@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K6_HUMAN: (2015-10-12 )
MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPVTSGP
Atome Classification :
(79 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650----.......660.......670.......680.----.......-----690.......700--.........710.......720..-.....730--..--...--------------.--------------.740--------.---......750.......760.......770.......780-.--.......790...-....800-..--.....810......-.---820--........830.......840.......850-.......860---..---.-.-...870--------.--.------.......880.......890.......900.......910..----------------.....920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGPCPRS
G
A
E
RAGS
C
W
Q
D
P
L
A
V
A
L
SRGRQLAAPPGRGCARSR
P
L
S
V
V
Y
V
L
TREPQPGLEPREGTEAEP
L
P
L
R
C
L
R
E
A
C
AQVPRPRPPPQLRSLPF
G
T
LELG
D
T
A
A
L
D
A
FYNA
D
V
V
V
L
EV
S
S
SLVQP
S
L
F
Y
H
LGV
R
E
SFSMTN
N
V
L
L
CSQADL
P
D
L
Q
A
L
R
E
D
V
F
QKNSDCVGS
Y
T
L
I
P
Y
V
V
TAT
G
R
V
L
CG
D
A
G
L
L
R
G
L
A
D
G
L
V
QAGV
G
T
E
A
L
L
T
P
L
V
G
R
L
A
R
L
L
EATPTD
S
C
G
Y
F
R
E
T
I
R
R
D
I
R
Q
A
R
E
RFS
G
P
Q
L
R
Q
E
L
A
R
L
Q
R
R
L
D
S
VELL
S
P
D
I
I
M
N
L
L
L
S
Y
R
D
V
Q
D
Y
S
A
I
I
E
L
V
E
T
L
Q
ALPTCD
V
A
E
QH
N
V
C
F
H
Y
T
F
A
LNRRNRP
G
D
R
A
K
A
L
S
V
L
L
P
L
V
QLEGSVA
P
D
L
Y
C
M
C
G
R
I
Y
K
D
M
F
F
SSGFQDAG
H
R
E
Q
A
Y
H
W
Y
R
K
AFDVE
P
S
L
HSG
I
N
A
A
V
L
L
I
AAGQHFED
S
K
E
L
R
L
I
G
M
K
L
G
C
L
L
A
R
K
G
C
V
E
K
M
Q
Y
Y
W
D
V
G
F
Y
L
G
A
Q
I
LANDPT
Q
V
V
L
A
A
E
Q
L
Y
KLNA
P
I
W
Y
L
V
S
V
M
E
T
F
L
L
Y
Q
HFRPTPEPPGGP
P
R
R
A
H
F
W
L
H
F
L
L
QSC
Q
P
F
K
T
A
CAQG
D
Q
C
L
V
L
V
L
EMNKVLLP
A
K
L
E
V
RGTDP
V
S
T
V
T
L
S
LLEP
E
T
QDIPSSWT
F
P
V
A
S
I
CGVSASKRDE
R
C
C
F
L
Y
ALPPAQ
D
V
Q
L
CFPSV
G
H
C
Q
W
F
C
G
L
I
Q
A
W
VTNPDSTAP
A
E
E
AEGAGE
M
L
E
F
DYEYTETG
E
R
L
----
V
LGKG
T
Y
G
V
V
Y
AGRDR
H
T
R
V
R
I
A
I
K
EIP-ER----D
S
R
FSQ
P
-----
L
H
E
E
I
A
L
H
R
R
L
----
R
H
K
N
I
V
R
Y
L
GSASQG
G
Y
L
K
I
F
M
E
E-VPG
G
S
L
S
S
--
L
L
--
R
S
V
--------------W--------------GPLK--------D---NE
S
T
I
S
F
Y
T
R
Q
I
L
Q
G
L
G
Y
LHDN
H
I
V
H
RDIKGD
N
V
L
I
NT--F--SG
L
L
K
ISDFGTSK-RLAGITP-C
T
--
E
TF
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---DQ---GPRGYGKA
A
D
I
W
S
LG
C
T
V
I
EMATGRP
P
F
H
EL-GSP
Q
A
A
M
F
Q
V
---
G
M
---
Y
-
K
-VHPP----------M--P------SS
L
S
A
E
A
Q
A
F
L
LRTFEPDPRL
R
A
S
A
Q
T
LLGDPFLQPGKRSRS----------------PSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPS
P
P
K
R
C
L
SYGGTSQLRVPEEPAAEEPASPEESS
G
L
S
L
L
H
Q
E
S
K
R
R
A
M
L
A
A
V
L
E
Q
E
L
P
A
L
A
E
N
L
H
Q
E
Q
K
Q
E
Q
G
A
RL
G
R
N
H
V
E
E
L
L
R
C
L
G
AHIHTP
N
R
R
Q
L
A
Q
E
L
R
A
L
Q
G
R
L
R
AQGL
G
P
A
L
L
HR
P
L
FA
F
P
D
A
V
K
Q
I
L
R
KRQIR
P
H
W
M
F
V
L
D
S
L
L
S
R
A
V
R
A
A
L
G
VLG
P
E
V
E
K
EAVSP
R
S
E
E
LSNEGDSQQSPGQQSPLPVEPEQGPA
P
L
M
V
Q
L
S
L
L
RA
E
T
D
R
L
R
E
I
LAGK
E
R
E
Y
Q
A
L
V
Q
R
A
L
Q
R
L
N
E
E
A
R
T
Y
V
LAPEPPTALS
T
D
Q
G
L
V
Q
W
L
Q
ELNVDS
G
T
I
Q
M
L
LNHS
F
T
L
H
T
L
L
T
YATRD
D
L
I
Y
T
RIRG
G
M
V
C
R
I
W
R
A
I
L
A
QRAGSTPVTSGP
4
PsiBlast_PDB
87.14
69%
-60
- C1 -
4BIC
2
M3K5_HUMAN
A:
[11-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---------
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.10
75%
-57
- C1 -
2CLQ
1
B:
[14-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
--------
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
-----------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.77
75%
-56
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[14-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
----
D
S
---
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
G
--------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
86.27
69%
-61
- C1 -
4BIC
2
B:
[11-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
--------
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
------------
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.23
69%
-63
- C1 -
4BIE
2
B:
[11-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
----------------
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
-----------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.87
69%
-59
- C1 -
4BF2
1
B:
[28-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
------------------
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
------------
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
