@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ITK_HUMAN: (2013-07-21 )
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
Atome Classification :
(88 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-..-.....210.-.-.....220.......--230.......240.......250....-.-.-.-260.....-..270........280.......290.......300.......310.......320.......330.......340.....------------..-------------------350-........360....-.-..370.......380.---.---.---.----.--..390......--.---400-.........410.......420......-.430.......440......-.-450---.--.-..-.-...460.......470.......480.......490.......500.......510..--.....-520.......530--.......540.......550.......560-.-......570.......580--........590.......600.......610.......620
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLD-SS-EIHWWRVQD-R-NGHEGYVPSSYLVEK--SPNNLETYEWYNKSISRDKAEKLLLDT-G-K-E-GAFMVRDS-RTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPV------------TA-------------------GL--RYGKWVIDPSELTFV-Q-EIGSGQFGLVHLGYWL---N---K---D----K--VAIKTIREGAM--S---E---EDFIEEAEVMMKLSHPKLVQLYGVCLEQ-APICLVFEFMEHGCLSDYLR-T-Q-R---G--L-FA-A-ETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTS--STGTK-FPVKWASPEVFSF--SRYSSKSDVWSFGVLMWEVFSEGKIPYENR-S-NSEVVEDISTGFRLYKPR---LASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
3
PsiBlast_PDB
85.48
99%
-131
- C5 -
4HCV
1
A:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
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--
1
PsiBlast_PDB
84.98
99%
-129
- C5 -
4HCT
1
A:
[3-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
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--
21
PsiBlast_CBE
84.77
100%
-136
- C5 -
3V8W
1
B:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
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129
HHSearch
84.68
99%
-129
- C5 -
4HCU
1
A:
[5-267]
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25
PsiBlast_CBE
84.21
100%
-140
- C5 -
3V5J
1
B:
[3-266]
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23
PsiBlast_CBE
83.51
100%
-135
- C5 -
3V5L
1
D:
[3-265]
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8
PsiBlast_PDB
83.34
100%
-136
- C5 -
3V8W
1
ITK_HUMAN
A:
[3-265]
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24
PsiBlast_CBE
83.05
100%
-134
- C5 -
3V5L
1
ITK_HUMAN
C:
[3-262]
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L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
131
HHSearch
83.04
99%
-129
- C5 -
3T9T
3
A:
[3-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
22
PsiBlast_CBE
83.02
100%
-132
- C5 -
3V8T
1
B:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
---
A
M
--
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
12
PsiBlast_PDB
82.98
98%
-132
- C5 -
3QGW
1
ITK_HUMAN
A:
[24-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
K
E
G
S
M
--
S
---
E
---
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
13
PsiBlast_PDB
82.52
98%
-128
- C5 -
3QGY
1
ITK_HUMAN
A:
[23-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
K
E
G
S
M
--
S
---
E
---
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
7
PsiBlast_PDB
82.11
100%
-136
- C5 -
3V8T
1
ITK_HUMAN
A:
[3-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
--------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
5
PsiBlast_PDB
82.09
100%
-134
- C5 -
3V5J
1
ITK_HUMAN
A:
[3-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
R
E
G
----
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
9
PsiBlast_PDB
81.96
100%
-131
- C5 -
1SM2
1
ITK_HUMAN
A:
[1-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
15
PsiBlast_PDB
81.91
98%
-123
- C5 -
3MJ2
1
A:
[3-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
S
--
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
27
PsiBlast_CBE
81.30
100%
-135
- C5 -
1SM2
1
B:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
10
PsiBlast_PDB
81.07
100%
-127
- C5 -
1SNU
1
ITK_HUMAN
A:
[1-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
6
PsiBlast_PDB
80.89
100%
-131
- C5 -
3V5L
1
ITK_HUMAN
A:
[3-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
----
M
--
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
114
HHSearch
80.66
37%
-111
- C5 -
1QCF
1
HCK_HUMAN
A:
[6-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
-
M
-
L
-
G
S
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
D
Y
D
P
--
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
G
--
S
--
K
-
Q
P
-
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
--
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
---
113
HHSearch
80.54
37%
-107
- C5 -
1OPK
3
ABL1_MOUSE
A:
[44-478]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
-
Y
N
H
N
G
E
W
C
E
A
Q
T
-
K
--
N
G
Q
G
W
V
P
S
N
Y
I
T
P
----
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
-
I
-
N
-
G
S
F
L
V
R
E
S
E
S
S
P
-
G
Q
R
S
I
S
L
R
Y
-------
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
I
Y
------------
G
V
-------------------
S
P
--
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y--
S
---
L
----
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
-
C
N
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
---
26
PsiBlast_CBE
80.43
100%
-134
- C5 -
1SNU
1
B:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
---
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
117
HHSearch
80.20
35%
-114
- C5 -
4FL3
1
KSYK_HUMAN
A:
[136-632]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
N
L
Q
G
-
Q
-
A
L
E
Q
A
I
I
S
Q
K
P
Q
L
E
K
L
I
A
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
-
S
K
T
-
N
-
G
K
F
L
I
R
A
R
-
D
N
N
-
G
S
Y
A
L
C
L
L
H
E
-------
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
--
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
