@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDKL3_HUMAN: (2015-10-05 )
MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRVIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQEDPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW
Atome Classification :
(102 SA)
.........10........20...-.....30..-......--40.-..-......50........60........70.-----.------......80........90--...---------..--...100.......110.......120.......130.......140.......150.......160.......170.......180.......190....-...200.......210.......----220.......----230.......240....--.....250----....-.--------------....260---........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
M
Y
E
T
L
GKVGEGSYG
T
V
M
K
C
KHK-NT
G
Q
I
V
A
I
K
-
I
F
Y
ER
P
--
E
-
Q
-
S
V
-
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
QK-----K------
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
--
H
Y
C
---------HG--L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
HSNNIIHRDIKPE
N
I
L
VSQSG
I
T
K
L
C
DFG
F
A
RTLAAPG
D
I
Y
T
D
Y
V
A
T
R
WYRAP
E
L
V
L
KDTSYGKP
V
D
I
W
A
L
G
C
M
I
I
E
MAT-GNPYLPSSS
D
L
D
L
L
H
K
I
V
L
K
VGN----L
S
P
H
L
Q
N
I
FS----KSP
I
F
A
G
V
VLP--QVQH--
P
K
N
A
R
K
------KYP
K
-
L
--------------
N
G
L
L
A
D
----
I
V
H
A
C
LQI
D
P
A
DRISSSD
L
L
H
H
E
YFTRDG
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
N
S
LIKPKESS
K
E
N
E
L
R
K
D
ER
K
T
V
Y
T
N
T
L
L
S
S
S
V
L
G
K
E
I
E
KEKKPK
E
I
K
V
R
V
I
K
V
KGGRGDISEP
K
K
K
E
YEGGLGQQDANENVHPMSPDT
K
L
V
T
IEPPNPINPSTNCNGLKENPHCGG
S
V
TMPPINLTNSN
L
M
A
ANLSSNLFHPS
V
R
L
T
E
R
A
K
KRRTSS
Q
S
I
G
Q
VMPNSRQEDPG
P
I
Q
S
Q
M
E
KGIFNERTGHS
D
Q
MANENKRKLNFSRSDRKEFHFPEL
P
V
T
I
QSKDTKG
M
E
V
K
Q
I
K
M
L
K
R
E
SKKTESSKI
P
T
L
L
NVDQN
Q
E
KQEGGDGHCEGKNLKRNRFFFW
110
HHSearch
96.63
99%
-128
- C3 -
3ZDU
3
CDKL3_HUMAN
A:
[2-310]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
-
N
T
G
Q
I
V
A
I
K
-
I
F
Y
------------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
-----
K
------
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
--
H
Y
C
---------
H
G
--
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
N
----
L
S
P
H
L
Q
N
I
F
S
----
K
S
P
I
F
A
G
V
V
L
P
--
Q
V
Q
H
--
P
K
N
A
R
K
------
K
Y
P
K
-
L
--------------
N
G
L
L
A
D
----
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.63
99%
-128
- C3 -
3ZDU
3
CDKL3_HUMAN
A:
[2-310]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
-
N
T
G
Q
I
V
A
I
K
-
I
F
Y
------------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
-----
K
------
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
--
H
Y
C
---------
H
G
--
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
N
----
L
S
P
H
L
Q
N
I
F
S
----
K
S
P
I
F
A
G
V
V
L
P
--
Q
V
Q
H
--
P
K
N
A
R
K
------
K
Y
P
K
-
L
--------------
N
G
L
L
A
D
----
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
83.59
58%
-129
- C3 -
4AAA
7
CDKL2_HUMAN
A:
[24-325]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
-
D
T
G
R
I
V
A
I
K
-
K
F
L
E
S
D
--
D
-
D
K
M
V
-
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
-----
K
------
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
--
L
F
P
---------
N
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
----
L
I
P
R
H
Q
E
L
F
N
----
K
N
P
V
F
A
G
V
R
L
P
--
E
I
K
E
--
R
E
P
L
E
R
------
R
Y
P
K
-
L
--------------
S
E
V
V
I
D
----
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.58
57%
-129
- C3 -
4AAA
7
CDKL2_HUMAN
A:
[24-325]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
-
D
T
G
R
I
V
A
I
K
-
K
F
L
E
S
D
--
D
D
K
-
M
V
-
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
-----
K
------
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
--
L
F
P
---------
N
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
----
L
I
P
R
H
Q
E
L
F
N
----
K
N
P
V
F
A
G
V
R
L
P
--
E
I
K
E
--
R
E
P
L
E
R
------
R
Y
P
K
-
L
--------------
S
E
V
V
I
D
----
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.06
57%
-121
- C3 -
4BBM
3
CDKL2_HUMAN
A:
[24-331]
M
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
-
D
T
G
R
I
V
A
I
K
-
K
F
L
E
S
D
--
D
D
K
-
M
V
-
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
-----
K
------
