@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MAPK5_HUMAN: (2015-10-13 )
MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
Atome Classification :
(32 SA)
.........10........20......-..30........40........50..--.-----.-----.--------------.-----.--.--60--.--------........70-----........80........90........100.......110.....--.----.120.......130.......140.......150.......160..-.....170..---.---.-.-.-.-180....-....190.......200.......210.......220.......230.......240......-----.250--.......260.......270.......280.......290.......300.-.-.....310..-......320-........330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
E
E
S
D
M
D
K
A
I
K
E
T
S
I
L
E
E
YSI
N
W
T
Q
K
-LGAGISG
P
V
R
V
C
V
KKSTQE
R
F
A
L
K
I
L
--L-----D-----R--------------P-----K--A--R---N--------
E
V
R
L
H
M
M
CAT-----HP
N
I
V
Q
I
I
E
V
F
A
N
SVQFPHESSPR
A
R
L
L
I
V
M
E
M
MEG
G
E
L
F
H
R
I
S
Q
H--R----H
F
T
E
K
Q
A
S
Q
V
T
K
Q
I
A
L
A
L
R
H
C
H
L
L
N
I
A
HRDLKPE
N
L
L
FKDNSLDAP-
V
K
L
CDFGFAK---I---D-Q-G-D-LM-TPQF-T
P
Y
YV
A
P
Q
V
L
E
A
Q
R
R
H
Q
K
E
KSGIIPTSPTPYTYNKSCD
L
W
S
L
G
V
I
I
Y
V
M
LCGYPPFYSKHHSR-----TI
P
K
--
D
M
R
R
K
IMTGSFEF
P
E
E
E
W
S
Q
I
S
E
M
A
K
D
V
V
R
K
L
L
KVKPEE
R
L
T
I
E
GVLDHPW-L-N
S
T
E
A
L
D
-
N
V-L
P
S
A
Q
L
M
-
M
-
D
K
A
V
V
A
G
I
Q
Q
A
H
A
E
Q
L
A
N
M
R
I
Q
D
L
K
V
S
L
K
P
L
H
SVN
N
P
I
L
R
K
R
K
LLGTKPK
D
S
V
Y
I
HDHENGAE
D
S
N
V
A
L
E
K
L
R
D
V
I
A
Q
C
ILPQAGKGE
N
E
D
E
K
L
N
E
V
M
Q
E
A
W
KY
N
R
E
C
K
L
L
R
D
T
L
Q
SFSWNGRGFT
D
K
V
D
R
L
K
L
A
E
I
V
K
Q
V
I
E
E
QTTSHESQ
60
PsiBlast_CBE
78.93
43%
-106
- C2 -
2PZY
1
MAPK2_HUMAN
C:
[14-319]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET-
T
--------------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
L
-----
A
I
S
P
--
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
-----------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.75
43%
-107
- C2 -
3KA0
1
MAPK2_HUMAN
A:
[8-318]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET----------------------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
-----------------
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.22
42%
-113
- C2 -
1NY3
1
MAPK2_HUMAN
A:
[54-345]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET-
T
---
S
-
H
--------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.03
43%
-112
- C2 -
3R2Y
1
MAPK2_HUMAN
A:
[9-300]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET-
T
----------------------------------------------------
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
------------------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
75.77
43%
-109
- C2 -
2PZY
1
MAPK2_HUMAN
B:
[14-305]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET-
T
--------------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
75.43
42%
-103
- C2 -
3R1N
1
MAPK3_HUMAN
A:
[3-312]
-----------
K
K
Y
A
V
T
D
D
Y
Q
L
S
-
K
Q
V
-
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--
Y
-----
D
-----
S
--------------
P
-----
K
--
A
--
R
---
Q
--------
E
V
D
H
H
W
Q
A
S
G
-----
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
----
H
H
G
--
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
G------
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
-
L
K
L
T
D
F
G
F
A
K
E--
T
---
T
--------------------------------------------
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
----------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
-
I
-
N
Q
S
M
V
V
P
-
Q
T
P
L
H
T
A
R
V
L
-
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
-------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
75.22
42%
-105
- C2 -
3FHR
1
MAPK3_HUMAN
A:
[22-331]
-----------
K
K
Y
A
V
T
D
D
Y
Q
L
S
-
K
Q
V
-
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--
Y
-----
D
-----
S
--------------
P
-----
K
--
A
--
R
---
Q
--------
E
V
D
H
H
W
Q
A
S
G
-----
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
----
H
H
G
--
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
D-
Q
----
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
-
L
K
L
T
D
F
G
F
A
K
E--
T
-------------------------------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-----------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
-
I
-
N
Q
S
M
V
V
P
-
Q
T
P
L
H
T
A
R
V
L
-
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.05
43%
-103
- C2 -
3FYK
1
MAPK2_HUMAN
X:
[10-320]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET-
T
---
S
----------------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
------------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
74.69
46%
-106
- C2 -
1NXK
1
MAPK2_HUMAN
A:
[59-345]
---------------
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
------
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-------
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
---
E
---
T
-
T
--------------
P
Y
Y
V
A
P
E
V
L
G
P
----------------
E
--
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
------
A
I
S
P
--
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
-
I
-
M
Q
S
T
K
V
P
-
Q
T
P
L
H
T
S
R
V
L
-
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
74.31
42%
-120
- C2 -
3F3Z
5
?
