@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MYLK_HUMAN: (2015-10-15 )
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE
Atome Classification :
(46 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460....--..-1470......1480......1490.-----.--....1500----.------.---..--....1510.....-.1520......1530......1540......1550-......-..1560......1570......1580......1590--..-.-.--.-.--1600.......1610....-..1620.---......1630--.--.....1640......1650......1660.-.....1670......1680......1690......1700......1710......1720..---.-.....1730.--.---..-------...---..1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
D
V
K
L
V
A
SSHISKTSLSV
D
P
S
RVDSMPLTEA
P
A
F
ILPPRN
L
C
IKEGATAKFEGRVRGYPEP
Q
V
T
WHRNGQPITSG
G
R
F
L
L
DCGIR
G
T
F
S
L
V
I
H
A
VHEEDRG
K
Y
T
C
EATNGSG
A
R
Q
V
T
V
E
L
T
VE
G
S
F
A
K
Q
LG
Q
P
V
V
S
K
T
LGDRFSAPAVETRPSIWGEC
P
P
K
F
A
T
K
L
G
R
V
VVKEGQM
G
R
F
S
C
K
ITGRPQP
Q
V
T
W
LKGNVPLQPSA
R
V
S
VSEKN
G
M
Q
V
L
E
I
HGVNQDD
V
G
V
Y
T
C
L
V
VNGSGKA
S
M
S
A
E
L
S
I
Q
GLDSA
N
R
S
F
V
R
ETKAT
N
S
D
V
R
K
E
V
T
N
V
I
S
K
ESK
L
D
S
L
E
A
A
AKSKNCSSPQRGGSPPWAANSQPQP
P
R
E
S
K
L
E
S
CKDSPRTAPQTP
V
L
QKTSS
S
I
T
L
Q
A
A
RVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGL
G
S
Q
D
V
V
S
K
AANRRIPMEGQRDSAFPKFESKPQ
S
Q
EVKEN
Q
T
V
K
F
R
C
E
VSGIPKP
E
V
A
W
F
LEGTPVRRQEG
S
I
E
V
Y
EDAG
S
H
Y
L
C
L
L
K
A
RTRDS
G
T
Y
S
C
TASNAQ
G
Q
L
S
C
S
W
T
L
Q
V
E
R
L
A
V
M
EVA
P
S
F
S
S
V
L
K
D
C
A
VIEGQ
D
F
V
L
Q
C
SVRGTPV
P
R
I
T
W
L
LNGQ
P
I
Q
Y
A
R
S
T
C
EA
G
V
A
E
L
H
I
Q
DALPEDHG
T
Y
T
C
L
AENALGQ
V
S
C
S
A
W
V
T
V
H
EKKSSRKS
E
Y
L
L
P
VAPSKPTA
P
I
F
LQGLSD
L
K
VMDG
S
Q
V
T
M
T
V
Q
VSGNPP
P
E
V
I
W
L
HNGNEIQESEDFHFEQRGT
Q
H
S
L
C
I
Q
E
VFPEDTG
T
Y
T
C
EAWNSAGE
V
R
T
Q
A
V
L
T
V
QEPHDGTQ
P
W
F
ISKP
R
S
V
T
A
S
L
G
Q
S
V
L
I
S
C
A
IAGDPF
P
T
V
H
W
LRD
G
K
A
L
CKDTG
H
F
E
V
LQNE
D
V
F
T
L
V
L
K
KVQPWHAG
Q
Y
E
I
L
L
KNRVGE
C
S
C
Q
V
S
L
M
L
QNSSARALPRGREPA
S
C
E
D
LCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDG
E
D
V
R
G
V
L
K
R
R
V
E
T
R
Q
H
T
E
E
A
I
R
Q
Q
E
V
E
Q
L
D
F
R
D
L
LGKKVSTKTL
S
E
D
D
L
K
EI
P
A
E
Q
M
D
F
R
A
N
L
Q
RQVKPKTV
S
E
E
E
R
KVHSPQQV
D
F
R
S
V
L
A
KKGTSKTPVPEKVPPPKPATP
D
F
R
S
V
LGGKKKLPAENGSSSAE
T
L
N
A
KAVESSKPLSNAQPSGPLKPVGNAKP
A
E
T
LKPMGNAKP
A
E
T
LKPMGNAKP
D
E
N
L
K
SA
S
K
E
E
L
K
K
D
V
KNDVNCKRGHAGTTDNEKRSESQGT
A
P
A
F
K
Q
K
L
Q
D
V
H
VAEG
K
K
L
L
L
Q
C
QVSSDPP
A
T
I
I
W
T
LNG
K
T
L
K
T
T
K
F
I
I
LSQEG
S
L
C
S
V
S
I
E
KALPEDRGL
Y
K
C
VAKNDAGQA
E
C
S
C
Q
V
T
VDDAPASENTKAP
E
M
KSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGE
S
V
E
L
F
G
KVTGTQ
P
I
T
C
T
W
M
K
F
R
K
Q
IQESE
H
M
KVENSENG
S
K
L
T
I
L
A
ARQEHC
G
C
Y
T
L
L
V
ENKLGS
R
Q
A
Q
V
N
L
T
V
V
DKPDPPAGT
P
C
A
S
DIRSS
S
L
T
L
S
W
YGSSYDGGS
A
V
Q
S
Y
S
I
E
I
WDSA
N
K
T
W
K
E
L
A
T
CRSTSF
N
V
Q
DLLPDH
E
Y
K
F
R
V
R
A
I
N
V
Y
GTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEV
D
Y
R
T
V
T
INT