85.51
75%
-58
- C1 -
4BF2
2
M3K5_HUMAN
A:
[28-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
-------------------
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
---------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
85.39
69%
-60
- C1 -
4BIB
1
B:
[11-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
--------
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.16
69%
-61
- C1 -
4BID
1
M3K5_HUMAN
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
-----------------
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.68
69%
-58
- C1 -
4BID
1
B:
[11-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
--------
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
83.62
69%
-59
- C1 -
4BHN
2
B:
[27-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
--------
S
Q
P
-----
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
-----------
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.31
69%
-58
- C1 -
4BIE
2
M3K5_HUMAN
A:
[11-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
-----------------
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.27
69%
-58
- C1 -
4BF2
2
M3K5_HUMAN
A:
[28-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
-------------------
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
L
A
---------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.59
69%
-58
- C1 -
4BIB
3
M3K5_HUMAN
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
----
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
-----------------
L
H
E
E
I
A
L
H
K
H
L
----
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
-
V
P
G
G
S
L
S
A
--
L
L
--
R
S
K
--------------
W
--------------
G
P
L
K
--------
D
---
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
--
Y
--
S
G
V
L
K
I
S
D
F
G
T
S
K
-
R
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
-
I
---
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
-
G
E
P
Q
A
A
M
F
K
V
---
G
M
---
F
-
K
-
V
H
P
E
----------
I
--
P
------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
61.23
34%
-53
- C1 -
4B6L
1
PLK3_HUMAN
A:
[16-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
-
Q
------
S
R
V
A
K
P
H
Q
R
E
K
I
L
N
E
I
E
L
H
R
D
L
----
Q
H
R
H
I
V
R
F
S
H
H
F
E
D
A
D
N
I
Y
I
F
L
E
L
-
C
S
R
K
S
L
A
H
--
I
W
--
K
A
R
--------------
H
--------------
T
L
L
--------------
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
-
T
--
E
--
N
M
E
L
K
V
G
D
F
G
L
A
A
-
R
L
E
P
P
E
Q
-
R
K
--
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
-
L
---
L
R
-----
Q
G
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
E
T
A
-
D
L
K
E
T
Y
R
------
C
I
---
K
-
Q
-
V
H
Y
T
----------
L
--
P
------
A
S
L
S
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
----------------
L
P
I
S
S
C
V
T
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
60.88
34%
-57
- C1 -
5AJQ
2
STK10_HUMAN
A:
[24-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--------
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
-
C
P
G
G
A
V
D
A
--
I
M
--
L
E
L
--------------
D
--------------
R
G
L
-------------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
--
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
-
K
N
L
K
T
---------
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
MCE
T
M
---
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
D
P
P
TLL-------
T
--
P
------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----------------
L
R
E
L
V
A
E
A
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
60.53
32%
-53
- C1 -
4I5P
1
PLK2_HUMAN
A:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
-
H
------
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
----
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
-
C
S
R
R
S
M
A
H
--
I
L
K
A
R
K
V
--------------
L
------------------------------
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
-----
S
M
E
L
K
V
G
D
F
G
L
A
A
-
R
L
E
P
L
E
H
-
R
R
--
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
-
L
---
N
K
-----
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
-
N
L
K
E
T
Y
R
------
S
I
---
R
-
E
-
A
R
Y
T
----------
M
--
P
------
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
----------------
L
S
S
S
C
C
H
T
V
P
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
59.85
35%
-50
* C1 *
3FXZ
1
?
