@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FES_HUMAN: (2013-07-20 )
MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Atome Classification :
(86 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..----.----.--..---.----480.....-.-.490.....-----..500------.......-510--.-....-...520.......-------530.-....--------..--------540--.----..---...-----.550---.-........560...-.-...570.......-580.---..---.....590..-.....600.-......610.......620.......-630.......640.......650.-.------.---.....--.--660.......670.......680.......690---.......700......-.710.......720.......730.......740.......750.......760...-....770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELL----V----H--SG---D----FLVRESQG-K-QEYVLSVLW-----DGLPR------HFIIQSL-D-N--L-YRLE-GEGFPSIPLLIDH-------LLST-QQPL--------TK--------KSG--V----VL---HRA-----VP-----K-DKWVLNHEDLVLGE-Q-IGRGNFGEVFSGR-LR-A---DN---TLVAVKSCRE-TLPPDLKAK-FLQEARILKQYSHPNIVRLIGVCTQK-QPIYIVMELVQGGDFLTFLRT--E-G------A---RLRVK--T--LLQMVGDAAAGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREE-ADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLS-NQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
2
PsiBlast_PDB
95.75
99%
-110
- C1 -
3BKB
9
A:
[4-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
--
S
G
---
D
----
F
L
V
R
E
S
Q
G
-
K
-
Q
E
Y
V
L
S
V
L
W
-----
D
G
L
P
R
------
H
F
I
I
Q
S
L
-
D
-
N
--
L
-
Y
R
L
E
-
G
E
G
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
P
L
--------
T
K
--------
K
S
G
--
V
----
V
L
---
H
R
A
-----
V
P
-----
K
-
D
K
W
V
L
N
H
E
D
L
V
L
G
E
-
Q
-
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
R
-
A
---
D
N
---
T
L
V
A
V
K
S
C
R
E
-
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
--
E
-
G
------
A
---
R
L
R
V
K
--
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
-
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
21
PsiBlast_CBE
72.73
38%
-99
- C1 -
1OPL
1
ABL1_HUMAN
B:
[140-515]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
Y
L
----
L
----
S
--
S
G
ING
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
------
H
Y
R
I
N
T
A
-
S
-
D
G
K
L
-
Y
V
S
S
-
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
VADG
L
I
T
T
L
H
Y
P
A
--------
P
-----------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
114
HHSearch
72.03
38%
-96
- C1 -
1OPK
3
ABL1_MOUSE
A:
[99-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI
N
G
---
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
------
H
Y
R
I
N
T
A
S
D
-
G
--
K
L
Y
V
S
S
-
E
S
R
F
N
T
L
A
E
L
V
H
H
-------
H
S
T
V
-
A
D
G
L
--------
I
T
TLHYPAPK
R
N
K
P-
T
----
I
Y
---
G
V
S
-----
P
N
-----
Y
-
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
-
D
T
M
--
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
--
C
N
R
------
Q
---
E
V
S
A
V
--
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
----
5
PsiBlast_PDB
70.87
38%
-96
- C1 -
1OPL
2
ABL1_HUMAN
A:
[131-515]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
N
Y
I
T
P
V
N
S
-
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
Y
L
----
L
----
S
--
S
G
ING
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
------
H
Y
R
I
N
T
A
-
S
-
D
G
K
L
-
Y
V
S
S
-
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
VADG
L
I
T
T
L
H
Y
P
A
--------
P
K
--------
R
N
K
--
P
----
T
V
---
Y
G
V
-----
S
P
-----
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
84
PsiBlast_CBE
70.75
36%
-105
- C1 -
3VS5
1
HCK_HUMAN
A:
[67-433]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
-----G-
F
-
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
-------
Y
K
K
G
-
N
D
G
L
--------
C
Q
--------
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
P
QKPWE
K
-
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-
K
----
H
---
T
K
V
A
V
K
T
M
K
----
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
-
G
------
S
---
K
Q
P
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
------------
113
HHSearch
69.81
34%
-101
- C1 -
2OZO
1
ZAP70_HUMAN
A:
[155-599]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
----
Y
SGAQ
T
--
D
G
---
K
----
F
L
L
R
P
R
K
E
-
Q
-
G
T
Y
A
L
S
L
I
Y
-----
G
K
T
V
Y
------
H
Y
L
I
S
Q
D
K
A
-
G
--
K
-
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
-------
L
K
L
K
-
A
D
G
L
IYCLKEAC
P
N
--------------MDTS
V
F
---
E
S
P
FSDPE
E
L
-----
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
-
L
G
C
G
N
F
G
S
V
R
Q
G
V
-
Y
R
-
M
RK-
K
Q
---
I
D
V
A
I
K
V
L
K
Q
-
G
T
E
K
A
D
T
E
E
-
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
--
K
-
R
------
E
---
E
I
P
V
S
--
N
--
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
---
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
-
G