E
Q
K
V
S
D
F
Y
D
I
E
--
E
R
-LGSG
K
F
G
Q
V
F
R
L
V
E
K
K
T
R
K
V
W
A
G
K
F
-----
F
--
K
A
YS
A
K
------
E
------
K
---
E
N
--
I
R
Q
E
I
S
I
M
N
CLHH-
P
K
L
V
Q
C
V
D
A
F
E
EKA
N
I
V
M
V
L
E
IVS
G
G
E
L
F
E
R
I
I
---DEDFEL-
T
E
R
E
C
I
K
Y
M
R
Q
I
S
E
G
V
E
Y
I
H
KQ
G
I
V
H
L
DLKPE
N
I
M
C
--VN-K-T--G-
T
--
R
-
I
K
L
I
D
F
G
L
A
R
R
L
ENAG
S
-
L
K
V
-
L
FG---TPEFVAPEVI--N--YEPIGYA
T
D
M
W
S
I
G
V
I
C
Y
I
L
V
SGL
S
P
FMGD-NDNE
T
L
ANVTSATWDFD
D
E
A
F
D
E
I
S
D
D
A
K
D
F
I
S
N
L
L
K
K
D
M
K
N
RL
D
C
T
Q
C
L
QHPWLM-K-DT---K-N
M
E
A
K
K---L--
S
---
K
D
-------
R
M
K
---
K
Y
M
A
R
R
K
W
Q
KTG
N
A
V
R
A
I
G
R
L
S
S
M
A
M
I
SGLSGRKSSTGSPTSPL
N
A
E
KLE
S
E
E
D
V
S
Q
A
F
L
E
A
V
A
EEKPHV
K
P
Y
F
S
K
T
I
R
D
L
EVVEGSA
A
R
F
D
C
K
IEGYPDP
E
V
V
W
FKD
D
Q
S
I
R
ESR
H
F
Q
I
D
YDEDG
N
C
S
L
I
I
SDVCGDDDA
K
Y
T
C
K
A
V
N
SLGE
A
T
C
T
A
E
L
I
V
E
T
M
E
EGEGEGEEEEE
9
PsiBlast_PDB
71.47
44%
-63
- C6 -
2W4K
1
DAPK1_HUMAN
A:
[2-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
---
Q
-
Q
A
L
S
R
K
---
A
--
S
AVN
M
E
-------
K
F
K
---
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.39
44%
-74
- C6 -
2YAA
1
DAPK2_MOUSE
B:
[7-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
-----
I
--
K
K
R
Q
S
R
------
A
SRRGVC
R
---
E
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
---
Q
K
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
K
-
N
--
I
-
P
I
P
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
-
D
T
---
Q
-
Q
A
M
V
R
R
E
S
V
V
--
N
---
L
E
-------
N
F
K
---
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
71.26
43%
-71
- C6 -
2CKE
1
DAPK2_HUMAN
C:
[7-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
-----
I
--
K
K
R
Q
S
R
ASRRGV
S
------
R
---
E
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
---
Q
K
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
K
-
N
--
I
-
P
IP
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
-
D
N
---
Q
-
Q
A
M
V
R
R
ESV
V
--
N
---
L
E
-------
N
F
R
---
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.94
43%
-75
- C6 -
2CKE
1
DAPK2_HUMAN
A:
[7-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
-----
I
--
K
K
R
Q
S
R
ASR
R
G
V
S
------
R
---
E
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
---
Q
K
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
K
-
N
--
I
-
P
I
P
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
-
D
N
---
Q
-
Q
A
M
V
R
R
E
SV
V
--
N
---
L
E
-------
N
F
R
---
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
70.54
43%
-74
- C6 -
2CKE
1
DAPK2_HUMAN
B:
[7-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
-----
I
--
K
K
R
Q
S
R
ASR
R
G
V
S
------
R
---
E
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
---
Q
K
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
K
-
N
--
I
-
P
I
P
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
-
D
N
---
Q
-
Q
A
M
V
R
R
E
SV
V
--
N
---
L
E
-------
N