---------------------REALPMDTEVFESPFADPE
E
I
--
R
P
K
E
V
Y
L
D
R
K
L
L
T
L
E
-
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
---
M
KK
V
V
---
K
----
T
--
V
A
V
K
I
L
K
N
E
A
N
--
D
---
P
AL
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
-
Q
---
N
---
R
--
H
-
V
K
-
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
--------------
P
V
K
W
Y
A
P
E
C
I
N
Y
--
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
-
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
---
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
--
111
HHSearch
79.83
37%
-106
- C5 -
2H8H
1
SRC_HUMAN
A:
[87-521]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
-
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
----
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
-
E
-
N
P
R
-
G
T
F
L
V
R
E
S
E
T
T
K
-
G
A
Y
C
L
S
V
S
D
F
D
--
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
---
S
K
P
Q
------------
T
Q
-------------------
G
L
--
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
---
T
---
T
----
R
--
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
---
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
-
E
T
G
---
K
--
Y
-
L
R
-
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
--
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
--
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
---
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
---
28
PsiBlast_CBE
79.65
98%
-120
- C5 -
3QGY
1
B:
[23-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
K
E
G
S
M
--
S
---
E
---
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
14
PsiBlast_PDB
79.16
98%
-132
- C5 -
3MJ1
1
A:
[3-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
-------------------
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
29
PsiBlast_CBE
78.82
98%
-128
- C5 -
3QGW
1
B:
[24-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
-
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
---
K
---
D
----
K
--
V
A
I
K
T
I
K
E
G
S
M
--
S
---
E
---
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
-
Q
-
R
---
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
---
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
41
PsiBlast_CBE
78.09
37%
-109
- C5 -
1OPL
2
ABL1_HUMAN
A:
[81-508]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
----
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
S
-
G
-
I
-
N
-
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
-------
Y
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--
K
R
N
K
P
T
------------
V
Y
-------------------
G
V
SP
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
-
R
---
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
39
PsiBlast_CBE
76.85
37%
-107
- C5 -
2FO0
4
ABL1_HUMAN
A:
[37-466]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
----
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
S
-
G
-
I
-
N
-
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
Y
-------
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--
K
R
N
K
P
T
------------
V
Y
-------------------
G
V
SP
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
-
R
---
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
43
PsiBlast_CBE
76.78
37%
-101
- C5 -
2SRC
1
SRC_HUMAN
A:
[3-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
----
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
-
P
-
R
-
G
T
F
L
V
R
E
S
-
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
--
V
K
H
Y
K
I
R
K
L
D
S
G
G
--
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
-
T
V
C
--
P
T
S
K
P
Q
------------
T
Q
-------------------
G
L
--
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
---
T
---
T
----
R
--
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
---
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
-
E
-
T
---
G
--
K
-
Y
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
--
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
--
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
---
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
------------
66
PsiBlast_CBE
76.37
37%
-102
- C5 -
2C0T
1
HCK_HUMAN
A:
[10-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
--------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
45
PsiBlast_CBE
76.11
37%
-101
- C5 -
1KSW
1
SRC_HUMAN
A:
[3-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
----
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
-
P
-
R
-
G
T
F
L
V
R
E
S
-
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
--
V
K
H
Y
K
I
R
K
L
D
S
G
G
--
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
-
T
V
C
--
P
T
S
K
P
Q
------------
T
Q
-------------------
G
L
--
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
---
T
---
T
----
R
--
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
---
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
-
E
-
T
---
G
--
K
-
Y
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
--
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
--
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
---
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
------------
48
PsiBlast_CBE
76.09
37%
-105
- C5 -
3VS6
1
HCK_HUMAN
A:
[10-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
56
PsiBlast_CBE
75.71
37%
-106
- C5 -
3VS2
1
HCK_HUMAN
A:
[10-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
49
PsiBlast_CBE
75.66
37%
-107
- C5 -
3VS5
1
HCK_HUMAN
B:
[10-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
--------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
55
PsiBlast_CBE
75.59
37%
-105
- C5 -
3VS2
1
HCK_HUMAN
B:
[10-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
65
PsiBlast_CBE
75.57
37%
-105
- C5 -
2C0T
1
HCK_HUMAN