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
--
L
F
P
---------
N
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
----
L
I
P
R
H
Q
E
L
F
N
----
K
N
P
V
F
A
G
V
R
L
P
--
E
I
K
E
--
R
E
P
L
E
R
------
R
Y
P
K
-
L
--------------
S
E
V
V
I
D
----
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
77.37
42%
-127
- C3 -
4BGQ
3
CDKL5_HUMAN
A:
[11-301]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
-
E
T
H
E
I
V
A
I
K
-
K
F
K
----------
V
-
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
-----
G
------
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
--
E
M
P
---------
N
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
----
L
P
S
E
Q
M
K
L
F
Y
----
S
N
P
R
F
H
G
L
R
F
P
--
A
V
N
H
--
P
Q
S
L
E
R
------
R
Y
L
G
I
L
--------------
N
S
V
L
L
D
----
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
76.99
57%
-122
- C3 -
4BBM
3
CDKL2_HUMAN
B:
[24-331]
M
E
K
Y
E
N
L
G
-----
S
Y
G
M
V
M
K
C
R
N
K
-
D
T
G
R
I
V
A
I
K
-
K
F
-------------
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
-----------------
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
--
L
F
P
---------
N
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
----
L
I
P
R
H
Q
E
L
F
N
----
K
N
P
V
F
A
G
V
R
L
P
--
E
I
K
E
--
R
E
P
L
E
R
------
R
Y
P
K
-
L
--------------
S
E
V
V
I
D
----
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.83
42%
-127
- C3 -
4BGQ
3
CDKL5_HUMAN
A:
[11-298]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
-
E
T
H
E
I
V
A
I
K
-
K
F
K
----------
V
-
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
-----
G
------
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
--
E
M
P
---------
N
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
----------
T
R
W
Y
R
S
P
E
L
L
L
-
G
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
----
L
P
S
E
Q
M
K
L
F
Y
----
S
N
P
R
F
H
G
L
R
F
P
--
A
V
N
H
--
P
Q
S
L
E
R
------
R
Y
L
G
I
L
--------------
N
S
V
L
L
D
----
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.65
49%
-118
- C3 -
4AGU
1
CDKL1_HUMAN
C:
[3-288]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
-
D
T
G
Q
I
V
A
I
K
-
K
F
L
E
S
E
--
D
-
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
-----
R
------
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
--
R
Y
Q
---------
R
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
----
L
I
P
R
H
Q
Q
V
F
S
----
T
N
Q
Y
F
S
G
V
K
I
P
--
D
P
E
D
--
M
E
P
L
E
L
------
K
F
P
N
-
I
--------------
S
Y
P
A
L
G
----
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
76.35
48%
-117
- C3 -
4AGU
1
CDKL1_HUMAN
A:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
-
D
T
G
Q
I
V
A
I
K
-
K
F
L
E
S
E
--
D
--
P
V
I
-
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
-----
R
------
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
--
R
Y
Q
---------
R
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
----
L
I
P
R
H
Q
Q
V
F
S
----
T
N
Q
Y
F
S
G
V
K
I
P
--
D
P
E
D
--
M
E
P
L
E
L
------
K
F
P
N
-
I
--------------
S
Y
P
A
L
G
----
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.75
49%
-119
- C3 -
4AGU
1
CDKL1_HUMAN
A:
[3-288]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
-
D
T
G
Q
I
V
A
I
K
-
K
F
L
E
S
E
--
D
---
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
-----
R
------
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
--
R
Y
Q
---------
R
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
----
L
I
P
R
H
Q
Q
V
F
S
----
T
N
Q
Y
F
S
G
V
K
I
P
--
D
P
E
D
--
M
E
P
L
E
L
------
K
F
P
N
-
I
--------------
S
Y
P
A
L
G
----
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
75.54
49%
-121
- C3 -
4AGU
1
CDKL1_HUMAN
B:
[4-288]
--
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
-
D
T
G
Q
I
V
A
I
K
-
K
F
L
E
S
-----
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
-----
R
------
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
--
R
Y
Q
---------
R
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
----
L
I
P
R
H
Q
Q
V
F
S
----
T
N
Q
Y
F
S
G
V
K
I
P
--
D
P
E
D
--
M
E
P
L
E
L
------
K
F
P
N
-
I
--------------
S
Y
P
A
L
G
----
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
68.76
37%
-115
- C3 -
3NIZ
1
?