F
R
---
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.49
52%
-85
- C6 -
2X4F
4
MYLK4_HUMAN
A:
[74-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
R
I
V
T
A
K
-
Q
G
A
V
N
S
F
Y
T
V
S
KT
E
I
-
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
-----
I
--
K
T
R
G
M
K
------
D
------
K
---
E
E
--
V
K
N
E
I
S
V
M
N
Q
L
D
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
---
D
E
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
N
-
R
-
D
--
A
-
K
--
Q
-
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
K
-
L
K
V
-
N
F
G
---
T
P
E
F
L
A
P
E
V
V
--
N
--
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
-
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
-
D
-
H
K
---
L
-
H
S
R
L
S
A
---
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
70.47
52%
-89
- C6 -
2X4F
3
MYLK4_HUMAN
B:
[74-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
R
I
V
T
A
K
-
Q
G
A
V
N
S
F
Y
T
V
S
KT
E
I
-
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
-----
I
--
K
T
R
G
M
K
------
D
------
K
---
E
E
--
V
K
N
E
I
S
V
M
N
Q
L
D
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
---
D
E
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
N
-
R
-
D
--
A
-
K
--
Q
-
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
K
-
L
K
V
-
N
F
G
---
T
P
E
F
L
A
P
E
V
V
--
N
--
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
-
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
-
D
-
H
K
---
L
-
H
S
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.35
44%
-73
- C6 -
2YAA
1
DAPK2_MOUSE
A:
[7-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
-----
I
--
K
K
R
Q
S
R
------
A
SRRGVC
R
---
E
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
---
Q
K
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
K
-
N
--
I
-
P
I
P
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
-
D
T
---
Q
-
Q
A
M
V
R
R
E
SV
V
--
N
---
L
E
-------
N
F
K
---
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
69.80
46%
-70
- C6 -
4TXC
7
DAPK1_HUMAN
A:
[21-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
69.59
46%
-72
- C6 -
2YAK
1
DAPK1_HUMAN
A:
[2-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.49
44%
-57
- C6 -
4B4L
3
DAPK1_HUMAN
A:
[7-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
---
Q
-
Q
A
L
S
R
K
---
A
--
S
---
A
V
-------
N
M
E
---
K
F
K
K
F
A
A
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
69.30
43%
-73
- C6 -
2CKE
1
DAPK2_HUMAN
D:
[7-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
-----
I
--
K
K
R
Q
S
R
ASRRGV
S
------
R
---
E
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
---
Q
K
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
K
-
N
--
I
-
P
IP
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
-
D
N
---
Q
-
Q
A
M
V
R
R
ESV
V
--
N
---
L
E
-------
N
F
R
---
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.11
45%
-64
- C6 -
4UV0
1
?