A:
[27-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
-
L
Q
----
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
------------------------------
C
M
D
-------------
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-----
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
E
Q
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
---
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
--
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
G
T
-
P
E
L
Q
----------
N
--
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
59.43
34%
-49
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[29-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-
L
Q
----
Q
-
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
E
Q
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
59.31
32%
-55
- C1 -
4I6H
1
PLK2_HUMAN
A:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
-
H
------
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
----
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
-
C
S
R
R
S
M
A
H
--
I
L
K
A
R
K
V
--------------
L
------------------------------
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
-----
S
M
E
L
K
V
G
D
F
G
L
A
A
-
R
L
E
P
L
E
H
-
R
R
--
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
-
L
---
N
K
-----
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
-
N
L
K
E
T
Y
R
------
S
I
---
R
-
E
-
A
R
Y
T
----------
M
--
P
------
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
----------------
L
S
S
S
C
C
H
T
V
P
D
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
58.53
34%
-48
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[29-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-
L
Q
----
Q
-
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
E
Q
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
58.20
34%
-45
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[29-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----------
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
E
Q
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
58.11
32%
-53
- C1 -
4I6B
1
PLK2_HUMAN
A:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
-
H
------
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
----
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
-
C
S
R
R
S
M
A
H
--
I
L
K
A
R
K
V
--------------
L
------------------------------
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
-----
S
M
E
L
K
V
G
D
F
G
L
A
A
-
R
L
E
P
L
E
H
-
R
R
--
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
-
L
---
N
K
-----
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
-
N
L
K
E
T
Y
R
------
S
I
---
R
-
E
-
A
R
Y
T
----------
M
--
P
------
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
----------------
L
S
S
S
C
C
H
T
V
P
D
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
57.88
32%
-53
- C1 -
4I5M
1
PLK2_HUMAN
A:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
-
H
------
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
----
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
-
C
S
R
R
S
M
A
H
--
I
L
K
A
R
K
V
--------------
L
------------------------------
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
-----
S
M
E
L
K
V
G
D
F
G
L
A
A
-
R
L
E
--------------
T
P
N
Y
L
S
P
E
V
-
L
---
N
K
-----
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
-
N
L
K
E
T
Y
R
------
S
I
---
R
-
E
-
A
R
Y
T
----------
M
--
P
------
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
----------------
L
S
S
S
C
C
H
T
V
P
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.84
34%
-45
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-
L
Q
--------
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
57.67
33%
-43
- C1 -
4O0R
1
PAK1_HUMAN
A:
[28-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-
L
Q
----
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
E
Q
S
-
K
R
--
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.62
34%
-46
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-
L
---------
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
57.12
33%
-47
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[29-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
-
L
---------
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
E
Q
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
57.05
34%
-47
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-
L
Q
---------
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
57.03
34%
-44
- C1 -
4ZY5
1
PAK1_HUMAN
A:
[29-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
----------
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
E
Q
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.43
38%
-44
- C1 -
2XIK
2
STK25_HUMAN
A:
[27-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
----
A
E
-
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
----
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
-
L
G
G
G
S
A
L
D
--
L
L
--
K
P
------------------------------
G
P
L
E
-------------
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-----
Q
G
D
V
K
L
A
D
F
G
V
A
G
-
Q
L
T
D
T
Q
I
-
K
R
--
N
T
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
K
Q
---
S
--
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
--
H
P
M
R
V
L
F
L
I
---
P
------
K
-
N
S
P
P
T
---------
L
--
E
------
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
----------------
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
56.28
34%
-50
- C1 -
4USF
1
?