B:
[10-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
116
HHSearch
75.20
33%
-120
- C5 -
2OZO
1
ZAP70_HUMAN
A:
[154-598]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
-
A
Q
T
-
D
-
G
K
F
L
L
R
P
R
-
K
E
Q
-
G
T
Y
A
L
S
L
I
Y
-------
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
--
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
-------MDTSVFESPFSD
P
E
-------------------
E
L
--
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
-
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
RK
K
---
Q
---
I
----
D
--
V
A
I
K
V
L
K
Q
G
T
E
KA
D
---
T
---
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
-
G
-
K
-
R
---
E
--
E
-
I
P
-
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
---------------
P
L
K
W
Y
A
P
E
C
I
N
F
--
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
-
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
---
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
---
60
PsiBlast_CBE
74.98
37%
-105
- C5 -
3VS0
1
HCK_HUMAN
A:
[10-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-------
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
47
PsiBlast_CBE
74.82
37%
-103
- C5 -
3VS6
1
HCK_HUMAN
B:
[10-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
50
PsiBlast_CBE
74.77
37%
-106
- C5 -
3VS5
1
HCK_HUMAN
A:
[10-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
44
PsiBlast_CBE
74.63
37%
-103
- C5 -
1Y57
1
SRC_HUMAN
A:
[3-431]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
----
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
-
P
-
R
-
G
T
F
L
V
R
E
S
-
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
--
V
K
H
Y
K
I
R
K
L
D
S
G
G
--
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
-
T
V
C
--
P
T
S
K
P
Q
------------
T
Q
-------------------
G
L
--
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
---
T
---
T
----
R
--
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
---
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
-
E
-
T
---
G
--
K
-
Y
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
--
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
--
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
---
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
------------
73
PsiBlast_CBE
74.58
36%
-99
- C5 -
1AD5
1
HCK_HUMAN
B:
[1-414]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
----
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
-----------------------------------
W
--
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
---
H
---
T
----
K
--
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
---
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
-
D
-
E
---
G
--
S
-
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------
V
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
---
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
---------------
40
PsiBlast_CBE
74.51
37%
-112
- C5 -
1OPL
1
ABL1_HUMAN
B:
[140-508]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
S
-
G
-
I
-
N
-
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
-------
Y
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
-----------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
-
R
---
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
31
PsiBlast_CBE
74.48
58%
-137
- C5 -
3PJ2
1
A:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
---
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
---
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
30
PsiBlast_CBE
74.39
58%
-135
- C5 -
3PJ3
1
A:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
---------------
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
---
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
----------------------
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
18
PsiBlast_PDB
74.30
58%
-128
- C5 -
3PIX
1
A:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
---
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
---
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
--
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
20
PsiBlast_PDB
73.47
58%
-135
- C5 -
3PIZ
1
A:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
-------
S
---
E
---
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
---
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
32
PsiBlast_CBE
73.12
58%
-137
- C5 -
3PJ1
2
A:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
-------
S
---
E
---
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
--------
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
34
PsiBlast_CBE
72.94
57%
-134
- C5 -
3OCT
1
A:
[3-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
--
Q
F
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
K
---
M
--
S
---
E
---
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
---
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
33
PsiBlast_CBE
72.92
57%
-122
- C5 -
3OCS
2
A:
[4-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
---
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
---
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
--
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
N
-
19
PsiBlast_PDB
72.66
58%
-124
- C5 -
3PIY
1
A:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
-----------
E
---
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
---
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
--
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
127
HHSearch
72.49
58%
-127
- C5 -
3GEN
1
A:
[16-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
---
F
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
---
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
---
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