A:
[7-267]
---------------
I
N
Q
Y
Y
T
L
--
E
N
T
-
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
--
P
-----
K
YFVED
V
--------------
D
-----
R
--
F
--
K
---
Q
--------
E
I
E
I
M
K
S
L
-
D
-----
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
----------
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
K
--
R
----
V
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
T
D
S
P
D
S
P
-
L
K
L
I
D
F
G
L
A
A
---
R
---
F
-
K
P
G
K
M
-
M
R
-
T
K
V
G
-
T
P
Y
Y
V
S
P
Q
V
L
E
----------
G
---------
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
----------
D
S
--
E
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
-
F
-
E
K
Q
L
S
S
S
-
P
R
-
N
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.98
43%
-106
- C2 -
2PZY
1
MAPK2_HUMAN
A:
[14-306]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-------
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET-
T
--------------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
L
-----
A
I
S
P
--
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
K
------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.77
41%
-106
- C2 -
1NXK
1
MAPK2_HUMAN
A:
[54-345]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-------
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET-
T
--------------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
L
-----
A
I
S
P
--
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
-
I
M
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
73.39
42%
-106
- C2 -
3SHE
1
MAPK3_HUMAN
A:
[3-312]
-----------
K
K
Y
A
V
T
D
D
Y
Q
L
S
-
K
Q
V
-
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--
Y
-----
D
-----
S
--------------
P
-----
K
--
A
--
R
---
Q
--------
E
V
D
H
H
W
Q
A
S
G
-----
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
----
H
H
G
--
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
--------
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
-
L
K
L
T
D
F
G
F
A
K
E--
T
-------------------------------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
----------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
-
I
-
N
Q
S
M
V
V
P
-
Q
T
P
L
H
T
A
R
V
L
-
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
-------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.30
43%
-101
- C2 -
3FYJ
1
MAPK2_HUMAN
X:
[10-320]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET-
T
---
S
----------------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
------------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.16
43%
-107
- C2 -
2P3G
1
MAPK2_HUMAN
X:
[10-320]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
ET-
T
---
S
----------------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
------------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
71.22
42%
-106
- C2 -
3FXW
1
MAPK3_HUMAN
A:
[22-331]
-----------
K
K
Y
A
V
T
D
D
Y
Q
L
S
-
K
Q
V
-
L
G
L
G
V
-
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--
Y
-----
D
-----
S
--------------
P
-----
K
--
A
--
R
---
Q
--------
E
V
D
H
H
W
Q
A
S
G
-----
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
----
H
H
G
--
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
D-
Q
----
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
-
L
K
L
T
D
F
G
F
A
K
E----------------------------------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-----------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
-
I
-
N
Q
S
M
V
V
P
-
Q
T
P
L
H
T
A
R
V
L
-
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
70.00
40%
-98
- C2 -
3M42
1
MAPK2_HUMAN
A:
[10-299]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
---
E
---
T
-
T
-
G
-
E
----------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------
P
--
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
69.71
40%
-95
- C2 -
3M2W
1
MAPK2_HUMAN
A:
[10-299]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
---
E
---
T
-
T
-
G
-
E
----------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------
P
--
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
69.31
40%
-97
- C2 -
3KGA
1
MAPK2_HUMAN
A:
[10-299]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--
Q
-----
D
-----
C
--------------
P
-----
K
--
A
--
R
---
R
--------
E
V
E
L
H
W
R
A
S
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
-
L
K
L
T
D
F
G
F
A
K
---
E
---
T
-
T
-
G
-
E
----------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------
P
--
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
-
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
-