-------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
--
93
PsiBlast_CBE
69.71
36%
-106
- C1 -
3VS0
1
HCK_HUMAN
B:
[67-433]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
-
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
-------
Y
K
K
G
-
N
D
G
L
--------
C
Q
--------
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
P
Q
KPWE
K
-
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-
K
----
H
---
T
K
V
A
V
K
T
M
K
----
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
-
G
------
S
---
K
Q
P
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
------------
121
HHSearch
69.57
41%
-93
* C1 *
4AOJ
1
NTRK1_HUMAN
A:
[35-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
-
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
H
-
N
LLP-
K
---
M
L
V
A
V
K
A
L
K
E
-
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
--
H
-
G
------
P
DPG
P
L
G
L
G
--
Q
--
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
83
PsiBlast_CBE
69.19
36%
-104
- C1 -
3VS5
1
HCK_HUMAN
B:
[67-433]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
---
N
MLG
S
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
--------
F
-
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
-------
Y
K
K
G
-
N
D
G
L
--------
C
Q
--------
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
P
QKPWE
K
-
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-
K
----
H
---
T
K
V
A
V
K
T
M
K
----
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
-
G
------
S
---
K
Q
P
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
------------
117
HHSearch
68.94
37%
-96
- C1 -
1QCF
1
HCK_HUMAN
A:
[65-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
APG
N
----
M
--
L
G
---
S
----
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
------
H
Y
K
I
R
T
L
-
D
N
G
G
-
F
-
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
-------
Y
K
K
G
-
N
D
G
L
--------
C
Q
--------
K
L
S
VP
C
----
M
S
SKP
Q
K
P
-----
W
E
-----
K
-
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-----
K
H
---
T
K
V
A
V
K
T
M
K
P
-
G
S
M
--
S
V
E
A
-
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
--
D
E
G
------
S
---
K
Q
P
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
---
82
PsiBlast_CBE
68.71
36%
-104
- C1 -
3VS6
1
HCK_HUMAN
A:
[67-433]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
-
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
-------
Y
K
K
G
-
N
D
G
L
--------
C
Q
--------
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
P
QKPWE
K
-
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-
K
----
H
---
T
K
V
A
V
K
T
M
K
----
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
-
G
------
S
---
K
Q
P
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
------------
99
PsiBlast_CBE
68.68
36%
-101
- C1 -
2C0T
1
HCK_HUMAN
B:
[67-433]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
---
N
MLG
S
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
-----G-
F
-
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
-------
Y
K
K
G
-
N
D
G
L
--------
C
Q
--------
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
P
QKPWE
K
-
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-
K
----
H
---
T
K
V
A
V
K
T
M
K
----
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
-
G
------
S
---
K
Q
P
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
------------
4
PsiBlast_PDB
68.40
38%
-91
- C1 -
2FO0
4
ABL1_HUMAN
A:
[89-473]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
N
Y
I
T
P
V
N
S
-
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
Y
L
----
L
----
S
--
S
G
ING
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
------
H
Y
R
I
N
T
A
-
S
-
D
G
K
L
-
Y
V
S
S
-
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
VADG
L
I
T
T
L
H
Y
P
A
--------
P
K
--------
R
N
K
--
P
----
T
V
---
Y
G
V
-----
S
P
-----
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
81
PsiBlast_CBE
68.34
36%
-105
- C1 -
3VS6
1
HCK_HUMAN
B:
[67-433]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
Y
D
P
R
QGDTVK
H
Y
K
I
R
T
L
-
D
-
N
GG
F
-
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
-------
Y
K
K
G
-
N
D
G
L
--------
C
Q
--------
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
P
QKPWE
K
-
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-
K
----
H
---
T
K
V
A
V
K
T
M
K
----
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D-
E
-
G
------
S
---
K
Q
P
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
------------
94
PsiBlast_CBE
68.19
36%
-101
- C1 -
3VS0
1
HCK_HUMAN
A:
[67-433]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
---
N
MLG
S
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------G-
F
-
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
-------