A:
[5-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
---
Q
-
Q
A
L
S
R
K
---
A
--
C
---
A
V
-------
N
M
E
---
K
F
K
K
F
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.98
45%
-59
- C6 -
2Y0A
1
DAPK1_HUMAN
A:
[3-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
---
Q
-
Q
A
L
S
R
K
---
A
--
S
---
A
V
-------
N
M
E
---
K
F
K
K
F
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
68.83
46%
-68
- C6 -
1WVY
1
DAPK1_HUMAN
A:
[4-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
68.71
46%
-64
- C6 -
2W4J
1
DAPK1_HUMAN
A:
[2-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
-
I
F
G
---
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.35
43%
-56
- C6 -
2XUU
1
DAPK1_HUMAN
A:
[2-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
-
I
F
G
---
T
P
A
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
---
Q
-
Q
A
L
S
R
K
---
A
--
S
---
A
V
-------
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
66.97
46%
-76
- C6 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
---------------VS----
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
---------------
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
65.94
46%
-76
- C6 -
3ZXT
1
DAPK1_HUMAN
C:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
SRRGVS
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
----------------
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
65.52
46%
-71
- C6 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
--------------
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
--VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
-----------------
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
65.01
46%
-69
- C6 -
3ZXT
1
DAPK1_HUMAN
B:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
--
K
K
R
R
T
K
------
S
RRGVS-
R
---
E
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
K
---
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
-
R
-
N
VP
K
-
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
---------------
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
64.93
33%
-71
- C6 -
3F3Z
5
?
A:
[6-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
N
Q
Y
Y
T
L
E
--
N
T
-
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
-----
I
--
P
K
Y
F
V
E
------
D
------
V
---
D
R
--
F
K
Q
E
I
E
I
M
K
S
L
D
H
-
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
---
H
K
R
V
-
F
-
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
--
L
T
-
D
-
S
P-
D
-
S
--
P
-
L
K
L
I
D
F
G
L
A
A
R
F
K
P
G
K
M
-
M
R
T
-
K
V
G
---
T
P
Y
Y
V
S
P
Q
V
L
--
E
GL
Y
G
P
---
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
-
T
D
S
E
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
E
-
K
-
Q
L
---
S
-
S
S
P
R
N
L
---
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
64.36
31%
-68
- C6 -
3MFR
1
CSKP_HUMAN
A:
[24-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
--
E
V
-
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
--
T
S
S
P
G
L
------
S
------
T
---
E
D
--
L
K
R
E
A
S
I
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
--
A
S
-
K
-
E
--
N
-
S
--
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
-
V
A
G
G
R
V
G
---
T
P
H
F
M
A
P
E
V
V
--
K
--
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
-
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
-
E
-
R
D
---
R
-
Y
A
Y
K
I
H
---
L
P
E
T
---
V
E
-------
Q
L
R
---
K
F
N
A
R
R
K
L
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
63.85
38%
-67
- C6 -
4FG8
1
KCC1A_HUMAN
B:
[14-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
F
R
--
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-----
I
--
A
K
---------------------------
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
---
E
K
G
F
-
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
L
D
-
E
--
D
-
S
--
K
-
I
M
I
S
D
F
G
--------
G
S
V
L
S
T
-
A
C
G
---
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
ALD
K
-
N
I
H
Q
S
-------
V
---
S
E
-------
Q
I
K
---
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
63.69
31%
-68
- C6 -
3MFS
1
CSKP_HUMAN
A:
[24-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
--
E
V
-
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
--
T
S
S
P
G
L
------
S
------
T
---
E
D
--
L
K
R
E
A
S
I
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
--
A
S
-
K
-
E
--
N
-
S
--
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
-
V