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
67.84
36%
-123
- C2 -
3KN5
1
KS6A5_HUMAN
A:
[2-280]
-----------
K
D
S
P
F
Y
Q
H
Y
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
--
S
-----
K
-----
R
--------------
M
-----
E
--
A
N
T
Q
---
K
--------
E
I
T
A
L
K
L
C
E
G
-----
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
----------
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
----
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
-
I
K
I
I
D
F
G
F
A
R
---
L
K
P
P----------------------------
N
------------------
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
------------
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
-
L
-
Q
D
G
S
Q
L
S
-
S
N
-
P
L
M
T
P
D
I
-
L
-
G
S
S
G
A
A
V
H
T
C
V
K
A
T
F
H
A
F
N
K
Y
K
R
E
G
-------------------------------------------------------------------------------------------------------------------------------
142
HHSearch
67.73
36%
-112
- C2 -
1PHK
1
PHKG1_RABIT
A:
[17-289]
-----------------
E
N
Y
E
P
--
K
E
I
-
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
--
D
-----
V
-----
T
GGGSFS
A
E
E
V
Q
E
L
R
E
-----
A
--
T
--
L
---
K
--------
E
V
D
I
L
R
K
V
S
G
-----
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
----------
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
---
M
N
-
I
K
L
T
D
F
G
F
S
C
---
Q
---
L
D
P
-
G
-
E
K
L
R
-
E
V
C
G
-
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
------------
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
----------
Q
M
--
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
-
F
-
Q
Q
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
64.44
36%
-118
- C2 -
3KN5
1
B:
[2-280]
-----------
K
D
S
P
F
Y
Q
H
Y
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
--
S
-----
K
-----
R
--------------
M
-----
E
--
A
N
T
Q
---
K
--------
E
I
T
A
L
K
L
C
E
G
-----
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
----------
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
----
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
-
I
K
I
I
D
F
G
F
A
R
---
L
K
P
P----------------------------
N
------------------
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
S
H
D
R
S
L
-----
T
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
-
L
-
Q
D
G
S
Q
L
S
-
S
N
-
P
L
M
T
P
D
I
-
L
-
G
S
S
G
A
A
V
H
T
C
V
K
A
T
F
H
A
F
N
K
Y
K
R
E
G
-------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
64.11
35%
-114
- C2 -
3C0I
1
CSKP_HUMAN
A:
[20-295]
-------------
V
L
F
E
D
V
Y
E
L
--
C
E
V
-
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--
D
V
A
K
F
T
S
SPGLS
T
--------------
E
-----
D
--
L
--
K
---
R
--------
E
A
S
I
C
H
M
L
-
K
-----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
----------
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
---
Q
---
L
-
G
E
S
-
G
L
V
A
G
G
R
V
G
-
T
P
H
F
M
A
P
E
V
V
K
R
----------------
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
-----------
K
E
--
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-
L
-
K
E
R
D
R
Y
A
-
Y
K
-
I
H
L
P
E
T
V
-
E
-
Q
L
R
K
F
N
A
R
R
K
----------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
62.61
36%
-113
- C2 -
2JAM
3
KCC1G_HUMAN
A:
[17-285]
----------------------------
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
-----
K
-----
S
---------------------------
S
L
E
N
--------
E
I
A
V
-
L
K
K
I
K
-----
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
----------
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
-
I
M
I
T
D
F
G
L
S
K
---
M
---
E
-
Q
-
N
-
G
-
I
M
S
T
A
C
G
-
T
P
G
Y
V
A
P
E
V
L
-
A
Q
K
-----------------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
------------
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
-
I
-
D
G
N
T
A
L
H
R
D
I
-
Y
P
S
V
S
L
Q
-
I
-
Q
K
N
F
A
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
60.54
36%
-109
- C2 -
2JAM
3
KCC1G_HUMAN
B:
[17-285]
----------------------------
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
-----
K
-----
S
---------------------------
S
L
E
N
--------
E
I
A
V
-
L
K
K
I
K
-----
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
----------
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
-
I
M
I
T
D
F
G
L
S
K
---
M
---
E
-
Q
-
N
-
G
-
I
M
S
T
A
C
G
-
T
P
G
Y
V
A
P
E
V
L
-
A
Q
K
-----------------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
------------
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
-
I
-
D
G
N
T
A
L
H
R
D
I
-
Y
P
S
V
S
L
Q
-
I
-
Q
K
N
F
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
59.51
34%
-120
- C2 -
2WEI
1
?
