@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PAK6_HUMAN: (2015-10-16 )
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
Atome Classification :
(76 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400--........410--........420.......430.......440-......-----.450........460-.......470.------......480.......490......---------..500.......510.......520.......530...---....540.......550.--....-..560.......570---.-----.-----...-----..580.......590.......600.......610.......620..-------.....630.......640.......650.......660...-.....670.......680
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFRKKKKKRPEISAPQN
F
Q
H
RVHTSFDPKEG
K
F
VGL
P
P
Q
W
Q
N
I
L
D
T
LRRPKPVV
D
P
S
R
I
T
R
V
Q
L
Q
P
M
K
T
V
VRGSAM
P
V
D
G
Y
I
S
G
L
L
N
D
I
Q
K
L
S
VISSNTLRGRSP
T
S
R
R
R
A
Q
S
LGLLGDEHWAT
D
P
D
M
YLQSPQSERTDPH
G
L
Y
L
SCNGGTPAGHKQMPWPEPQSPRVLPN
G
L
A
A
K
A
QSL
G
P
A
E
FQ
G
A
S
Q
R
C
L
Q
L
G
A
C
LQSSPPGASPPTGTNRHGM
K
A
AKHGSEEARPQS
C
L
VGSATGRPGGEGSPSPK
T
R
E
S
S
L
K
R
R
L
F
R
S
M
F
L
S
TAATAPPSSSKPGPPPQSKPNSSFRPPQKDN
P
P
S
L
V
A
K
A
QSLPSDQPVGTFSPLTTSDTSS
P
Q
K
S
LRTAPATGQLPGRSSPAGSP
R
T
W
H
A
Q
ISTS
N
L
YLPQDPTVAKGALAGEDTGV
V
T
H
E
Q
F
K
A
A
L
R
M
V
VDQG---D
P
R
L
L
L
D
S
Y
V
---KIGEGS
T
G
I
V
C
L
AREKHS
G
R
Q
V
A
V
K
M
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
RD
Y
Q
H
F
-
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
E
L
W
V
L
M
E
F
LQGG
A
L
T
D
-
I
V
S
Q
VR---------L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
AQG
V
I
H
RDIKSD
S
I
L
L
T
---LDG
R
V
K
LSD
F
G
F
C
A
Q
I
S
K
--DVP
K
-
R
KSLVGTPYWM
A
P
E
V
---
I
-----
S
-----RSL-----Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
MVDGEPPYFSD
S
P
V
Q
A
M
K
R
L
RDSPPPKLKNS-------HK
V
S
P
V
L
R
D
F
L
E
R
M
L
VRD
P
Q
E
R
A
T
A
Q
E
L
LDH
P
F
L
L
Q-TG
L
P
-
E
C
L
V
P
L
I
Q
L
Y
R
K
QTSTC
2
PsiBlast_PDB
90.06
99%
-126
- C1 -
4KS7
2
A:
[4-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
---
D
P
R
L
L
L
D
S
Y
V
---
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
F
-
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
-
I
V
S
Q
V
R
---------
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
--
D
V
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
---
I
-----
S
-----
R
S
L
-----
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
-
T
G
L
P
-
E
C
L
V
P
L
I
Q
---------
22
PsiBlast_CBE
89.82
75%
-120
- C1 -
4FIE
1
PAK4_HUMAN
B:
[131-421]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
-----
5
PsiBlast_PDB
89.12
75%
-120
- C1 -
4FIE
1
PAK4_HUMAN
A:
[131-421]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
-----
3
PsiBlast_PDB
86.49
99%
-126
- C1 -
4KS8
1
A:
[3-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
---
D
P
R
L
L
L
D
S
Y
V
---
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
F
-
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
-
I
V
S
Q
V
R
---------
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
--
D
V
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
---
I
-----
S
-----
R
S
L
-----
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
-
T
G
L
P
-
E
C
L
V
P
L
I
----------
4
PsiBlast_PDB
85.16
75%
-128
- C1 -
2F57
1
PAK7_HUMAN
A:
[25-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
---
D
P
R
E
Y
L
A
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
H
H
D
-
N
V
V
D
M
Y
S
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
---
I
-----
S
-----
R
L
P
-----
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
L
-
A
G
P
P
-
S
C
I
V
P
L
M
R
Q
--------
13
PsiBlast_PDB
85.00
75%
-125
- C1 -
2CDZ
1
PAK4_HUMAN
A:
[11-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
-----
20
PsiBlast_PDB
83.44
74%
-122
- C1 -
2X4Z
3
A:
[4-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
-----
7
PsiBlast_PDB
83.31
75%
-121
- C1 -
4FIG
1
?
