@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC1A_HUMAN: (2015-10-10 )
MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGTELSPTLPHQL
Atome Classification :
(63 SA)
.........10........20........30........40........50------...-.....----.-----60.----.-----.......70...-.....80........90........100.......---------------110---------------.----.-------.......120.......130.......140.......150.-..---....160....-...-----170........180.......190----..---.......200.......210.......220.-...-....230.......240.......250.......260.......270.....-.-.280.......-..290-.......-.300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLGAVEGPRWK
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
LGTG
A
F
S
E
V
I
LAEDKRT
Q
K
L
V
A
I
K
C
-------
I
A
K
-
E
ALEG----K-----E-G----S-----ME
N
E
I
A
V
L
HKIK-HP
N
I
V
A
L
D
D
I
Y
ESG
G
H
L
Y
L
I
M
Q
L
VSG
G
E
L
F
D
R
I
V
E
---------------K-----------------G----F-------YTE
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
HRDLKPE
N
L
L
Y
Y
SLD-ED---
S
K
I
M
I
SDFGLS-KME-----D-P
G
S
V
L
S
TACGTPGYV
A
P
E
V
L
------AQ---KPYSKA
V
D
C
W
S
I
G
V
I
A
Y
I
L
LCGYPPFYD-E
N
-
D
A
K
-
L
F
E
Q
I
L
K
A
EYEFDSPYWDD
I
S
D
S
A
K
D
F
I
R
H
L
M
EKDPEKRF
T
C
E
Q
A
LQHPWIA-G-D
T
--
A
L
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
H
M
R
K
L
QLGTSQEGQGQTASHG
E
L
LTPVAGGPA
A
G
C
C
C
R
D
C
CVEPGTELSPTLPHQL
4
PsiBlast_PDB
85.86
100%
-145
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-299]
---------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-------
I
A
K
-
E
-----------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
F
-------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
------------------------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
--
A
L
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
-
A
-----------------------------------------------------------------------
6
PsiBlast_PDB
85.66
84%
-136
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[15-314]
----------
K
Q
A
E
D
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
-------
I
P
K
-
K
A
---------------
S
----
S
-----
I
E
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
F
-------
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
-
E
E
---
S
K
I
M
I
S
---------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
-
G
-
D
T
--
A
L
N
K
N
I
H
-
E
S
V
S
--
A
Q
I
R
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
A
T
------------------------------------------------------------
2
PsiBlast_PDB
85.60
100%
-129
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-314]
---------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-------
I
A
K
-
E
----------------------------
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
F
-------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
-------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
--
A
L
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------
23
PsiBlast_CBE
85.25
84%
-137
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[15-314]
----------
K
Q
A
E
D
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
-------
I
P
K
-
K
A
--------------------
S
-----
I
E
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
F
-------
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
-
E
E
---
S
K
I
M
I
S
---------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
-
G
-
D
T
--
A
L
N
K
N
I
H
-
E
S
V
S
--
A
Q
I
R
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
A
T
------------------------------------------------------------
120
HHSearch
84.20
100%
-147
* C1 *
4FG7
1
KCC1A_HUMAN
A:
[9-277]
--------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-------
I
A
------------------------
S
-----
M
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
F
-------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
G
L
S
-
K
M
E
-----
D
-
P
G
--------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.20
100%
-147
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-277]
--------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-------
I
A
------------------------
S
-----
M
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
F
-------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
G
L
S
-
K
M
E
-----
D
-
P
G
--------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.21
100%
-133
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-314]
-------------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-------
I
A
K
--------------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
F
-------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
-----------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
--
A
L
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------
22
PsiBlast_CBE
81.27
100%
-140
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-299]
-------------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-------
I
A
K
-------------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
F
-------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
---
S
K
I
M
I
S
D
F
G
--------------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
--
A
L
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
-
A
-----------------------------------------------------------------------
121
HHSearch
71.99
71%
-125
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
--------------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
-------
I
K
K
-
S
---------------------
S
-----
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
-----------------
G
----
V
-------
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
---
S
K
I
M
I
T
D
F
G
L
S
-
K
M
E
-----
Q
-
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
-
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
-
G
-
N
T
--
A
L
H
R
D
I
Y
-
P
S
V
S
--
L
Q
I
Q
K
N
F
-
A
K
S
---------------------------------------------------------------------
7
PsiBlast_PDB
71.82
70%
-124
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
--------------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
-------
I
-
K
-
K
S
--------------------
S
-----
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
-----------------
G
----
V
-------
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
---
S
K
I
M
I
T
D
F
G
L
S
-
K
M
E
-----
Q
-
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
-
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
-
G
-
N
T
--
A
L
H
R
D
I
Y
-
P
S
V
S
--
L
Q
I
Q
K
N
F
-
A
K
S
---------------------------------------------------------------------
24
PsiBlast_CBE
71.71
70%
-123
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[4-289]
------------
T
T
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
-------
I
-
K
-
K
S
--------------------
S
-----
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
-----------------
G
----
V
-------
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
---
S
K
I
M
I
T
D
F
G
L
S
-
K
M
E
-----
Q
-
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
-
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
-
G
-
N
T
--
A
L
H
R
D
I
Y
-
P
S
V
S
--
L
Q
I
Q
K
N
F
-
A
K
----------------------------------------------------------------------
138
HHSearch
64.49
35%
-126
- C1 -
3HKO
2
?