Y
K
K
G
-
N
D
G
L
--------
C
Q
--------
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
P
QKPWE
K
-
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-
K
----
H
---
T
K
V
A
V
K
T
M
K
----
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
-
G
------
S
---
K
Q
P
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
------------
90
PsiBlast_CBE
67.88
36%
-104
- C1 -
3VS2
1
HCK_HUMAN
A:
[67-433]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
--
P
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
----G-
F
-
Y
I
S
P
-
R
S
T
F
S
T
L
Q
E
L
V
D
H
-------
Y
K
K
G
-
N
D
G
L
--------
C
Q
--------
K
L
S
--
V
----
P
C
---
M
S
S
-----
K
P
QKPWE
K
-
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
-
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-
K
----
H
---
T
K
V
A
V
K
T
M
K
----
P
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
-
G
------
S
---
K
Q
P
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
------------
57
PsiBlast_CBE
64.83
43%
-95
- C1 -
3DK3
1
ABL1_MOUSE
A:
[4-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
----
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
F
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
12
PsiBlast_PDB
64.65
43%
-93
- C1 -
2Z60
1
ABL1_MOUSE
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
---
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
52
PsiBlast_CBE
64.59
43%
-98
- C1 -
3CS9
1
ABL1_HUMAN
B:
[10-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
---
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
55
PsiBlast_CBE
64.51
43%
-94
- C1 -
2HZI
1
ABL1_HUMAN
A:
[10-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
54
PsiBlast_CBE
64.29
43%
-95
- C1 -
2HZI
1
ABL1_HUMAN
B:
[10-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
----
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
61
PsiBlast_CBE
64.21
44%
-94
- C1 -
3GVU
2
ABL2_HUMAN
A:
[25-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
E
E
V
T
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
G
D
T
Y
T
----
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
-----
50
PsiBlast_CBE
64.15
43%
-93
- C1 -
2QOH
1
ABL1_MOUSE
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
---
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
49
PsiBlast_CBE
63.83
43%
-94
- C1 -
2QOH
1
ABL1_MOUSE
B:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
---
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
103
Fugue
63.69
44%
-101
- C1 -
1BYG
1
CSK_HUMAN
A:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
-
I
G
K
G
E
F
G
D
V
M
L
G
D
-
Y
R
G---------
N
K
V
A
V
K
C
I
K
------
N
D
A
Q
A
-
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G--
R
------
S
---
V
L
G
G
D
--
C
--
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
---
E
D
N
V
A
K
V
S
D
F
G
------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
14
PsiBlast_PDB
63.49
43%
-93
- C1 -
3PYY
1
ABL1_HUMAN
A:
[19-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
----
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
60
PsiBlast_CBE
63.38
44%
-90
- C1 -
3HMI
1
ABL2_HUMAN
A:
[25-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
E
E
V
T
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
-----
26
PsiBlast_CBE
63.29
43%
-83
- C1 -
3QRJ
1
ABL1_HUMAN
B:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
51
PsiBlast_CBE
63.21
43%
-87
- C1 -
3CS9
1
ABL1_HUMAN
D:
[10-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
------------
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
32
PsiBlast_CBE
63.13
43%
-97
- C1 -
3PYY
3
ABL1_HUMAN
B:
[19-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
130
HHSearch
62.95
39%
-97
- C1 -
2J0J
1
FAK1_CHICK
A:
[383-652]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
-
C
-
I
G
E
G
Q
F
G
D
V
H
Q
G
I
-
Y
M
-
S
---
P
E
N
P
A
M
A
V
A
I
K
T
C
K
N
-
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
-
K
------
F
---
S
L
D
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-
E
D
-----------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
--
10
PsiBlast_PDB
62.89
43%
-87
- C1 -
2G2H
1
ABL1_HUMAN
A:
[8-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
123
HHSearch
62.88
38%
-98
- C1 -
4FYO
1
A:
[11-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
-
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
-
Y
Q
-
M
---
K
K
V
V
-
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
-
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
-
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
--
N
--------
R
---
H
V
K
D
K
--
N
--
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
---
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
---
43
PsiBlast_CBE