A:
[54-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
-----
15
PsiBlast_PDB
82.16
75%
-121
- C1 -
2Q0N
7
PAK4_HUMAN
A:
[9-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
R
----
17
PsiBlast_PDB
81.64
75%
-120
- C1 -
4O0X
1
?
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
------
14
PsiBlast_PDB
81.56
75%
-122
- C1 -
2J0I
4
PAK4_HUMAN
A:
[12-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
------
21
PsiBlast_CBE
81.52
75%
-118
- C1 -
2F57
1
B:
[25-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
---
D
P
R
E
Y
L
A
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
H
H
D
-
N
V
V
D
M
Y
S
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
---
I
-----
S
-----
R
L
P
-----
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
L
-
A
G
P
P
-
S
C
I
V
P
L
M
R
Q
Y
R
H
-----
23
PsiBlast_CBE
81.42
75%
-118
- C1 -
4FIG
1
?
B:
[54-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
-----
18
PsiBlast_PDB
80.85
75%
-118
- C1 -
4O0Y
1
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
------
12
PsiBlast_PDB
80.28
75%
-118
- C1 -
4JDI
1
PAK4_HUMAN
A:
[55-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
------
24
PsiBlast_CBE
79.90
75%
-116
- C1 -
4FIF
1
PAK4_HUMAN
B:
[54-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
------
6
PsiBlast_PDB
79.80
75%
-115
- C1 -
4FIF
1
PAK4_HUMAN
A:
[54-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
------
26
PsiBlast_CBE
78.55
74%
-119
- C1 -
4APP
2
A:
[4-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
T
R
----
16
PsiBlast_PDB
78.13
75%
-118
- C1 -
4O0V
1
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
------
25
PsiBlast_CBE
78.12
74%
-120
- C1 -
4NJD
1
PAK4_HUMAN
A:
[4-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
------
39
PsiBlast_CBE
74.27
48%
-122
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[2-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
---
47
PsiBlast_CBE
70.69
47%
-122
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
I
I
V
S
V
G
---
D
P
K
-----
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
L
------
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
38
PsiBlast_CBE
70.58
48%
-125
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[8-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
--
36
PsiBlast_CBE
70.50
48%
-123
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[8-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
----------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
--
43
PsiBlast_CBE
70.25
48%
-114
- C1 -
4O0T
1
PAK1_HUMAN
A:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
--
44
PsiBlast_CBE
70.13
48%
-119
- C1 -
4O0R
1
PAK1_HUMAN
A:
[1-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
---
35
PsiBlast_CBE
69.08
48%
-125
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[8-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
--
31
PsiBlast_CBE
67.89
48%
-126
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[3-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-----
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
-----
34
PsiBlast_CBE
67.51
48%
-127
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[8-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
------
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
----
37
PsiBlast_CBE
67.37
48%
-115
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
--
30
PsiBlast_CBE
67.13
48%
-129
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[5-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
-----
40
PsiBlast_CBE
66.94
48%
-115
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[2-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----
Q
-
Q
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
---
45
PsiBlast_CBE
64.46
48%
-125
- C1 -
4P90
1
PAK1_HUMAN
B:
[9-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---------------
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
-------------
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
--
81
PsiBlast_CBE
63.69
36%
-117
- C1 -
4U44
2
M4K4_HUMAN
A:
[21-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
---
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SH---
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
T
K
GNT------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
---
E
N
A
E
V
K
L
V
D
F
G
V
S
A
-------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
---
I
-----
A
CDENP
D
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
-
Q
P
N
E
-
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
--
78
PsiBlast_CBE
63.20
36%
-118
- C1 -
4ZK5
2
?
A:
[21-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
---
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
T
K
GNT------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
---
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
---
I
-----
A
CDENP
D
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
-
Q
P
N
E
-
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
-
80
PsiBlast_CBE
62.66
36%
-115
- C1 -
4U45
1
M4K4_HUMAN
A:
[21-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
---
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
T
K
GNT------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
---
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
---
I
-----
A
CDENP
D
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
-
Q
P
N
E
-
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
-
32
PsiBlast_CBE
60.86
48%
-120
- C1 -
4ZJI
1
?