A:
[21-336]
------------
L
L
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
-------
M
N
K
-
N
K
I
R
Q
K---
D
-----
V
-
E
----
R
-----
I
K
T
E
V
R
L
M
K
K
L
H
-
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
K
T
QICPC
P
E
C
N
E
E
A
I
N
G
SI-----
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
-
T
N
-
K
S
---
F
E
I
K
L
V
D
F
G
L
S
-
K
E
F
YKLNN
G
---------
A
G
T
P
Y
F
V
A
P
E
V
L
------
N
T
TN-
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
-
V
N
-
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
-
Q
-
F
S
--
D
K
I
Y
K
M
S
---------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.98
41%
-112
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[2-293]
---------------
M
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
A
----
R
-----
D
-
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
-----------------
E
----
Y
-------
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
-
Q
-
R
S
--
T
V
A
S
M
M
H
R
Q
E
T
V
--
E
C
L
K
K
F
N
-
A
R
R
K
L
K
------------------------------------------------------------------
96
PsiBlast_CBE
62.51
37%
-111
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[6-302]
-----------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
-------
I
K
K
R
Q
S
R
A
S
----
R
-----
R
-
G
VC
R
E
E
-----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
-----------------
E
----
S
-------
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
-----
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
T
--
Q
Q
A
M
V
R
R
-
E
S
V
V
N
L
E
N
F
K
K
Q
Y
-
V
-----------------------------------------------------------------------
15
PsiBlast_PDB
62.32
41%
-122
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[2-301]
---------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
A
----
R
-----
D
H
Q
----
K
-----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
-----------------
E
----
Y
-------
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
-
Q
-
R
------
S
M
M
H
R
Q
E
T
V
--
D
C
L
K
K
F
N
-
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
---------------------------------------------------
124
HHSearch
61.53
35%
-111
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-317]
-------------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
-------
V
D
V
-
A
K
F
T
S
SPGL
S
-----
T
-
E
----
D
-----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
---------------
R
-----------------
A
D
A
G
F
V
-------
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
---
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
-----
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
--
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
-
E
-
R
D
--
R
Y
A
Y
K
I
H
L
P
E
T
V
--
E
Q
L
R
K
F
N
-
A
R
R
K
--------------------------------------------------------------------
97
PsiBlast_CBE
61.33
37%
-113
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[6-302]
-----------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
-------
I
K
K
R
Q
S
R
A
S
----
R
-----
R
-
G
VC
R
E
E
-----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---------------
K
-----------------
E
----
S
-------
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
-----
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
T
--
Q
Q
A
M
V
R
R
-
E
S
V
V
N
L
E
N
F
K
K
Q
Y
-
V
-----------------------------------------------------------------------
12
PsiBlast_PDB
60.40
41%
-109
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[31-321]
-----------------
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
A
----
R
-----
D
-
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
-----------------
E
----
Y
-------
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
-
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
-
Q
-
R
S
--
T
V
A
S
M
M
H
R
Q
E
T
V
--
E
C
L
R
K
F
N
-
A
R
R
K
L
K
G
-----------------------------------------------------------------
29
PsiBlast_CBE
60.08
41%
-112
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-293]
---------------
M
T
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
A
----
R
-----
D
-
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
-----------------
E
----
Y
-------
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
K
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
-
Q
-
R
S
--
T
V
A
S
M
M
H
R
Q
E
T
V
--
E
C
L
K
K
F
N
-
A
R
R
K
L
K
------------------------------------------------------------------
17
PsiBlast_PDB
58.79
41%
-106
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[2-301]
---------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
A
----
R
-----
D
-
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
-----------------
E
----
Y
-------
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
-
Q
-
R
S
--
T
V
A
S
M
M
H
R
Q
E
T
V
--
D
C
L
K
K
F
N
-
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------
26
PsiBlast_CBE
58.20
41%
-105
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[2-301]
---------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
A
----
R
-----
D
-
H
----
Q
K----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---------------
R
-----------------
E
----
Y
-------
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-----
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
-
Q
-
R
S
--
T
V
A
S
M
M
H
R
Q
E
T
V
--
D
C
L
