@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TRPM6_HUMAN: (2015-10-21 )
MKEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTCKKLPHSWSNVICAEVLGSMEIAGEKKYQYYSMPSSLLRSLAGGRHPPRVQRGALLEITNSKREATNVRNDQERQETQSSIVVSGVSPNRQAHSKYGQFLLVPSNLKRVPFSAETVLPLSRPSVPDVLATEQDIQTEVLVHLTGQTPVVSDWASVDEPKEKHEPIAHLLDGQDKAEQVLPTLSCTPEPMTMSSPLSQAKIMQTGGGYVNWAFSEGDETGVFSIKKKWQTCLPSTCDSDSSRSEQHQKQAQDSSLSDNSTRSAQSSECSEVGPWLQPNTSFWINPLRRYRPFARSHSFRFHKEEKLMKICKIKNLSGSSEIGQGAWVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQLNPEPGENSISEEEYSKNWFTVSKFSHTGVEPYIHQKMKTKEIGQCAIQISDYLKQSQEDLSKNSLWNSRSTNLNRNSLLKSSIGVDKISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITVYRLEESSPLNLDKSMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQVFIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVFLIYCHSANQWLTIEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDLKRNDYSPERINSTFGLEIKIESAEEPPARETGRNSPEDDMQL
Atome Classification :
(12 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......-1850......1860......1870-........1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKE
Q
P
V
L
E
R
L
Q
S
Q
K
S
W
I
K
G
V
FDK
R
E
C
S
T
IIPSSKNPHRC
T
P
V
C
Q
V
C
Q
N
L
I
R
C
Y
C
G
R
L
I
GDHAGI
D
Y
S
W
T
I
SAAKGKESE
Q
W
SVEKHTTKSPTDT
F
G
T
I
N
FQDGEHTH
H
A
K
Y
I
RTSYD
T
K
L
D
H
L
L
H
L
M
L
K
E
W
K
M
E
L
P
K
L
V
I
S
VHGGIQNFTM
P
S
K
F
K
E
I
F
S
Q
G
L
V
K
AAETT
G
A
W
I
I
TEGINT
G
V
S
K
H
V
G
D
A
L
K
SHSSHS
L
R
K
I
W
TVGIPPWGVIE
N
Q
R
D
L
I
G
K
D
V
V
C
L
Y
Q
T
LD
N
P
L
S
K
L
T
T
L
N
SMH
S
H
F
I
LSDDGTVGKYG
N
E
M
K
L
R
R
N
L
E
K
Y
L
S
L
Q
K
I
HCRSRQGV
P
V
V
G
L
V
VEGGP
N
V
I
L
S
V
W
E
TVKDKD
P
V
V
V
CEGTG
R
A
A
D
L
L
A
F
T
H
K
H
L
A
DEGMLR
P
Q
V
K
E
E
I
I
C
M
I
QNTFNF
S
L
KQ
S
K
H
L
F
Q
I
L
M
E
C
M
VHR
D
C
I
T
I
FDADS
E
E
Q
Q
D
L
D
L
A
I
L
T
A
L
L
KGTNLSAS
E
Q
L
N
L
A
M
A
W
D
R
V
D
I
A
K
K
H
I
L
I
Y
EQHWK
P
D
A
L
E
Q
A
M
S
D
A
L
V
M
D
R
V
D
F
V
K
L
L
I
E
YGV
N
L
H
R
FLT
I
P
R
L
E
E
L
YNTKQG
P
T
N
T
L
L
H
H
L
V
Q
D
V
K
Q
H
TLLSG
Y
R
I
T
L
I
D
I
G
L
V
V
E
Y
L
I
G
R
A
Y
RSNY
T
R
K
H
F
R
A
L
Y
N
N
L
Y
R
K
Y
K
H
Q
RHSSGNRNE
S
A
E
S
T
L
H
S
Q
F
I
RTAQPYKFKE
K
S
I
V
L
H
K
SRKKSKEQNVSDDPEST
G
F
LY
P
Y
N
D
L
L
V
W
A
V
L
M
K
R
Q
K
M
A
M
F
F
W
QHGE
E
A
T
V
K
A
V
I
A
C
I
L
Y
R
A
M
A
H
E
A
K
E
SHMVD
D
A
S
E
E
L
K
N
Y
S
K
Q
F
G
Q
L
A
L
D
L
L
E
K
A
F
KQNE
R
M
A
M
T
L
L
T
Y
ELRNWSN
S
T
C
L
K
L
A
VSGGL
R
P
F
V
S
H
T
C
T
Q
M
L
L
T
D
M
W
M
G
R
L
KMRK
N
S
W
L
K
I
I
I
S
I
ILPP
T
I
L
T
L
E
FKSKAEMSHVPQSQ
D
F
Q
F
M
W
Y
YSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHL
P
W
T
R
K
V
Y
E
F
Y
SA
P
I
V
K
F
W
F
Y
T
M
A
Y
L
A
F
L
M
L
F
T
Y
T
V
L
V
EMQPQP
S
V
Q
E
W
L
V
S
I
Y
I
F
T
N
A
I
E
V
V
R
E
I
CISEP
G
K
F
T
Q
K
V
K
V
W
I
S
E
YWN
L
T
E
T
V
A
I
G
L
FSA
G
F
V
L
R
WGDPPFHTA
G
R
L
I
Y
C
I
D
I
I
F
W
F
S
R
L
L
D
F
F
A
VNQHAG
P
Y
V
T
M
I
A
K
M
TA
N
M
F
Y
I
V
I
I
M
A
I
V
L
L
S
F
G
V
A
R
K
AILSPKEPPS
W
S
L
A
R
D
I
VFE
P
Y
W
M
I
Y
G
E
V
Y
A
G
E
I
D
VCSSQPSCPP
G
S
F
L
T
P
F
L
Q
A
V
Y
L
F
V
Q
Y
I
I
M
V
N
L
L
I
A
F
F
N
N
V
Y
L
D
M
E
S
ISNNLWKY
N
R
Y
R
Y
I
M
T
YHEKPWLP
P
P
L
I
L
L
S
H
V
G
L
L
L
R
R
L
CCHRAPHDQEEGDV
G
L
K
L
Y
L
S
K
E
D
L
K
K
L
H
D
F
E
E
Q
C
V
E
K
Y
F
H
E
K
M
EDVNC
S
C
E
E
R
I
R
V
T
S
E
R
V
T
E
M
Y
F
Q
L
K
E
M
N
E
K
V
S
F
I
K
D
S
L
L
S
L
D
S
QVG
H
L
Q
D
L
S
A
L
T
V
D
T
L
K
V
L
S
A
V
D
T
LQ
E
D
E
A
L
L
A
K
R
K
H
S
T
C
K
KLPH
S
W
S
N
V
I
C
A
E
V
LGSMEIAGEK
K
Y
Q
Y
YSM
P
S
S
L
L
R
S
L
AGGRHPPRVQR
G
A
L
L
E
ITNSKREATNVR
N
D
Q
E
R
Q
E
T
Q
S
S
I
V
V
SGVSP
N
R
Q
A
H
S
KYG
Q
F
L
L
VPSNLKRVPFSAETVLPLSRPSVPDVLATEQDI
Q
T
E
V
L
V
H
LTGQTPVVSDWASVDEP
K
E
K
H
E
P
I
A
H
LLDGQ
D
K
A
E
Q
VLPTLSCTPEPMTMSSPLSQ