A:
[20-304]
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
-
D
-
S
Q
G
R
I
V
A
L
K
R
I
R
----------
G
I
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
S
E
-----
R
------
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
--
E
N
K
---------
T
G
--
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
----
P
N
P
R
E
W
P
Q
V
Q
----
E
L
P
L
W
K
Q
R
T
F
---
Q
V
F
E
--
K
K
P
W
S
S
------
I
I
P
G
-
F
--------------
C
Q
E
G
I
D
----
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
67.98
35%
-111
- C3 -
4AU8
2
CDK5_HUMAN
A:
[6-292]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
-
E
T
H
E
I
V
A
L
K
-
R
V
-------------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
--------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
--
S
C
N
---------
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
----
P
T
E
E
Q
W
P
S
M
T
----
K
L
P
D
Y
K
P
--
Y
P
--
M
Y
P
A
--
T
T
S
L
V
N
------
V
V
P
K
-
L
--------------
N
A
T
G
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.53
37%
-110
- C3 -
4Y72
1
?
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
-
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
--
E
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
D
-----
S
------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
--
S
I
P
---------
P
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
P
N
N
E
----------------
V
W
P
--
E
V
E
S
--
L
Q
D
Y
K
N
------
T
F
P
K
-
W
K
P
GSLASHVKNLD
E
N
G
L
--
D
----
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
66.39
36%
-122
- C3 -
3S00
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
65.79
36%
-115
- C3 -
3QRU
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
65.75
36%
-120
- C3 -
3RM7
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
65.61
36%
-119
- C3 -
3RPO
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
65.60
36%
-117
- C3 -
3QTQ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
65.52
36%
-120
- C3 -
3R83
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
65.40
36%
-119
- C3 -
3R8V
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
65.09
36%
-120
- C3 -
3R1S
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.09
34%
-115
- C3 -
4KRC
1
PHO85_YEAST
A:
[7-298]
---
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
K
-
T
T
G
V
Y
V
A
L
K
-
E
V
K
L
D
S
--
E
-
E
-
G
T
-
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
H
T
E
-----
N
------
K
L
T
L
V
F
E
F
M
D
----
N
D
L
K
--
K
Y
M
D
S
R
TP----
R
G
--
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
K
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
----
P
N
E
S
L
W
P
S
V
T
----
K
L
P
K
Y
N
----
P
--
N
I
Q
Q
R
P
P
R
D
L
R
Q
V
L
QPHT
K
E
P
--
L
--------------
D
G
N
L
M
D
----
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
Y
Y
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
65.02
36%
-118
- C3 -
3R7Y
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
64.90
33%
-119
- C3 -
1CM8
1
MK12_HUMAN
A:
[25-314]
-
A
V
Y
R
D
L
Q
P
V
------
A
V
C
S
A
V
D
G
-
R
T
G
A
K
V
A
I
K
-
K
L
Y
R
P
F
Q-
S
-
E
-
L
F
-
A
K
R
A
Y
R
E
L
R
L
L
K
H
M
R
H
E
N
V
I
G
L
L
D
V
F
T
P
D
-----
E
TLDDFT
D
F
Y
L
V
M
P
F
M
G
T
D
L
G
K
L
M
K
--
H
-----------
E
K
--
L
G
E
D
R
I
Q
F
L
V
Y
Q
M
L
K
G
L
R
Y
I
H
A
A
G
I
I
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
Q
A
D
---
S
E
M
T
G
Y
V
V
T
R
W
Y
R
A
P
E
V
I
L
N
W
M
R
Y
T
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
I
T
-
G
K
T
L
F
K
G
S
D
H
L
D
Q
L
K
E
I
M
K
V
T
G
T
----
P
P
A
E
F
V
Q
R
L
Q
S
D
E
A
K
N
-
Y
M
K
--
G
L
P
--
E
L
E
---
K
K
D
F
A
S
------
I
L
T
N
-
A
--------------
S
P
L
A
V
N
----
L
L
E
K
M
L
V
L
D
A
E
Q
R
V
T
A
G
E
A
L
A
H
P
Y
F
E
S
L
H
Q
V
Q
K
Y
D
D
S
R
T
L
D
E
W
K
R
V
T
Y
K
E
V
L
S
F
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
64.90
36%
-120
- C3 -
3R6X
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.82
35%
-113
- C3 -
4EOK
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
--
A
S
A
L--------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
64.81
36%
-122
- C3 -
3QQF
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
64.81
36%
-122
- C3 -
3R8Z
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
----
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
64.73
36%
-122
- C3 -
4EZ3
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
64.72
36%
-119
- C3 -
3R8P
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
64.71
36%
-118
- C3 -
3QX2
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
64.68
36%
-120
- C3 -
3R73
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
64.45
36%
-118
- C3 -
3QQG
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
64.31