B:
[24-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
----
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
----
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
-
C
A
G
G
A
V
D
A
--
V
M
--
L
E
L
--------------
E
--------------
R
P
L
-------------
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
--
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
-
K
N
------------
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
MCE
T
S
---
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
E
P
P
TLA-------
Q
--
P
------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
----------------
R
E
L
I
A
E
A
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
55.85
35%
-38
- C1 -
4KS7
2
A:
[31-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
-
L
R
----
K
Q
Q
R
R
E
L
-----
L
F
N
E
V
V
I
M
R
D
Y
----
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
E
E
L
W
V
L
M
E
F
-
L
Q
G
G
A
L
T
D
--
I
V
--
S
Q
V
--------------------------------
R
--------
L
---
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
--
L
--
D
G
R
V
K
L
S
D
F
G
F
C
A
-
Q
I
S
K
D
V
P
-
K
R
--
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
-
I
---
S
R
---
S
L
--
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
--
D
S
P
V
Q
A
M
K
R
L
----------
R
-
D
S
P
P
P
K
LK------
N
--
S
------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
E
C
----------------
L
V
P
L
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
55.80
34%
-50
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[29-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-
L
Q
----
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
---------
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.79
34%
-55
- C1 -
4USF
1
?
A:
[24-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
----
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
----
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
-
C
A
G
G
A
V
D
A
--
V
M
--
L
E
L
--------------
E
--------------
R
P
L
-------------
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
--
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
-
K
----------------
T
P
Y
W
M
A
P
E
V
-
V
M
C
E-------
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
E
P
P
TLA-------
Q
--
P
------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
----------------
R
E
L
I
A
E
A
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
54.79
35%
-41
- C1 -
3GGF
1
STK26_HUMAN
A:
[31-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
----
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
----
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
-
L
G
G
G
S
A
L
D
--
L
L
--
R
A
------------------------------
G
P
F
-------------
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-----
Q
G
D
V
K
L
A
D
F
G
V
A
-----------
R
--
N
T
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
Q
Q
---
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
--
H
P
M
R
V
L
F
L
I
---
P
------
K
-
N
N
P
P
T
---------
L
--
V
------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
----------------
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
54.73
34%
-47
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-
L
---------
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
54.68
31%
-41
- C1 -
2YIT
1
CHK2_HUMAN
A:
[18-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
-
K
------------LN---
V
E
T
E
I
E
I
L
K
K
L
----
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
-
M
E
G
G
E
L
-----
F
--
D
K
V
--------------
V
--------------
G
N
K
R
--------
L
---
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QE
E
--
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
-
G
E
T
S
-
L
M
--
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
---
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
---
Y
-
N
-
F
I
P
E
----------
V
--
W
------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
LPQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
54.50
35%
-41
- C1 -
3GGF
1
STK26_HUMAN
B:
[31-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
----
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
----
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
-
L
G
G
G
S
A
L
D
--
L
L
--
R
A
------------------------------
G
P
F
-------------
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-----
Q
G
D
V
K
L
A
D
F
G
V
A
--------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
Q
Q
---
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
--
H
P
M
R
V
L
F
L
I
---
P
------
K
-
N
N
P
P
T
---------
L
--
V
------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
----------------
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
54.49
31%
-53
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[23-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
----
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-------------
S
-----
M
E
N
E
I
A
V
L
H
K
I
----
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
-
V
S
G
G
E
L
F
D
--
R
I
--
V
E
K
--------------
G
--------------
F
-----------
Y
---
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
LD
E
--
D
S
K
I
M
I
S
D
F
G
L
S
K
--
M
E
D
P
G
-----------
T
P
G
Y
V
A
P
E
V
-
L
---
A
Q
---
K
----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
---
A
E
---
Y
-
E
-
F
D
S
P
----------
Y
--
W
------
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
54.20
34%
-58
- C1 -
4USD
1
?