62.62
43%
-85
- C1 -
3QRK
1
ABL1_HUMAN
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
24
PsiBlast_CBE
62.57
43%
-86
- C1 -
2G1T
1
ABL1_HUMAN
C:
[7-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
69
PsiBlast_CBE
62.48
43%
-91
- C1 -
2HYY
1
ABL1_HUMAN
C:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
-
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
---
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
11
PsiBlast_PDB
62.48
43%
-87
- C1 -
2G2I
1
ABL1_HUMAN
A:
[4-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
P
N
-----
Y
-
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
---
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
48
PsiBlast_CBE
62.44
43%
-92
- C1 -
3KF4
1
ABL1_MOUSE
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
-----
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
38
PsiBlast_CBE
62.42
43%
-90
- C1 -
1OPJ
2
ABL1_MOUSE
B:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
41
PsiBlast_CBE
62.41
43%
-92
- C1 -
1FPU
1
ABL1_MOUSE
B:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
------
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
42
PsiBlast_CBE
62.35
43%
-91
- C1 -
2F4J
1
ABL1_HUMAN
A:
[7-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
56
PsiBlast_CBE
62.33
43%
-93
- C1 -
3DK3
1
ABL1_MOUSE
B:
[4-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
----
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
F
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
47
PsiBlast_CBE
62.30
43%
-93
- C1 -
3KF4
1
ABL1_MOUSE
B:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
---
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
22
PsiBlast_CBE
62.23
43%
-91
- C1 -
3UE4
1
ABL1_HUMAN
B:
[8-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
--
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
78
PsiBlast_CBE
62.20
44%
-91
- C1 -
4HCT
1
A:
[4-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
-
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
-
K
---
D
K
-----
V
A
I
K
T
I
R
E
-
G
A
M
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
--
Q
-
R
------
G
---
L
F
A
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
-
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
6
PsiBlast_PDB
62.08
43%
-89
- C1 -
2G1T
1
ABL1_HUMAN
A:
[7-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
9
PsiBlast_PDB
62.06
43%
-92
- C1 -
2G2F
1
ABL1_HUMAN
A:
[7-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
18
PsiBlast_PDB
62.05
43%
-89
- C1 -
1M52
1
ABL1_MOUSE
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
79
PsiBlast_CBE
62.03
44%
-94
- C1 -
3T9T
3
A:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
-
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
-
K
---
D
K
-----
V
A
I
K
T
I
R
E
-
G
A
M
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
--
Q
-
R
------
G
---
L
F
A
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
-
L
D
D
Q
Y
T
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
39
PsiBlast_CBE
61.92
43%
-87
- C1 -
1M52
3
ABL1_MOUSE
B:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
28
PsiBlast_CBE
61.88
43%
-92
- C1 -
2G2I
1
ABL1_HUMAN
B:
[7-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
----
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
31
PsiBlast_CBE
61.82
43%
-86
- C1 -
3IK3
1
ABL1_MOUSE
B:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
29
PsiBlast_CBE
61.79
43%
-91
- C1 -
2G2H
1
ABL1_HUMAN
B:
[8-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
68
PsiBlast_CBE
61.73
43%
-90
- C1 -
2HYY
1
ABL1_HUMAN
D:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
--
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
46
PsiBlast_CBE
61.72
43%
-88
- C1 -
3KFA
1
ABL1_MOUSE
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
53
PsiBlast_CBE
61.66
43%
-85
- C1 -
3CS9
1
ABL1_HUMAN
A:
[10-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
----
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
25
PsiBlast_CBE
61.65
43%
-86
- C1 -
2G1T
1
ABL1_HUMAN
B:
[5-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
-----
Y
-
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
13
PsiBlast_PDB
61.43
43%
-91
- C1 -
3IK3
1
ABL1_MOUSE
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
33
PsiBlast_CBE
61.33
43%
-90
- C1 -
2HIW
1
ABL1_HUMAN
B:
[8-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
23
PsiBlast_CBE
61.28
43%
-85
- C1 -
2G1T
1
ABL1_HUMAN
D:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
-----
P
N
-----
Y
-
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
34
PsiBlast_CBE
61.01
43%
-91
- C1 -
3MS9
2
ABL1_MOUSE
B:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
---