A
K
I
M
QTGG
G
Y
V
N
W
A
FSEGDET
G
V
F
S
I
K
K
K
W
Q
TCLPSTCDSDS
S
R
S
E
Q
H
Q
K
Q
AQDSSLSDNSTRSAQSS
E
C
S
EVGPWLQPNT
S
F
W
I
N
P
L
R
R
YR
P
F
A
RSHS
F
R
F
H
K
E
E
K
L
M
K
I
C
K
IKNLSGSSEIGQG
A
W
V
K
A
K
M
L
T
K
D
R
R
L
S
K
KKKNTQG
L
Q
V
P
I
I
T
V
NACSQSDQLNPEPGENSI
S
E
E
E
YSKN
W
F
T
V
SKFSHTGV
E
P
Y
I
H
Q
K
M
K
T
K
E
I
G
Q
C
A
I
Q
I
S
D
Y
L
K
Q
S
Q
E
D
L
SKNSLWNSRSTNL
N
R
N
S
L
L
K
S
SI
G
V
D
K
I
S
A
S
LKSPQEPH
H
H
Y
S
A
I
E
RN
N
L
M
R
L
SQTIPFT
P
V
Q
L
FAG
E
E
I
T
V
Y
R
LEESSPLN
L
D
K
S
M
S
S
W
S
QR
G
R
A
A
M
I
Q
V
L
S
R
E
E
M
D
G
G
L
R
K
A
M
R
V
V
STWSEDDILKPG
Q
V
F
I
V
K
S
F
L
P
E
V
V
R
T
W
H
K
I
F
Q
ES
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
I
Y
T
F
NQVKP-QTIPY
T
P
R
F
L
E
V
F
L
I
YCHSAN
Q
---
W
L
T
I
EKYMTG
E
F
RKYNNNNGDEITP
T
N
T
L
E
E
L
M
L
A
F
S
HW
T
Y
E
YTRG
E
L
L
V
L
DLQGVGENLTDPSVI
K
P
E
V
K
QSR
G
M
V
FGPANL
G
E
D
A
I
R
N
F
I
A
K
H
H
C
N
S
C
C
R
KLKLPDLKRNDY
S
P
E
RINSTF
G
L
E
I
K
IESAEEPPARETGRNSPEDDMQL
21
PsiBlast_CBE
91.02
76%
-48
- C5 -
1IA9
2
B:
[2-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
Y
Y
S
A
V
E
R
N
N
L
M
R
L
S
Q
S
I
P
F
V
P
V
P
P
-
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
S
K
E
E
M
G
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
H
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
-
K
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
H
S
A
G
Q
---
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
N
L
T
D
P
S
V
I
K
A
E
E
K
R
S
C
D
M
V
F
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
T
------------------------------------
20
PsiBlast_CBE
89.85
76%
-48
- C5 -
1IAH
2
B:
[2-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
Y
Y
S
A
V
E
R
N
N
L
M
R
L
S
Q
S
I
P
F
V
P
V
P
P
-
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
S
K
E
E
M
G
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
H
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
-
K
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
H
S
A
G
Q
---
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
N
L
T
D
P
S
V
I
K
A
E
E
K
R
S
C
D
M
V
F
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
T
------------------------------------
1
PsiBlast_PDB
89.31
76%
-50
- C5 -
1IA9
2
TRPM7_MOUSE
A:
[3-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
N
N
L
M
R
L
S
Q
S
I
P
F
V
P
V
P
P
-
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
S
K
--
M
G
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
H
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
-
K
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
H
S
A
G
Q
---
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
N
L
T
D
P
S
V
I
K
A
E
E
K
R
S
C
D
M
V
F
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
T
------------------------------------
23
Fugue
89.10
76%
-48
- C5 -
1IA9
2
TRPM7_MOUSE
A:
[3-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
N
N
L
M
R
L
S
Q
S
I
P
F
V
P
V
P
P
-
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
S
K
M
G
--
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
H
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
-
K
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
H
S
A
G
Q
---
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
N
L
T
D
P
S
V
I
K
A
E
E
K
R
S
C
D
M
V
F
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
T
------------------------------------
2
PsiBlast_PDB
88.93
76%
-50
- C5 -
1IAH
2
TRPM7_MOUSE
A:
[3-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
N
N
L
M
R
L
S
Q
S
I
P
F
V
P
V
P
P
-
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