--
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
130
HHSearch
71.87
58%
-122
- C5 -
3SXS
1
A:
[1-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
-
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
---
G
---
Q
---
Y
----
D
--
V
A
V
K
M
I
K
E
G
S
M
--
S
---
E
---
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
-
H
-
G
---
K
--
G
-
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
--
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
--
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
-
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
---
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
74
PsiBlast_CBE
71.87
37%
-113
- C5 -
3BKB
9
A:
[15-372]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
-
G
-
D
-----
F
L
V
R
E
S
-
Q
G
K
-
Q
E
Y
V
L
S
V
L
W
D
G
L
P
-------
R
H
F
I
I
Q
S
L
D
N
----
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
T
-
K
K
S
G
V
V
L
------------
H
R
-------------------
A
V
--
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
-
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
---
A
---
D
----
N
T
L
V
A
V
K
S
C
R
E
T
L
P
--
P
---
D
L
K
-
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
-
E
-
G
---
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
--
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
--
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
---
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
-----
36
PsiBlast_CBE
70.22
59%
-118
- C5 -
3SXR
1
B:
[9-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
T
L
L
-
K
-
E
L
------
V
V
K
L
G
K
W
K
---
G
---
Q
---
Y
----
D
--
V
A
V
K
M
I
K
E
G
S
M
--
S
---
E
---
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
-
H
-
G
---
K
--
G
-
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
--
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
--
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
-
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
---
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
37
PsiBlast_CBE
68.83
59%
-118
- C5 -
3SXR
1
BMX_HUMAN
A:
[9-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
T
L
L
-
K
-
E
L
G
S
----
V
V
K
L
G
K
W
K
---
G
---
Q
---
Y
----
D
--
V
A
V
K
M
I
K
E
G
S
M
--
S
---
E
---
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
-
H
-
G
---
K
--
G
-
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
--
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
--
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
-
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
---
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
17
PsiBlast_PDB
68.70
57%
-131
- C5 -
3K54
1
A:
[16-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
-
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
---
Q
---
Y
----
D
--
V
A
I
K
M
I
K
---------------
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-
M
-
R
---
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
--------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
--
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
-
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
---
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
94
PsiBlast_CBE
66.11
43%
-115
- C5 -
2QOH
1
ABL1_MOUSE
A:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
-----
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
102
Fugue
65.81
44%
-127
- C5 -
1BYG
1
CSK_HUMAN
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
-
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
---
G
--------
N
---
K
--
V
A
V
K
C
I
K
---
N
--
D
---
A
---
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
-
R
-
G
----RS
V
-
L
G
-
G
-
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
------------------
L
-
L
P
V
K
W
T
A
P
E
A
L
R
E
--
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
-
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
---
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
81
PsiBlast_CBE
65.70
43%
-116
- C5 -
2OF4
1
LCK_HUMAN
A:
[7-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
P
R
E
T
L
K
L
V
-
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
---
H
---
T
----
K
--
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
---
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
-
P
-
S
---
G
--
I
K
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
--
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
--
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
---
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
------------
120
HHSearch
65.51
38%
-117
* C5 *
4AOJ
1
NTRK1_HUMAN
A:
[34-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
H
H
I
K
R
R
D
I
V
L
K
-
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
---
N
LLP
K
---
M
----
L
--
V
A
V
K
A
L
K
E
A
S
E
--
S
---
A
R
--
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
-
S
-
H
-
G
PDP
G
--
P
-
L
G
-
L
-
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
-
L
P
I
R
W
M
P
P
E
S
I
L
Y
--
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
-
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
---
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
93
PsiBlast_CBE
65.33
43%
-113
- C5 -
2QOH
1
ABL1_MOUSE
B:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L---
T
--
V
A
V
K
T
L
K
---
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
121
HHSearch
64.94
36%
-120
- C5 -
4I4E
1
A:
[9-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
-
R
-
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
---
S
---
P
----NP
A
L
A
--
V
A
I
K
T
C
K
N
C
T
S
--
D
---
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
-
V
-
R
-
K
---
Y
--
S
-
L
D
-
L
-