D:
[7-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
-----
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
---
87
PsiBlast_CBE
60.47
36%
-120
- C1 -
4RVT
2
M4K4_HUMAN
A:
[23-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
---
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-----
E
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
T
K
GNT------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
---
E
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
---
I
-----
A
CDENP
D
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
-
Q
P
N
E
-
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
---
84
PsiBlast_CBE
60.24
36%
-120
- C1 -
4OBP
2
M4K4_HUMAN
A:
[21-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
---
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
T
K
GNT------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
---
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
---
I
-----
A
CDENP
D
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
-
Q
P
N
E
-
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
--
59
PsiBlast_CBE
60.19
37%
-121
- C1 -
5AJQ
2
STK10_HUMAN
A:
[13-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
---
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
E
L
E
D
-----
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
-
I
M
L
E
L
D
R
G
-------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
--
T
-------
F
I
G
T
P
Y
W
M
A
P
E
V
---
V
MCETM
K
-----
D
T
P
-----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
-----
33
PsiBlast_CBE
60.03
48%
-120
- C1 -
4ZJI
1
?
C:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
-------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
---
82
PsiBlast_CBE
59.91
36%
-117
- C1 -
4U43
1
M4K4_HUMAN
A:
[21-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
---
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
T
K
GNT------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
---
E
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
---
I
-----
A
CDENP
D
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
-
Q
P
N
E
-
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
-
52
PsiBlast_CBE
59.34
38%
-104
* C1 *
4O27
1
STK24_HUMAN
B:
[2-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
D
P
E
E
L
F
T
K
L
E
---
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
E
P
G
P
---------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
---
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
--
T
Q
I
K
-
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
---
I
-----
K
-----
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
-------
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-
86
PsiBlast_CBE
59.18
36%
-123
- C1 -
4OBO
2
M4K4_HUMAN
A:
[21-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
---
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
------
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
T
K
GNT------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
---
E
N
A
E
V
K
L
V
D
F
G
--------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
---
I
-----
A
CDENP
D
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
-
Q
P
N
E
-
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
--
54
PsiBlast_CBE
58.75
37%
-124
- C1 -
4USF
1
?
A:
[23-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
E
D
-----
Y
M
V
-
E
I
D
I
L
A
S
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
-
V
M
L
E
L
E
RP-------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
---
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
----------------
T
P
Y
W
M
A
P
E
V
---
V
-----
M
-----
C
E
-RP---
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-
D
S
N
K
-
P
I
R
E
L
I
A
E
A
K
A
E
-----
67
PsiBlast_CBE
58.13
37%
-121
- C1 -
4AOT
1
STK10_HUMAN
A:
[16-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
---
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
E
D
-----
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
-
I
M
L
E
L
D
R
G
-------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
S
A
----------------
G
T
P
Y
W
M
A
P
E
V
---
V
M------------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
---
53
PsiBlast_CBE
57.84
37%
-120
- C1 -
4USF
1
?
B:
[23-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
E
D
-----
Y
M
V
-
E
I
D
I
L
A
S
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
-
V
M
L
E
L
E
R
P
-------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
---
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
------------
F
I
G
T
P
Y
W
M
A
P
E
V
---
V
-----
M
-----
C
E
T
SKDRP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-
D
S
N
K
-
P
I
R
E
L
I
A
E
A
K
A
E
-----
28
PsiBlast_CBE
57.83
48%
-129
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[6-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
E
K
L
R
S
I
V
S
V
------
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
N
L
----
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
--------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
----
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-----
R
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
---
63
PsiBlast_CBE
57.72
37%
-125
- C1 -
4USD
1
?