B:
[27-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
----
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
-
C
P
G
G
A
V
D
A
--
I
M
--
L
E
L
--------------
D
--------------
R
G
L
-------------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
--
L
--
E
G
D
I
R
L
A
D
F
G
V
-------------------
G
T
P
Y
W
M
A
P
E
V
-
V
MC----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
D
P
P
TLL-------
T
--
P
------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----------------
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
54.18
34%
-45
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[29-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
----------
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
E
Q
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
54.07
35%
-42
- C1 -
4KS8
1
A:
[31-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
-
L
R
----
K
Q
Q
R
R
E
L
-----
L
F
N
E
V
V
I
M
R
D
Y
----
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
E
E
L
W
V
L
M
E
F
-
L
Q
G
G
A
L
T
D
--
I
V
--
S
Q
V
--------------------------------
R
--------
L
---
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
--
L
--
D
G
R
V
K
L
S
D
F
G
F
C
A
-
Q
I
S
K
D
V
P
-
K
R
--
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
-
I
---
S
R
---
S
L
--
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
--
D
S
P
V
Q
A
M
K
R
L
----------
R
-
D
S
P
P
PKLK------
N
--
S
------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
E
C
----------------
L
V
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
53.89
36%
-43
- C1 -
4O27
1
STK24_HUMAN
B:
[14-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
----
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
----
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
-
L
G
G
G
S
A
L
D
--
L
L
--
E
P
------------------------------
G
P
L
-------------
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-----
H
G
E
V
K
L
A
D
F
G
V
A
G
-
Q
L
T
D
T
Q
I
-
K
R
--
N
E
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
K
Q
---
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
--
H
P
M
K
V
L
F
L
I
---
P
------
K
-
N
N
P
P
T---------
L
--
E
------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
----------------
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
53.51
33%
-39
- C1 -
4O0T
1
PAK1_HUMAN
A:
[28-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-
L
Q
----
Q
Q
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
I
T
P
E
Q
S
-
K
R
--
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
53.39
33%
-41
- C1 -
2F57
1
PAK7_HUMAN
A:
[53-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
-
L
R
----
K
Q
Q
R
R
E
L
-----
L
F
N
E
V
V
I
M
R
D
Y
----
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
-
L
E
G
G
A
L
T
D
--
I
V
--
T
H
T
--------------------------------
R
--------
M
---
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
--
S
--
D
G
R
I
K
L
S
D
F
G
F
C
A
-
Q
V
S
K
E
V
P
-
K
R
--
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
-
I
---
S
R
---
L
P
--
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
-
P
P
L
Q
A
---------
M
---
R
-
R
-
I
R
D
S
----------
L
--
P
PRVKDL
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
L
A
G
P
P
S
C
----------------
I
V
P
L
M
R
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
53.34
31%
-43
- C1 -
2YIR
1
CHK2_HUMAN
A:
[18-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
-
K
------------LN---
V
E
T
E
I
E
I
L
K
K
L
----
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
-
M
E
G
G
E
L
-----
F
--
D
K
V
--------------
V
--------------
G
N
K
R
--------
L
---
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QE
E
--
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
-
G
E
T
S
-
L
M
--
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
---
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
---
Y
-
N
-
F
I
P
E
----------
V
--
W
------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
NESTALP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
53.12
34%
-37
- C1 -
4FZF
1
?
B:
[16-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
----
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
----
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
-
L
G
G
G
S
A
L
D
--
L
L
--
R
A
------------------------------
G
P
F
-------------
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-----
Q
G
D
V
K
L
A
A
F
G
V
A
G
-
Q
L
T
D
T
Q
I
-
K
R
--
N
T
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
Q
Q
---
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
--
H
P
M
R
V
L
F
L
I
---
P
------
K
-
N
N
P
P
T
---------
L
--
V
------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
----------------
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
52.93
34%
-34
- C1 -
4FZA
3
STK26_HUMAN
B:
[16-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
----
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
----
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
-
L
G
G
G
S
A
L
D
--
L
L
--
R
A
------------------------------
G
P
F
-------------
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-----
Q
G
D
V
K
L
A
A
F
G
V
A
G
-
Q
L
T
D
T
Q
I
-
K
R
--
N
T
F
V
G
T
P
F
W
M
A
P
E
V
-
I
---
Q
Q
---
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
--
H
P
M
R
V
L
F
L
I
---
P
------
K
-
N
N
P
P
T
---------
L
--
V
------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
----------------
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
52.71
31%
-35
- C1 -
2YCF
1
CHK2_HUMAN
A:
[18-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
-
K
------------N----
V
E
T
E
I
E
I
L
K
K
L
----
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
-
M
E
G
G
E
L
-----
F
--
D
K
V
--------------
V
--------------
G
N
K
R
--------
L
---
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QE
E
--
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
-
G
E
T
S
-
L
M
--
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
---
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
---
Y
-
N
-
F
I
P
E
----------
V
--
W
------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
NESTALPQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
52.18
31%
-41
