
G
D
F
L
T
F
L
R
R
K
K
D
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L
K
L
K
Q
L
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F
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L
D
A
A
A
G
M
L
Y
L
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K
N
C
I
H
R
D
L
A
A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
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F
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L
G
V
C
P
Y
P
G
M
T
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Q
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A
R
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R
G
Y
R
M
S
A
P
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H
C
P
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D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
146
-
100%
-95
- C2 -
U146
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
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Y
V
L
S
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Y
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D
G
Q
R
R
H
F
I
I
Q
Y
---
M
Y
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G
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N
I
P
Q
L
I
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H
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Y
T
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K
K
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V
L
L
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P
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P
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L
L
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G
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F
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K
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K
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A
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---
P
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G
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K
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L
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A
A
A
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L
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L
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I
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A
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C
L
V
G
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N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
------------
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
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F
G
I
L
L
W
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T
F
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L
G
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C
P
Y
P
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Q
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A
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G
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A
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I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
147
-
100%
-95
- C2 -
U147
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
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Y
V
L
S
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Y
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D
G
Q
R
R
H
F
I
I
Q
Y
---
M
Y
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F
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G
T
G
F
S
N
I
P
Q
L
I
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H
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Y
T
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K
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V
L
L
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P
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P
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L
L
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K
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F
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A
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---
P
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A
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L
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G
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N
N
V
L
K
I
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D
F
G
M
S
R
Q
E
------------
I
P
I
K
W
T
A
P
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A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
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I
L
L
W
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F
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L
G
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C
P
Y
P
G
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Q
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A
R
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R
G
Y
R
M
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A
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I
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I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
148
-
100%
-98
- C2 -
U148
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
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A
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---
P
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N
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L
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D
F
G
M
S
R
Q
E
-------------
P
I
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W
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A
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A
L
N
Y
G
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Y
S
S
E
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V
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L
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L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
149
-
100%
-95
- C2 -
U149
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
I
I
Q
Y
---
M
Y
R
F
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G
T
G
F
S
N
I
P
Q
L
I
D
H
H
Y
T
T
K
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V
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K
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V
L
L
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P
I
P
K
D
K
K
W
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L
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L
L
G
K
G
N
F
G
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Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
---
P
Q
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L
K
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K
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L
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A
K
I
L
K
Q
Y
D
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-
R
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G
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L
R
R
K
K
D
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L
K
L
K
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L
V
K
F
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L
D
A
A
A
G
M
L
Y
L
E
S
K
N
C
I
H
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L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
------------
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
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L
G
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C
P
Y
P
G
M
T
N
Q
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A
R
E
Q
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R
G
Y
R
M
S
A
P
Q
H
C
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D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
150
-
100%
-95
- C2 -
U150
1
A:
[455-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
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F
L
V
R
E
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H
G
K
P
G
E
Y
V
L
S
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Y
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D
G
Q
R
R
H
F
I
I
Q
Y
V
D
N
M
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G
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G
F
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I
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L
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H
H
Y
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K
K
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V
L
L
N
P
I
P
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D
K
K
W
I
L
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H
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V
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L
G
E
L
L
G
K
G
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F
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Y
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L
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D
K
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V
A
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K
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C
K
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L
-
Q
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-
K
F
L
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L
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L
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L
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L
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L
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F
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L
D
A
A
A
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M
L
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L
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L
A
A
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L
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N
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G
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K
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A
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A
L
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Y
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V
W
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F
G
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L
L
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L
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P
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P
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M
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Q
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A
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V
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A
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C
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K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
151
-
100%
-94
- C2 -
U151
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
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F
L
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R
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S
H
G
K
P
G
E
Y
V
L
S
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Y
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D
G
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F
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N
M
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P
Q
L
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H