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
58
PsiBlast_CBE
60.96
43%
-98
- C1 -
2HZ0
1
ABL1_HUMAN
B:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
------
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
----
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
27
PsiBlast_CBE
60.92
43%
-85
- C1 -
3OY3
1
ABL1_MOUSE
B:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
45
PsiBlast_CBE
60.90
43%
-88
- C1 -
3KFA
1
ABL1_MOUSE
B:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
36
PsiBlast_CBE
60.86
43%
-87
- C1 -
3K5V
2
ABL1_MOUSE
B:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
---
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
15
PsiBlast_PDB
60.83
43%
-91
- C1 -
2HIW
1
ABL1_HUMAN
A:
[8-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
37
PsiBlast_CBE
60.80
43%
-86
- C1 -
3K5V
2
ABL1_MOUSE
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D-
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
44
PsiBlast_CBE
60.68
43%
-84
- C1 -
3QRI
1
ABL1_HUMAN
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
64
PsiBlast_CBE
60.67
44%
-89
- C1 -
2XYN
2
ABL2_HUMAN
A:
[26-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
--D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
E
E
V
T
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
-----
63
PsiBlast_CBE
60.57
44%
-89
- C1 -
2XYN
4
ABL2_HUMAN
B:
[26-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
--D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
E
E
V
T
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
-----
71
PsiBlast_CBE
60.51
43%
-90
- C1 -
2HYY
1
ABL1_HUMAN
A:
[8-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
-D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
66
PsiBlast_CBE
60.46
43%
-94
- C1 -
2HZ4
1
ABL1_HUMAN
B:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
-----
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
19
PsiBlast_PDB
60.42
43%
-86
- C1 -
1OPJ
2
ABL1_MOUSE
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
62
PsiBlast_CBE
60.32
44%
-91
- C1 -
2XYN
4
ABL2_HUMAN
C:
[27-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
--
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
E
E
V
T
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
-----
132
HHSearch
60.17
43%
-78
- C1 -
3L9P
4
A:
[63-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
D
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
-
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G----
S
P
---
L
Q
V
A
V
K
T
L
P
E
-
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
--
T
-
R
PRPSQP
S
---
S
L
A
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
-
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
122
HHSearch
60.11
39%
-98
- C1 -
4I4E
1
A:
[9-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
Y
E
I
Q
R
E
R
I
E
L
G
R
-
C
-
I
G
E
G
Q
F
G
D
V
H
Q
G
I
-
Y
M
-
S
---
P
-NP
A
L
A
V
A
I
K
T
C
K
N
-
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
--
R
-
K
------
Y
---
S
L
D
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
--
35
PsiBlast_CBE
60.02
43%
-89
- C1 -
3MS9
2
ABL1_MOUSE
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
---
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
8
PsiBlast_PDB
59.71
43%
-84
- C1 -
3OY3
1
ABL1_MOUSE
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
16
PsiBlast_PDB
59.52
43%
-91
- C1 -
1FPU
1
ABL1_MOUSE
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
7
PsiBlast_PDB
59.51
43%
-87
- C1 -
3UE4
1
ABL1_HUMAN
A:
[8-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
17
PsiBlast_PDB
59.03
43%
-88
- C1 -
1IEP
1
ABL1_MOUSE
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
70
PsiBlast_CBE
59.01
43%
-86
- C1 -
2HYY
1
ABL1_HUMAN
B:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
-
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
59
PsiBlast_CBE
58.88
43%
-82
- C1 -
2HZ0
1
ABL1_HUMAN
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
40
PsiBlast_CBE
58.39
43%
-84
- C1 -
1IEP
1
ABL1_MOUSE
B:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
30
PsiBlast_CBE
57.84
43%
-89
- C1 -
2G2F
1
ABL1_HUMAN
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
-----
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
N
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
20
PsiBlast_PDB
53.74
43%
-83
- C1 -
2HZN
1
ABL1_MOUSE
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
-
L
G
G
G
---
E
V
Y
E
G
V
-
W
K
-
K
---
Y
S
---
L
T
V
A
V
K
T
L
--D
T
M
E
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
---
E
-
C
------
N
---
R
Q
E
V
S
A
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
Add PDB User Result:
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
133
-
100%