A
G
G
R
V
G
---
T
P
H
F
M
A
P
E
V
V
--
K
--
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
-
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
-
E
-
R
D
---
R
-
Y
A
Y
K
I
H
---
L
P
E
T
---
V
E
-------
Q
L
R
---
K
F
N
A
R
R
K
L
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
63.46
40%
-80
- C6 -
4FG7
1
KCC1A_HUMAN
A:
[14-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
F
R
--
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-----
I
--
A
-----------------------
S
--
M
E
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
---
E
K
G
F
-
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
L
D
-
E
--
D
-
S
--
K
-
I
M
I
S
D
F
G
L
S
K
-
M
E
D
P
---------
G
---
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
63.33
31%
-67
- C6 -
3MFU
1
CSKP_HUMAN
A:
[24-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
--
E
V
-
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
--
T
S
S
P
G
L
------
S
------
T
---
E
D
--
L
K
R
E
A
S
I
C
H
M
L
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
--
A
S
-
K
-
E
--
N
-
S
--
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
-
V
A
G
G
R
V
G
---
T
P
H
F
M
A
P
E
V
V
--
K
--
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
-
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
-
E
-
R
D
---
R
-
Y
A
Y
K
I
H
---
L
P
E
T
---
V
E
-------
Q
L
R
---
K
F
N
A
R
R
K
L
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
62.87
33%
-72
- C6 -
2WEL
7
KCC2D_HUMAN
A:
[2-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
--
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
-----
I
NT
K
K
L
S
A
R
------
D
------
H
---
Q
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
---
A
R
E
Y
-
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
-
K
-
S
K-
G
-
A
--
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
-
Q
Q
A
-
W
F
G
FAG
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
-
Q
-
R
------
S
M
M
H
R
Q
---
E
--
T
---
V
D
-------
C
L
K
---
K
F
N
A
R
R
K
L
K
---
G
A
I
-----
L
T
T
M
L
A
T
R
N
F
S
A
-------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
62.73
37%
-75
- C6 -
3LM0
2
ST17B_HUMAN
A:
[24-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
N
N
F
Y
I
L
T
--
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
-----
L
--
K
K
R
R
R
G
------
Q
DC----
R
---
A
E
--
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
---
P
E
L
A
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
SS
I
Y
-
P
-
L
--
G
-
D
----
I
K
I
V
D
F
G
M
S
R
K
I
-----------
M
G
---
T
P
E
Y
L
A
P
E
I
L
--
N
--
Y
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
-
D
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
-
Q
W
D
F
---
E
-
N
L
F
H
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
62.69
37%
-75
- C6 -
3LM5
1
ST17B_HUMAN
A:
[24-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
N
N
F
Y
I
L
T
--
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
-----
L
--
K
K
R
R
R
G
------
Q
DC----
R
---
A
E
--
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
---
P
E
L
-
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
SS
I
Y
-
P
-
L
--
G
-
D
----
I
K
I
V
D
F
G
M
S
R
K
I
-----------
M
G
---
T
P
E
Y
L
A
P
E
I
L
--
N
--
Y
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
-
D
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
-
Q
W
D
F
---
E
-
N
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
62.65
33%
-58
- C6 -
2V7O
3
KCC2G_HUMAN
A:
[28-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
T
D
D
Y
Q
L
F
--
E
E
-
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
-----
I
NT
K
K
L
S
A
R
------
D
------
H
---
Q
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
---
A
R
E
Y
-
Y
-
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
-
K
-
C
K-
G
-
A
--
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
E
-
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
-
Q
-
R
S
TV-
A
-
S
M
M
H
R
Q
---
E
--
T
---
V
E
-------
C
L
R
---
K
F
N
A
R
R
K
L
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
62.54
34%
-61
- C6 -
2VN9
2
KCC2D_HUMAN
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
--
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
-----
I
NT
K
K
L
S
A
R
------
D
------
H
---
Q
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
---
A
R
E
Y
-
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
-
K
-
S
K-
G
-
A
--