L
N
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
S
K
--
M
G
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
H
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
-
K
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
H
S
A
G
Q
---
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
N
L
T
D
P
S
V
I
K
A
E
E
K
R
S
C
D
M
V
F
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
T
------------------------------------
9
PsiBlast_PDB
47.72
30%
40
- C5 -
4ZS4
1
?
A:
[109-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
--
Q
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
S
P
S
S
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
N
R
S
T
P
Q
----
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
A
I
Q
G
V
D
D
L
Y
T
D
P
Q
I
H
T
P
D
-----
G
K
G
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
-------------------------------------------
5
PsiBlast_PDB
47.70
31%
40
- C5 -
3LLA
1
MHCKA_DICDI
A:
[109-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
--
Q
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
S
P
S
S
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
N
R
S
T
P
Q
----
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
L
Y
T
D
P
Q
I
H
T
P
D
-----
G
K
G
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
L
-----------------------------------------
7
PsiBlast_PDB
47.24
30%
39
- C5 -
4ZME
1
?
A:
[109-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
---
Q
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
S
P
S
S
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
N
R
S
T
P
Q
----
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
L
Y
T
-
P
Q
I
H
T
P
D
-----
G
K
G
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
L
G
G
V
L
S
G
-----------------------------------
4
PsiBlast_PDB
47.23
31%
41
- C5 -
3LKM
1
A:
[109-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
--
Q
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
S
P
S
S
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
N
R
S
T
P
Q
----
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
L
Y
T
D
P
Q
I
H
T
P
D
-----
G
K
G
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
-------------------------------------------
6
PsiBlast_PDB
46.96
31%
41
- C5 -
3PDT
1
A:
[109-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
--
Q
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
S
P
S
S
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
N
R
S
T
P
Q
----
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
L
Y
T
D
P
Q
I
H
T
P
D
-----
G
K
G
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
L
-----------------------------------------
22
PsiBlast_CBE
46.84
31%
40
- C5 -
3LLA
1
B:
[109-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
--
Q
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
S
P
S
-
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
N
R
S
T
P
Q
----
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
L
Y
T
D
P
Q
I
H
T
P
D
-----
G
K
G
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
L
G
G
---------------------------------------
8
PsiBlast_PDB
46.74
30%
33
- C5 -
4ZMF
1
?
A:
[109-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
L
Y
K
K
E
A
----
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
S
P
S
S
N
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
N
R
S
T
P
Q
----
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
L
Y
T
-
P
Q
I
H
T
P
D
-----
G
K
G
F
G
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
------------------------------------------