-101
- C1 -
U133
1
A:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
--
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
134
-
100%
-101
- C1 -
U134
1
A:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
--
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
135
-
100%
-101
- C1 -
U135
1
A:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
--
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
136
-
99%
-110
- C1 -
U136
1
B:
[453-817]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
H
E
Q
L
W
Y
H
G
A
I
P
R
-
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
G
K
Q
E
Y
V
L
S
V
L
W
D
G
L
P
R
H
F
I
I
Q
S
L
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
-------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
137
-
100%
-94
- C1 -
U137
1
D:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-----
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
138
-
99%
-118
- C1 -
U138
1
B:
[455-808]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
G
K
Q
E
Y
V
L
S
V
L
-
D
G
L
P
R
H
F
I
I
Q
S
---
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
N
-
T
L
V
A
V
K
S
C
R
---
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
--------------
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
--------------
139
-
100%
-100
- C1 -
U139
1
A:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
------
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
140
-
100%
-101
- C1 -
U140
1
A:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
--
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
141
-
100%
-100
- C1 -
U141
1
B:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
---
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
142
-
99%
-118
- C1 -
U142
1
B:
[455-808]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
G
K
Q
E
Y
V
L
S
V
L
-
D
G
L
P
R
H
F
I
I
Q
S
---
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
N
-
T
L
V
A
V
K
S
C
R
---
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
--------------
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
--------------
143
-
99%
-115
- C1 -
U143
1
A:
[455-808]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
G
K
Q
E
Y
V
L
S
V
L
-
D
G
L
P
R
H
F
I
I
Q
----
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
N
-
T
L
V
A
V
K
S
C
R
---
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
--------------
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
--------------
144
-
99%
-120
- C1 -
U144
1
B:
[455-808]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
G
K
Q
E
Y
V
L
S
V
L
-
D
G
L
P
R
H
F
I
I
Q
S
L
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
N
-
T
L
V
A
V
K
S
C
R
---
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
-------------
E
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
--------------
145
-
100%
-100
- C1 -
U145
1
A:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
------
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
146
-
100%
-96
- C1 -
U146
1
A:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
147
-
99%
-110
- C1 -
U147
1
B:
[453-817]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
H
E
Q
L
W
Y
H
G
A
I
P
R
-
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
G
K
Q
E
Y
V
L
S
V
L
W
D
G
L
P
R
H
F
I
I
Q
S
L
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
-------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
148
-
100%
-100
- C1 -
U148
1
A:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
------
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
149
-
100%
-96
- C1 -
U149
1
A:
[553-817]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
--
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
150
-
100%
-100
- C1 -
U150
1
A:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
------
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
151
-
99%
-107
- C1 -
U151
1
A:
[552-820]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
-
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
-------------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
152
-
99%
-115
- C1 -
U152
1
A:
[455-808]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
G
K
Q
E
Y
V
L
S
V
L
-
D
G
L
P
R
H
F
I
I
Q
----
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
N
-
T
L
V
A
V
K
S
C
R
---
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
--------------
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
--------------
153
-
100%
-99
- C1 -
U153
1
B:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
154
-
100%
-99
- C1 -
U154
1
B:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
155
-
100%
-99
- C1 -
U155
1
B:
[552-817]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----