B:
[16-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
---
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
E
D
-----
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
-
I
M
L
E
L
D
R
G
-------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
------------------
G
T
P
Y
W
M
A
P
E
V
---
V
MC-----------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
---
29
PsiBlast_CBE
57.37
48%
-123
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[5-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
---
D
P
K
K
K
Y
T
R
F
E
---
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
----
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
---------
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
---
V
-----
T
-------
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
-
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
--
83
PsiBlast_CBE
57.09
36%
-120
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[21-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
---
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
------------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
K
N
T
K
GNT------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
---
E
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
---
I
-----
A
CDENP
D
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
-
Q
P
N
E
-
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
-
89
PsiBlast_CBE
56.00
36%
-117
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[18-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
------
T
F
V
G
T
P
C
W
M
A
P
E
V
---
M
-----
E
-----
Q
V
R
G----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
K
--------------------
73
PsiBlast_CBE
55.67
37%
-111
- C1 -
4NZW
1
STK25_HUMAN
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
SRV
D
P
E
E
L
F
T
K
L
D
---
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
I
T
R
Y
F
G
S
Y
L
K
------
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
K
P
G
P
---------
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
---
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
-----------------
T
P
F
W
M
A
P
E
V
---
I
-----
K
-----
Q
-------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
P
T
L
E
G
Q
-------
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
-
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
--
91
PsiBlast_CBE
54.50
36%
-117
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[18-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG---------
V
G
T
P
C
W
M
A
P
E
V
---
M
-----
E
-----
Q
V
R
G----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
K
--------------------
76
PsiBlast_CBE
54.43
37%
-110
- C1 -
4FZD
1
STK26_HUMAN
B:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
D
P
E
E
L
F
T
K
L
E
---
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
G
P
---------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
---
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
---------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
---
I
-----
Q
-----
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
D
-------
F
T
K
S
--
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
S
K
K
-
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
88
PsiBlast_CBE
54.24
36%
-119
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[18-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
I
T
R
N---
F
V
G
T
P
C
W
M
A
P
E
V
---
M
-----
E
-----
Q
V
R
G----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
K
--------------------
56
PsiBlast_CBE
53.66
37%
-120
- C1 -
2J51
5
SLK_HUMAN
A:
[44-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
E
D
-----
Y
M
V
-
E
I
D
I
L
A
S
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
-
V
M
L
E
L
E
RP-------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
---
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
--
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
---
V
-----
M
-----
C
E
T
SKDRP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-
D
S
N
K
-
P
I
R
E
L
I
A
E
A
K
-------
90
PsiBlast_CBE
52.97
36%
-118
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[18-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
----------
T
P
C
W
M
A
P
E
V
---
M
-----
E
-----
Q
V
R
G----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
K
--------------------
65
PsiBlast_CBE
52.19
37%
-123
- C1 -
4EQU
2
STK10_HUMAN
A:
[16-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
---
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
L
E
D
-----
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
-
I
M
L
E
L
D
R
G
-------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
------------
I
G
T
P
Y
W
M
A
P
E
V
---
V
M
C
E
T
M
K
-----
D
T
P
-----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
62
PsiBlast_CBE
52.16
37%
-122
- C1 -
4USE
1
?
A:
[16-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
---
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
E
D
-----
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
-
I
M
L
E
L
D
R
G
-------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
--
T
L
Q
--------
T
P
Y
W
M
A
P
E
V
---
V
M
C
E
T
M
K
-----
D
T
P
-----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-
64
PsiBlast_CBE
52.06
37%
-122
- C1 -
4EQU
2
STK10_HUMAN
B:
[16-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
---
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
-----
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
-
I
M
L
E
L
D
R
G
-------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----------
F
I
G
T
P
Y
W
M
A
P
E
V
---
V
M
C
E
T
M
K
-----
D
T
P
-----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
55
PsiBlast_CBE
51.63
37%
-122
- C1 -
2UV2
6
SLK_HUMAN
A:
[44-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
E
D
-----
Y
M
V
-
E
I
D
I
L
A
S
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
-
V
M
L
E
L
E
R
P
-------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
---
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
--
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
---
V
-----
M
-----
C
E
T
SKDRP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-
D
S
N
K
-
P
I
R
E
L
I
A
E
A
K
-------
75
PsiBlast_CBE
51.56
37%
-102
- C1 -
4FZF
1
?
B:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
D
P
E
E
L
F
T
K
L
E
---
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
G
P
---------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
---
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
--
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
---
I
-----
Q
-----
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
D
-------
F
T
K
S
--
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
S
K
K
-
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
19
PsiBlast_PDB
50.03
75%
-85
- C1 -
5BMS
1
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
---
D
P
R
S
Y
L
D
N
F
I
---
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
-
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
T
H
T
R
---------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
---
I
-----
S
-----
R
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
-
A
G
P
P
-
A
S
I
V
P
L
M
R
Q
N
R
------
58
PsiBlast_CBE
49.75
38%
-104
- C1 -
3GGF
1
STK26_HUMAN
A:
[19-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
D
P
E
E
L
F
T
K
L
E
---
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
G
P
---------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
---
E
Q
G
D
V
K
L
A
D
F
G
V
A
------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
---
I
-----
Q
-----
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
D
-------
F
T
K
S
--
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
S
K
K
-
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
57
PsiBlast_CBE
48.78
38%
-102
- C1 -
3GGF
1
STK26_HUMAN
B:
[19-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
D
P
E
E
L
F
T
K
L
E
---
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
G
P
---------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
---
E
Q
G
D
V
K
L
A
D
F
G
V
A
-------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
---
I
-----
Q
-----
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
D
-------
F
T
K
S
--
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
S
K
K
-
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
77
PsiBlast_CBE
48.53
37%
-100
- C1 -
4FZA
3
STK26_HUMAN
B:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
D
P
E
E
L
F
T
K
L
E
---
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
R
A
G
P
---------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
---
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
--
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
---
I
-----
Q
-----
Q
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
D
-------
F
T
K
S
--
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
S
K
K
-
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
92
PsiBlast_CBE
47.87
36%
-114
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[23-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG-------
T
F
V
G
T
P
C
W
M
A
P
E
V
---
M
-----
E
-----
Q
V
R
G----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
K
N
K
-
E
----------------
95
PsiBlast_CBE
44.80
36%
-105
- C1 -
5D9H
1
?