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
-
Q
Q
A
-
W
F
G
FAG
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
-
Q
-
R
S
TV-
A
-
S
M
M
H
R
Q
---
E
--
T
---
V
D
-------
C
L
K
---
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
62.16
32%
-61
- C6 -
3BHH
1
KCC2B_HUMAN
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
Y
--
E
D
-
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
-----
I
N
T
K
K
L
S
A
R
------
D
------
H
---
Q
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
---
A
R
E
Y
-
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
-
K
-
C
K-
G
-
A
--
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
-
Q
Q
A
-
W
F
G
FAG
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
-
Q
-
R
S
TV-
A
-
S
M
M
H
R
Q
---
E
--
T
---
V
E
-------
C
L
K
---
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
61.98
36%
-61
- C6 -
2JC6
1
KCC1D_HUMAN
C:
[18-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
K
K
I
F
E
F
K
--
E
T
-
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
-----
I
--
P
K
K
A
---------------------S-
I
E
N
E
I
A
V
L
R
K
I
K
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
---
E
K
G
F
-
Y
-
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
-
Q
-
D
--
E
E
S
--
K
-
I
M
I
S
-------------------------
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
-
G
-
D
T
---
A
L
N
K
N
I
H
E
---
S
--
V
---
S
A
-------
Q
I
R
---
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
61.57
34%
-60
* C6 *
2VN9
1
KCC2D_HUMAN
B:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
--
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
-----
I
NT
K
K
L
S
A
R
------
D
------
H
---
Q
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
---
A
R
E
Y
-
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
-
K
-
S
K-
G
-
A
--
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
-
Q
Q
A
-
W
F
G
FAG
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
-
Q
-
R
S
TV-
A
-
S
M
M
H
R
Q
---
E
--
T
---
V
D
-------
C
L
K
---
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
61.53
32%
-62
- C6 -
3BHH
1
KCC2B_HUMAN
B:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
Y
--
E
D
-
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
-----
I
NT
K
K
L
S
A
R
------
D
------
H
---
Q
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
---
A
R
E
Y
-
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
-
K
-
C
K
-
G
-
A
--
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
-
Q
Q
A
-
W
F
G
FAG
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
-
Q
-
R
S
TV-
A
-
S
M
M
H
R
Q
---
E
--
T
---
V
E
-------
C
L
K
---
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
61.52
36%
-59
- C6 -
2JC6
1
KCC1D_HUMAN
A:
[18-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
K
K
I
F
E
F
K
--
E
T
-
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
-----
I
--
P
K
K
A
--------------------
S
S
-
I
E
N
E
I
A
V
L
R
K
I
K
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
---
E
K
G
F
-
Y
-
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
-
Q
-
D
--
E
E
S
--
K
-
I
M
I
S
-------------------------
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
-
G
-
D
T
---
A
L
N
K
N
I
H
E
---
S
--
V
---
S
A
-------
Q
I
R
---
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
61.25
38%
-70
- C6 -
4FG8
1
KCC1A_HUMAN
A:
[14-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
F
R
--
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-----
I
--
A
K
E
--------------------------
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
---
E
K
G
F
-
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
L
D
-
E
--
D
-
S
--
K
-
I
M
I
S
D
F
----------------------
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
ALD
K
-
N
I
H
Q
S
-------
V
---
S
E
-------
Q
I
K
---
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
60.36
37%
-62
- C6 -
4FG9
1
KCC1A_HUMAN
B:
[14-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
F
R
--
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-----
I
--
A
K
----------------------------
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
---
E
K
G
F
-
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
L
D
-
E
--
D
-
S
--
K
-
I
M
I
S
D
F
-----------V
L
S
T
-
A
C
G
---
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
ALD
K
-
N
I
H
Q
S
-------
V
---
S
E
-------
Q
I
K
---
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