36%
-116
- C3 -
3QQK
6
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
64.30
36%
-117
- C3 -
3R1Y
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
64.25
36%
-115
- C3 -
3RPV
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
64.22
36%
-119
- C3 -
3QQL
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
64.16
36%
-120
- C3 -
3R7E
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
64.14
36%
-120
- C3 -
3QTR
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
64.11
36%
-117
- C3 -
3QZH
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.11
36%
-119
- C3 -
3R71
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
64.07
36%
-120
- C3 -
3QXO
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
64.04
36%
-115
- C3 -
3R8U
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
64.03
36%
-117
- C3 -
3RAI
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
63.97
36%
-120
- C3 -
3QZG
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
63.96
36%
-121
- C3 -
3R8L
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
63.93
36%
-121
- C3 -
3QTS
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.93
35%
-113
- C3 -
4EOJ
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
--
A
S
A
L--------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
63.84
36%
-117
- C3 -
3QZI
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
63.69
36%
-119
- C3 -
3QTZ
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
63.69
36%
-116
- C3 -
3R28
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
63.65
36%
-121
- C3 -
3RPR
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
63.45
36%
-118
- C3 -
3RNI
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
63.39
34%
-108
- C3 -
1UA2
1
CDK7_HUMAN
A:
[13-298]
----
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
-
N
T
N
Q
I
V
A
I
K
-
K
I
-------------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
H
K
-----
S
------
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
--
D
N
S
---------
L
V
--
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
----
P
T
E
E
Q
W
P
D
M
C
----
S
L
P
D
Y
--
V
T
F
K
--
S
F
-
P
--
G
I
P
L
H
H
------
I
F
S
A
-
A
--------------
G
D
D
L
L
D
----
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
R
P
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
63.35
36%
-118
- C3 -
3R7V
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
63.33
36%
-114
- C3 -
3RK9
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
63.32
36%
-120
- C3 -
3RJC
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
63.21
36%
-117
- C3 -
3R9H
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
63.19
36%
-114
- C3 -
4GCJ
5
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.18
36%
-111
- C3 -
3PXF
7
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
63.14
36%
-117
- C3 -
3ROY
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.07
35%
-111
- C3 -
4EOI
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
--
A
S
A
L--------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
63.06
36%
-117
- C3 -
3RK5
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
63.03
36%
-120
- C3 -
3R9N
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
62.98
36%
-119
- C3 -
3QQJ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
62.93
36%
-119
- C3 -
3S0O
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
62.87
36%
-118
- C3 -
3QU0
5
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
62.83
36%
-117
- C3 -
3R1Q
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
62.80
36%
-118
- C3 -
3QRT
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
62.76
36%
-117
- C3 -
3QTX
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
62.64
36%
-116
- C3 -
3QXP
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.63
35%
-112
- C3 -
4EOL
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
--
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
--
A
S
-L--------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
62.62
34%
-114
- C3 -
2PMI
2
PHO85_YEAST
A:
[19-298]
---------------
A
T
V
Y
K
G
L
N
K
-
T
T
G
V
Y
V
A
L
K
-
E
V
K
L
D
S
--
E
-
E
-
G
T
-
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
H
T
E
-----
N
------
K
L
T
L
V
F
E
F
M
D
----
N
D
L
K
--
K
Y
M
D
S
R
TVGN
T
P
R
G
--
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
K
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
----
P
N
E
S
L
W
P
S
V
T
----
K
L
P
K
Y
N
----
P
--
N
I
Q
Q
RP
P
R
D
L
R
Q
VLQPHT
K
E
P
--
L
--------------
D
G
N
L
M
D
----
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
Y
Y
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
62.54
30%
-106
- C3 -
4QNY
1
?