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[18-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
-
K
------------N----
V
E
T
E
I
E
I
L
K
K
L
----
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
-
M
E
G
G
E
L
-----
F
--
D
K
V
--------------
V
--------------
G
N
K
R
--------
L
---
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QE
E
--
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
-
G
E
T
S
-
L
M
--
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
---
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
---
Y
-
N
-
F
I
P
E
----------
V
--
W
------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
LPQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
52.17
34%
-44
- C1 -
4AOT
1
STK10_HUMAN
A:
[27-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
----
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
-
C
P
G
G
A
V
D
A
--
I
M
--
L
E
L
--------------
D
--------------
R
G
L
-------------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
--
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
-----------------
G
T
P
Y
W
M
A
P
E
V
-
V
M-----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
D
P
P
TLL-------
T
--
P
------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----------------
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
52.02
38%
-47
- C1 -
4NZW
1
STK25_HUMAN
B:
[28-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
----
A
E
D
E
I
E
D
-----
I
Q
Q
E
I
T
V
L
S
Q
C
----
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
-
L
G
G
G
S
A
L
D
--
L
L
--
K
P
------------------------------
G
P
L
E
-------------
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-----
Q
G
D
V
K
L
A
A
F
G
V
A
G
------------------
T
P
F
W
M
A
P
E
V
-
I
---
K
Q
-------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
--
H
P
M
R
V
L
F
L
I
---
P
------
K
-
N
S
P
P
T---------
L
--
E
------
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
----------------
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
51.56
34%
-44
- C1 -
4AOT
1
STK10_HUMAN
B:
[27-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
----
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
-
C
P
G
G
A
V
D
A
--
I
M
--
L
E
L
--------------
D
--------------
R
G
L
-------------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
--
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
-
K
--------------
I
G
T
P
Y
W
M
A
P
E
V
-
V
M----------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
D
P
P
TLL-------
T
--
P
------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----------------
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
51.22
34%
-44
- C1 -
2JFL
6
SLK_HUMAN
A:
[45-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
----
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
----
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
-
C
A
G
G
A
V
D
A
--
V
M
--
L
E
L
--------------
E
--------------
R
P
L
-------------
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
--
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
-
K
N
T
R
T
I
Q
-
R
R
--
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
MCE
T
S
---
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
E
P
P
TLA-------
Q
--
P
------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
----------------
R
E
L
I
A
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
51.18
34%
-44
- C1 -
2J51
5
SLK_HUMAN
A:
[45-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
----
S
E
E
E
L
E
D
-----
Y
M
V
E
I
D
I
L
A
S
C
----
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
-
C
A
G
G
A
V
D
A
--
V
M
--
L
E
L
--------------
E
--------------
R
P
L
-------------
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
--
L
--
D
G
D
I
K
L
A
D
F
G
V
S
A
-
K
N
T
R
T
I
Q
-
R
R
--
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
M
CE
T
S
---
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
E
P
P
TLA-------
Q
--
P
------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
----------------
R
E
L
I
A
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
51.03
31%
-55
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[23-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
----
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-
K
E
------------------
N
E
I
A
V
L
H
K
I
----
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
-
V
S
G
G
E
L
F
D
--
R
I
--
V
E
K
--------------
G
--------------
F
Y
T
E
--------
R
---
D
A
S
R
L
I
F
---
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
--
L
DE
D
S
K
I
M
I
S
D
F
----------------------
T
P
G
Y
V
A
P
E
V
-
L
---
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---
E
N
D
A
K
L
F
E
Q
---
I
L
K
AE
Y
-
E
-
F
D
S
P
----------
Y
--
W
------
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
----------------
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
50.66
30%
-46
- C1 -
2IWI
1
PIM2_HUMAN
A:
[33-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
G
-----
P
----
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
-
R
N
----
R
V
L
--
V
T
-----
C
P
L
E
V
A
L
L
W
K
V
G
AGG
G
H
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
--
Y
I
--
T
E
K
-----------------------------
G
P
L
G
-------------
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
--
R
--
R
G
C
A
K
L
I
D
F
G
S
G
A
-
L
L
H
D
--
E
-
P
Y
--
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
-
I
---
S
R
---
H
Q
-
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
----
Q
E
I
------------
L
-
E
-
A
E
L
H
----------
F
--
P
------
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
50.41
34%
-37
- C1 -
2J7T
1
STK10_HUMAN
A:
[26-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
-
C
P
G
G
A
V
D
A
--
I
M
--
L
E
L
--------------
D
--------------
R
G
L
T
-------------
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-----
E
G
D
I
R
L
A
D
F
G
V
S
A
-
K
N
L
K
T
L
Q
-
K
------
I
G
T
P
Y
W
M
A
P
E
V
-
V
---
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
-
P
M
R
V
L
L
K
I
---
A
K
---
S
D
P
-
P
T
L
L
----------
T
--
P
------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----------------
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
50.15
30%
-42
- C1 -
3HKO
2
?