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
--
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
---
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
-
88
PsiBlast_CBE
64.91
43%
-116
- C5 -
2Z60
1
ABL1_MOUSE
A:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
-----
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
83
PsiBlast_CBE
64.44
42%
-110
- C5 -
3MPM
2
LCK_HUMAN
A:
[4-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
-
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
---
H
---
T
----
K
--
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
---
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
-
P
-
S
---
G
--
I
K
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
--
R
-----
F
P
I
K
W
T
A
P
E
A
I
N
Y
--
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
---
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
------------
76
PsiBlast_CBE
64.34
43%
-111
- C5 -
2PL0
1
LCK_HUMAN
A:
[17-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
P
R
E
T
L
K
L
V
-
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
---
H
---
T
----
K
--
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
---
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
-
P
-
S
---
G
--
I
K
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
--
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
--
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
---
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
------------
86
PsiBlast_CBE
64.28
43%
-113
- C5 -
3IK3
1
ABL1_MOUSE
B:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
97
PsiBlast_CBE
64.10
43%
-113
- C5 -
3MS9
2
ABL1_MOUSE
A:
[10-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
-----------
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
92
PsiBlast_CBE
64.10
43%
-112
- C5 -
3KF4
1
ABL1_MOUSE
A:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
----------
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
98
PsiBlast_CBE
64.08
43%
-115
- C5 -
3K5V
2
ABL1_MOUSE
B:
[10-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
---
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
96
PsiBlast_CBE
63.95
43%
-113
- C5 -
3MS9
2
ABL1_MOUSE
B:
[10-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
---
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
91
PsiBlast_CBE
63.73
43%
-112
- C5 -
3KF4
1
ABL1_MOUSE
B:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
---
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
95
PsiBlast_CBE
63.70
43%
-108
- C5 -
3QRJ
1
ABL1_HUMAN
B:
[11-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
87
PsiBlast_CBE
63.59
43%
-115
- C5 -
3IK3
1
ABL1_MOUSE
A:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
89
PsiBlast_CBE
63.15
43%
-111
- C5 -
3KFA
1
ABL1_MOUSE
B:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
99
PsiBlast_CBE
63.04
43%
-116
- C5 -
3K5V
2
ABL1_MOUSE
A:
[10-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
D
-
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
79
PsiBlast_CBE
62.98
43%
-117
- C5 -
2OFV
1
LCK_HUMAN
A:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
P
R
E
T
L
K
L
V
-
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
---
H
---
T
----
K
--
V
A
V
K
S
L
K
Q
G
---------------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
-
P
-
S
---
G
--
I
K
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------------
I
K
W
T
A
P
E
A
I
N
Y
--
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
---
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
------------
75
PsiBlast_CBE
62.67
43%
-116
- C5 -
3BYU
1
LCK_HUMAN
A:
[13-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
P
R
E
T
L
K
L
V
-
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
---
H
---
T
----
K
--
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
---
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
-
P
-
S
---
G
--
I
K
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
--
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
---
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
------------
77
PsiBlast_CBE
62.64
43%
-114
- C5 -
3B2W
1
LCK_HUMAN
A:
[13-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
-
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
---
H
---
T
----
K
--
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
---
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
-
P
-
S
---
G
--
I
K
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
----
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
--
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
---
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
------------
90
PsiBlast_CBE
62.61
43%
-112
- C5 -
3KFA
1
ABL1_MOUSE
A:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
85
PsiBlast_CBE
62.37
43%
-110
- C5 -
3OY3
1
ABL1_MOUSE
A:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
122
HHSearch
62.25
39%
-115
- C5 -
4FYO
1
A:
[11-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
-
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
---
M
---
K
K
V
V
K
----
T
--
V
A
V
K
I
L
-----------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
-
Q
---
N
---
R
--
H
-
V
K
-
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
KA----
K
-
W
P
V
K
W
Y
A
P
E
C
I
N
Y
--
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
-
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
---
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
----
84
PsiBlast_CBE
61.92
43%
-111
- C5 -
3OY3
1
ABL1_MOUSE
B:
[5-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L---
T
--
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
78
PsiBlast_CBE
61.69
43%
-121
- C5 -
2OFV
1
?
B:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
P
R
E
T
L
K
L
V
-
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
---
H
---
T
----
K
--
V
A
V
K
S
L
K
Q
G
-------------
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
-
P
-
S
---
G
--
I
K
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
--------------
P
I
K
W
T
A
P
E
A
I
N
Y
--
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
---------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
---
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
------------
100
PsiBlast_CBE
61.59
43%
-110
- C5 -
2HZN
1
ABL1_MOUSE
A:
[10-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
---
E
V
Y
E
G
V
W
K
---
K
---
Y
---
S
L
---
T
--
V
A
V
K
T
L
--
D
T
M
--
E
---
V
---
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-
N
-
R
---
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
A
--
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
--
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
---
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------
80
PsiBlast_CBE
61.33
43%
-111
- C5 -
2OG8
1
?
B:
[2-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
P
R
E
T
L
K
L
V
-
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
---
H
---
T
----
K
--
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
---
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
-
P
-
S
---
G
--
I
K
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-------------------
P
I
K
W
T
A
P
E
A
I
N
Y
--
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
---
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
------------
126
HHSearch
55.96
30%
-110
- C5 -
4ITJ
1
RIPK1_HUMAN
A:
[8-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
I
K
M
K
S
S
D
F
L
E
----------
F
G
K
V
S
L
A
F
H
R
---
T
---
Q
---
G
----
L
--
M
I
M
K
T
V
Y
K
G
P
N
--
C
IEH
N
---
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
-
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
-
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---
E
---
M
--
S
-
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L
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---------
G
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A
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P
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P
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K
F
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P
F
-----
Add PDB User Result:
(33 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
132
-
100%
-134
- C5 -
U132
1
A:
[357-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
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L
T
F
V
Q
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I
G
S
G
Q
-
G
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------------------
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A
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--
133
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100%
-134
- C5 -
U133
1
A:
[357-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
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------------------
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--
134
-
100%
-126
- C5 -
U134
1
A:
[353-608]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
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D
R
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A
F
S
R
L
------------
135
-
100%
-134
- C5 -
U135
1
B:
[358-617]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
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-------------------
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136
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-126
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1
A:
[353-608]
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Y
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---
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------------
137
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-126
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U137
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A:
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U138
1
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[358-617]
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D
R
P
A
F
S
R
L
------------
141
-
100%
-129
- C5 -
U141
1
A:
[357-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
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L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
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------------------
P
V
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R
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L
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Q
L
A
E
I
A
E
S
--
142
-
100%
-132
- C5 -
U142
1
A:
[357-615]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
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L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
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K
D
K
V
A
I
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T
I
-----------
E
E
A
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V
S
D
F
-------------------
P
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Y
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R
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R
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L
L
R
Q
L
A
E
I
-----
143
-
100%
-134
- C5 -
U143
1
A:
[353-619]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
K
W
V
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P
S
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L
T
F
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Q
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I
G
---
F
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L
L
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A
E
I
A
E
S
G
-
144
-
100%
-135
- C5 -
U144
1
A:
[357-619]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
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P
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L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
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-
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V
I
K
V
S
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F
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------------------
P
V
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A
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R
L
L
R
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L
A
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I
A
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S
G
-
145
-
99%
-118
- C5 -
U145
1
A:
[175-603]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
A
L
Y
D
Y
Q
T
N
D
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L
A
L
R
R
N
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W
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N
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--
N
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-------
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----
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F
G
M
T
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F
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-------------
P
V
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A
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F
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F
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R
Y
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A
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H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
-----------------
146
-
100%
-131
- C5 -
U146
1
A:
[357-616]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
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L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
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A
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----
M
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M
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----------------
P
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D
R
P
A
F
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R
L
L
R
Q
L
A
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I
A
----
147
-
99%
-119
- C5 -
U147
1
A:
[175-603]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
A
L
Y
D
Y
Q
T
N
D
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L
A
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R
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Y
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--
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--
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----
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N
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V
I
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V
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D
F
G
M
T
R
F
V
------------
F
P
V
K
W
A
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F
S
F
S
R
Y
S
S