59.95
37%
-55
- C6 -
4FG9
1
KCC1A_HUMAN
A:
[14-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
F
R
--
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-----
I
--
A
K
E
-------------------------
E
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
---
E
K
G
F
-
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
L
D
-
E
--
D
-
S
--
K
-
I
M
I
S
D
F
-----------------------
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
ALD
K
-
N
I
H
Q
S
-------
V
---
S
E
-------
Q
I
K
---
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
59.83
36%
-51
- C6 -
2W4O
1
KCC4_HUMAN
A:
[51-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
D
F
F
E
V
E
--
S
E
-
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
-----
L
--
K
--
K
---------------------------
I
G
V
L
L
R
L
S
H
-
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
---
E
K
G
Y
-
Y
-
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
A
T
-
P
-
A
P-
D
-
A
--
P
-
L
K
I
A
D
F
------------------
G
---
T
P
G
Y
C
A
P
E
I
L
--
R
--
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
-
G
-
K
A
---
A
-
N
F
V
H
M
D
---
T
--
A
---
Q
K
-------
K
L
Q
---
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
58.47
35%
-57
- C6 -
2JAM
3
KCC1G_HUMAN
A:
[15-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
-
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
-----
I
--
K
K
---------------------
S
S
--
L
E
N
E
I
A
V
L
K
K
I
K
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
---
E
R
G
V
-
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
L
T
P
E
-
E
--
N
-
S
--
K
-
I
M
I
T
D
F
G
L
S
K
-
M
E
Q
N
G
I
-
M
S
T
-
A
C
G
---
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
-
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
-
G
-
N
T
----------
A
---
L
--
H
---
R
D
I
Y
P
S
V
S
L
Q
I
Q
---
K
N
F
A
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
57.71
35%
-58
- C6 -
2JAM
3
KCC1G_HUMAN
B:
[15-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
-
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
-----
I
--
K
K
---------------------
S
S
--
L
E
N
E
I
A
V
L
K
K
I
K
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
---
E
R
G
V
-
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
L
T
P
E
-
E
--
N
-
S
--
K
-
I
M
I
T
D
F
G
L
S
K
-
M
E
Q
N
G
I
-
M
S
T
-
A
C
G
---
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
-
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
-
G
-
N
T
----------
A
---
L
--
H
---
R
D
I
Y
P
S
V
S
L
Q
I
Q
---
K
N
F
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
57.70
34%
-55
- C6 -
3MA6
1
?
A:
[31-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
K
G
Q
--
R
V
-
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-----
I
--
S
K
R
Q
V
K
------
Q
------
K
TD
K
E
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
---
S
R
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
-
K
-
S
K-
D
-
A
--
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
-
S
K
K
-
M
K
D
-
K
I
G
---
T
A
Y
Y
I
A
P
E
V
L
--
H
GT
Y
D
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-
T
-
Y
T
---
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
57.33
37%
-57
- C6 -
2WEI
1
?
A:
[24-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
I
V
--
C
M
-
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
-----
I
--
N
K
A
S
A
K
------
N
------
K
---
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
---
K
R
K
-
R
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
-
K
E
K
--
D
-
C
--
D
-
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
K
-
M
K
D
-
R
I
G
---
T
A
Y
Y
I
A
P
E
V
L
R
G
T
--
Y
D
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
-
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
-
K
-
Y
S
---
S
-
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
54.80
34%
-55
- C6 -
3MA6
1
?
B:
[31-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
K
G
Q
--
R
V
-
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-----
I
--
S
K
R
Q
V
K
------
Q
-------TDK
E
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
---
S
R
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
-
K
-
S
K-
D
-
A
--
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
-
M
K
D
-
K
I
G
---
T
A
Y
Y
I
A
P
E
V
L
--
H
GT
Y
D
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-
T
-
Y
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------