A:
[33-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
-
K
N
K
I
R
Q--
K
D
V
E
R
-----
I
K
T
E
V
R
L
M
K
K
L
----
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
-
C
H
G
G
H
L
L
D
--
K
L
--
N
V
F
I
DDSTG
K
C
A
M
D
V
V
K
T
QICPC
P
E
C
N
E
E
A
I
N
G
S
I
-F
R
E
S
L
D
F
V
Q
---
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
--
N
K-
S
F
E
I
K
L
V
D
F
G
L
S
K
-
E
F
Y
K
L
N
N
G-------
A
G
T
P
Y
F
V
A
P
E
V
-
L
---
N
T
---
T
N
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
-
N
D
A
-
D
T
I
S
Q
V
L
N
-
K
K
---
L
-
C
-
F
E
N
P
----------
N
--
Y
------
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
----------------
K
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
49.83
30%
-39
- C1 -
4G3F
1
A:
[49-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Y
E
Y
R
E
E
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
-
L
E
----
V
F
R
----------
V
E
E
L
V
A
C
A
G
L
----
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
-
L
E
G
G
S
L
G
Q
--
L
I
--
K
Q
M
-----------------------------
G
C
L
P
-------------
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
--
D
--
G
S
R
A
A
L
C
D
F
G
H
A
L
-
C
L
----------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
-
V
---
M
G
---
K
--
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
Y
-
F
R
G
P
-
L
C
L
K
I
---
A
S
---
E
-
P
P
P
I
R
E
----------
I
--
P
------
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
G
G
L
----------------
K
S
P
W
K
G
E
Y
K
E
P
R
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
49.58
33%
-37
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[11-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
---------
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
----
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
----
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
-
L
S
G
G
S
V
L
D
--
I
I
--
K
H
I
--------------
V
A
K
------------
G
E
H
K
--------
S
GVL
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-----
D
G
S
V
Q
I
A
D
F
G
V
S
A
-
F
L
A
T
G
G
D
------
T
F
V
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
----
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
L
T
L
----------
Q
-
N
D
P
P
SLETGVQDKE
M
--
L
------
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
49.58
33%
-37
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[16-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
---------
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
----
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
----
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
-
L
S
G
G
S
V
L
D
--
I
I
--
K
H
I
--------------
V
A
K
------------
G
E
H
K
--------
S
GVL
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-----
D
G
S
V
Q
I
A
D
F
G
V
S
A
-
F
L
A
T
G
G
D
----------
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
----
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
L
T
L
----------
Q
-
N
D
P
P
SLETG-----
M
--
L
------
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
49.48
31%
-39
- C1 -
2CN5
1
CHK2_HUMAN
A:
[24-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
-
K
R
-----------N----
V
E
T
E
I
E
I
L
K
K
L
----
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
-
M
E
G
G
E
L
-----
F
--
D
K
V
--------------
V
--------------
G
N
K
R
--------
L
---
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QE
E
--
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
-
G
E
T
S
-
L
M
--
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
---
S
V
---
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
---
Y
-
N
-
F
I
P
E
----------
V
--
W
------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
49.38
34%
-47
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
N
-
L
-------
P
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
--
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
-----
P
E
Q
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
49.15
31%
-55
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[23-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
----
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-
K
-------------------
N
E
I
A
V
L
H
K
I
----
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
-
V
S
G
G
E
L
F
D
--
R
I
--
V
E
K
--------------
G
--------------
F
Y
T
E
--------
R
---
D
A
S
R
L
I
F
---
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
--
L
DE
D
S
K
I
M
I
S
D
F
G
---------
G
S
-
V
L
--
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
-
L
---
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---
E
N
D
A
K
L
F
E
Q
---
I
L
K
AE
Y
-
E
-
F
D
S
P
----------
Y
--
W
------
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
----------------
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
49.09
34%
-46
- C1 -
4ZJI
1
?
D:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
----------
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
-
A
-
Q
I
T
---
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
49.07
34%
-47
- C1 -
4EQU
2
STK10_HUMAN
B:
[27-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
-
C
P
G
G
A
V
D
A
--
I
M
--
L
E
L
--------------
D
--------------
R
G
L
-------------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
--
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
-
K
N
L
-----------
F
I
G
T
P
Y
W
M
A
P
E
V
-
V
M
C
E
T
M
---
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
D
P
P
TLL-------
T
--
P
------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----------------
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
48.88
33%
-39
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[16-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
---------
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
----
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
----
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
-
L
S
G
G
S
V
L
D
--
I
I
--
K
H
I
--------------
V
A
K
------------
G
E
H
K
--------
S
GVL
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-----
D
G
S
V
Q
I
A
D
F
G
V
S
A
-
F
L
A
T
G
G
-------
T
F
V
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
----
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
L
T
L
----------
Q
-
N
D
P
P
SLETGVQDKE
M
--
L
------
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
N
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
47.91
34%
-45
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
-
L
Q
-------
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
--------
E
Q
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
-------
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
47.20
34%
-38
- C1 -
4USE
1
?