H
Y
T
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K
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G
V
V
L
L
N
P
I
P
K
D
K
K
W
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L
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L
L
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K
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F
G
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Y
K
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L
K
D
K
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S
V
A
V
K
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C
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---
P
Q
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L
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L
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A
K
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L
K
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R
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G
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L
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L
R
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K
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D
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L
K
L
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L
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F
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L
D
A
A
A
G
M
L
Y
L
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K
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C
I
H
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D
L
A
A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
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L
G
V
C
P
Y
P
G
M
T
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Q
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A
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R
G
Y
R
M
S
A
P
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H
C
P
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D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
152
-
100%
-94
- C2 -
U152
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
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L
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H
G
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L
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K
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V
L
L
N
P
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P
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K
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L
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H
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L
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L
L
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K
G
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F
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Y
K
G
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L
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K
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S
V
A
V
K
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C
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---
P
Q
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L
K
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L
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A
K
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L
K
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L
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L
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L
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K
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D
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L
K
L
K
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L
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F
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L
D
A
A
A
G
M
L
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L
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I
H
R
D
L
A
A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
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N
Q
Q
A
R
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Q
V
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R
G
Y
R
M
S
A
P
Q
H
C
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I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
153
-
100%
-95
- C2 -
U153
1
A:
[553-814]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
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A
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L
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F
L
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D
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L
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L
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A
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L
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L
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L
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F
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L
L
W
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L
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C
P
Y
P
G
M
T
N
Q
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A
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G
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R
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A
P
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H
C
P
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I
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I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
154
-
100%
-95
- C2 -
U154
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
I
I
Q
Y
---
M
Y
R
F
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G
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G
F
S
N
I
P
Q
L
I
D
H
H
Y
T
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V
L
L
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L
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F
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K
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A
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K
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---
P
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L
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L
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G
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K
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A
A
A
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L
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L
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A
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C
L
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N
N
V
L
K
I
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D
F
G
M
S
R
Q
E
------------
I
P
I
K
W
T
A
P
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A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
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L
L
W
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C
P
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P
G
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Q
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R
G
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R
M
S
A
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H
C
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K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
155
-
100%
-93
- C2 -
U155
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
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P
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Y
V
L
S
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Y
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D
G
Q
R
R
H
F
I
I
Q
----
M
Y
R
F
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G
T
G
F
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N
I
P
Q
L
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D
H
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Y
T
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V
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L
L
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I
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A
V
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---
P
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A
K
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L
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G
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L
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K
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L
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L
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L
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A
A
A
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L
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L
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L
A
A
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C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
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A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
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F
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I
L
L
W
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F
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L
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C
P
Y
P
G
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A
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E
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R
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Y
R
M
S
A
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S
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I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
156
-
100%
-95
- C2 -
U156
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
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L
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P
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V
L
S
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D
G
Q
R
R
H
F
I
I
Q
Y
---
M
Y
R
F
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F
S
N
I
P
Q
L
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D
H
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Y
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L
L
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L
L
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F
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A
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---
P
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A
G
M
L
Y
L
E
S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
------------
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
157
-
100%
-94
- C2 -
U157
1
B:
[554-814]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
-----
Q
E
L
K
-
K
F
L
Q
E
A
K
I
L
K
Q
Y
D
H
P
N
I
V
K
L
I
G
V
C
T
Q
R
Q
P
V
Y
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L
V
S
G
G
D
F
L
T
F
L
R
R
K
K
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L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
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K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
D
G
G
V
Y
S
S
S
G
L
K
Q
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
158
-
100%
-94
- C2 -
U158
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
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D