K
K
F
N
-
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------
127
HHSearch
56.15
41%
-121
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[5-279]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
S
----
S
RRGVS
R
-
E
----
D
-----
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
E
----
S
-------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
---
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-----
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-
P
-
K
D
--
T
Q
Q
A
L
S
R
-
K
A
S
A
--
V
N
M
E
K
F
K
-
K
F
A
A
R
-------------------------------------------------------------------
100
PsiBlast_CBE
54.51
38%
-109
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[5-302]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
S
----
S
-----
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
E
----
S
-------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-----
D
-
F
G
N
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
Q
Q
A
L
S
R
K
A
S
-
A
V
N
M
--
E
K
F
K
K
F
A
-
A
R
----------------------------------------------------------------------
102
PsiBlast_CBE
52.59
40%
-119
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[82-363]
-----
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
MEVTAER
L
S
P
-
E
Q
L
E
E
----
V
-----
R
-
E
----
A
-----
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
---------------
K
-----------------
V
----
A
-------
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
-
D
N
---
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
-----
E
-
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
---
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
R
-
Q
I
L
-
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-
R
---------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
51.64
41%
-123
- C1 -
4BDC
2
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------
63
PsiBlast_CBE
51.54
43%
-119
- C1 -
2WEI
1
?
A:
[24-280]
-------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
-------
I
N
K
-
A
S
A
K
N
----
K
-----
D
-
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
---------------
R
-----------------
K
----
R
-------
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
---
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
-----
Q
-
Q
N
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
-
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
-
K
-
Y
S
--
S
E
--------------------------------------------------------------------------------------------
31
PsiBlast_CBE
51.50
41%
-120
- C1 -
4BDK
4
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------A
L
--
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
------------------------------------------------------------------
134
HHSearch
51.35
47%
-123
- C1 -
2W4O
1
KCC4_HUMAN
A:
[49-342]
-------------
D
A
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
-------
L
K
K
---------------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
Y
-------
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
---
A
P
L
K
I
A
D
F
-----------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
G
---
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
R
-
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
-
G
-
K
A
--
A
N
F
V
H
-
M
-
D
T
A
Q
--
K
K
L
Q
E
F
N
-
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
--------------------------------------------------------
33
PsiBlast_CBE
51.21
41%
-118
- C1 -
4BDI
6
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------A
L
--
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
Q
P
----------------------------------------------------------------
103
PsiBlast_CBE
51.20
40%
-121
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-363]
-----
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
EVTA
E
R
L
S
P
-
E
Q
L
E
E
----
V
-----
R
-
E
----
A
-----
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
---------------
K
-----------------
V
----
A
-------
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
-
D
N
---
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
-----
E
-
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
---
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
R
-
Q
I
L
-
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-
R
---------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
51.20
41%
-120
- C1 -
2YIT
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------L---
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
---------------------------------------------------------------------
92
PsiBlast_CBE
51.09
42%
-118
- C1 -
3MA6
1
?
A:
[32-295]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
Q
----
K
TD---
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
-----------------
K
----
R
-------
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
--
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-
T
-
Y
T
--
K
---------------------------------------------------------------------------------------------
35
PsiBlast_CBE
50.89
41%
-119
- C1 -
4BDG
2
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------
57
PsiBlast_CBE
50.82
41%
-119
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
---------------------------------------------------------------------
108
PsiBlast_CBE
50.71
38%
-105
- C1 -
4UV0
1
?