A:
[27-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
----
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
-
C
P
G
G
A
V
D
A
--
I
M
--
L
E
L
--------------
D
--------------
R
G
L
-------------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
--
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
-
K
N
L
K
T
L
Q
----------
T
P
Y
W
M
A
P
E
V
-
V
M
C
E
T
M
---
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
D
P
P
TLL-------
T
--
P
------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----------------
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
46.80
34%
-41
- C1 -
4USE
1
?
B:
[27-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----
W
I
M
I
E
F
-
C
P
G
G
A
V
D
A
--
I
M
--
L
E
L
--------------
D
--------------
R
G
L
-------------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
--
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
-
K
N
L
K
T
L
Q
-
K
--------
T
P
Y
W
M
A
P
E
V
-
V
M
C
E
T
M
---
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
D
P
P
TLL-------
T
--
P
------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----------------
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
46.58
33%
-35
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[11-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
---------
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
----
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
----
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
-
L
S
G
G
S
V
L
D
--
I
I
--
K
H
I
--------------
V
A
K
------------
G
E
H
K
--------
S
GVL
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-----
D
G
S
V
Q
I
A
D
F
G
V
S
A
-
F
L
A
T
G
G
---------
V
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
----
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
L
T
L
----------
Q
-
N
D
P
P
SLETGVQDKE
M
--
L
------
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
46.30
33%
-39
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[11-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
---------
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
----
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
----
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
-
L
S
G
G
S
V
L
D
--
I
I
--
K
H
I
--------------
V
A
K
------------
G
E
H
K
--------
S
GVL
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-----
D
G
S
V
Q
I
A
D
F
G
V
S
A
-
F
L
A
T
G
G
D
-
I
T
RN--
F
V
G
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
----
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
L
T
L
----------
Q
-
N
D
P
P
SLETGVQDKE
M
--
L
------
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
46.09
34%
-42
- C1 -
4ZJI
1
?
C:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
----------
K
K
E
L
-----
I
I
N
E
I
L
V
M
R
E
N
----
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
-
L
A
G
G
S
L
T
D
--
V
V
--
T
E
T
--------------
C
--------------
M
---------------
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
--
D
G
S
V
K
L
T
D
F
G
F
C
A
-
Q
-----
S
-
K
R
--
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
-
V
---
T
R
-----
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
---
A
T
---
N
-
G
-
T
-
P
E
----------
L
QN
P
------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
----------------
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
45.51
33%
-37
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[11-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
L
Q
E
---------
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
----
C
Q
T
S
M
D
E
-----
L
L
K
E
I
Q
A
M
S
Q
C
----
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
-
L
S
G
G
S
V
L
D
--
I
I
--
K
H
I
--------------
V
A
K
------------
G
E
H
K
--------
S
GVL
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-----
D
G
S
V
Q
I
A
D
F
G
V
S
A
-
F
L
A
T
G
G
D
----------
T
P
C
W
M
A
P
E
V
-
M
---
E
Q
----
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
L
T
L
----------
Q
-
N
D
P
P
SLETGVQDKE
M
--
L
------
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
44.68
34%
-41
- C1 -
4BC6
2
STK10_HUMAN
A:
[19-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
----
S
E
E
E
L
E
D
-----
Y
I
V
E
I
E
I
L
A
T
C
----
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
-
C
P
G
G
A
V
D
A
--
I
M
--
L
E
L
--------------
D
--------------
R
G
L
-------------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
--
L
--
E
G
D
I
R
L
A
D
F
G
V
S
A
-
K
N
L
K
T
L
Q
-----------
P
Y
W
M
A
P
E
V
-
V
M
C
E
T
M
---
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
--
N
P
M
R
V
L
L
K
I
---
A
------
K
-
S
D
P
P
TLL-------
T
--
P
------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----------------
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
44.35
32%
-47
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[16-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
-
K
S
----------
S
-----
L
E
N
E
I
A
V
L
K
K
I
----
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
-
V
S
G
G
E
L
F
D
R
I
L
E
--
R
G
V
--------------
Y
------------------------------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
PE
E
--
N
S
K
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
G
I
----
M
--
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
-
L
---
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
---
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
---
Y
-
E
-
F
E
S
P
----------
F
--
W
------
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
----------------
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
42.82
32%
-45
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[16-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
-
K
S
----------
S
-----
L
E
N
E
I
A
V
L
K
K
I
----
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
-
V
S
G
G
E
L
F
D
R
I
L
E
--
R
G
V
--------------
Y
------------------------------
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
PE
E
--
N
S
K
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
G
I
----
M
--
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
-
L
---
A
Q
---
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
---
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
---
Y
-
E
-
F
E
S
P
----------
F
--
W
------
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
----------------
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------