G
Q
R
R
H
F
I
I
Q
Y
V
D
N
M
Y
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G
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I
P
Q
L
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D
H
H
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K
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K
K
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V
V
L
L
N
P
I
P
K
D
K
K
W
I
L
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H
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D
V
I
L
G
E
L
L
G
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
---
P
Q
E
L
K
I
K
F
L
Q
E
A
K
I
L
K
Q
Y
D
H
P
N
I
V
K
L
I
G
V
C
T
-
R
Q
P
V
Y
I
I
M
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L
V
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G
G
D
F
L
T
F
L
R
R
K
K
D
E
L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
E
S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
159
-
100%
-94
- C2 -
U159
1
B:
[554-814]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
-----
Q
E
L
K
-
K
F
L
Q
E
A
K
I
L
K
Q
Y
D
H
P
N
I
V
K
L
I
G
V
C
T
Q
R
Q
P
V
Y
I
I
M
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L
V
S
G
G
D
F
L
T
F
L
R
R
K
K
D
E
L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
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S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
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D
G
G
V
Y
S
S
S
G
L
K
Q
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
160
-
100%
-91
- C2 -
U160
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
I
I
Q
Y
V
D
N
M
Y
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G
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F
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I
P
Q
L
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D
H
H
Y
T
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K
Q
V
I
T
K
K
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G
V
V
L
L
N
P
I
P
K
D
K
K
W
I
L
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H
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D
V
I
L
G
E
L
L
G
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
---
P
Q
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L
K
I
K
F
L
Q
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A
K
I
L
K
Q
Y
D
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P
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L
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C
T
-
R
Q
P
V
Y
I
I
M
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L
V
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G
G
D
F
L
T
F
L
R
R
K
K
D
E
L
K
L
K
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L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
E
S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
------------
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
161
-
100%
-94
- C2 -
U161
1
B:
[554-814]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
-----
Q
E
L
K
-
K
F
L
Q
E
A
K
I
L
K
Q
Y
D
H
P
N
I
V
K
L
I
G
V
C
T
Q
R
Q
P
V
Y
I
I
M
E
L
V
S
G
G
D
F
L
T
F
L
R
R
K
K
D
E
L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
E
S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
D
G
G
V
Y
S
S
S
G
L
K
Q
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
162
-
100%
-98
- C2 -
U162
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
I
I
Q
Y
V
D
N
M
Y
R
F
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G
T
G
F
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N
I
P
Q
L
I
D
H
H
Y
T
T
K
Q
V
I
T
K
K
S
G
V
V
L
L
N
P
I
P
K
D
K
K
W
I
L
S
H
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D
V
I
L
G
E
L
L
G
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
---
P
Q
E
L
K
I
K
F
L
Q
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A
K
I
L
K
Q
Y
D
H
P
N
I
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K
L
I
G
V
C
T
-
R
Q
P
V
Y
I
I
M
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L
V
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G
G
D
F
L
T
F
L
R
R
K
K
D
E
L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
E
S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
163
-
100%
-98
- C2 -
U163
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
I
I
Q
Y
V
D
N
M
Y
R
F
E
G
T
G
F
S
N
I
P
Q
L
I
D
H
H
Y
T
T
K
Q
V
I
T
K
K
S
G
V
V
L
L
N
P
I
P
K
D
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
---
P
Q
E
L
K
I
K
F
L
Q
E
A
K
I
L
K
Q
Y
D
H
P
N
I
V
K
L
I
G
V
C
T
-
R
Q
P
V
Y
I
I
M
E
L
V
S
G
G
D
F
L
T
F
L
R
R
K
K
D
E
L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
E
S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
164
-
99%
-94
- C2 -
U164
1
A:
[551-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
D
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
G
E
V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
E
E
L
K
-----
K
F
L
Q
E
A
K
I
L
K
Q
Y
D
H
P
N
I
V
K
L
I
G
V
C
T
Q
R
Q
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I
M
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L
V
S
G
G
D
F
L
T
F
L
R
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K
K
D
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L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
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L
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S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
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G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
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D
G
G
V
Y
S
S
S
G
L
K
Q
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
165
-
100%
-98
- C2 -
U165
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
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A
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---
P
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N
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L
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F
G
M
S
R
Q
E
-------------
P
I
K
W
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A
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A
L
N
Y
G
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S
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V
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W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
166
-
100%
-93
- C2 -
U166
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
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Y
H
G
A
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----
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---
P
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N
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L
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F
G
M
S
R
Q
E
-------------
P
I
K
W
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A
L
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Y
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S
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V
W
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W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
167
-
100%
-94
- C2 -
U167
1
A:
[551-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
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R
P
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L
Q
K
E
L
--------
168
-
100%
-94
- C2 -
U168
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
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Y
H
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A
I
P
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S
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Q
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-------------
P
I
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F
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L
Q
K
----------
169
-
100%
-95
- C2 -
U169
1
A:
[553-814]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
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V
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L
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K
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L
--------
170
-
100%
-95
- C2 -
U170
1
A:
[553-814]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
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V
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L
Q
K
E
L
--------
171
-
100%
-98
- C2 -
U171
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
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D
W
Y
H
G
A
I
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R
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A
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L
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S
R
Q
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-------------
P
I
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L
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W
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R
P
K
F
S
E
L
Q
K
----------
172
-
100%
-98
- C2 -
U172
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
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W
Y
H
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A
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A
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G
M
S
R
Q
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-------------
P
I
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P
K
F
S
E
L
Q
K
----------
173
-
100%
-95
- C2 -
U173
1
A:
[553-814]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
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S
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Q
E
D
G
G
V
Y
S
S
S
G
L
K
Q
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
174
-
100%
-89
- C2 -
U174
1
B:
[551-814]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
D
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
G
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V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
E
D
L
-
Q
E
L
K
-
K
F
L
Q
E
A
K
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L
K
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D
H
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N
I
V
K
L
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L
V
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G
G
D
F
L
T
F
L
R
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K
K
D
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L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
E
S
K
N
C
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
-----
V
Y
S
S
S
G
L
K
Q
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
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C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
E
D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
175
-
100%
-94
- C2 -
U175
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
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D
G
Q
R
R
H
F
I
I
Q
----
M
Y
R
F
E
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T
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F
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N
I
P
Q
L
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D
H
H
Y
T
T
K
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G
V
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L
L
N
P
I
P
K
D
K
K
W
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H
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L
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L
L
G
K
G
N
F
G
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V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
---
P
Q
E
L
K
I
K
F
L
Q
E
A
K
I
L
K
Q
Y
D
H
P
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T
-
R
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Y
I
I
M
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L