A:
[7-304]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
S
----
S
-----
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
E
----
S
-------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-----
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
Q
Q
A
L
S
R
K
A
C
-
A
V
N
M
--
E
K
F
K
K
F
A
-
A
R
----------------------------------------------------------------------
45
PsiBlast_CBE
50.70
41%
-120
- C1 -
4A9R
2
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
------------------------------------------------------------------
20
PsiBlast_PDB
50.23
41%
-118
- C1 -
2YCR
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
K
P
Q
---------------------------------------------------------------------
44
PsiBlast_CBE
50.01
41%
-122
- C1 -
4A9S
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
------------------------------------------------------------------
58
PsiBlast_CBE
50.00
41%
-120
- C1 -
2W0J
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
T
A
L
-
P
Q
----------------------------------------------------------------------
8
PsiBlast_PDB
49.88
47%
-118
- C1 -
2W4O
1
KCC4_HUMAN
A:
[51-343]
---------------
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
-------
L
K
K
---------------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
---------------
K
-----------------
G
----
Y
-------
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
---
A
P
L
K
I
A
D
F
-----------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
G
---
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
R
G
D
Q
F
-
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
-
G
-
K
A
--
A
--
N
F
V
H
-
M
D
T
A
--
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
--------------------------------------------------------
49
PsiBlast_CBE
49.78
41%
-121
- C1 -
2WTD
4
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------
101
PsiBlast_CBE
49.72
40%
-115
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[82-363]
-----
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
MEVR---
L
S
P
-
E
Q
L
E
E
----
V
-----
R
-
E
----
A
-----
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
---------------
K
-----------------
V
----
A
-------
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
-
D
N
---
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
-----
E
-
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
---
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
R
-
Q
I
L
-
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-
R
---------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
49.60
40%
-119
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[7-277]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
S
----
S
-----
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
-----------------
E
----
S
-------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-----
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-
P
-
K
D
--
T
Q
Q
A
L
S
R
-
K
A
S
A
--
V
N
M
E
K
F
K
-
K
F
A
A
A
K
------------------------------------------------------------------
54
PsiBlast_CBE
49.56
41%
-119
- C1 -
2YIR
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------L---
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
----------------------------------------------------------------------
34
PsiBlast_CBE
49.15
41%
-126
- C1 -
4BDH
4
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
------------------------------------------------------------------
42
PsiBlast_CBE
48.93
41%
-121
- C1 -
4A9U
10
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------DP
A
L
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
------------------------------------------------------------------
38
PsiBlast_CBE
48.84
41%
-125
- C1 -
4BDD
3
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------
40
PsiBlast_CBE
48.59
41%
-123
- C1 -
4BDB
10
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------L---
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
------------------------------------------------------------------
55
PsiBlast_CBE
48.20
41%
-118
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------------
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
---------------------------------------------------------------------
37
PsiBlast_CBE
48.18
41%
-122
- C1 -
4BDE
5
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------A
L
--
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
------------------------------------------------------------------
32
PsiBlast_CBE
48.12
41%
-122
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
------------------------------------------------------------------
51
PsiBlast_CBE
47.84
41%
-122
- C1 -
2CN8
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
------
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H----
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
-----------------------------------------------------------------------------
30
PsiBlast_CBE
47.31
41%
-113
- C1 -
2YCF
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
---------------------------------------------------------------------
36
PsiBlast_CBE
47.28
41%
-121
- C1 -
4BDF
3
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------
48
PsiBlast_CBE
47.17
41%
-118
- C1 -
2WTI
3
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------
56
PsiBlast_CBE
47.15
41%
-120
- C1 -
2YCS
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
---------------------------------------------------------------------
52
PsiBlast_CBE
46.87
41%
-118
- C1 -
2CN5
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-
R
---------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
----------------------------------------------------------------------------
43
PsiBlast_CBE
46.79
41%
-111
- C1 -
4A9T
4
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
A
------------------------------------------------------------------
41
PsiBlast_CBE
46.60
41%
-123
- C1 -
4BDA
8
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-----------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------
91
PsiBlast_CBE
46.46
42%
-117
- C1 -
3MA6
1
?
B:
[32-295]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
Q
-----TD---
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
-----------------
K
----
R
-------
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-----
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-
T
-
Y
T
------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
46.18
41%
-120
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------
46
PsiBlast_CBE
46.10
41%
-112
- C1 -
2XM9
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
-----
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------
50
PsiBlast_CBE
44.64
41%
-119
- C1 -
2WTC
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-------------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
-----------------
K
----
R
-------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
L
--------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
-
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
M
K
R
K
F
Q
-
D
L
L
S
--
E
E
N
E
S
T
A
-
L
P
Q
V
L
-------------------------------------------------------------------