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W
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V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
-----------------
148
-
100%
-129
- C5 -
U148
1
A:
[357-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
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L
T
F
V
Q
E
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G
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G
Q
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G
L
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V
I
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V
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D
F
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------------------
P
V
K
W
A
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F
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F
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A
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R
L
L
R
Q
L
A
E
I
A
E
S
--
149
-
100%
-132
- C5 -
U149
1
B:
[357-619]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
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A
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---
A
M
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F
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----------------
P
V
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A
F
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R
L
L
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A
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I
A
E
S
G
-
150
-
99%
-118
- C5 -
U150
1
A:
[175-603]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
A
L
Y
D
Y
Q
T
N
D
P
Q
E
L
A
L
R
R
N
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E
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C
L
L
D
S
S
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-
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-------
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----
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-------------
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Y
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N
H
C
W
K
E
R
P
E
D
R
P
-----------------
151
-
100%
-127
- C5 -
U151
1
B:
[233-608]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
E
T
Y
E
W
Y
N
K
S
I
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R
D
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A
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-
L
L
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-------
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--
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Y
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C
--------------
G
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H
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W
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D
R
P
A
F
S
R
L
------------
152
-
99%
-116
- C5 -
U152
1
A:
[175-603]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
A
L
Y
D
Y
Q
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N
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--
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H
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--------
Y
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----
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-------------
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Y
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N
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C
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K
E
R
P
E
D
R
P
-----------------
153
-
99%
-118
- C5 -
U153
1
A:
[175-603]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
A
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Y
D
Y
Q
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N
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--
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-------
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----
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-------------
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Y
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N
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C
W
K
E
R
P
E
D
R
P
-----------------
154
-
100%
-134
- C5 -
U154
1
A:
[353-619]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
K
W
V
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D
P
S
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L
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Q
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I
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---
F
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A
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A
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G
-
155
-
100%
-128
- C5 -
U155
1
B:
[353-608]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
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L
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F
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---
A
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H
C
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D
R
P
A
F
S
R
L
------------
156
-
100%
-125
- C5 -
U156
1
A:
[355-608]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
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V
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---------------
K
F
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F
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Y
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S
K
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H
C
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D
R
P
A
F
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R
L
------------
157
-
100%
-128
- C5 -
U157
1
B:
[353-608]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
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---
A
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H
C
W
K
E
R
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D
R
P
A
F
S
R
L
------------
158
-
100%
-145
- C5 -
U158
1
A:
[352-617]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
G
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W
V
I
D
P
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E
L
T
F
V
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E
I
G
S
G
---
L
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L
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Y
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I
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E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
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N
R
S
N
S
E
V
V
E
D
I
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T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
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N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
159
-
99%
-116
- C5 -
U159
1
A:
[175-603]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
A
L
Y
D
Y
Q
T
N
D
P
Q
E
L
A
L
R
R
N
E
E
Y
C
L
L
D
S
S
E
-
H
W
W
R
V
Q
D
R
N
G
H
E
G
Y
V
P
S
S
Y
L
V
E
K
--
N
N
L
E
T
Y
E
W
Y
N
K
S
I
S
R
D
K
A
E
K
L
L
L
D
T
G
K
E
G
A
F
M
V
R
D
S
R
T
A
G
T
Y
T
V
S
V
--
K
A
V
V
S
E
N
N
P
C
I
K
H
Y
H
I
K
--------
Y
Y
V
A
E
K
Y
V
F
D
S
I
P
L
L
I
N
Y
H
Q
H
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G
G
G
L
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R
L
R
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V
C
F
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R
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K
A
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----
L
R
Y
G
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W
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L
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F
V
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G
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F
G
L
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H
L
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Y
W
L
N
K
D
K
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A
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K
T
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R
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A
M
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E
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D
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V
M
M
K
L
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K
L
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L
Y
G
V
C
L
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P
-
I
C
L
V
F
E
F
M
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H
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C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
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G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
-------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
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V
L
M
W
E
V
F
S
E
G
K