A:
[26-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
-
E
I
Q
A
M
S
Q
C
S
H
P
-
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
-
I
I
K
Y
I
V
N
R
GEHKNGV
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
V
T
R
-----
V
G
T
P
C
W
M
A
P
E
V
---
M
-----
E
-----
Q
V
R
G----
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
T
L
E
T
G
VKEMM--
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
-
A
K
N
R
-
E
Y
L
I
E
K
L
L
---------
108
PsiBlast_CBE
43.15
31%
-114
- C1 -
4A9T
4
CHK2_HUMAN
A:
[11-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------P
A
L
N
-
V
E
T
-
E
I
E
I
L
K
K
L
N
H
P
-
C
I
I
K
I
-
K
N
F
F
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
C
L
I
K
I
T
D
F
G
H
-
S
K
I
L
G
--
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
-----
G
-----
T
A
G
-----
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-
E
D
M
K
-
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
94
PsiBlast_CBE
41.81
36%
-108
- C1 -
5D9H
1
?
B:
[26-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
-----
L
L
K
-
E
I
Q
A
M
S
Q
C
S
H
P
-
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
-
I
I
K
Y
I
V
NRGEHKNGV
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
V
T
R
N-----
G
T
P
C
W
M
A
P
E
V
---
M
-----
E
-----
Q
V
R
G----
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
T
L
E
T
G
VEDKEMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
-
A
K
N
R
-
E
Y
L
I
E
K
L
L
T
--------
97
PsiBlast_CBE
41.05
31%
-124
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[11-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------N----
V
E
T
-
E
I
E
I
L
K
K
L
N
H
P
-
C
I
I
K
I
-
K
N
F
F
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
C
L
I
K
I
T
D
F
G
H
-
S
K
I
L
---
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
-----
G
-----
T
A
G
-----
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
T
S
G
K
Y
N
F
IPEVW--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-
E
D
M
K
-
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
101
PsiBlast_CBE
40.48
31%
-118
- C1 -
4BDF
3
CHK2_HUMAN
A:
[11-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------N----
V
E
T
-
E
I
E
I
L
K
K
L
N
H
P
-
C
I
I
K
I
-
K
N
F
F
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
C
L
I
K
I
T
D
F
G
H
-
S
K
I
L
G
--
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
-----
G
-----
T
A
G
-----
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
T
S
G
K
Y
N
F
IPEVW--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-
E
D
M
K
-
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
107
PsiBlast_CBE
40.08
31%
-118
- C1 -
4A9U
10
CHK2_HUMAN
A:
[11-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------DP
A
L
N
V
E
T
-
E
I
E
I
L
K
K
L
N
H
P
-
C
I
I
K
I
-
K
N
F
F
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
C
L
I
K
I
T
D
F
G
H
-
S
K
I
L
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
-----
G
-----
T
A
G
-----
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
T
S
G
K
Y
N
F
IPEVW--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-
E
D
M
K
-
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
109
PsiBlast_CBE
39.95
31%
-121
- C1 -
4A9S
1
CHK2_HUMAN
A:
[11-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------P
A
L
N
-
V
E
T
-
E
I
E
I
L
K
K
L
N
H
P
-
C
I
I
K
I
-
K
N
F
F
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
SQE
E
D
C
L
I
K
I
T
D
F
G
H
-
S
K
I
L
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
-----
G
-----
T
A
G
-----
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
T
S
G
K
Y
N
F
IPEVW--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-
E
D
M
K
-
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
106
PsiBlast_CBE
38.75
31%
-121
- C1 -
4BDA
8
CHK2_HUMAN
A:
[11-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------N----
V
E
T
-
E
I
E
I
L
K
K
L
N
H
P
-
C
I
I
K
I
-
K
N
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