A:
[20-314]
-
D
R
Y
L
L
E
R
I
I
G
A
G
S
Y
G
V
V
I
R
A
R
D
T
K
S
D
N
R
L
V
A
M
K
-
R
V
N
K
E
I
F
E
E
-
V
-
I
L
-
A
K
R
I
L
R
E
I
K
L
L
A
H
F
N
D
D
N
I
I
G
L
R
N
I
L
T
P
E
DPENF
D
------
H
F
Y
I
V
M
D
I
M
E
T
D
L
K
Q
V
L
R
--
S
-
G
---------
Q
E
--
L
T
E
A
H
I
Q
F
F
I
Y
Q
A
L
R
A
L
H
I
I
H
S
A
G
V
I
H
R
D
I
T
P
A
N
I
L
V
N
T
N
C
D
L
K
I
C
D
F
G
L
A
K
E
E
---
G
E
Y
M
T
D
Y
V
T
M
R
W
Y
R
A
P
E
L
V
M
E
D
K
D
Y
S
A
Q
I
D
V
W
G
I
G
C
I
L
G
E
L
L
G
-
S
R
P
L
F
Q
G
K
D
R
V
N
Q
L
D
K
I
V
D
V
I
G
T
----
P
S
E
E
D
I
N
S
V
G
----
S
S
A
--
A
Q
K
Y
L
K
K
K
S
H
R
P
--
Q
A
D
W
R
Q
------
R
Y
P
T
-
A
--------------
S
P
E
A
L
D
----
L
L
R
H
M
L
V
F
N
P
K
R
R
I
T
V
L
Q
A
M
R
H
P
F
L
E
Q
L
H
D
D
Y
A
L
F
R
F
D
T
I
V
D
V
K
R
A
I
Y
E
E
S
V
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
62.52
36%
-122
- C3 -
3RAH
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
62.44
36%
-116
- C3 -
3R9D
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
62.35
36%
-119
- C3 -
3QQH
4
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
62.33
36%
-117
- C3 -
3QTU
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
62.31
36%
-123
- C3 -
3R7I
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
62.27
36%
-122
- C3 -
3RAK
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
62.15
36%
-119
- C3 -
3QWK
5
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
62.02
36%
-117
- C3 -
3QWJ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
61.99
36%
-116
- C3 -
3RKB
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
61.92
36%
-121
- C3 -
3S1H
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
61.89
36%
-120
- C3 -
3RZB
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
61.88
36%
-121
- C3 -
3RMF
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
61.82
36%
-108
- C3 -
4EZ7
7
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.71
36%
-117
- C3 -
3SQQ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
------
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
61.70
36%
-123
- C3 -
3R7U
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
61.67
36%
-122
- C3 -
3RPY
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
61.66
36%
-117
- C3 -
3QZF
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
61.52
36%
-115
- C3 -
3RK7
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.33
36%
-120
- C3 -
1OIT
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
-
G
E
V
V
A
L
K
K
I
----------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
61.08
36%
-119
- C3 -
3R8M
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
61.05
36%
-120
- C3 -
3QX4
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
60.88
36%
-111
- C3 -
3QTW
6
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
60.70
36%
-118
- C3 -
3R9O
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
60.39
36%
-112
- C3 -
3PXQ
4
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
60.13
36%
-122
- C3 -
3RAL
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
58.74
36%
-114
- C3 -
3RM6
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
-
L
T
G
E
V
V
A
L
K
K
I
R
------
T
-
E
-
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-----
N
------
K
L
Y
L
V
F
E
F
L
-
H
Q
D
L
K
K
F
M
D
A
S
A
L
---------
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
P
G
V
T
S
M
P
D
----
Y
K
P
S
F
--------------
P
K
W
A
R
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------