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P
Y
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N
R
S
N
S
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V
V
E
D
I
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T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
-----------------
160
-
100%
-130
- C5 -
U160
1
A:
[356-618]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
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L
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W
L
N
K
D
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T
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M
M
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L
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L
M
W
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F
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S
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V
V
E
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G
F
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L
Y
K
P
R
L
A
S
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H
V
Y
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N
H
C
W
K
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R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
161
-
100%
-145
- C5 -
U161
1
A:
[352-617]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
G
K
W
V
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
N
K
D
K
V
A
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K
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A
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C
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L
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C
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M
A
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A
A
R
N
C
L
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N
Q
V
I
K
V
S
D
F
------------------
F
P
V
K
W
A
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P
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V
F
S
F
S
R
Y
S
S
K
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D
V
W
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V
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W
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N
R
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N
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V
V
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D
I
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F
R
L
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K
P
R
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A
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C
W
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R
P
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D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
162
-
99%
-116
- C5 -
U162
1
A:
[175-603]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
A
L
Y
D
Y
Q
T
N
D
P
Q
E
L
A
L
R
R
N
E
E
Y
C
L
L
D
S
S
E
-
H
W
W
R
V
Q
D
R
N
G
H
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G
Y
V
P
S
S
Y
L
V
E
K
--
N
N
L
E
T
Y
E
W
Y
N
K
S
I
S
R
D
K
A
E
K
L
L
L
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G
K
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A
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V
R
D
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R
T
A
G
T
Y
T
V
S
V
--
K
A
V
V
S
E
N
N
P
C
I
K
H
Y
H
I
K
--------
Y
Y
V
A
E
K
Y
V
F
D
S
I
P
L
L
I
N
Y
H
Q
H
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G
G
G
L
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R
L
R
Y
P
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C
F
G
R
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K
A
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----
L
R
Y
G
K
W
V
I
D
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E
L
T
F
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E
I
G
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G
Q
F
G
L
V
H
L
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Y
W
L
N
K
D
K
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A
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K
T
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R
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G
A
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A
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M
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-
I
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F
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L
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L
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A
A
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L
L
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M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
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R
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L
A
A
R
N
C
L
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E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
-------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
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F
S
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G
K
I
P
Y
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N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
-----------------
163
-
100%
-127
- C5 -
U163
1
B:
[233-608]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
E
T
Y
E
W
Y
N
K
S
I
S
R
D
K
A
E
-
L
L
L
D
T
G
K
E
G
A
F
M
V
R
D
S
R
T
A
G
T
Y
T
V
S
V
F
T
K
A
V
V
-------
K
H
Y
H
I
K
E
T
N
D
N
--
R
Y
Y
V
A
E
K
Y
V
F
D
S
I
P
L
L
I
N
Y
H
Q
H
N
G
G
G
L
V
T
R
L
R
Y
P
V
C
--------------
G
K
W
V
I
D
P
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E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
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Y
W
L
N
K
D
K
V
A
I
K
T
I
R
E
G
A
M
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E
E
D
F
I
E
E
A
E
V
M
M
K
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L
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A
A
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L
L
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C
L
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C
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A
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L
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A
C
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L
A
A
R
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C
L
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E
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V
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L
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D
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Y
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S
T
G
T
K
F
P
V
K
W
A
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P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
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F
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V
L
M
W
E
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F
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G
K
I
P
Y
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N
R
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N
S
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V
V
E
D
I
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T
G
F
R
L
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P
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L
A
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H
V
Y
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N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
------------
164
-
100%
-127
- C5 -
U164
1
B:
[233-608]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
E
T
Y
E
W
Y
N
K
S
I
S
R
D
K
A
E
-
L
L
L
D
T
G
K
E
G
A
F
M
V
R
D
S
R
T
A
G
T
Y
T
V
S
V
F
T
K
A
V
V
-------
K
H
Y
H
I
K
E
T
N
D
N
--
R
Y
Y
V
A
E
K
Y
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F
D
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I
P
L
L
I
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Y
H
Q
H
N
G
G
G
L
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R
L
R
Y
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C
--------------
G
K
W
V
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P
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T
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E
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G
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G
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M
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A
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F
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F
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Y
S
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K
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N
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C
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R
P
A
F
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R
L
------------