A:
[30-280]
----------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
-----
K
--------------
A
-----
S
--
A
--
K
---
N
KD
T
S
T
I
L
R
E
V
E
L
-
L
K
K
L
D
-----
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
----------
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
-
I
K
I
I
D
F
G
L
S
T
C--
F
---
Q
-
Q
-
N
-
T
-
K
M
-
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-------------------
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
------------
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
-
I
-
Q
K
Y
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
58.91
32%
-91
- C2 -
2WNT
2
B:
[33-320]
-------------------------
E
T
-
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
--------
D
-----
K
--------------
S
-----
K
RD
P
--
S
---
E
--------
E
I
E
I
L
L
R
Y
G
Q
-----
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
----------
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
--
K
----
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
C
L
R
I
C
D
F
G
F
A
K
QLR
A
---
E
-
N
-
G
-
L
-
L
M
-
T
P
C
Y
-----------
K
R
Q
------------------
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
--
A
N
G
P
S
-----
D
T
P
E
--
E
I
L
T
R
I
G
S
G
K
F
T
L
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
V
L
Q
H
P
W
-
V
-
T
Q
K
D
K
------
L
P
Q
S
Q
L
S
H
Q
-
D
L
Q
L
V
K
G
---
A
M
A
A
T
Y
S
A
L
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
58.59
34%
-115
- C2 -
2HW7
1
MKNK2_HUMAN
A:
[21-302]
----------------------------
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
--
E
-----
K
-----
Q
--------------
P
GH
I
R
S
R
--
V
--
F
---
R
--------
E
V
E
M
L
Y
Q
C
Q
G
-----
H
R
N
V
L
E
L
I
E
F
F
E
E
E
----------
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
-
V
K
I
C
D
F
G
------------------------
G
-
S
A
E
Y
M
A
P
E
V
V
E
A
-------------
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---CGAC
P
A
C
Q
N
--
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
-
V
-
Q
G
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
57.82
35%
-123
- C2 -
4FG7
1
KCC1A_HUMAN
A:
[26-277]
----------------------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
-----------------------------------------------------
S
M
E
N
E
I
A
V
L
H
K
IK
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
----------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
L
S
K
---
M
E
--
D
-
P
-
G
-----------
T
P
G
Y
V
A
P
E
V
L
-
A
Q
K
-------------------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
------------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
-
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
56.04
35%
-113
- C2 -
2W4O
1
KCC4_HUMAN
A:
[60-314]
--------------------------
E
-
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K-----------------------------------------------------
I
G
V
-
L
L
R
L
S
-----
H
P
N
I
I
K
L
K
E
I
F
----
E
T
P
T
E
I
S
------
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
--
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
P
D
A
P
-
L
K
I
A
D
F
-------------------------
G
-
T
P
G
Y
C
A
P
E
I
L
R
G
C
------------------
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
-----
F
------
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
-
V
-
T
G
K
A
A
N
F
-
V
H
-
M
D
T
A
Q
K
K
-
L
-
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
54.76
35%
-112
- C2 -
4FG8
1
KCC1A_HUMAN
B:
[26-283]
----------------------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
-----
K
--------------------------------------------------
N
E
I
A
V
L
H
K
IK
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
----------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
--------------
G
-
S
-
V
L
S
T
A
C
G
-
T
P
G
Y
V
A
P
E
V
L
-
A
Q
K
-----------------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
------------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
-
A
G
D
T
A
L
D
-
K
N
-
I
H
Q
S
V
S
E
-
Q
-
I
K
K
N
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
53.36
35%
-119
- C2 -
4FG8
1
KCC1A_HUMAN
A:
[26-283]
----------------------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
-----
K
-----
E
--------------------------------------------
N
E
I
A
V
L
H
K
IK
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
----------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
---------------------------
T
P
G
Y
V
A
P
E
V
L
-
A
Q
K
-----------------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
------------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
-
A
G
D
T
A
L
D
-
K
N
-
I
H
Q
S
V
S
E
-
Q
-
I
K
K
N
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------