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G
G
D
F
L
T
F
L
R
R
K
K
D
E
L
K
L
K
Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
E
S
K
N
C
I
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R
D
L
A
A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
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L
G
V
C
P
Y
P
G
M
T
N
Q
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A
R
E
Q
V
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R
G
Y
R
M
S
A
P
Q
H
C
P
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D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
176
-
100%
-91
- C2 -
U176
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
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Y
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D
G
Q
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R
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F
I
I
Q
Y
V
D
N
M
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P
Q
L
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H
H
Y
T
T
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K
K
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G
V
V
L
L
N
P
I
P
K
D
K
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L
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H
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L
G
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L
L
G
K
G
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F
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Y
K
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K
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V
A
V
K
T
C
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---
P
Q
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L
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L
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A
K
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L
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D
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-
R
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L
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G
G
D
F
L
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F
L
R
R
K
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D
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L
K
L
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Q
L
V
K
F
S
L
D
A
A
A
G
M
L
Y
L
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S
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N
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I
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L
A
A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
------------
I
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
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F
G
I
L
L
W
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T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
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R
G
Y
R
M
S
A
P
Q
H
C
P
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D
I
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I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
177
-
100%
-95
- C2 -
U177
1
A:
[553-814]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
K
W
I
L
S
H
E
D
V
I
L
G
E
L
L
G
K
G
N
F
G
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Y
K
G
T
L
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D
K
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V
A
V
K
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C
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L
-
Q
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L
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-
K
F
L
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G
G
D
F
L
T
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L
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K
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D
E
L
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L
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Q
L
V
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F
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A
A
A
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M
L
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L
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I
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L
A
A
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L
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L
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I
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K
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A
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A
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Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
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Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
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D
I
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K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
E
L
--------
178
-
100%
-98
- C2 -
U178
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
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L
V
R
E
S
H
G
K
P
G
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Y
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P
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L
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V
V
L
L
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P
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L
L
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F
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L
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A
V
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---
P
Q
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L
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L
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A
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L
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T
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R
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L
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G
G
D
F
L
T
F
L
R
R
K
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D
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L
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L
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L
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F
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L
D
A
A
A
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M
L
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L
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C
I
H
R
D
L
A
A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
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D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
179
-
100%
-93
- C2 -
U179
1
A:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
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D
G
Q
R
R
H
F
I
I
Q
----
M
Y
R
F
E
G
T
G
F
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N
I
P
Q
L
I
D
H
H
Y
T
T
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V
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K
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S
G
V
V
L
L
N
P
I
P
K
D
K
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W
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L
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H
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D
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L
G
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L
L
G
K
G
N
F
G
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Y
K
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L
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K
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V
A
V
K
T
C
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---
P
Q
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L
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L
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A
K
I
L
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L
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C
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-
R
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L
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G
G
D
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L
T
F
L
R
R
K
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D
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L
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L
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Q
L
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F
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L
D
A
A
A
G
M
L
Y
L
E
S
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N
C
I
H
R
D
L
A
A
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N
C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
Q
E
-------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
V
C
P
Y
P
G
M
T
N
Q
Q
A
R
E
Q
V
E
R
G
Y
R
M
S
A
P
Q
H
C
P
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D
I
S
K
I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------
180
-
100%
-94
- C2 -
U180
1
B:
[455-812]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
Q
D
W
Y
H
G
A
I
P
R
I
E
A
Q
E
L
L
K
K
Q
G
D
F
L
V
R
E
S
H
G
K
P
G
E
Y
V
L
S
V
Y
S
D
G
Q
R
R
H
F
I
I
Q
Y
---
M
Y
R
F
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G
T
G
F
S
N
I
P
Q
L
I
D
H
H
Y
T
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K
K
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G
V
V
L
L
N
P
I
P
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D
K
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W
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L
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H
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D
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I
L
G
E
L
L
G
K
G
N
F
G
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V
Y
K
G
T
L
K
D
K
T
S
V
A
V
K
T
C
K
---
P
Q
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L
K
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F
L
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A
K
I
L
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L
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C
T
-
R
Q
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Y
I
I
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E
L
V
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G
G
D
F
L
T
F
L
R
R
K
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D
E
L
K
L
K
Q
L
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K
F
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L
D
A
A
A
G
M
L
Y
L
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N
C
I
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L
A
A
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C
L
V
G
E
N
N
V
L
K
I
S
D
F
G
M
S
R
---------------
P
I
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
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L
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C
P
Y
P
G
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T
N
Q
Q
A
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E
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V
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R
G
Y
R
M
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A
P
Q
H
C
P
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D
I
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I
M
M
K
C
W
D
Y
K
P
E
N
R
P
K
F
S
E
L
Q
K
----------